{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:20:10Z","timestamp":1792041610671,"version":"4.4.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-186193"],"award-info":[{"award-number":["PJT-186193"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Thorax Foundation"},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-186193"],"award-info":[{"award-number":["PJT-186193"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Thorax Foundation"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IRP2 (iron regulatory protein 2), a post-transcriptional regulator of cellular iron metabolism, has been associated with susceptibility to chronic obstructive pulmonary disease. Resistive breathing (RB) is the hallmark of the pathophysiology of obstructive airway diseases, especially during exacerbations, when increased mechanical stress is imposed on the lung. We have previously shown that RB, through tracheal banding, mimicking severe airway obstruction, induces pulmonary inflammation and injury in previously healthy mice. To characterize the role of IRP2 in RB-induced lung injury, wild-type and Irp2\u2212\/\u2212 mice were subjected to tracheal banding surgery. RB increased tissue elasticity and viscance in wild-type but not in Irp2\u2212\/\u2212 mice, denoting that the latter were protected against lung injury. Moreover, Irp2\u2212\/\u2212 mice exhibited a lower score of lung inflammation. In addition, only wild-type but not Irp2\u2212\/\u2212 mice responded to RB by increasing BAL cellularity due to higher macrophage count, which was accompanied by elevated BAL IL-1\u03b2 and IL-6 concentrations. Lung proteomics and functional enrichment analysis revealed significant differences among wild-type and Irp2\u2212\/\u2212 mice in RB-induced regulation of proteins involved in inflammatory and defense response pathways but also of many proteins with unknown function. We conclude that IRP2 supports proinflammatory activities in the lungs, whereas its deficiency protects against RB-induced pulmonary inflammation via remodeling of the lung proteome.<\/jats:p>","DOI":"10.1165\/rcmb.2024-0286oc","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T17:27:26Z","timestamp":1736184446000},"page":"96-108","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":5,"title":["Iron Regulatory Protein 2 Deficiency Is Protective Against Resistive Breathing\u2013induced Pulmonary Inflammation"],"prefix":"10.1093","volume":"73","author":[{"given":"Dimitrios","family":"Toumpanakis","sequence":"first","affiliation":[{"name":"\u201cMarianthi Simou\u201d Applied Biomedical Research and Training Center and Experimental Surgery Unit, Evangelismos Hospital, Medical School"},{"name":"2nd Department of Critical Care Medicine, \u201cAttikon University Hospital\u201d, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4843-5604","authenticated-orcid":false,"given":"Vyronia","family":"Vassilakopoulou","sequence":"additional","affiliation":[{"name":"\u201cMarianthi Simou\u201d Applied Biomedical Research and Training Center and Experimental Surgery Unit, Evangelismos Hospital, Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9765-7153","authenticated-orcid":false,"given":"Wen","family":"Gu","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftheria","family":"Mizi","sequence":"additional","affiliation":[{"name":"\u201cMarianthi Simou\u201d Applied Biomedical Research and Training Center and Experimental Surgery Unit, Evangelismos Hospital, Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasia","family":"Chatzianastasiou","sequence":"additional","affiliation":[{"name":"\u201cMarianthi Simou\u201d Applied Biomedical Research and Training Center and Experimental Surgery Unit, Evangelismos Hospital, Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7224-1290","authenticated-orcid":false,"given":"Vincent","family":"Richard","sequence":"additional","affiliation":[{"name":"Segal Cancer Proteomics Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2394-6512","authenticated-orcid":false,"given":"Christoph H.","family":"Borchers","sequence":"additional","affiliation":[{"name":"Segal Cancer Proteomics Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada"},{"name":"Gerald Bronfman Department of Oncology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3265-3332","authenticated-orcid":false,"given":"Yassene","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Segal Cancer Proteomics Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada"},{"name":"Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3541-4054","authenticated-orcid":false,"given":"Carine","family":"Fillebeen","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoros","family":"Vassilakopoulos","sequence":"additional","affiliation":[{"name":"\u201cMarianthi Simou\u201d Applied Biomedical Research and Training Center and Experimental Surgery Unit, Evangelismos Hospital, Medical School"},{"name":"Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2305-0057","authenticated-orcid":false,"given":"Kostas","family":"Pantopoulos","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research, and"},{"name":"Department of Medicine, McGill University, Montreal, Quebec, Canada; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"2026012204151302700_bib1","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1016\/S0140-6736(22)00470-6","article-title":"Chronic obstructive pulmonary disease","volume":"399","author":"Christenson","year":"2022","journal-title":"Lancet"},{"key":"2026012204151302700_bib2","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.ajhg.2009.09.004","article-title":"Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene","volume":"85","author":"DeMeo","year":"2009","journal-title":"Am J Hum Genet"},{"key":"2026012204151302700_bib3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1165\/rcmb.2012-0011OC","article-title":"CHRNA3\/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland","volume":"47","author":"Hardin","year":"2012","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012204151302700_bib4","doi-asserted-by":"crossref","first-page":"e24395","DOI":"10.1371\/journal.pone.0024395","article-title":"Genetics of sputum gene expression in chronic obstructive pulmonary disease","volume":"6","author":"Qiu","year":"2011","journal-title":"PLoS One"},{"key":"2026012204151302700_bib5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1471-2350-12-24","article-title":"The role of IREB2 and transforming growth factor beta-1 genetic variants in COPD: a replication case-control study","volume":"12","author":"Chappell","year":"2011","journal-title":"BMC Med Genet"},{"key":"2026012204151302700_bib6","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/jhg.2012.104","article-title":"Association of IREB2 and CHRNA3\/5 polymorphisms with COPD and COPD-related phenotypes in a Chinese Han population","volume":"57","author":"Zhou","year":"2012","journal-title":"J Hum Genet"},{"key":"2026012204151302700_bib7","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1165\/rcmb.2014-0210OC","article-title":"IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease","volume":"52","author":"Lee","year":"2015","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012204151302700_bib8","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3389\/fphar.2014.00176","article-title":"The IRP\/IRE system in vivo: insights from mouse models","volume":"5","author":"Wilkinson","year":"2014","journal-title":"Front Pharmacol"},{"key":"2026012204151302700_bib9","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1039\/C4MT00164H","article-title":"Iron regulatory proteins and their role in controlling iron metabolism","volume":"7","author":"Kuhn","year":"2015","journal-title":"Metallomics"},{"key":"2026012204151302700_bib10","doi-asserted-by":"crossref","first-page":"e96285","DOI":"10.1371\/journal.pone.0096285","article-title":"Increased iron sequestration in alveolar macrophages in chronic obstructive pulmonary disease","volume":"9","author":"Philippot","year":"2014","journal-title":"PLoS One"},{"key":"2026012204151302700_bib11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nm.4021","article-title":"Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice","volume":"22","author":"Cloonan","year":"2016","journal-title":"Nat Med"},{"key":"2026012204151302700_bib12","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1164\/rccm.202108-1819PP","article-title":"An updated definition and severity classification of chronic obstructive pulmonary disease exacerbations: the Rome proposal","volume":"204","author":"Celli","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204151302700_bib13","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1136\/thx.2005.041830","article-title":"COPD exacerbations. 3: Pathophysiology","volume":"61","author":"O\u2019Donnell","year":"2006","journal-title":"Thorax"},{"key":"2026012204151302700_bib14","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.2147\/COPD.S113877","article-title":"Can resistive breathing injure the lung? Implications for COPD exacerbations","volume":"11","author":"Vassilakopoulos","year":"2016","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2026012204151302700_bib15","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.2147\/COPD.S256750","article-title":"Spontaneous breathing through increased airway resistance augments elastase-induced pulmonary emphysema","volume":"15","author":"Toumpanakis","year":"2020","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2026012204151302700_bib16","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.2147\/COPD.S424560","article-title":"Synergistic effects of resistive breathing on endotoxin-induced lung injury in mice","volume":"18","author":"Toumpanakis","year":"2023","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2026012204151302700_bib17","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12871-018-0576-7","article-title":"Deferoxamine preconditioning ameliorates mechanical ventilation-induced lung injury in rat model via ROS in alveolar macrophages: a randomized controlled study","volume":"18","author":"Zhu","year":"2018","journal-title":"BMC Anesthesiol"},{"key":"2026012204151302700_bib18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/gene.20169","article-title":"Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes","volume":"43","author":"Galy","year":"2005","journal-title":"Genesis"},{"key":"2026012204151302700_bib19","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1165\/rcmb.2014-0092OC","article-title":"Guanylyl cyclase activation reverses resistive breathing-induced lung injury and inflammation","volume":"52","author":"Glynos","year":"2015","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012204151302700_bib20","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1002\/hep4.1780","article-title":"Tissue-specific regulation of ferroportin in wild-type and Hjv\u2212\/\u2212 mice following dietary iron manipulations","volume":"5","author":"Katsarou","year":"2021","journal-title":"Hepatol Commun"},{"key":"2026012204151302700_bib21","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00109-012-0937-5","article-title":"Differences in activation of mouse hepcidin by dietary iron and parenterally administered iron dextran: compartmentalization is critical for iron sensing","volume":"91","author":"Daba","year":"2013","journal-title":"J Mol Med"},{"key":"2026012204151302700_bib22","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.3390\/ijms24054402","article-title":"Discovery-based proteomics identify skeletal muscle mitochondrial alterations as an early metabolic defect in a mouse model of beta-thalassemia","volume":"24","author":"Reboucas","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026012204151302700_bib23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s42003-022-03108-2","article-title":"Hemojuvelin deficiency promotes liver mitochondrial dysfunction and predisposes mice to hepatocellular carcinoma","volume":"5","author":"Allameh","year":"2022","journal-title":"Commun Biol"},{"key":"2026012204151302700_bib24","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026012204151302700_bib25","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40248-015-0031-2","article-title":"The role of iron in pulmonary pathology","volume":"10","author":"Khiroya","year":"2015","journal-title":"Multidiscip Respir Med"},{"key":"2026012204151302700_bib26","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1164\/rccm.201702-0311PP","article-title":"The \u201ciron\u201d-y of iron overload and iron deficiency in chronic obstructive pulmonary disease","volume":"196","author":"Cloonan","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204151302700_bib27","doi-asserted-by":"crossref","first-page":"252","DOI":"10.5578\/tt.69934","article-title":"Is serum iron responsive protein-2 level associated with pulmonary functions and frequent exacerbator phenotype in COPD?","volume":"68","author":"Acet \u00d6zt\u00fcrk","year":"2020","journal-title":"Tuberk Toraks"},{"key":"2026012204151302700_bib28","doi-asserted-by":"crossref","first-page":"10562","DOI":"10.1038\/s41598-020-67047-w","article-title":"Increased airway iron parameters and risk for exacerbation in COPD: an analysis from spiromics","volume":"10","author":"Zhang","year":"2020","journal-title":"Sci Rep"},{"key":"2026012204151302700_bib29","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1136\/thorax.57.10.847","article-title":"Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease","volume":"57","author":"Donaldson","year":"2002","journal-title":"Thorax"},{"key":"2026012204151302700_bib30","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1164\/rccm.201001-0116OC","article-title":"Inspiratory resistive breathing induces acute lung injury","volume":"182","author":"Toumpanakis","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204151302700_bib31","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1165\/rcmb.2021-0531ST","article-title":"Update on the features and measurements of experimental acute lung injury in animals: an official American Thoracic Society Workshop report","volume":"66","author":"Kulkarni","year":"2022","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012204151302700_bib32","doi-asserted-by":"crossref","first-page":"343","DOI":"10.2147\/COPD.S336108","article-title":"Trpv4 inhibition exerts protective effects against resistive breathing induced lung injury","volume":"17","author":"Toumpanakis","year":"2022","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2026012204151302700_bib33","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1165\/rcmb.2017-0143OC","article-title":"Erythropoietin-producing hepatoma receptor tyrosine kinase A2 modulation associates with protective effect of prone position in ventilator-induced lung injury","volume":"58","author":"Park","year":"2018","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012204151302700_bib34","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1165\/rcmb.2020-0197OC","article-title":"Role of dual oxidases in ventilator-induced lung injury","volume":"64","author":"Cagle","year":"2021","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012204151302700_bib35","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.1038\/s41598-018-23175-y","article-title":"Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts","volume":"8","author":"Li","year":"2018","journal-title":"Sci Rep"},{"key":"2026012204151302700_bib36","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.cmet.2010.06.007","article-title":"Iron regulatory proteins secure mitochondrial iron sufficiency and function","volume":"12","author":"Galy","year":"2010","journal-title":"Cell Metab"},{"key":"2026012204151302700_bib37","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1182\/blood-2013-03-492454","article-title":"IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2\u03b1 mRNA translation","volume":"122","author":"Wilkinson","year":"2013","journal-title":"Blood"},{"key":"2026012204151302700_bib38","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/sj.emboj.7600041","article-title":"Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis","volume":"23","author":"Meyron-Holtz","year":"2004","journal-title":"EMBO J"},{"key":"2026012204151302700_bib39","first-page":"e175845","article-title":"Iron regulatory proteins 1 and 2 have opposing roles in regulating inflammation in bacterial orchitis","volume":"9","author":"Ghatpande","year":"2024","journal-title":"JCI Insight"},{"key":"2026012204151302700_bib40","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1038\/s41467-019-10991-7","article-title":"Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis","volume":"10","author":"Yoshida","year":"2019","journal-title":"Nat Commun"},{"key":"2026012204151302700_bib41","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12931-022-01929-7","article-title":"Iron in airway macrophages and infective exacerbations of chronic obstructive pulmonary disease","volume":"23","author":"Ho","year":"2022","journal-title":"Respir Res"},{"key":"2026012204151302700_bib42","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.3390\/nu14193929","article-title":"Iron depletion in systemic and muscle compartments defines a specific phenotype of severe COPD in female and male patients: implications in exercise tolerance","volume":"14","author":"P\u00e9rez-Peir\u00f3","year":"2022","journal-title":"Nutrients"},{"key":"2026012204151302700_bib43","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/1753465815617082","article-title":"Asthma and chronic obstructive pulmonary disease overlap: asthmatic chronic obstructive pulmonary disease or chronic obstructive asthma?","volume":"10","author":"Slats","year":"2016","journal-title":"Ther Adv Respir Dis"},{"key":"2026012204151302700_bib44","doi-asserted-by":"crossref","first-page":"5184","DOI":"10.1096\/fj.14-254862","article-title":"The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling","volume":"28","author":"Lindskog","year":"2014","journal-title":"FASEB J"},{"key":"2026012204151302700_bib45","doi-asserted-by":"crossref","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Proteomics: tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"key":"2026012204151302700_bib46","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.pharmtox.010909.105600","article-title":"Mechanisms of cell protection by heme oxygenase-1","volume":"50","author":"Gozzelino","year":"2010","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"2026012204151302700_bib47","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1038\/s41467-020-17254-w","article-title":"The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function","volume":"11","author":"Bennett","year":"2020","journal-title":"Nat Commun"},{"key":"2026012204151302700_bib48","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1165\/rcmb.2012-0252OC","article-title":"Cyclic stretch-induced oxidative stress increases pulmonary alveolar epithelial permeability","volume":"49","author":"Davidovich","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012204151302700_bib49","doi-asserted-by":"crossref","first-page":"L431","DOI":"10.1152\/ajplung.90256.2008","article-title":"Endothelial EphA receptor stimulation increases lung vascular permeability","volume":"295","author":"Larson","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026012204151302700_bib50","first-page":"OA4829","article-title":"Resistive breathing aggravates cigarette smoke-induced pulmonary inflammation [abstract]","volume":"50","author":"Mizi","year":"2017","journal-title":"Eur Respir J"},{"key":"2026012204151302700_bib51","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1165\/rcmb.2013-0179OC","article-title":"Proteoglycans maintain lung stability in an elastase-treated mouse model of emphysema","volume":"51","author":"Takahashi","year":"2014","journal-title":"Am J Respir Cell Mol Biol"}],"container-title":["American Journal of Respiratory Cell and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/73\/1\/96\/66194764\/ajrcmb_73_1_96.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/73\/1\/96\/66194764\/ajrcmb_73_1_96.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:17:57Z","timestamp":1769073477000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article\/73\/1\/96\/8405574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,7,1]]},"published-print":{"date-parts":[[2025,7,1]]}},"URL":"https:\/\/doi.org\/10.1165\/rcmb.2024-0286oc","relation":{},"ISSN":["1044-1549","1535-4989"],"issn-type":[{"value":"1044-1549","type":"print"},{"value":"1535-4989","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"2024-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}