{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:45:28Z","timestamp":1790181928178,"version":"4.1.0"},"reference-count":56,"publisher":"American Scientific Publishers","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j biomed nanotechnol"],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"<jats:p>The mortality rate of ethanol induced liver disease has substantially raised to alert level with an increasing use of alcohol, but development of definite hepatoprotective drug is still challenging. The efficacy of Saikosaponin D, one of the natural herbal medicine has been studied\n in different diseases. Nonetheless, its clinical application is restricted by poor bioavailability, stability and solubility. This study sought to develop a Saikosaponin D loaded liposome via thin film hydration method. The surface morphology, encapsulation efficiency and drug loading capacity\n were detected with transmission electron microscopy and HPLC, <jats:italic>in vitro<\/jats:italic> dissolution was via dialysis method, but efficacy and safety evaluation was through pharmacokinetics, while the assessment of hepatoprotective activity on alcohol induced acute hepatitis mice models was conducted.\n The optimized liposomes showed significant greater therapeutic effect on liver, through decreased serum levels of alanine transaminase (ALT) and aspartate transaminase (AST), malondialdehyde (MDA), tumor necrosis factor alpha (TNF-<jats:italic>\u03b1<\/jats:italic>), total cholesterol (TC) and triglyceride (TG)\n in liver homogenate. In contrast, levels of glutathione peroxidase (GSH-Px) and total superoxide dismutase (T-SOD) were increased significantly. Pathological study exhibited remarkable alteration of hepatitis liver architecture to almost normal state after administration of Saikosaponin D\n liposome. The increased hepatoprotective effect of Saikosaponin D liposome was observed during the attenuation of alcoholic hepatitis in mice, which might be ascribable to the anti-oxidative and anti-inflammatory properties of the drug. This study provides a theoretical basis for developing\n advanced system of Saikosaponin D delivery for the promotion of the therapeutic effects of the liposome against various kinds of diseases.<\/jats:p>","DOI":"10.1166\/jbn.2021.3054","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T04:38:08Z","timestamp":1642739888000},"page":"627-639","source":"Crossref","is-referenced-by-count":16,"title":["Development of Saikosaponin D Liposome Nanocarrier with Increased Hepatoprotective Effect Against Alcoholic Hepatitis Mice"],"prefix":"10.1166","volume":"17","author":[{"given":"Xiao","family":"Yu","sequence":"first","affiliation":[{"name":"Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jielu","family":"Pan","sequence":"additional","affiliation":[{"name":"Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Shen","sequence":"additional","affiliation":[{"name":"Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zou","sequence":"additional","affiliation":[{"name":"Experiment Center for Teaching & Learning, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Miao","sequence":"additional","affiliation":[{"name":"Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianjun","family":"Xing","sequence":"additional","affiliation":[{"name":"Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"17","reference":[{"key":"R123_275_491","first-page":"05","volume":"0","journal-title":"p <"},{"key":"R126_277_629","first-page":"05","volume":"0","journal-title":"p <"},{"key":"R130_461_694","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ajps.2014.09.004","volume":"10","journal-title":"Asian Journal of Pharmaceutical Sciences,","ISSN":"https:\/\/id.crossref.org\/issn\/0129-4172","issn-type":"print"},{"key":"R130_448_664","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/08982104.2017.1343836","volume":"28","journal-title":"J. Liposome Res.,","ISSN":"https:\/\/id.crossref.org\/issn\/0898-2104","issn-type":"print"},{"key":"R130_420_634","first-page":"5922","volume":"49","journal-title":"Cancer Research,","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"key":"R130_349_593","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1081\/DDC-120018380","volume":"29","journal-title":"Drug Development & Industrial Pharmacy,","ISSN":"https:\/\/id.crossref.org\/issn\/0363-9045","issn-type":"print"},{"key":"R130_377_563","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nprot.2013.032","volume":"8","journal-title":"Nature Protocols,"},{"key":"R130_529_523","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3109\/09687688.2010.521200","volume":"27","journal-title":"Mol. Membr. Biol.,","ISSN":"https:\/\/id.crossref.org\/issn\/0968-7688","issn-type":"print"},{"key":"R130_421_423","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1080\/10717544.2016.1177136","volume":"23","journal-title":"Drug Delivery,","ISSN":"https:\/\/id.crossref.org\/issn\/1071-7544","issn-type":"print"},{"key":"R130_517_383","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1080\/1061186X.2018.1527337","volume":"27","journal-title":"Journal of Drug Targeting,","ISSN":"https:\/\/id.crossref.org\/issn\/1061-186X","issn-type":"print"},{"key":"R130_470_192","first-page":"1240","volume":"25","journal-title":"Arzneimittel-Forschung,","ISSN":"https:\/\/id.crossref.org\/issn\/0004-4172","issn-type":"print"},{"key":"R130_369_152","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.intimp.2012.04.021","volume":"13","journal-title":"International Immunopharmacology,","ISSN":"https:\/\/id.crossref.org\/issn\/1567-5769","issn-type":"print"},{"key":"R130_528_112","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/0192-0561(90)90117-6","volume":"12","journal-title":"International Journal of Immunopharmacology,","ISSN":"https:\/\/id.crossref.org\/issn\/0192-0561","issn-type":"print"},{"key":"R130_95_734","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/term.3090","volume":"14","journal-title":"Journal of Tissue Engineering and Regenerative Medicine,"},{"key":"R130_303_694","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1006\/cimm.1994.1291","volume":"159","journal-title":"Cel- lular Immunology,","ISSN":"https:\/\/id.crossref.org\/issn\/0008-8749","issn-type":"print"},{"key":"R130_178_554","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3748\/wjg.v13.i4.557","volume":"13","journal-title":"World Journal of Gastroenterology,","ISSN":"https:\/\/id.crossref.org\/issn\/1007-9327","issn-type":"print"},{"key":"R130_189_524","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.lfs.2004.03.008","volume":"75","journal-title":"Life Sciences,","ISSN":"https:\/\/id.crossref.org\/issn\/0024-3205","issn-type":"print"},{"key":"R130_174_484","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.intimp.2012.06.010","volume":"14","journal-title":"International Immunopharmacology,","ISSN":"https:\/\/id.crossref.org\/issn\/1567-5769","issn-type":"print"},{"key":"R130_95_443","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1142\/S0192415X14500797","volume":"42","journal-title":"American Journal of Chinese Medicine,","ISSN":"https:\/\/id.crossref.org\/issn\/0192-415X","issn-type":"print"},{"key":"R130_95_393","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ejphar.2009.09.047","volume":"626","journal-title":"European Journal of Pharmacology,","ISSN":"https:\/\/id.crossref.org\/issn\/0014-2999","issn-type":"print"},{"key":"R130_207_353","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0040-4039(01)98750-7","volume":"9","journal-title":"Tetrahedron Letters,","ISSN":"https:\/\/id.crossref.org\/issn\/0040-4039","issn-type":"print"},{"key":"R130_123_333","first-page":"2","volume":"38","journal-title":"Journal of Hepatology,","ISSN":"https:\/\/id.crossref.org\/issn\/0168-8278","issn-type":"print"},{"key":"R130_292_303","first-page":"147","volume":"38","journal-title":"Alcohol Research: Current Reviews,"},{"key":"R130_140_283","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/hep.23258","volume":"51","journal-title":"Hepatology,","ISSN":"https:\/\/id.crossref.org\/issn\/0270-9139","issn-type":"print"},{"key":"R130_140_263","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1111\/add.12899","volume":"110","journal-title":"Addiction,","ISSN":"https:\/\/id.crossref.org\/issn\/0965-2140","issn-type":"print"},{"key":"R130_538_734","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.fct.2018.01.017","volume":"113","journal-title":"Food and Chemical Toxicology,","ISSN":"https:\/\/id.crossref.org\/issn\/0278-6915","issn-type":"print"},{"key":"R130_349_503","first-page":"8","volume":"11","journal-title":"Carbohydrate Polymers,","ISSN":"https:\/\/id.crossref.org\/issn\/0144-8617","issn-type":"print"},{"key":"R130_407_453","first-page":"8","volume":"4","journal-title":"The Journal of Pharmacy and Pharmacology,","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3573","issn-type":"print"},{"key":"R130_402_353","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.jep.2015.12.058","volume":"179","journal-title":"Journal of Ethnopharmacology,","ISSN":"https:\/\/id.crossref.org\/issn\/0378-8741","issn-type":"print"},{"key":"R130_365_313","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1166\/jbn.2020.2996","volume":"16","journal-title":"Journal of Biomedical Nanotechnology,","ISSN":"https:\/\/id.crossref.org\/issn\/1550-7033","issn-type":"print"},{"key":"R130_512_273","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/sj.bjp.0703559","volume":"131","journal-title":"British Journal of Pharmacology,","ISSN":"https:\/\/id.crossref.org\/issn\/0007-1188","issn-type":"print"},{"key":"R130_497_233","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000049892","volume":"10","journal-title":"Nephron Experimental Nephrology,"},{"key":"R130_193_654","first-page":"3","volume":"22","journal-title":"Chemico-Biological Interactions,","ISSN":"https:\/\/id.crossref.org\/issn\/0009-2797","issn-type":"print"},{"key":"R130_188_614","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neuro.2018.11.006","volume":"70","journal-title":"Neurotoxicology,","ISSN":"https:\/\/id.crossref.org\/issn\/0161-813X","issn-type":"print"},{"key":"R130_199_233","first-page":"6","volume":"9","journal-title":"Medicine,","ISSN":"https:\/\/id.crossref.org\/issn\/0025-7974","issn-type":"print"},{"key":"R130_292_183","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1166\/jbn.2020.2921","volume":"16","journal-title":"Journal of Biomedical Nanotechnology,","ISSN":"https:\/\/id.crossref.org\/issn\/1550-7033","issn-type":"print"},{"key":"R131_348_421","doi-asserted-by":"crossref","first-page":"9141","DOI":"10.1021\/jf9013923","volume":"57","journal-title":"Journal of Agricultural and Food Chemistry,","ISSN":"https:\/\/id.crossref.org\/issn\/0021-8561","issn-type":"print"},{"key":"R131_540_371","first-page":"264","volume":"12","journal-title":"Pharma- ceutics,"},{"key":"R131_396_351","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.curtheres.2009.05.002","volume":"70","journal-title":"Current Therapeutic Research,","ISSN":"https:\/\/id.crossref.org\/issn\/0011-393X","issn-type":"print"},{"key":"R131_518_291","first-page":"245","volume":"9","journal-title":"European Jour- nal of Pharmaceutical Sciences Official Journal of the European Federation for Pharmaceutical Sciences,"},{"key":"R131_476_252","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1248\/cpb.35.1228","volume":"35","journal-title":"Chemical & Pharmaceutical Bulletin,","ISSN":"https:\/\/id.crossref.org\/issn\/0009-2363","issn-type":"print"},{"key":"R131_468_192","doi-asserted-by":"crossref","first-page":"15","DOI":"10.14227\/DT040497P15","volume":"4","journal-title":"Dissolution Technologies,","ISSN":"https:\/\/id.crossref.org\/issn\/1521-298X","issn-type":"print"},{"key":"R131_348_162","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ijpharm.2004.07.010","volume":"285","journal-title":"International Journal of Pharmaceutics,","ISSN":"https:\/\/id.crossref.org\/issn\/0378-5173","issn-type":"print"},{"key":"R131_529_112","first-page":"25","volume":"8","journal-title":"Pharmaceu- tics,"},{"key":"R131_132_481","doi-asserted-by":"crossref","first-page":"10866","DOI":"10.1021\/acsomega.9b00825","volume":"4","journal-title":"ACS Omega,"},{"key":"R131_157_451","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.1016\/j.biomaterials.2006.03.006","volume":"27","journal-title":"Biomaterials,","ISSN":"https:\/\/id.crossref.org\/issn\/0142-9612","issn-type":"print"},{"key":"R131_262_401","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1080\/21691401.2017.1290647","volume":"45","journal-title":"Artificial Cells Nanomedicine & Biotechnology,"},{"key":"R131_114_381","first-page":"6249","volume":"59","journal-title":"Angewandte Chemie,","ISSN":"https:\/\/id.crossref.org\/issn\/0044-8249","issn-type":"print"},{"key":"R131_242_321","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/pharmaceutics10020057","volume":"10","journal-title":"Pharmaceutics,"},{"key":"R131_255_272","first-page":"195727","volume":"2012","journal-title":"ISRN Pharmaceu- tics,"},{"key":"R131_237_202","first-page":"1835","volume":"27","journal-title":"Chinese Journal of New Drugs,"},{"key":"R131_172_112","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1080\/10717540902836715","volume":"16","journal-title":"Drug Delivery,","ISSN":"https:\/\/id.crossref.org\/issn\/1071-7544","issn-type":"print"},{"key":"R131_375_222","first-page":"459","volume":"10","journal-title":"Separation Science & Technology,","ISSN":"https:\/\/id.crossref.org\/issn\/0149-6395","issn-type":"print"},{"key":"R131_135_351","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/978-1-4939-7352-1_8","volume":"1682","journal-title":"Methods Mol. Biol.,","ISSN":"https:\/\/id.crossref.org\/issn\/1064-3745","issn-type":"print"},{"key":"R131_148_252","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.jff.2016.10.007","volume":"27","journal-title":"Journal of Functional Foods,"},{"key":"R131_131_152","doi-asserted-by":"crossref","first-page":"8779","DOI":"10.2147\/IJN.S150196","volume":"12","journal-title":"International Journal of Nanomedicine,"}],"container-title":["Journal of Biomedical Nanotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/asp\/jbn\/2021\/00000017\/00000004\/art00008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T04:40:07Z","timestamp":1642740007000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.1166\/jbn.2021.3054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4,1]]}},"alternative-id":["1550-7033(20210401)17:4L.627;1-"],"URL":"https:\/\/doi.org\/10.1166\/jbn.2021.3054","relation":{},"ISSN":["1550-7033"],"issn-type":[{"value":"1550-7033","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4,1]]}}}