{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:26:24Z","timestamp":1789129584772,"version":"build-2803163510"},"reference-count":0,"publisher":"American Scientific Publishers","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j biomed nanotechnol"],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:p>The current study aims to investigate the possibility of using solid lipid nanoparticles (SLNs)-enhanced magnetic resonance (MR) colonography to diagnose colorectal cancer. Gd-FITC-SLNs were synthesized by loading gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) and fluorescein\n isothiocyanate (FITC) simultaneously. Twenty mice received azoxymethane\/dextran sulfate sodium (AOM\/DSS) to induce adenocarcinoma of the colon and were divided into 4 groups, and 5 in per group. MR colonography were performed at different time periods before and after enema or intravenous\n injection of Gd-FITC-SLNs or Gd-DTPA. The results demonstrated SNR (signal-to-noise ratio) significantly increased from 1.56- to 1.76-fold within the colorectal tumors after the enema of Gd-FITC-SLNs (<jats:italic>p &lt;<\/jats:italic> 0.001). No differences in SNR were observed after the enema of Gd-DTPA (<jats:italic>p\n &gt;<\/jats:italic> 0.05). Besides, SNR increased from 1.54- to 1.72-fold within the colorectal tumors after the intravenous injection of Gd-FITC-SLNs (<jats:italic>p &lt;<\/jats:italic> 0.001) while SNR increased from 1.39to 1.57-fold within the colorectal tumors after the injection of Gd-DTPA (<jats:italic>p &lt;<\/jats:italic> 0.001). In\n addition, SNR within colorectal tumors significantly increased ranging from 20th to 140th min, and lasted for about 120 min (<jats:italic>p &lt;<\/jats:italic> 0.05) after the enema of Gd-FITC-SLNs and SNR within colorectal tumors also significantly increased ranging from 0th hour to 8th hour, lasted for about\n 8 hour (<jats:italic>p &lt;<\/jats:italic> 0.05) after the injection of Gd-FITC-SLNs. However, after the injection of Gd-DTPA, SNR within colorectal tumors significantly increased only ranging from 0th min to 20th min after administration (<jats:italic>p &lt;<\/jats:italic> 0.01). Furthermore, hematoxylin and eosin (H&amp;E) staining\n revealed that all mice developed adenocarcinoma of the colon. In summary, it is feasible by using Gd-FITC-SLNs in MR colonography to diagnose colorectal cancer. Enema of Gd-FITC-SLNs can provide marked enhancement of colorectal tumors quickly, and safer while intravenous injection of Gd-FITC-SLNs\n can provide a long-lasting enhancement of colorectal tumors in MR colonography. These findings present a potential clinical application of Gd-FITC-SLNs on MR colonography.<\/jats:p>","DOI":"10.1166\/jbn.2020.2922","type":"journal-article","created":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T04:30:45Z","timestamp":1599971445000},"page":"594-602","source":"Crossref","is-referenced-by-count":12,"title":["Gadolinium-Loaded Solid Lipid Nanoparticles for Colorectal Tumor in MR Colonography"],"prefix":"10.1166","volume":"16","author":[{"given":"Huiyang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiu","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjie","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xisong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"17","container-title":["Journal of Biomedical Nanotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/asp\/jbn\/2020\/00000016\/00000005\/art00003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T04:30:52Z","timestamp":1599971452000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.1166\/jbn.2020.2922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5,1]]}},"alternative-id":["1550-7033(20200501)16:5L.594;1-"],"URL":"https:\/\/doi.org\/10.1166\/jbn.2020.2922","relation":{},"ISSN":["1550-7033"],"issn-type":[{"value":"1550-7033","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5,1]]}}}