{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:17:01Z","timestamp":1788455821181,"version":"build-2803163510"},"reference-count":52,"publisher":"American Scientific Publishers","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j biomed nanotechnol"],"published-print":{"date-parts":[[2021,2,28]]},"abstract":"<jats:p>Sericin, a silk protein, has a high potential for use as an extracellular matrix in tissue engineering applications. In this study, novel gelatin (GEL) and silk sericin (SS) were incorporated with a polyvinyl alcohol) PVA hydrogel nanocomposite (GEL-SS-PVA) scaffold that can be applied to repair cartilage. Glutaraldehyde was used as a cross-linking agent, with hydrochloric acid acting as an initiator. The microstructure characteristics of the obtained GEL-SS and GEL-SS-PVA scaffolds were also examined using FTIR and XRD spectra and their enhanced thermal stability was assessed by TGA. The blended GEL-SS and GEL-SS-PVA scaffolds were confirmed by SEM analysis to be highly porous with optimum pore sizes of 172 and 58<jats:italic>\u00b5<\/jats:italic>m, respectively. Smaller pore sizes and improved uniformity were observed as the concentration of PVA in the GEL-SS-PVA scaffold increased. PVA decreased the tensile strength and elongation of the membranes but increased the modulus. Swelling studies showed high swellability and complete degradation in the presence of phosphate-buffered saline. Cytocompatibility of the GEL-SS-PVA scaffolds showed that these had the highest potential to promote cell proliferation as evaluated with standard microscopy using L929 fibroblasts. The prepared GEL-SS composite scaffold incorporated with the PVA hydrogel was implanted in full-thickness articular cartilage defects in rats. The repair effect of cartilage defects was observed and evaluated among the GEL-SS-PVA, GEL-SS, and control operation groups. The defects were almost completely repaired after 14 weeks in the GEL-SS-PVA group, thereby indicating that the GEL-SS-PVA composite had a favorable effect on articular cartilage defects in rat knee joint repair.<\/jats:p>","DOI":"10.1166\/jbn.2021.3024","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T09:40:35Z","timestamp":1617183635000},"page":"242-252","source":"Crossref","is-referenced-by-count":10,"title":["Development of Gelatin-Silk Sericin Incorporated with Poly(vinyl alcohol) Hydrogel-Based Nanocomposite for Articular Cartilage Defects in Rat Knee Joint Repair"],"prefix":"10.1166","volume":"17","author":[{"given":"Ji-Jun","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Wuxi People\u2019s Hospital, Wuxi 214023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Cheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Wuxi People\u2019s 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