{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:54:37Z","timestamp":1789646077160,"version":"4.0.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21HD092934"],"award-info":[{"award-number":["R21HD092934"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21HD105050"],"award-info":[{"award-number":["R21HD105050"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["U01HL075904"],"award-info":[{"award-number":["U01HL075904"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Study Project for Institutes of Higher Learning, Ministry of Education, Liaoning Province","award":["LJKM2022115"],"award-info":[{"award-number":["LJKM2022115"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects preterm infants. Disrupted microvascular growth is a well-recognized pathologic feature of BPD, which plays a critical role in arrested alveologenesis. Recent studies have identified two subpopulations of pulmonary microvascular endothelial cells (ECs): general capillary (gCap) and aerocyte (aCap) cells. In this study, we validated proposed markers for gCap (GPIHBP1, PLVAP, CD93) and aCap (CA4, HPGD) at the protein level and investigated their abundance during late-stage lung development in murine and nonhuman primate (NHP) lungs. We also examined alterations in the abundance and proliferation of gCap and aCap cells in NHP and murine models of BPD. Our studies confirmed CA4 and HPGD as specific markers for aCap, and all three putative gCap markers were also detected in nonmicrovascular ECs. All markers except for HPGD showed a gradual increase in abundance during the saccular and alveolar stages of development in NHP lungs. In the NHP model of BPD, the abundance of both aCap markers and GPIHBP1 were decreased, whereas those of PLVAP and CD93 were increased. Additionally, there was an emergence of CA4+HPGD\u2212 aCap cells in BPD lungs. In late-stage control lungs, aCap proliferation was more robust than gCap proliferation, whereas no significant differences were observed between aCap and gCap proliferation rates in NHP BPD. Notably, in BPD lungs, gCap proliferation was more robust compared with control lungs. This study provides new insights into the distinct regulation patterns of microvascular ECs during lung development and neonatal lung injury in a translationally relevant NHP model.<\/jats:p>","DOI":"10.1165\/rcmb.2025-0009oc","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T20:49:31Z","timestamp":1755895771000},"page":"119-128","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":7,"title":["Capillary Endothelial Cell Subtypes in the Lung: Markers and Response to Developmental Lung Injury"],"prefix":"10.1093","volume":"74","author":[{"given":"Abhijeet","family":"Thakur","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, 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