{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:25:36Z","timestamp":1772929536552,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Previous investigations have evidenced the importance of CCAAT\/enhancer-binding proteins (C\/EBPs) and peroxisome proliferator\u2013activated receptor (PPAR)\u03b3 for lung development, especially for alveolar type II cells (ATII). This prompted us to explore whether ATII maturation-promoting mediators controlled their expression in isolated ATII. In whole rat lung, C\/EBP\u03b1, \u03b2, \u03b4, and PPAR\u03b3 mRNAs increased 3\u20135 times between gestational day 18 and term (Day 22), dropped around birth, then reincreased. C\/EBP\u03b2 and \u03b4, but not PPAR\u03b3, displayed similar profile in isolated ATII; C\/EBP\u03b1 transcript disappeared and the protein became hardly detectable in isolated cells. In cultured ATII, dexamethasone increased C\/EBP\u03b2 and PPAR\u03b3 mRNAs 2\u20134 times, and cyclic AMP increased C\/EBP\u03b2 and \u03b4 mRNAs \u223c 1.5 times. Whereas retinoic acid increased C\/EBP\u03b2 and PPAR\u03b3 mRNAs 1.5 times in ATII in vitro, vitamin-A deficiency strongly decreased fetal lung C\/EBP\u03b1, \u03b2, and PPAR\u03b3 transcripts in vivo. C\/EBP\u03b2, \u03b4, and PPAR\u03b3 mRNAs were also increased in vitro by epidermal growth factor and keratinocyte growth factor, whereas they were unchanged by the maturation inhibitor transforming growth factor-\u03b2. C\/EBP\u03b1 expression was not reinduced by any mediator. Changes in transcripts were reflected in protein levels analyzed through Western blotting. These results argue for a role of these factors in ATII functional maturation, and indicate a multifactorial control of their ontogeny.<\/jats:p>","DOI":"10.1165\/rcmb.4912","type":"journal-article","created":{"date-parts":[[2003,10,20]],"date-time":"2003-10-20T18:21:09Z","timestamp":1066674069000},"page":"620-626","source":"Crossref","is-referenced-by-count":16,"title":["Maturational Factors Modulate Transcription Factors CCAAT\/Enhancer-Binding Proteins \u03b1, \u03b2, \u03b4, and Peroxisome Proliferator\u2013Activated Receptor-\u03b3 in Fetal Rat Lung Epithelial Cells"],"prefix":"10.1093","volume":"29","author":[{"given":"Anne-Marie","family":"Barlier-Mur","sequence":"first","affiliation":[{"name":"Inserm U 492, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris XII, Cr\u00e9teil; and Inserm E 213, H\u00f4pital Trousseau Assistance Publique-Hopitaux de Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadette","family":"Chailley-Heu","sequence":"additional","affiliation":[{"name":"Inserm U 492, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris XII, Cr\u00e9teil; and Inserm E 213, H\u00f4pital Trousseau Assistance Publique-Hopitaux de Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudie","family":"Pinteur","sequence":"additional","affiliation":[{"name":"Inserm U 492, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris XII, Cr\u00e9teil; and Inserm E 213, H\u00f4pital Trousseau Assistance Publique-Hopitaux de Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Henrion-Caude","sequence":"additional","affiliation":[{"name":"Inserm U 492, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris XII, Cr\u00e9teil; and Inserm E 213, H\u00f4pital Trousseau Assistance Publique-Hopitaux de Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Delacourt","sequence":"additional","affiliation":[{"name":"Inserm U 492, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris XII, Cr\u00e9teil; and Inserm E 213, H\u00f4pital Trousseau Assistance Publique-Hopitaux de Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques R.","family":"Bourbon","sequence":"additional","affiliation":[{"name":"Inserm U 492, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris XII, Cr\u00e9teil; and Inserm E 213, H\u00f4pital Trousseau Assistance Publique-Hopitaux de Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,11,1]]},"reference":[{"key":"2026030623513915400_BIB1","doi-asserted-by":"crossref","first-page":"28545","DOI":"10.1074\/jbc.273.44.28545","volume":"273","year":"1998","journal-title":"J. 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