{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:15:50Z","timestamp":1789776950247,"version":"4.0.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":235,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K12HD047349"],"award-info":[{"award-number":["K12HD047349"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1F32HL167572-01A1"],"award-info":[{"award-number":["1F32HL167572-01A1"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1P01HL152961"],"award-info":[{"award-number":["1P01HL152961"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1R35HL139726"],"award-info":[{"award-number":["1R35HL139726"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["CDA 23CDA1045594"],"award-info":[{"award-number":["CDA 23CDA1045594"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K12HD047349"],"award-info":[{"award-number":["K12HD047349"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1F32HL167572-01A1"],"award-info":[{"award-number":["1F32HL167572-01A1"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1P01HL152961"],"award-info":[{"award-number":["1P01HL152961"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1R35HL139726"],"award-info":[{"award-number":["1R35HL139726"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"American Heart Association","doi-asserted-by":"publisher","award":["CDA 23CDA1045594"],"award-info":[{"award-number":["CDA 23CDA1045594"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute respiratory distress syndrome is a serious illness accounting for 10% of ICU admissions and has a high mortality of 31\u201345%, with a paucity of pharmacologic treatment options. Dysregulated inflammation and oxidative stress are hallmark features of acute respiratory distress syndrome. We previously showed that transgenic mice expressing a naturally occurring polymorphism of the antioxidant enzyme EC-SOD (extracellular superoxide dismutase) are protected against Staphylococcus aureus pneumonia, acute lung injury, and pulmonary neutrophilia. In this mouse strain, an R213G amino acid substitution leads to lower tissue-binding affinity and elevated alveolar and plasma EC-SOD amounts, although the redox-regulated mechanisms responsible for protection against S. aureus are not yet elucidated. Neutrophils are recruited to the areas of injury and inflammation, in part by activated platelets, which contain multiple redox-sensitive targets. Thus, we hypothesize that increased circulating EC-SOD due to the EC-SOD R213G variant protects against S. aureus pneumonia by reducing platelet activation and subsequent neutrophil recruitment to the lung. We demonstrate that, compared with wild-type mice with S. aureus pneumonia, platelet activation, formation of platelet\u2013neutrophil aggregates, and influx of neutrophils and platelet\u2013neutrophil aggregates into the lung are decreased in the infected R213G mice. Furthermore, pretreatment with a MnTE-2-PyP SOD mimetic protects against S. aureus\u2013induced platelet activation, pulmonary neutrophilia, and acute lung injury. Our data highlight the redox regulation of platelet activation as a driver of S. aureus\u2013induced acute lung injury.<\/jats:p>","DOI":"10.1165\/rcmb.2024-0292oc","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T16:32:51Z","timestamp":1731429171000},"page":"653-662","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":7,"title":["Increased Circulating Extracellular Superoxide Dismutase Attenuates Platelet\u2013Neutrophil Interactions"],"prefix":"10.1093","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7304-881X","authenticated-orcid":false,"given":"Christina","family":"Sul","sequence":"first","affiliation":[{"name":"Division of Critical Care"},{"name":"Cardiovascular Pulmonary Research Group, Departments of Pediatrics and Internal Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin V.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Division of Critical Care"},{"name":"Cardiovascular Pulmonary Research Group, Departments of Pediatrics and Internal Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2846-9260","authenticated-orcid":false,"given":"Janelle","family":"Posey","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariah","family":"Jordan","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Colon Hidalgo","sequence":"additional","affiliation":[{"name":"Division of Pulmonology and Critical Care, Department of Internal Medicine, and"},{"name":"Cardiovascular Pulmonary Research Group, Departments of Pediatrics and Internal Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Porfilio","sequence":"additional","affiliation":[{"name":"Division of Critical Care"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan","family":"Elajaili","sequence":"additional","affiliation":[{"name":"Division of Critical Care"},{"name":"Cardiovascular Pulmonary Research Group, Departments of Pediatrics and Internal Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve","family":"McCormack","sequence":"additional","affiliation":[{"name":"Division of Critical Care"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Burciaga","sequence":"additional","affiliation":[{"name":"Division of Critical Care"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassidy","family":"Delaney","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics"},{"name":"Cardiovascular Pulmonary Research Group, Departments of Pediatrics and Internal Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva S.","family":"Nozik","sequence":"additional","affiliation":[{"name":"Division of Critical Care"},{"name":"Cardiovascular Pulmonary Research Group, Departments of Pediatrics and Internal Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,1]]},"reference":[{"key":"2026053120014661900_bib1","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1001\/jama.2016.0291","article-title":"Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries","volume":"315","author":"Bellani","year":"2016","journal-title":"JAMA"},{"key":"2026053120014661900_bib2","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJM200005043421801","article-title":"Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome","volume":"342","author":"Brower","year":"2000","journal-title":"N Engl J Med"},{"key":"2026053120014661900_bib3","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1164\/rccm.202311-2011ST","article-title":"An update on management of adult patients with acute respiratory distress syndrome: an official American Thoracic Society clinical practice guideline","volume":"209","author":"Qadir","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"key":"2026053120014661900_bib4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-3-319-63245-2_8","article-title":"ROS signaling in the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)","volume":"967","author":"Kellner","year":"2017","journal-title":"Adv Exp Med Biol"},{"key":"2026053120014661900_bib5","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.3390\/antiox10121956","article-title":"Friend or foe? The roles of antioxidants in acute lung injury","volume":"10","author":"Liu","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"2026053120014661900_bib6","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1089\/ars.2019.7752","article-title":"Peroxiredoxins and beyond; redox systems regulating lung physiology and disease","volume":"31","author":"Elko","year":"2019","journal-title":"Antioxid Redox Signal"},{"key":"2026053120014661900_bib7","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1016\/j.biocel.2005.06.012","article-title":"Extracellular superoxide dismutase","volume":"37","author":"Nozik-Grayck","year":"2005","journal-title":"Int J Biochem Cell Biol"},{"key":"2026053120014661900_bib8","doi-asserted-by":"crossref","first-page":"L680","DOI":"10.1152\/ajplung.00191.2002","article-title":"Evidence for extracellular superoxide dismutase as a mediator of hemorrhage-induced lung injury","volume":"284","author":"Bowler","year":"2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026053120014661900_bib9","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1165\/rcmb.2004-0057OC","article-title":"Extracellular superoxide dismutase attenuates lipopolysaccharide-induced neutrophilic inflammation","volume":"31","author":"Bowler","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026053120014661900_bib10","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1007\/s00134-011-2309-y","article-title":"Overexpression of pulmonary extracellular superoxide dismutase attenuates endotoxin-induced acute lung injury","volume":"37","author":"Hassett","year":"2011","journal-title":"Intensive Care Med"},{"key":"2026053120014661900_bib11","doi-asserted-by":"crossref","first-page":"e26870","DOI":"10.1371\/journal.pone.0026870","article-title":"Aerosolized human extracellular superoxide dismutase prevents hyperoxia-induced lung injury","volume":"6","author":"Yen","year":"2011","journal-title":"PLoS One"},{"key":"2026053120014661900_bib12","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41598-019-57147-7","article-title":"Extracellular superoxide dismutase regulates early vascular hyaluronan remodeling in hypoxic pulmonary hypertension","volume":"10","author":"Tseng","year":"2020","journal-title":"Sci Rep"},{"key":"2026053120014661900_bib13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.2174\/187152011795677544","article-title":"Superoxide dismutase in redox biology: the roles of superoxide and hydrogen peroxide","volume":"11","author":"Buettner","year":"2011","journal-title":"Anticancer Agents Med Chem"},{"key":"2026053120014661900_bib14","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s11307-023-01826-5","article-title":"Use of electron paramagnetic resonance (EPR) to evaluate redox status in a preclinical model of acute lung injury","volume":"26","author":"Elajaili","year":"2024","journal-title":"Mol Imaging Biol"},{"key":"2026053120014661900_bib15","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1161\/CIRCGENETICS.113.000504","article-title":"A common polymorphism in extracellular superoxide dismutase affects cardiopulmonary disease risk by altering protein distribution","volume":"7","author":"Hartney","year":"2014","journal-title":"Circ Cardiovasc Genet"},{"key":"2026053120014661900_bib16","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1042\/BJ20041218","article-title":"The high concentration of Arg213\u2013&gt;Gly extracellular superoxide dismutase (EC-SOD) in plasma is caused by a reduction of both heparin and collagen affinities","volume":"385","author":"Petersen","year":"2005","journal-title":"Biochem J"},{"key":"2026053120014661900_bib17","doi-asserted-by":"crossref","first-page":"L445","DOI":"10.1152\/ajplung.00217.2022","article-title":"Release of extracellular superoxide dismutase into alveolar fluid protects against acute lung injury and inflammation in Staphylococcus aureus pneumonia","volume":"324","author":"Sul","year":"2023","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026053120014661900_bib18","doi-asserted-by":"crossref","first-page":"13465","DOI":"10.1096\/fj.201901038RR","article-title":"Redistribution of EC-SOD resolves bleomycin-induced inflammation via increased apoptosis of recruited alveolar macrophages","volume":"33","author":"Allawzi","year":"2019","journal-title":"FASEB J"},{"key":"2026053120014661900_bib19","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1089\/ars.2013.5337","article-title":"Reactive oxygen species play a critical role in collagen-induced platelet activation via SHP-2 oxidation","volume":"20","author":"Jang","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"2026053120014661900_bib20","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1172\/JCI108613","article-title":"Superoxide production and reducing activity in human platelets","volume":"59","author":"Marcus","year":"1977","journal-title":"J Clin Invest"},{"key":"2026053120014661900_bib21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.resp.2007.09.011","article-title":"Exacerbation of wood smoke-induced acute lung injury by mechanical ventilation using moderately high tidal volume in mice","volume":"160","author":"Yang","year":"2008","journal-title":"Respir Physiol Neurobiol"},{"key":"2026053120014661900_bib22","doi-asserted-by":"crossref","first-page":"L413","DOI":"10.1152\/ajplung.00519.2020","article-title":"Platelet activation contributes to hypoxia-induced inflammation","volume":"320","author":"Delaney","year":"2021","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026053120014661900_bib23","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1182\/blood.2023019940","article-title":"A key role for platelet GPVI in neutrophil recruitment, migration, and NETosis in the early stages of acute lung injury","volume":"142","author":"Burkard","year":"2023","journal-title":"Blood"},{"key":"2026053120014661900_bib24","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/MOH.0000000000000665","article-title":"Brothers in arms: platelets and neutrophils in ischemic stroke","volume":"28","author":"Denorme","year":"2021","journal-title":"Curr Opin Hematol"},{"key":"2026053120014661900_bib25","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.pupt.2017.05.005","article-title":"Lipopolysaccharide (LPS) induced pulmonary neutrophil recruitment and platelet activation is mediated via the P2Y(1) and P2Y(14) receptors in mice","volume":"45","author":"Amison","year":"2017","journal-title":"Pulm Pharmacol Ther"},{"key":"2026053120014661900_bib26","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1165\/rcmb.2018-0182OC","article-title":"LPS-induced lung platelet recruitment occurs independently from neutrophils, PSGL-1, and P-selectin","volume":"61","author":"Cleary","year":"2019","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026053120014661900_bib27","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1152\/physrev.00038.2015","article-title":"Platelets in pulmonary immune responses and inflammatory lung diseases","volume":"96","author":"Middleton","year":"2016","journal-title":"Physiol Rev"},{"key":"2026053120014661900_bib28","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.3390\/ijms23073868","article-title":"Beyond hemostasis: platelet innate immune interactions and thromboinflammation","volume":"23","author":"Mandel","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026053120014661900_bib29","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1172\/JCI26989","article-title":"Structure and function of the platelet integrin alphaIIbbeta3","volume":"115","author":"Bennett","year":"2005","journal-title":"J Clin Invest"},{"key":"2026053120014661900_bib30","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1161\/01.CIR.102.16.1931","article-title":"P-selectin expression on platelets determines size and stability of platelet aggregates","volume":"102","author":"Merten","year":"2000","journal-title":"Circulation"},{"key":"2026053120014661900_bib31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3389\/fcvm.2020.00015","article-title":"Procoagulant phosphatidylserine-exposing platelets in vitro and in vivo","volume":"7","author":"Reddy","year":"2020","journal-title":"Front Cardiovasc Med"},{"key":"2026053120014661900_bib32","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.intimp.2013.06.004","article-title":"Neutrophil and platelet complexes and their relevance to neutrophil recruitment and activation","volume":"17","author":"Page","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"2026053120014661900_bib33","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1152\/japplphysiol.01086.2009","article-title":"Circulating platelet-neutrophil complexes are important for subsequent neutrophil activation and migration","volume":"109","author":"Kornerup","year":"2010","journal-title":"J Appl Physiol (1985)"},{"key":"2026053120014661900_bib34","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1161\/CIRCRESAHA.117.310795","article-title":"Circulating platelets as mediators of immunity, inflammation, and thrombosis","volume":"122","author":"Koupenova","year":"2018","journal-title":"Circ Res"},{"key":"2026053120014661900_bib35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1046\/j.1365-2796.1997.00160.x","article-title":"Two variants of extracellular-superoxide dismutase: relationship to cardiovascular risk factors in an unselected middle-aged population","volume":"242","author":"Marklund","year":"1997","journal-title":"J Intern Med"},{"key":"2026053120014661900_bib36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1161\/01.CIR.0000105720.28086.6C","article-title":"Genetically reduced antioxidative protection and increased ischemic heart disease risk: the Copenhagen City Heart Study","volume":"109","author":"Juul","year":"2004","journal-title":"Circulation"},{"key":"2026053120014661900_bib37","doi-asserted-by":"crossref","first-page":"e95072","DOI":"10.1172\/jci.insight.95072","article-title":"The R213G polymorphism in SOD3 protects against allergic airway inflammation","volume":"2","author":"Gaurav","year":"2017","journal-title":"JCI Insight"},{"key":"2026053120014661900_bib38","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1164\/rccm.200509-1387OC","article-title":"Genetically increased antioxidative protection and decreased chronic obstructive pulmonary disease","volume":"173","author":"Juul","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"2026053120014661900_bib39","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/omi.12252","article-title":"The roles of NADPH oxidase in modulating neutrophil effector responses","volume":"34","author":"Zeng","year":"2019","journal-title":"Mol Oral Microbiol"},{"key":"2026053120014661900_bib40","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1161\/01.CIR.95.4.885","article-title":"Platelet activation by superoxide anion and hydroxyl radicals intrinsically generated by platelets that had undergone anoxia and then reoxygenated","volume":"95","author":"Leo","year":"1997","journal-title":"Circulation"},{"key":"2026053120014661900_bib41","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ajpath.2011.03.013","article-title":"Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis","volume":"179","author":"Narasaraju","year":"2011","journal-title":"Am J Pathol"},{"key":"2026053120014661900_bib42","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"2026053120014661900_bib43","doi-asserted-by":"crossref","first-page":"572009","DOI":"10.3389\/fphar.2020.572009","article-title":"Targeting neutrophils to treat acute respiratory distress syndrome in coronavirus disease","volume":"11","author":"Chiang","year":"2020","journal-title":"Front Pharmacol"},{"key":"2026053120014661900_bib44","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.bj.2020.09.001","article-title":"Understanding the role of neutrophils in acute respiratory distress syndrome","volume":"44","author":"Yang","year":"2021","journal-title":"Biomed J"},{"key":"2026053120014661900_bib45","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.freeradbiomed.2003.10.029","article-title":"Mechanistic analysis of the immunomodulatory effects of a catalytic antioxidant on antigen-presenting cells: implication for their use in targeting oxidation-reduction reactions in innate immunity","volume":"36","author":"Tse","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"2026053120014661900_bib46","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3390\/antiox7110156","article-title":"Superoxide dismutases (SODs) and SOD mimetics","volume":"7","author":"Borgstahl","year":"2018","journal-title":"Antioxidants (Basel)"},{"key":"2026053120014661900_bib47","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1165\/ajrcmb.25.2.4235","article-title":"Attenuation of bleomycin-induced pulmonary fibrosis by a catalytic antioxidant metalloporphyrin","volume":"25","author":"Oury","year":"2001","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026053120014661900_bib48","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.freeradbiomed.2007.10.058","article-title":"Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection","volume":"44","author":"Gauter-Fleckenstein","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"2026053120014661900_bib49","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1002\/jor.24967","article-title":"MnTE-2-PyP disrupts Staphylococcus aureus biofilms in a novel fracture model","volume":"39","author":"Lindsay","year":"2021","journal-title":"J Orthop Res"},{"key":"2026053120014661900_bib50","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1165\/rcmb.2008-0138OC","article-title":"The antioxidant mimetic, MnTE-2-PyP, reduces intracellular growth of Mycobacterium abscessus","volume":"41","author":"Oberley-Deegan","year":"2009","journal-title":"Am J Respir Cell Mol Biol"}],"container-title":["American Journal of Respiratory Cell and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/72\/6\/653\/66197771\/ajrcmb_72_6_653.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/72\/6\/653\/66197771\/ajrcmb_72_6_653.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:01:59Z","timestamp":1780272119000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article\/72\/6\/653\/8404993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,1]]},"references-count":50,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6,1]]},"published-print":{"date-parts":[[2025,6,1]]}},"URL":"https:\/\/doi.org\/10.1165\/rcmb.2024-0292oc","relation":{},"ISSN":["1044-1549","1535-4989"],"issn-type":[{"value":"1044-1549","type":"print"},{"value":"1535-4989","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2025,6,1]]},"assertion":[{"value":"2024-06-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}