{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:00:33Z","timestamp":1782234033832,"version":"3.54.5"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":752,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"DOI":"10.1165\/rcmb.2023-0327ed","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T16:38:17Z","timestamp":1696351097000},"page":"8-10","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":4,"title":["Pleural Fibrosis: Now That\u2019s What mTORC(ing) About"],"prefix":"10.1093","volume":"70","author":[{"given":"Steven E.","family":"Mutsaers","sequence":"first","affiliation":[{"name":"Institute for Respiratory Health and School of Biomedical Sciences The University of Western Australia Nedlands, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera P.","family":"Krymskaya","sequence":"additional","affiliation":[{"name":"Department of Medicine, Lung Biology Institute Perelman School of Medicine at the University of Pennsylvania Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,1]]},"reference":[{"key":"2026012204054952400_bib1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3389\/fphar.2015.00113","article-title":"Mesothelial cells in tissue repair and fibrosis","volume":"6","author":"Mutsaers","year":"2015","journal-title":"Front Pharmacol"},{"key":"2026012204054952400_bib2","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1440-1843.2004.00633.x","article-title":"Pathogenesis of pleural fibrosis","volume":"9","author":"Mutsaers","year":"2004","journal-title":"Respirology"},{"key":"2026012204054952400_bib3","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.exer.2015.07.009","article-title":"Myofibroblasts","volume":"142","author":"Hinz","year":"2016","journal-title":"Exp Eye Res"},{"key":"2026012204054952400_bib4","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.3390\/ijms23031587","article-title":"Update on novel targeted therapy for pleural organization and fibrosis","volume":"23","author":"Tucker","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026012204054952400_bib5","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/path.5680","article-title":"TGF-\u03b2 as a driver of fibrosis: physiological roles and therapeutic opportunities","volume":"254","author":"Budi","year":"2021","journal-title":"J Pathol"},{"key":"2026012204054952400_bib6","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/jcp.25879","article-title":"TGF\u03b2 signaling and the control of myofibroblast differentiation: implications for chronic inflammatory disorders","volume":"233","author":"Carthy","year":"2018","journal-title":"J Cell Physiol"},{"key":"2026012204054952400_bib7","doi-asserted-by":"crossref","first-page":"L1265","DOI":"10.1152\/ajplung.00396.2014","article-title":"Mesomesenchymal transition of pleural mesothelial cells is PI3K and NF-\u03baB dependent","volume":"308","author":"Owens","year":"2015","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026012204054952400_bib8","article-title":"The mTORC2\/SGK1\/NDRG1 signaling axis is critical for mesomesenchymal transition of pleural mesothelial cells and the progression of pleural fibrosis","author":"Keshava","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012204054952400_bib9","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41467-018-07858-8","article-title":"The mTORC1\/4E-BP1 axis represents a critical signaling node during fibrogenesis","volume":"10","author":"Woodcock","year":"2019","journal-title":"Nat Commun"},{"key":"2026012204054952400_bib10","doi-asserted-by":"crossref","first-page":"e106155","DOI":"10.1371\/journal.pone.0106155","article-title":"A critical role for the mTORC2 pathway in lung fibrosis","volume":"9","author":"Chang","year":"2014","journal-title":"PLoS One"},{"key":"2026012204054952400_bib11","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1242\/jcs.095299","article-title":"TGF-\u03b2-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion","volume":"125","author":"Lamouille","year":"2012","journal-title":"J Cell Sci"},{"key":"2026012204054952400_bib12","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1007\/s11033-014-3321-4","article-title":"Inhibition of mTOR pathway attenuates migration and invasion of gallbladder cancer via EMT inhibition","volume":"41","author":"Zong","year":"2014","journal-title":"Mol Biol Rep"},{"key":"2026012204054952400_bib13","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1111\/ajt.13132","article-title":"Fibrosis progression according to epithelial-mesenchymal transition profile: a randomized trial of everolimus versus CsA","volume":"15","author":"Rostaing","year":"2015","journal-title":"Am J Transplant"},{"key":"2026012204054952400_bib14","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1177\/0284185120950100","article-title":"Everolimus-induced pneumonitis in neuroendocrine neoplasms: correlation of CT findings and clinical signs","volume":"62","author":"Fehrenbach","year":"2021","journal-title":"Acta Radiol"},{"key":"2026012204054952400_bib15","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1056\/NEJMoa1100391","article-title":"Efficacy and safety of sirolimus in lymphangioleiomyomatosis","volume":"364","author":"McCormack","year":"2011","journal-title":"N Engl J Med"},{"key":"2026012204054952400_bib16","doi-asserted-by":"crossref","first-page":"230100","DOI":"10.1183\/16000617.0100-2023","article-title":"Lost in translation: a neglected mTOR target for lymphangioleiomyomatosis","volume":"32","author":"Evans","year":"2023","journal-title":"Eur Respir Rev"},{"key":"2026012204054952400_bib17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13578-020-00396-1","article-title":"mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges","volume":"10","author":"Zou","year":"2020","journal-title":"Cell Biosci"}],"container-title":["American Journal of Respiratory Cell and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/70\/1\/8\/66296244\/ajrcmb_70_1_8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/70\/1\/8\/66296244\/ajrcmb_70_1_8.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:11:47Z","timestamp":1769073107000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article\/70\/1\/8\/8416177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,1]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1,1]]},"published-print":{"date-parts":[[2024,1,1]]}},"URL":"https:\/\/doi.org\/10.1165\/rcmb.2023-0327ed","relation":{},"ISSN":["1044-1549","1535-4989"],"issn-type":[{"value":"1044-1549","type":"print"},{"value":"1535-4989","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1]]},"published":{"date-parts":[[2024,1,1]]},"assertion":[{"value":"2023-12-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}