{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:54:48Z","timestamp":1793663688826,"version":"4.5.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":113,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"the Royal Physiographic Society of Lund"},{"DOI":"10.13039\/501100001862","name":"the Swedish Research Council","doi-asserted-by":"crossref","award":["2023-02013"],"award-info":[{"award-number":["2023-02013"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Swedish Heart and Lung Foundation","award":["20220193"],"award-info":[{"award-number":["20220193"]}]},{"name":"the Swedish Government Funds for Clinical Research","award":["46402"],"award-info":[{"award-number":["46402"]}]},{"name":"the Alfred \u00d6sterlund Foundation"},{"name":"the Royal Physiographic Society of Lund"},{"DOI":"10.13039\/501100001862","name":"the Swedish Research Council","doi-asserted-by":"crossref","award":["2023-02013"],"award-info":[{"award-number":["2023-02013"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Swedish Heart and Lung Foundation","award":["20220193"],"award-info":[{"award-number":["20220193"]}]},{"name":"the Swedish Government Funds for Clinical Research","award":["46402"],"award-info":[{"award-number":["46402"]}]},{"name":"the Alfred \u00d6sterlund Foundation"}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Allergic asthma is characterized by Type 2 inflammation and eosinophilia. Tartrate-resistant acid phosphatase 5 (TRAP5; also referred to as acid phosphatase 5 [ACP5]) is a metallophosphatase expressed by alveolar macrophages that dephosphorylates osteopontin, a phosphoglycoprotein with increased expression in asthma. To investigate the role of TRAP5 during asthma, we used a murine model of ovalbumin (OVA)-induced allergic airway inflammation as well as IL-33\u2013induced airway inflammation, including Trap5\u2212\/\u2212 and wild-type (WT) mice. Histological analyses of murine lung revealed that OVA-induced inflammation induced the formation of inflammatory lesions and increased mucus production in both WT and Trap5\u2212\/\u2212 mice. However, lower cytokine levels (including IL-5 and IL-13) were detected by multiplex immunoassay in Trap5\u2212\/\u2212 mice after OVA-induced inflammation. Furthermore, quantitative PCR analysis detected different gene expression profiles of Trap5\u2212\/\u2212\/OVA mice, including upregulation of Il-17a and downregulation of Il-33. Lower eosinophil numbers were measured in BAL fluid of Trap5\u2212\/\u2212\/OVA mice using flow cytometry analysis, whereas immunofluorescence staining revealed a high eosinophil number in lung tissue of both groups with OVA challenge. In the IL-33 model of Type 2 inflammation, both WT and Trap5\u2212\/\u2212 mice showed similar inflammatory responses with regard to cytokine levels and cell recruitment patterns. In vitro, eosinophil chemotaxis was facilitated by nonphosphorylated, but not phosphorylated, osteopontin, an effect inhibited by an \u03b14\u03b21 integrin inhibitor. The results suggest that TRAP5 is important in the recruitment of immune cells, including eosinophils, as well as in shaping the profile and amplification of the inflammatory response during allergic airway inflammation. Thus, TRAP5 may serve as a therapeutic target in allergic asthma.<\/jats:p>","DOI":"10.1165\/rcmb.2024-0304oc","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T14:35:31Z","timestamp":1743604531000},"page":"612-622","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":4,"title":["Tartrate-Resistant Acid Phosphatase 5 (TRAP5) Promotes Eosinophil Migration During Allergic Asthma"],"prefix":"10.1093","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7089-2188","authenticated-orcid":false,"given":"M\u00e9dea","family":"Padra","sequence":"first","affiliation":[{"name":"Respiratory Medicine, Allergology, & Palliative Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Bergwik","sequence":"additional","affiliation":[{"name":"Respiratory Medicine, Allergology, & Palliative Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Adler","sequence":"additional","affiliation":[{"name":"Respiratory Medicine, Allergology, & Palliative Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve","family":"Marcoux","sequence":"additional","affiliation":[{"name":"Respiratory Medicine, Allergology, & Palliative Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi K. 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