{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:05:55Z","timestamp":1788897955616,"version":"build-2803163510"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.atsjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pulmonary blood volumes (PBVs), currently not assessed by computed tomography pulmonary angiography (CTPA), could provide additional information to routine investigations performed for chronic thromboembolic pulmonary hypertension (CTEPH). We investigated CTPA-based PBVs in evaluating hemodynamic outcome from pulmonary endarterectomy (PEA). A deep learning\u2013based CTPA vascular segmentation model, differentiating arteries and veins, was applied for automated PBV measurements in patients with CTEPH who underwent PEA at the United Kingdom\u2019s national CTEPH service. Pulmonary arteries were compartmentalized into \u201ccentral\u201d (main pulmonary and proximal lobar) and \u201cintrapulmonary.\u201d Mean pulmonary arterial pressure &amp;gt;30\u2009mm Hg post-PEA defined \u201cclinically relevant\u201d residual pulmonary hypertension (PH). Logistic regression models applying CTPA-based PBV to identify residual PH were trained and tested on the discovery and validation cohorts, respectively. Paired pre- and postoperative CTPA in the discovery (n\u2009=\u200971) and validation (n\u2009=\u2009102) cohorts showed that central pulmonary artery volume and total artery to vein volume ratio (A-VR) decreased and pulmonary vein volume increased with hemodynamic improvement post-PEA. Preoperative central pulmonary artery volume and A-VR helped identify patients at risk for clinically relevant residual PH post-PEA (area under the receiver operating characteristic curve [AUROC], 0.88 and 0.82 in the discovery and validation cohorts, respectively). Postoperative central pulmonary artery volume, A-VR, and pulmonary vein volume helped to noninvasively identify patients without clinically relevant residual PH (AUROC, 0.91 and 0.88 in the discovery and validation cohorts). Automated quantification of CTPA-based PBV at diagnosis can help stratify risk for residual PH in patients managed with PEA. Utilizing CTPA-derived PBV post-PEA to identify patients without residual PH can potentially reduce the need for routine postoperative right heart catheterization.<\/jats:p>","DOI":"10.1165\/rcmb.2025-0121oc","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:12:29Z","timestamp":1761156749000},"page":"792-804","update-policy":"https:\/\/doi.org\/10.1164\/crossmarkpolicies","source":"Crossref","is-referenced-by-count":6,"title":["Pulmonary blood volumes on computed tomography predict residual pulmonary hypertension post\u2013pulmonary endarterectomy"],"prefix":"10.1093","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0264-3355","authenticated-orcid":false,"given":"Hakim","family":"Ghani","sequence":"first","affiliation":[{"name":"National Pulmonary Hypertension Centre, Pulmonary Vascular Disease Unit, Royal Papworth Hospital , Cambridge,","place":["United Kingdom"]},{"name":"University of Cambridge School of Clinical Medicine, , 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