{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:46:15Z","timestamp":1790772375409,"version":"4.1.0"},"reference-count":139,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":570,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070001"],"award-info":[{"award-number":["82070001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Project of the 8th Center of Chinese PLA General Hospital","award":["2021ZD008"],"award-info":[{"award-number":["2021ZD008"]}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["21JCQNJC00510"],"award-info":[{"award-number":["21JCQNJC00510"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070001"],"award-info":[{"award-number":["82070001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Project of the 8th Center of Chinese PLA General Hospital","award":["2021ZD008"],"award-info":[{"award-number":["2021ZD008"]}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"crossref","award":["21JCQNJC00510"],"award-info":[{"award-number":["21JCQNJC00510"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alveoli are complex microenvironments composed of various cell types, including epithelial, fibroblast, endothelial, and immune cells, which work together to maintain a delicate balance in the lung environment, ensuring proper growth, development, and an effective response to lung injuries. However, prolonged inflammation or aging can disrupt normal interactions among these cells, leading to impaired repair processes and a substantial decline in lung function. Therefore, it is essential to understand the key mechanisms underlying the interactions among the major cell types within the alveolar microenvironment. We explored the key mechanisms underlying the interactions among the major cell types within the alveolar microenvironment. These interactions occur through the secretion of signaling factors and play crucial roles in the response to injury, repair mechanisms, and the development of fibrosis in the lungs. Specifically, we focused on the regulation of alveolar type 2\u2009cells by fibroblasts, endothelial cells, and macrophages. In addition, we explored the diverse phenotypes of fibroblasts at different stages of life and in response to lung injury, highlighting their impact on matrix production and immune functions. Furthermore, we summarize the various phenotypes of macrophages in lung injury and fibrosis as well as their intricate interplay with other cell types. This interplay can either contribute to the restoration of immune homeostasis in the alveoli or impede the repair process. Through a comprehensive exploration of these cell interactions, we aim to reveal new insights into the molecular mechanisms that drive lung injury toward fibrosis and identify potential targets for therapeutic intervention.<\/jats:p>","DOI":"10.1165\/rcmb.2023-0426tr","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T15:20:27Z","timestamp":1712330427000},"page":"30-42","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":62,"title":["Cell Cross-Talk in Alveolar Microenvironment: From Lung Injury to Fibrosis"],"prefix":"10.1093","volume":"71","author":[{"given":"Licheng","family":"Song","sequence":"first","affiliation":[{"name":"College of Pulmonary and Critical Care Medicine, 8th Medical Center of Chinese PLA General Hospital, Beijing, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Lung Regenerative Medicine, Haihe Hospital, Tianjin University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiyong","family":"Chen","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Lung Regenerative Medicine, Haihe Hospital, Tianjin University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Pulmonary and Critical Care Medicine, 8th Medical Center of Chinese PLA General Hospital, Beijing, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,1]]},"reference":[{"key":"2026012204194062900_bib1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41586-020-2922-4","article-title":"A molecular cell atlas of the human lung from single-cell RNA sequencing","volume":"587","author":"Travaglini","year":"2020","journal-title":"Nature"},{"key":"2026012204194062900_bib2","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.3390\/ijms22052566","article-title":"The history and mystery of alveolar epithelial type II cells: focus on their physiologic and pathologic role in lung","volume":"22","author":"Ruaro","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026012204194062900_bib3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41586-022-04541-3","article-title":"Human distal lung maps and lineage hierarchies reveal a bipotent progenitor","volume":"604","author":"Kadur Lakshminarasimha Murthy","year":"2022","journal-title":"Nature"},{"key":"2026012204194062900_bib4","doi-asserted-by":"crossref","first-page":"4362","DOI":"10.1073\/pnas.1813952116","article-title":"Early lineage specification defines alveolar epithelial ontogeny in the murine lung","volume":"116","author":"Frank","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026012204194062900_bib5","doi-asserted-by":"crossref","first-page":"e170498","DOI":"10.1172\/JCI170498","article-title":"The lung mesenchyme in development, regeneration, and fibrosis","volume":"133","author":"El Agha","year":"2023","journal-title":"J Clin Invest"},{"key":"2026012204194062900_bib6","first-page":"54","article-title":"The development and plasticity of alveolar type 1 cells","volume":"143","author":"Yang","year":"2016","journal-title":"Development"},{"key":"2026012204194062900_bib7","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nature13903","article-title":"p63+Krt5+ distal airway stem cells are essential for lung regeneration","volume":"517","author":"Zuo","year":"2015","journal-title":"Nature"},{"key":"2026012204194062900_bib8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41586-022-04552-0","article-title":"Human distal airways contain a multipotent secretory cell that can regenerate alveoli","volume":"604","author":"Basil","year":"2022","journal-title":"Nature"},{"key":"2026012204194062900_bib9","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1128\/IAI.00950-12","article-title":"Alveolar epithelial cells are critical in protection of the respiratory tract by secretion of factors able to modulate the activity of pulmonary macrophages and directly control bacterial growth","volume":"81","author":"Chuquimia","year":"2013","journal-title":"Infect Immun"},{"key":"2026012204194062900_bib10","doi-asserted-by":"crossref","first-page":"e152404","DOI":"10.1172\/jci.insight.152404","article-title":"Maladaptive functional changes in alveolar fibroblasts due to perinatal hyperoxia impair epithelial differentiation","volume":"7","author":"Riccetti","year":"2022","journal-title":"JCI Insight"},{"key":"2026012204194062900_bib11","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nature25786","article-title":"Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor","volume":"555","author":"Zacharias","year":"2018","journal-title":"Nature"},{"key":"2026012204194062900_bib12","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.3390\/biom12091273","article-title":"New insights into the alveolar epithelium as a driver of acute respiratory distress syndrome","volume":"12","author":"Sanches Santos Rizzo Zuttion","year":"2022","journal-title":"Biomolecules"},{"key":"2026012204194062900_bib13","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.stem.2020.06.020","article-title":"Inflammatory signals induce AT2 cell-derived damage-associated transient progenitors that mediate alveolar regeneration","volume":"27","author":"Choi","year":"2020","journal-title":"Cell Stem Cell"},{"key":"2026012204194062900_bib14","doi-asserted-by":"crossref","first-page":"2004168","DOI":"10.1183\/13993003.04168-2020","article-title":"Identification of a novel subset of alveolar type 2 cells enriched in PD-L1 and expanded following pneumonectomy","volume":"58","author":"Ahmadvand","year":"2021","journal-title":"Eur Respir J"},{"key":"2026012204194062900_bib15","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1126\/science.aam6603","article-title":"Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells","volume":"359","author":"Nabhan","year":"2018","journal-title":"Science"},{"key":"2026012204194062900_bib16","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1016\/j.celrep.2019.02.046","article-title":"Dlk1-mediated temporal regulation of notch signaling is required for differentiation of alveolar type II to type I cells during repair","volume":"26","author":"Finn","year":"2019","journal-title":"Cell Rep"},{"key":"2026012204194062900_bib17","doi-asserted-by":"crossref","first-page":"109092","DOI":"10.1016\/j.celrep.2021.109092","article-title":"Alveolar epithelial cell fate is maintained in a spatially restricted manner to promote lung regeneration after acute injury","volume":"35","author":"Liberti","year":"2021","journal-title":"Cell Rep"},{"key":"2026012204194062900_bib18","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0092-8674(00)81270-2","article-title":"PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis","volume":"85","author":"Bostr\u00f6m","year":"1996","journal-title":"Cell"},{"key":"2026012204194062900_bib19","doi-asserted-by":"crossref","first-page":"dev163485","DOI":"10.1242\/dev.163485","article-title":"Human lung development: recent progress and new challenges","volume":"145","author":"Nikoli\u0107","year":"2018","journal-title":"Development"},{"key":"2026012204194062900_bib20","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1165\/rcmb.2018-0313OC","article-title":"Defining the activated fibroblast population in lung fibrosis using single-cell sequencing","volume":"61","author":"Peyser","year":"2019","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012204194062900_bib21","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/sctm.20-0526","article-title":"Resident interstitial lung fibroblasts and their role in alveolar stem cell niche development, homeostasis, injury, and regeneration","volume":"10","author":"Ushakumary","year":"2021","journal-title":"Stem Cells Transl Med"},{"key":"2026012204194062900_bib22","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/s41556-020-0569-x","article-title":"STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury","volume":"22","author":"Paris","year":"2020","journal-title":"Nat Cell Biol"},{"key":"2026012204194062900_bib23","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.cell.2017.07.028","article-title":"Anatomically and functionally distinct lung mesenchymal populations marked by Lgr5 and Lgr6","volume":"170","author":"Lee","year":"2017","journal-title":"Cell"},{"key":"2026012204194062900_bib24","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41580-019-0141-3","article-title":"Cellular crosstalk in the development and regeneration of the respiratory system","volume":"20","author":"Zepp","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026012204194062900_bib25","doi-asserted-by":"crossref","first-page":"1258810","DOI":"10.1126\/science.1258810","article-title":"Mesenchymal cells. Defining a mesenchymal progenitor niche at single-cell resolution","volume":"346","author":"Kumar","year":"2014","journal-title":"Science"},{"key":"2026012204194062900_bib26","doi-asserted-by":"crossref","first-page":"L872","DOI":"10.1152\/ajplung.00254.2018","article-title":"The Tcf21 lineage constitutes the lung lipofibroblast population","volume":"316","author":"Park","year":"2019","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026012204194062900_bib27","doi-asserted-by":"crossref","first-page":"8242","DOI":"10.1073\/pnas.1511236113","article-title":"Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity","volume":"113","author":"Tsao","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026012204194062900_bib28","doi-asserted-by":"crossref","first-page":"eabc3172","DOI":"10.1126\/science.abc3172","article-title":"Genomic, epigenomic, and biophysical cues controlling the emergence of the lung alveolus","volume":"371","author":"Zepp","year":"2021","journal-title":"Science"},{"key":"2026012204194062900_bib29","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1165\/rcmb.2019-0079OC","article-title":"FGFR2 is required for AEC2 homeostasis and survival after bleomycin-induced lung injury","volume":"62","author":"Dorry","year":"2020","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012204194062900_bib30","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1016\/j.cell.2021.06.024","article-title":"Fibroblasts: origins, definitions, and functions in health and disease","volume":"184","author":"Plikus","year":"2021","journal-title":"Cell"},{"key":"2026012204194062900_bib31","doi-asserted-by":"crossref","first-page":"108549","DOI":"10.1016\/j.celrep.2020.108549","article-title":"Identification of a repair-supportive mesenchymal cell population during airway epithelial regeneration","volume":"33","author":"Moiseenko","year":"2020","journal-title":"Cell Rep"},{"key":"2026012204194062900_bib32","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.dib.2017.06.001","article-title":"Dataset on transcriptional profiles and the developmental characteristics of PDGFR\u03b1 expressing lung fibroblasts","volume":"13","author":"Endale","year":"2017","journal-title":"Data Brief"},{"key":"2026012204194062900_bib33","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1165\/rcmb.2012-0030OC","article-title":"Dynamic regulation of platelet-derived growth factor receptor \u03b1 expression in alveolar fibroblasts during realveolarization","volume":"47","author":"Chen","year":"2012","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012204194062900_bib34","doi-asserted-by":"crossref","first-page":"dev176354","DOI":"10.1242\/dev.176354","article-title":"Secondary crest myofibroblast PDGFR\u03b1 controls the elastogenesis pathway via a secondary tier of signaling networks during alveologenesis","volume":"146","author":"Li","year":"2019","journal-title":"Development"},{"key":"2026012204194062900_bib35","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1002\/jcb.24811","article-title":"Tissue crosstalk in lung development","volume":"115","author":"Hines","year":"2014","journal-title":"J Cell Biochem"},{"key":"2026012204194062900_bib36","doi-asserted-by":"crossref","first-page":"L455","DOI":"10.1152\/ajplung.00348.2009","article-title":"Control of HIF-1alpha and vascular signaling in fetal lung involves cross talk between mTORC1 and the FGF-10\/FGFR2b\/Spry2 airway branching periodicity clock","volume":"299","author":"Scott","year":"2010","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026012204194062900_bib37","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.devcel.2020.01.009","article-title":"Epithelial Vegfa specifies a distinct endothelial population in the mouse lung","volume":"52","author":"Vila Ellis","year":"2020","journal-title":"Dev Cell"},{"key":"2026012204194062900_bib38","first-page":"106","article-title":"Timing and expression of the angiopoietin-1-Tie-2 pathway in murine lung development and congenital diaphragmatic hernia","volume":"6","author":"Grzenda","year":"2013","journal-title":"Dis Model Mech"},{"key":"2026012204194062900_bib39","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s41467-022-28062-9","article-title":"Characterization of the COPD alveolar niche using single-cell RNA sequencing","volume":"13","author":"Sauler","year":"2022","journal-title":"Nat Commun"},{"key":"2026012204194062900_bib40","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/s41586-020-2822-7","article-title":"Capillary cell-type specialization in the alveolus","volume":"586","author":"Gillich","year":"2020","journal-title":"Nature"},{"key":"2026012204194062900_bib41","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1164\/rccm.201812-2312OC","article-title":"Postnatal alveologenesis depends on FOXF1 signaling in c-KIT+ endothelial progenitor cells","volume":"200","author":"Ren","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204194062900_bib42","doi-asserted-by":"crossref","first-page":"dev199505","DOI":"10.1242\/dev.199505","article-title":"Epithelial Wntless regulates postnatal alveologenesis","volume":"149","author":"Fang","year":"2022","journal-title":"Development"},{"key":"2026012204194062900_bib43","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.cell.2011.10.003","article-title":"Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization","volume":"147","author":"Ding","year":"2011","journal-title":"Cell"},{"key":"2026012204194062900_bib44","doi-asserted-by":"crossref","first-page":"64867","DOI":"10.18632\/oncotarget.19952","article-title":"Tsp1 promotes alveolar stem cell proliferation and its down-regulation relates to lung inflammation in intralobar pulmonary sequestration","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"2026012204194062900_bib45","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.cell.2013.12.039","article-title":"Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis","volume":"156","author":"Lee","year":"2014","journal-title":"Cell"},{"key":"2026012204194062900_bib46","doi-asserted-by":"crossref","first-page":"e56890","DOI":"10.7554\/eLife.56890","article-title":"Diverse homeostatic and immunomodulatory roles of immune cells in the developing mouse lung at single cell resolution","volume":"9","author":"Domingo-Gonzalez","year":"2020","journal-title":"eLife"},{"key":"2026012204194062900_bib47","doi-asserted-by":"crossref","first-page":"eadf9988","DOI":"10.1126\/sciimmunol.adf9988","article-title":"Early human lung immune cell development and its role in epithelial cell fate","volume":"8","author":"Barnes","year":"2023","journal-title":"Sci Immunol"},{"key":"2026012204194062900_bib48","doi-asserted-by":"crossref","first-page":"923235","DOI":"10.3389\/fimmu.2022.923235","article-title":"The emerging roles of interstitial macrophages in pulmonary fibrosis: a perspective from scRNA-seq analyses","volume":"13","author":"Gu","year":"2022","journal-title":"Front Immunol"},{"key":"2026012204194062900_bib49","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nature13989","article-title":"Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors","volume":"518","author":"Gomez Perdiguero","year":"2015","journal-title":"Nature"},{"key":"2026012204194062900_bib50","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.immuni.2022.08.010","article-title":"Biology of lung macrophages in health and disease","volume":"55","author":"Aegerter","year":"2022","journal-title":"Immunity"},{"key":"2026012204194062900_bib51","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/ni.3005","article-title":"Induction of the nuclear receptor PPAR-\u03b3 by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages","volume":"15","author":"Schneider","year":"2014","journal-title":"Nat Immunol"},{"key":"2026012204194062900_bib52","doi-asserted-by":"crossref","first-page":"eabj5761","DOI":"10.1126\/sciimmunol.abj5761","article-title":"Monocyte-derived alveolar macrophages autonomously determine severe outcome of respiratory viral infection","volume":"7","author":"Li","year":"2022","journal-title":"Sci Immunol"},{"key":"2026012204194062900_bib53","doi-asserted-by":"crossref","first-page":"e87536","DOI":"10.1172\/jci.insight.87536","article-title":"A ferret model of COPD-related chronic bronchitis","volume":"1","author":"Raju","year":"2016","journal-title":"JCI Insight"},{"key":"2026012204194062900_bib54","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.stemcr.2020.01.008","article-title":"Autophagy reprograms alveolar progenitor cell metabolism in response to lung injury","volume":"14","author":"Li","year":"2020","journal-title":"Stem Cell Reports"},{"key":"2026012204194062900_bib55","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nature14112","article-title":"Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury","volume":"517","author":"Vaughan","year":"2015","journal-title":"Nature"},{"key":"2026012204194062900_bib56","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1165\/rcmb.2021-0421OC","article-title":"Intermediary role of lung alveolar type 1 cells in epithelial repair upon Sendai virus infection","volume":"67","author":"Hernandez","year":"2022","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012204194062900_bib57","doi-asserted-by":"crossref","first-page":"6727","DOI":"10.1038\/ncomms7727","article-title":"Plasticity of Hopx+ type I alveolar cells to regenerate type II cells in the lung","volume":"6","author":"Jain","year":"2015","journal-title":"Nat Commun"},{"key":"2026012204194062900_bib58","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/j.stem.2021.04.026","article-title":"Age-dependent alveolar epithelial plasticity orchestrates lung homeostasis and regeneration","volume":"28","author":"Penkala","year":"2021","journal-title":"Cell Stem Cell"},{"key":"2026012204194062900_bib59","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41586-021-03569-1","article-title":"A molecular single-cell lung atlas of lethal COVID-19","volume":"595","author":"Melms","year":"2021","journal-title":"Nature"},{"key":"2026012204194062900_bib60","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.medin.2021.02.007","article-title":"Histopathological features in fatal COVID-19 acute respiratory distress syndrome","volume":"45","author":"Merdji","year":"2021","journal-title":"Med Intensiva"},{"key":"2026012204194062900_bib61","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0022-3476(85)80290-0","article-title":"Long-term sequelae in children surviving adult respiratory distress syndrome","volume":"106","author":"Fanconi","year":"1985","journal-title":"J Pediatr"},{"key":"2026012204194062900_bib62","doi-asserted-by":"crossref","first-page":"L755","DOI":"10.1152\/ajplung.00093.2020","article-title":"Aging impairs alveolar epithelial type II cell function in acute lung injury","volume":"319","author":"Yazicioglu","year":"2020","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026012204194062900_bib63","doi-asserted-by":"crossref","first-page":"e157338","DOI":"10.1172\/JCI157338","article-title":"The ZIP8\/SIRT1 axis regulates alveolar progenitor cell renewal in aging and idiopathic pulmonary fibrosis","volume":"132","author":"Liang","year":"2022","journal-title":"J Clin Invest"},{"key":"2026012204194062900_bib64","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1164\/rccm.202004-1274OC","article-title":"Senescence of alveolar type 2 cells drives progressive pulmonary fibrosis","volume":"203","author":"Yao","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204194062900_bib65","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0140-6736(22)01485-4","article-title":"Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes","volume":"400","author":"Bos","year":"2022","journal-title":"Lancet"},{"key":"2026012204194062900_bib66","doi-asserted-by":"crossref","first-page":"631235","DOI":"10.3389\/fimmu.2021.631235","article-title":"The epithelial-immune crosstalk in pulmonary fibrosis","volume":"12","author":"Plant\u00e9-Bordeneuve","year":"2021","journal-title":"Front Immunol"},{"key":"2026012204194062900_bib67","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/s41586-020-2424-4","article-title":"Structural cells are key regulators of organ-specific immune responses","volume":"583","author":"Krausgruber","year":"2020","journal-title":"Nature"},{"key":"2026012204194062900_bib68","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/s41586-020-2877-5","article-title":"Exuberant fibroblast activity compromises lung function via ADAMTS4","volume":"587","author":"Boyd","year":"2020","journal-title":"Nature"},{"key":"2026012204194062900_bib69","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1164\/rccm.200812-1837OC","article-title":"Macrophage tumor necrosis factor-alpha induces epithelial expression of granulocyte-macrophage colony-stimulating factor: impact on alveolar epithelial repair","volume":"180","author":"Cakarova","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204194062900_bib70","doi-asserted-by":"crossref","first-page":"e2016","DOI":"10.1038\/cddis.2015.282","article-title":"Lung epithelial cell-derived extracellular vesicles activate macrophage-mediated inflammatory responses via ROCK1 pathway","volume":"6","author":"Moon","year":"2015","journal-title":"Cell Death Dis"},{"key":"2026012204194062900_bib71","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1172\/JCI83931","article-title":"Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection","volume":"126","author":"Peteranderl","year":"2016","journal-title":"J Clin Invest"},{"key":"2026012204194062900_bib72","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1084\/jem.20080201","article-title":"Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand","volume":"205","author":"Herold","year":"2008","journal-title":"J Exp Med"},{"key":"2026012204194062900_bib73","doi-asserted-by":"crossref","first-page":"436","DOI":"10.3390\/cells10020436","article-title":"Macrophages in lung injury, repair, and fibrosis","volume":"10","author":"Cheng","year":"2021","journal-title":"Cells"},{"key":"2026012204194062900_bib74","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/ni.1637","article-title":"A critical function for CD200 in lung immune homeostasis and the severity of influenza infection","volume":"9","author":"Snelgrove","year":"2008","journal-title":"Nat Immunol"},{"key":"2026012204194062900_bib75","doi-asserted-by":"crossref","first-page":"2100880","DOI":"10.1183\/13993003.00880-2021","article-title":"VEGF-C\/VEGFR-3 signalling in macrophages ameliorates acute lung injury","volume":"59","author":"Yamashita","year":"2022","journal-title":"Eur Respir J"},{"key":"2026012204194062900_bib76","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nature12902","article-title":"Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity","volume":"506","author":"Westphalen","year":"2014","journal-title":"Nature"},{"key":"2026012204194062900_bib77","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.4049\/jimmunol.1601777","article-title":"Stat5 is required for CD103+ dendritic cell and alveolar macrophage development and protection from lung injury","volume":"198","author":"Eddy","year":"2017","journal-title":"J Immunol"},{"key":"2026012204194062900_bib78","doi-asserted-by":"crossref","first-page":"e1006140","DOI":"10.1371\/journal.ppat.1006140","article-title":"Alveolar macrophages prevent lethal influenza pneumonia by inhibiting infection of type-1 alveolar epithelial cells","volume":"13","author":"Cardani","year":"2017","journal-title":"PLoS Pathog"},{"key":"2026012204194062900_bib79","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41385-018-0096-2","article-title":"Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism","volume":"12","author":"Hung","year":"2019","journal-title":"Mucosal Immunol"},{"key":"2026012204194062900_bib80","doi-asserted-by":"crossref","first-page":"723217","DOI":"10.3389\/fmed.2021.723217","article-title":"Coagulation dysfunction in acute respiratory distress syndrome and its potential impact in inflammatory subphenotypes","volume":"8","author":"Livingstone","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"2026012204194062900_bib81","doi-asserted-by":"crossref","first-page":"e158079","DOI":"10.1172\/jci.insight.158079","article-title":"Single-cell transcriptomic profiling of lung endothelial cells identifies dynamic inflammatory and regenerative subpopulations","volume":"7","author":"Zhang","year":"2022","journal-title":"JCI Insight"},{"key":"2026012204194062900_bib82","doi-asserted-by":"crossref","first-page":"e124329","DOI":"10.1172\/jci.insight.124329","article-title":"Endothelial mitochondria determine rapid barrier failure in chemical lung injury","volume":"4","author":"Hough","year":"2019","journal-title":"JCI Insight"},{"key":"2026012204194062900_bib83","doi-asserted-by":"crossref","first-page":"e53072","DOI":"10.7554\/eLife.53072","article-title":"Defining the role of pulmonary endothelial cell heterogeneity in the response to acute lung injury","volume":"9","author":"Niethamer","year":"2020","journal-title":"eLife"},{"key":"2026012204194062900_bib84","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nm.4035","article-title":"Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis","volume":"22","author":"Cao","year":"2016","journal-title":"Nat Med"},{"key":"2026012204194062900_bib85","doi-asserted-by":"crossref","first-page":"107828","DOI":"10.1016\/j.celrep.2020.107828","article-title":"Angiocrine sphingosine-1-phosphate activation of S1PR2-YAP signaling axis in alveolar type II cells is essential for lung repair","volume":"31","author":"Chen","year":"2020","journal-title":"Cell Rep"},{"key":"2026012204194062900_bib86","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1038\/s41467-020-17358-3","article-title":"Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis","volume":"11","author":"Strunz","year":"2020","journal-title":"Nat Commun"},{"key":"2026012204194062900_bib87","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41586-021-03570-8","article-title":"COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets","volume":"595","author":"Delorey","year":"2021","journal-title":"Nature"},{"key":"2026012204194062900_bib88","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.stemcr.2019.04.003","article-title":"FGF10-FGFR2B signaling generates basal cells and drives alveolar epithelial regeneration by bronchial epithelial stem cells after lung injury","volume":"12","author":"Yuan","year":"2019","journal-title":"Stem Cell Reports"},{"key":"2026012204194062900_bib89","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/S2213-2600(17)30430-7","article-title":"An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study","volume":"5","author":"Maher","year":"2017","journal-title":"Lancet Respir Med"},{"key":"2026012204194062900_bib90","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/s41556-020-0542-8","article-title":"Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis","volume":"22","author":"Kobayashi","year":"2020","journal-title":"Nat Cell Biol"},{"key":"2026012204194062900_bib91","doi-asserted-by":"crossref","first-page":"104185","DOI":"10.1016\/j.ebiom.2022.104185","article-title":"COVID-19 lung disease shares driver AT2 cytopathic features with idiopathic pulmonary fibrosis","volume":"82","author":"Sinha","year":"2022","journal-title":"EBioMedicine"},{"key":"2026012204194062900_bib92","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.cell.2017.07.034","article-title":"Distinct mesenchymal lineages and niches promote epithelial self-renewal and myofibrogenesis in the lung","volume":"170","author":"Zepp","year":"2017","journal-title":"Cell"},{"key":"2026012204194062900_bib93","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1089\/ars.2013.5793","article-title":"The lung alveolar lipofibroblast: an evolutionary strategy against neonatal hyperoxic lung injury","volume":"21","author":"Rehan","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"2026012204194062900_bib94","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.stem.2016.10.004","article-title":"Two-way conversion between lipogenic and myogenic fibroblastic phenotypes marks the progression and resolution of lung fibrosis","volume":"20","author":"El Agha","year":"2017","journal-title":"Cell Stem Cell"},{"key":"2026012204194062900_bib95","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1136\/thoraxjnl-2020-214986","article-title":"Pretreatment of aged mice with retinoic acid supports alveolar regeneration via upregulation of reciprocal PDGFA signalling","volume":"76","author":"Gokey","year":"2021","journal-title":"Thorax"},{"key":"2026012204194062900_bib96","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1164\/rccm.201204-0754OC","article-title":"Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation","volume":"186","author":"Booth","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204194062900_bib97","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1039\/c2ib00149g","article-title":"The mechanical memory of lung myofibroblasts","volume":"4","author":"Balestrini","year":"2012","journal-title":"Integr Biol (Camb)"},{"key":"2026012204194062900_bib98","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1165\/rcmb.2015-0020TR","article-title":"Matrix metalloproteinases as therapeutic targets for idiopathic pulmonary fibrosis","volume":"53","author":"Craig","year":"2015","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012204194062900_bib99","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.3390\/ijms22062923","article-title":"Loss of MT1-MMP in alveolar epithelial cells exacerbates pulmonary fibrosis","volume":"22","author":"Placido","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026012204194062900_bib100","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.15252\/embj.201490594","article-title":"Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid","volume":"34","author":"Guti\u00e9rrez-Fern\u00e1ndez","year":"2015","journal-title":"EMBO J"},{"key":"2026012204194062900_bib101","doi-asserted-by":"crossref","first-page":"102551","DOI":"10.1016\/j.isci.2021.102551","article-title":"Categorization of lung mesenchymal cells in development and fibrosis","volume":"24","author":"Liu","year":"2021","journal-title":"iScience"},{"key":"2026012204194062900_bib102","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1084\/jem.20162152","article-title":"Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span","volume":"214","author":"Misharin","year":"2017","journal-title":"J Exp Med"},{"key":"2026012204194062900_bib103","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.immuni.2019.01.008","article-title":"A macrophage-pericyte axis directs tissue restoration via amphiregulin-induced transforming growth factor beta activation","volume":"50","author":"Minutti","year":"2019","journal-title":"Immunity"},{"key":"2026012204194062900_bib104","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"2026012204194062900_bib105","doi-asserted-by":"crossref","first-page":"L507","DOI":"10.1152\/ajplung.00263.2022","article-title":"Alveolar macrophages drive lung fibroblast function in cocultures of IPF and normal patient samples","volume":"324","author":"Novak","year":"2023","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026012204194062900_bib106","doi-asserted-by":"crossref","first-page":"e88947","DOI":"10.1172\/jci.insight.88947","article-title":"Epithelial-macrophage interactions determine pulmonary fibrosis susceptibility in Hermansky-Pudlak syndrome","volume":"1","author":"Young","year":"2016","journal-title":"JCI Insight"},{"key":"2026012204194062900_bib107","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.semarthrit.2020.12.003","article-title":"Fibroblasts and their responses to chronic injury in pulmonary fibrosis","volume":"51","author":"Wu","year":"2021","journal-title":"Semin Arthritis Rheum"},{"key":"2026012204194062900_bib108","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1165\/rcmb.2017-0154OC","article-title":"Deletion of c-FLIP from CD11bhi macrophages prevents development of bleomycin-induced lung fibrosis","volume":"58","author":"McCubbrey","year":"2018","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012204194062900_bib109","doi-asserted-by":"crossref","first-page":"6243","DOI":"10.1016\/j.cell.2021.11.033","article-title":"SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis","volume":"184","author":"Wendisch","year":"2021","journal-title":"Cell"},{"key":"2026012204194062900_bib110","doi-asserted-by":"crossref","first-page":"e202201458","DOI":"10.26508\/lsa.202201458","article-title":"ScRNA-seq expression of IFI27 and APOC2 identifies four alveolar macrophage superclusters in healthy BALF","volume":"5","author":"Li","year":"2022","journal-title":"Life Sci Alliance"},{"key":"2026012204194062900_bib111","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1164\/rccm.201712-2410OC","article-title":"Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis","volume":"199","author":"Reyfman","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204194062900_bib112","doi-asserted-by":"crossref","first-page":"1802441","DOI":"10.1183\/13993003.02441-2018","article-title":"Proliferating SPP1\/MERTK-expressing macrophages in idiopathic pulmonary fibrosis","volume":"54","author":"Morse","year":"2019","journal-title":"Eur Respir J"},{"key":"2026012204194062900_bib113","doi-asserted-by":"crossref","first-page":"e130","DOI":"10.1161\/ATVBAHA.118.312254","article-title":"Macrophage-derived legumain promotes pulmonary hypertension by activating the MMP (matrix metalloproteinase)-2\/TGF (transforming growth factor)-\u03b21 signaling","volume":"39","author":"Bai","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026012204194062900_bib114","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/hep.24701","article-title":"Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin \u03b1V\u03b23 engagement and PI3K\/pAkt\/NF\u03baB signaling","volume":"55","author":"Urtasun","year":"2012","journal-title":"Hepatology"},{"key":"2026012204194062900_bib115","doi-asserted-by":"crossref","first-page":"5036","DOI":"10.4049\/jimmunol.180.7.5036","article-title":"Macrophages produce TGF-beta-induced (beta-ig-h3) following ingestion of apoptotic cells and regulate MMP14 levels and collagen turnover in fibroblasts","volume":"180","author":"Nacu","year":"2008","journal-title":"J Immunol"},{"key":"2026012204194062900_bib116","doi-asserted-by":"crossref","first-page":"1900646","DOI":"10.1183\/13993003.00646-2019","article-title":"A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF\/M-CSFR signalling in monocyte-derived alveolar macrophages","volume":"55","author":"Joshi","year":"2020","journal-title":"Eur Respir J"},{"key":"2026012204194062900_bib117","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1165\/rcmb.2022-0174OC","article-title":"Myeloid- and epithelial-derived heparin-binding epidermal growth factor-like growth factor promotes pulmonary fibrosis","volume":"67","author":"Hult","year":"2022","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012204194062900_bib118","doi-asserted-by":"crossref","first-page":"818394","DOI":"10.3389\/fphys.2022.818394","article-title":"Mechanotransduction regulates the interplays between alveolar epithelial and vascular endothelial cells in lung","volume":"13","author":"Lin","year":"2022","journal-title":"Front Physiol"},{"key":"2026012204194062900_bib119","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00403-016-1635-x","article-title":"Does hypoxia play a role in infantile hemangioma?","volume":"308","author":"de Jong","year":"2016","journal-title":"Arch Dermatol Res"},{"key":"2026012204194062900_bib120","doi-asserted-by":"crossref","first-page":"e126","DOI":"10.1161\/ATVBAHA.120.313316","article-title":"Shear stress-induced miR-143-3p in collateral arteries contributes to outward vessel growth by targeting collagen V-\u03b12","volume":"40","author":"Troidl","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026012204194062900_bib121","article-title":"Single cell transcriptomics of fibrotic lungs unveils aging-associated alterations in endothelial and epithelial cell regeneration [preprint]","author":"Raslan","year":"2023"},{"key":"2026012204194062900_bib122","doi-asserted-by":"crossref","first-page":"E1475","DOI":"10.1073\/pnas.1117988108","article-title":"Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition","volume":"108","author":"Rock","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026012204194062900_bib123","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/labinvest.2015.100","article-title":"ROS-induced endothelial stress contributes to pulmonary fibrosis through pericytes and Wnt signaling","volume":"96","author":"Andersson-Sj\u00f6land","year":"2016","journal-title":"Lab Invest"},{"key":"2026012204194062900_bib124","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s10456-021-09795-5","article-title":"Characterization of the heterogeneity of endothelial cells in bleomycin-induced lung fibrosis using single-cell RNA sequencing","volume":"24","author":"Liu","year":"2021","journal-title":"Angiogenesis"},{"key":"2026012204194062900_bib125","doi-asserted-by":"crossref","first-page":"107798","DOI":"10.1016\/j.pharmthera.2020.107798","article-title":"Idiopathic pulmonary fibrosis: disease mechanisms and drug development","volume":"222","author":"Spagnolo","year":"2021","journal-title":"Pharmacol Ther"},{"key":"2026012204194062900_bib126","doi-asserted-by":"crossref","first-page":"6214","DOI":"10.3390\/ijms22126214","article-title":"Cellular senescence: pathogenic mechanisms in lung fibrosis","volume":"22","author":"Parimon","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026012204194062900_bib127","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41586-020-2496-1","article-title":"A single-cell transcriptomic atlas characterizes ageing tissues in the mouse","volume":"583","author":"Tabula Muris Consortium","year":"2020","journal-title":"Nature"},{"key":"2026012204194062900_bib128","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1165\/rcmb.2019-0092OC","article-title":"Impaired myofibroblast dedifferentiation contributes to nonresolving fibrosis in aging","volume":"62","author":"Kato","year":"2020","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012204194062900_bib129","doi-asserted-by":"crossref","first-page":"e141690","DOI":"10.1172\/jci.insight.141690","article-title":"Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia","volume":"6","author":"Morales-Nebreda","year":"2021","journal-title":"JCI Insight"},{"key":"2026012204194062900_bib130","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1164\/rccm.202109-2151OC","article-title":"CD38 mediates lung fibrosis by promoting alveolar epithelial cell aging","volume":"206","author":"Cui","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204194062900_bib131","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1016\/j.cell.2021.03.005","article-title":"The aging lung: physiology, disease, and immunity","volume":"184","author":"Schneider","year":"2021","journal-title":"Cell"},{"key":"2026012204194062900_bib132","doi-asserted-by":"crossref","first-page":"932723","DOI":"10.3389\/fcell.2022.932723","article-title":"Intersection of inflammation and senescence in the aging lung stem cell niche","volume":"10","author":"Allen","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"2026012204194062900_bib133","doi-asserted-by":"crossref","first-page":"e13790","DOI":"10.1111\/acel.13790","article-title":"Role of pulmonary epithelial arginase-II in activation of fibroblasts and lung inflammaging","volume":"22","author":"Zhu","year":"2023","journal-title":"Aging Cell"},{"key":"2026012204194062900_bib134","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.stemcr.2019.02.013","article-title":"IL-1 and TNF\u03b1 contribute to the inflammatory niche to enhance alveolar regeneration","volume":"12","author":"Katsura","year":"2019","journal-title":"Stem Cell Reports"},{"key":"2026012204194062900_bib135","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s42003-021-02118-w","article-title":"Wnt signaling in lung development, regeneration, and disease progression","volume":"4","author":"Aros","year":"2021","journal-title":"Commun Biol"},{"key":"2026012204194062900_bib136","doi-asserted-by":"crossref","first-page":"e91559","DOI":"10.1371\/journal.pone.0091559","article-title":"Interleukin-1\u03b2 attenuates myofibroblast formation and extracellular matrix production in dermal and lung fibroblasts exposed to transforming growth factor-\u03b21","volume":"9","author":"Mia","year":"2014","journal-title":"PLoS One"},{"key":"2026012204194062900_bib137","doi-asserted-by":"crossref","first-page":"e140299","DOI":"10.1172\/JCI140299","article-title":"The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging","volume":"131","author":"McQuattie-Pimentel","year":"2021","journal-title":"J Clin Invest"},{"key":"2026012204194062900_bib138","doi-asserted-by":"crossref","first-page":"e13196","DOI":"10.1111\/acel.13196","article-title":"Vascular dysfunction in aged mice contributes to persistent lung fibrosis","volume":"19","author":"Caporarello","year":"2020","journal-title":"Aging Cell"},{"key":"2026012204194062900_bib139","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1016\/j.cell.2023.05.022","article-title":"Targeted alveolar regeneration with Frizzled-specific agonists","volume":"186","author":"Nabhan","year":"2023","journal-title":"Cell"}],"container-title":["American Journal of Respiratory Cell and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/71\/1\/30\/66196689\/ajrcmb_71_1_30.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/71\/1\/30\/66196689\/ajrcmb_71_1_30.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:21:40Z","timestamp":1769073700000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article\/71\/1\/30\/8405593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,1]]},"references-count":139,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,7,1]]},"published-print":{"date-parts":[[2024,7,1]]}},"URL":"https:\/\/doi.org\/10.1165\/rcmb.2023-0426tr","relation":{},"ISSN":["1044-1549","1535-4989"],"issn-type":[{"value":"1044-1549","type":"print"},{"value":"1535-4989","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,7]]},"published":{"date-parts":[[2024,7,1]]},"assertion":[{"value":"2023-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}