{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:09:46Z","timestamp":1769152186919,"version":"3.49.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Special Scientific Research Project in the Health Industry of China","award":["201302017"],"award-info":[{"award-number":["201302017"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92269204"],"award-info":[{"award-number":["92269204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Special Scientific Research Project in the Health Industry of China","award":["201302017"],"award-info":[{"award-number":["201302017"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["92269204"],"award-info":[{"award-number":["92269204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Identifying inflammation-induced leukocyte subsets and their derived circulating factors has been instrumental in understanding the progression of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Nevertheless, how primary inflammation-induced nonleukocyte populations in distal organs contribute to ALI\/ARDS remains poorly defined. Here, we report one population of erythroblast-like cells (Ter-cells) deriving from megakaryocyte-erythroid progenitor cells with a unique Ter-119+CD45\u2212CD71+ phenotype in ALI\/ARDS. Ter-cells induced by the spleen are chemoattracted into the lung to inhibit the progression of ALI by secreting the neurotrophic factor artemin into the blood and BAL fluid. In vivo blockade of Ter-cell\u2013derived artemin aggravates lung injury, and artemin deficiency abolishes Ter-cells\u2019 antiinflammatory ability. We confirm the presence of circulating artemin in patients with ARDS and show that significantly elevated artemin correlates with good prognosis. We propose that Ter-cells and the secreted artemin play important roles in ALI\/ARDS, with prognostic and therapeutic implications.<\/jats:p>","DOI":"10.1165\/rcmb.2024-0407oc","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T17:08:51Z","timestamp":1736183331000},"page":"37-48","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":1,"title":["Inflammation-induced Generation of Splenic Erythroblast-like Ter-Cells Inhibits the Progression of Acute Lung Injury via Artemin"],"prefix":"10.1093","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0018-6901","authenticated-orcid":false,"given":"Qiao","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine"},{"name":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Long","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Changhai Hospital, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chao","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Hou","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Immunity and Inflammation, Institute of Immunology, Naval Medical University, Shanghai, P. R. China; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Guo","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Immunity and Inflammation, Institute of Immunology, Naval Medical University, Shanghai, P. R. China; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"2026012204152169500_bib1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41572-019-0069-0","article-title":"Acute respiratory distress syndrome","volume":"5","author":"Matthay","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"2026012204152169500_bib2","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1001\/jama.2016.0291","article-title":"Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries","volume":"315","author":"Bellani","year":"2016","journal-title":"JAMA"},{"key":"2026012204152169500_bib3","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1038\/s41591-020-0944-y","article-title":"A single-cell atlas of the peripheral immune response in patients with severe COVID-19","volume":"26","author":"Wilk","year":"2020","journal-title":"Nat Med"},{"key":"2026012204152169500_bib4","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/s41467-021-27716-4","article-title":"Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19","volume":"13","author":"Unterman","year":"2022","journal-title":"Nat Commun"},{"key":"2026012204152169500_bib5","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.cell.2020.11.007","article-title":"Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques","volume":"184","author":"Hoang","year":"2021","journal-title":"Cell"},{"key":"2026012204152169500_bib6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41577-020-0406-2","article-title":"Lactate modulation of immune responses in inflammatory versus tumour microenvironments","volume":"21","author":"Certo","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"2026012204152169500_bib7","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jconrel.2021.04.018","article-title":"Inflammatory microenvironment-targeted nanotherapies","volume":"334","author":"Zhang","year":"2021","journal-title":"J Control Release"},{"key":"2026012204152169500_bib8","doi-asserted-by":"crossref","first-page":"1702590","DOI":"10.1183\/13993003.02590-2017","article-title":"Impaired efferocytosis and neutrophil extracellular trap clearance by macrophages in ARDS","volume":"52","author":"Gr\u00e9goire","year":"2018","journal-title":"Eur Respir J"},{"key":"2026012204152169500_bib9","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1182\/blood.2020009417","article-title":"Upregulated PD-L1 delays human neutrophil apoptosis and promotes lung injury in an experimental mouse model of sepsis","volume":"138","author":"Wang","year":"2021","journal-title":"Blood"},{"key":"2026012204152169500_bib10","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.immuni.2022.12.017","article-title":"Dopamine inhibits group 2 innate lymphoid cell-driven allergic lung inflammation by dampening mitochondrial activity","volume":"56","author":"Cao","year":"2023","journal-title":"Immunity"},{"key":"2026012204152169500_bib11","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s41577-023-00834-4","article-title":"The role of platelets in immune-mediated inflammatory diseases","volume":"23","author":"Scherlinger","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"2026012204152169500_bib12","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41569-018-0110-0","article-title":"Platelet biology and functions: new concepts and clinical perspectives","volume":"16","author":"van der Meijden","year":"2019","journal-title":"Nat Rev Cardiol"},{"key":"2026012204152169500_bib13","doi-asserted-by":"crossref","first-page":"e153920","DOI":"10.1172\/JCI153920","article-title":"Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression","volume":"132","author":"Valet","year":"2022","journal-title":"J Clin Invest"},{"key":"2026012204152169500_bib14","doi-asserted-by":"crossref","first-page":"634","DOI":"10.3390\/cells9030634","article-title":"Stress erythropoiesis is a key inflammatory response","volume":"9","author":"Paulson","year":"2020","journal-title":"Cells"},{"key":"2026012204152169500_bib15","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41590-024-01754-8","article-title":"Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19","volume":"25","author":"Hanson","year":"2024","journal-title":"Nat Immunol"},{"key":"2026012204152169500_bib16","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/s41590-022-01245-8","article-title":"Single-cell transcriptomic analysis identifies an immune-prone population in erythroid precursors during human ontogenesis","volume":"23","author":"Xu","year":"2022","journal-title":"Nat Immunol"},{"key":"2026012204152169500_bib17","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.immuni.2013.10.010","article-title":"The spleen in local and systemic regulation of immunity","volume":"39","author":"Bronte","year":"2013","journal-title":"Immunity"},{"key":"2026012204152169500_bib18","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0140-6736(10)61493-6","article-title":"Post-splenectomy and hyposplenic states","volume":"378","author":"Di Sabatino","year":"2011","journal-title":"Lancet"},{"key":"2026012204152169500_bib19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41572-022-00399-x","article-title":"Asplenia and spleen hypofunction","volume":"8","author":"Lenti","year":"2022","journal-title":"Nat Rev Dis Primers"},{"key":"2026012204152169500_bib20","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.cell.2018.02.061","article-title":"Tumor-induced generation of splenic erythroblast-like Ter-cells promotes tumor progression","volume":"173","author":"Han","year":"2018","journal-title":"Cell"},{"key":"2026012204152169500_bib21","doi-asserted-by":"crossref","first-page":"eabb0130","DOI":"10.1126\/scitranslmed.abb0130","article-title":"Radiotherapy and immunotherapy converge on elimination of tumor-promoting erythroid progenitor cells through adaptive immunity","volume":"13","author":"Hou","year":"2021","journal-title":"Sci Transl Med"},{"key":"2026012204152169500_bib22","first-page":"2526","article-title":"Acute respiratory distress syndrome: the Berlin definition","volume":"307","author":"Ranieri","year":"2012","journal-title":"JAMA"},{"key":"2026012204152169500_bib23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1164\/rccm.202303-0558WS","article-title":"A new global definition of acute respiratory distress syndrome","volume":"209","author":"Matthay","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204152169500_bib24","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1080\/15476286.2016.1185591","article-title":"Increasing the efficiency of CRISPR\/Cas9-mediated precise genome editing in rats by inhibiting NHEJ and using Cas9 protein","volume":"13","author":"Ma","year":"2016","journal-title":"RNA Biol"},{"key":"2026012204152169500_bib25","doi-asserted-by":"crossref","first-page":"17413","DOI":"10.1073\/pnas.0909296106","article-title":"Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis","volume":"106","author":"Chen","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026012204152169500_bib26","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1046\/j.1365-2141.2000.02037.x","article-title":"The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage","volume":"109","author":"Kina","year":"2000","journal-title":"Br J Haematol"},{"key":"2026012204152169500_bib27","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12943-018-0772-6","article-title":"Extracellular vesicle-derived DNA for performing EGFR genotyping of NSCLC patients","volume":"17","author":"Hur","year":"2018","journal-title":"Mol Cancer"},{"key":"2026012204152169500_bib28","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/jama.2020.20317","article-title":"Acute pancreatitis: a review","volume":"325","author":"Mederos","year":"2021","journal-title":"JAMA"},{"key":"2026012204152169500_bib29","first-page":"5129314","article-title":"Mortality predictive value of APACHE II and SOFA scores in COVID-19 patients in the intensive care unit","volume":"2022","author":"Beigmohammadi","year":"2022","journal-title":"Can Respir J"},{"key":"2026012204152169500_bib30","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S0140-6736(21)00439-6","article-title":"Acute respiratory distress syndrome","volume":"398","author":"Meyer","year":"2021","journal-title":"Lancet"},{"key":"2026012204152169500_bib31","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S2213-2600(21)00157-0","article-title":"Advancing precision medicine for acute respiratory distress syndrome","volume":"10","author":"Beitler","year":"2022","journal-title":"Lancet Respir Med"},{"key":"2026012204152169500_bib32","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.immuni.2016.02.024","article-title":"Tissue-resident macrophage ontogeny and homeostasis","volume":"44","author":"Ginhoux","year":"2016","journal-title":"Immunity"},{"key":"2026012204152169500_bib33","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/ni.2638","article-title":"Origin of monocytes and macrophages in a committed progenitor","volume":"14","author":"Hettinger","year":"2013","journal-title":"Nat Immunol"},{"key":"2026012204152169500_bib34","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"2026012204152169500_bib35","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1182\/blood-2018-11-844548","article-title":"Neutrophil plasticity in the tumor microenvironment","volume":"133","author":"Giese","year":"2019","journal-title":"Blood"},{"key":"2026012204152169500_bib36","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/nm.3892","article-title":"Innate lymphoid cells in the initiation, regulation and resolution of inflammation","volume":"21","author":"Sonnenberg","year":"2015","journal-title":"Nat Med"},{"key":"2026012204152169500_bib37","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1038\/s41591-018-0205-5","article-title":"Late-stage tumors induce anemia and immunosuppressive extramedullary erythroid progenitor cells","volume":"24","author":"Zhao","year":"2018","journal-title":"Nat Med"},{"key":"2026012204152169500_bib38","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nature15530","article-title":"A perisinusoidal niche for extramedullary haematopoiesis in the spleen","volume":"527","author":"Inra","year":"2015","journal-title":"Nature"},{"key":"2026012204152169500_bib39","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.it.2019.01.003","article-title":"Neglected cells: immunomodulatory roles of CD71+ erythroid cells","volume":"40","author":"Elahi","year":"2019","journal-title":"Trends Immunol"},{"key":"2026012204152169500_bib40","doi-asserted-by":"crossref","first-page":"eaau8217","DOI":"10.1126\/scitranslmed.aau8217","article-title":"Treating murine inflammatory diseases with an anti-erythrocyte antibody","volume":"11","author":"Crow","year":"2019","journal-title":"Sci Transl Med"},{"key":"2026012204152169500_bib41","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrn812","article-title":"The GDNF family: signalling, biological functions and therapeutic value","volume":"3","author":"Airaksinen","year":"2002","journal-title":"Nat Rev Neurosci"},{"key":"2026012204152169500_bib42","doi-asserted-by":"crossref","first-page":"e12860","DOI":"10.1111\/cpr.12860","article-title":"The role of glial cell line-derived neurotrophic factor family member artemin in neurological disorders and cancers","volume":"53","author":"Zhu","year":"2020","journal-title":"Cell Prolif"},{"key":"2026012204152169500_bib43","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1136\/gut.2006.105528","article-title":"The neurotrophic factor artemin influences the extent of neural damage and growth in chronic pancreatitis","volume":"56","author":"Ceyhan","year":"2007","journal-title":"Gut"},{"key":"2026012204152169500_bib44","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/ni.3614","article-title":"The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin","volume":"18","author":"Hidaka","year":"2017","journal-title":"Nat Immunol"},{"key":"2026012204152169500_bib45","doi-asserted-by":"crossref","first-page":"e202000780","DOI":"10.26508\/lsa.202000780","article-title":"Neurturin regulates the lung-resident macrophage inflammatory response to viral infection","volume":"3","author":"Connolly","year":"2020","journal-title":"Life Sci Alliance"},{"key":"2026012204152169500_bib46","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1164\/rccm.201702-0405CP","article-title":"Fifty years of research in ARDS: genomic contributions and opportunities","volume":"196","author":"Reilly","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"2026012204152169500_bib47","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0896-6273(02)00774-2","article-title":"Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons","volume":"35","author":"Honma","year":"2002","journal-title":"Neuron"}],"container-title":["American Journal of Respiratory Cell and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/73\/1\/37\/66194990\/ajrcmb_73_1_37.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article-pdf\/73\/1\/37\/66194990\/ajrcmb_73_1_37.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:18:01Z","timestamp":1769073481000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrcmb\/article\/73\/1\/37\/8405579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,7,1]]},"published-print":{"date-parts":[[2025,7,1]]}},"URL":"https:\/\/doi.org\/10.1165\/rcmb.2024-0407oc","relation":{},"ISSN":["1044-1549","1535-4989"],"issn-type":[{"value":"1044-1549","type":"print"},{"value":"1535-4989","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"2024-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}