{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:00:26Z","timestamp":1760551226311},"reference-count":0,"publisher":"American Scientific Publishers","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j biomed nanotechnol"],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:p>Nano-titanium dioxide (nano-TiO<jats:sub>2<\/jats:sub>) has been widely used in food and cosmetic industries, and the medical sector. However, nano-TiO<jats:sub>2<\/jats:sub> is potentially toxic to the reproductive system. Previous research has shown that nano-TiO<jats:sub>2<\/jats:sub> can reduce sperm concentration\n but do not yet known whether this effect occurs because of dysfunctional meiosis in spermatogenic cells. In the present paper, we demonstrate that Nano-TiO<jats:sub>2<\/jats:sub> can penetrate through the blood-testis barrier of a mouse model and enter the testicular tissue, thus causing damage to the\n testis and epididymis. This reduced the number of developing sperm; we demonstrated that the mechanism underlying this effect was the inhibition or destruction of meiosis in spermatogenic cells, particularly during meiosis I. We also found that the inhibition of meiosis I caused by nano-TiO<jats:sub>2<\/jats:sub>\n exposure was related to dysfunctional meiosis and that the abnormal expression of meiosis-related factors. Therefore, our data demonstrate that nano-TiO<jats:sub>2<\/jats:sub> reduces sperm concentration by disrupting meiosis and related signaling pathways.<\/jats:p>","DOI":"10.1166\/jbn.2020.2926","type":"journal-article","created":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T04:30:45Z","timestamp":1599971445000},"page":"659-671","source":"Crossref","is-referenced-by-count":8,"title":["Nanostructured Titanium Dioxide (TiO<sub>2<\/sub>) Reduces Sperm Concentration Involving Disorder of Meiosis and Signal Pathway"],"prefix":"10.1166","volume":"16","author":[{"given":"Fashui","family":"Hong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wuyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhui","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Ze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enjie","family":"Diao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17","container-title":["Journal of Biomedical Nanotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/asp\/jbn\/2020\/00000016\/00000005\/art00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T04:30:55Z","timestamp":1599971455000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.1166\/jbn.2020.2926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5,1]]}},"alternative-id":["1550-7033(20200501)16:5L.659;1-"],"URL":"https:\/\/doi.org\/10.1166\/jbn.2020.2926","relation":{},"ISSN":["1550-7033"],"issn-type":[{"value":"1550-7033","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5,1]]}}}