{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:23:00Z","timestamp":1789050180215,"version":"build-2803163510"},"reference-count":31,"publisher":"American Scientific Publishers","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j biomed nanotechnol"],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:p>Naringenin (NGN) can be used to inhibit the progression of nonalcoholic fatty liver disease (NAFLD) in mice, but its poor water solubility limits its applications. Nanostructured lipid carriers (NLCs) have recently attracted much attention in the field of nanodrug delivery systems because\n they increase the drug loading capacity and impressively enhance the solubility of indissolvable drugs. Herein, a thin-film dispersion method was used to prepare naringenin-loaded nanostructured lipid carriers (NGN-NLCs). These NGN-NLCs have a narrow size distribution of 171.9 \u00b12.0\n nm, a high drug loading capacity of 23.7 \u00b1 0.3%, a high encapsulation efficiency of 99.9 \u00b1 0.0% and a drug release rate of 86.2 \u00b1 0.4%. NGN- NLCs elevated the pharmacokinetic parameters (C<jats:sub>max<\/jats:sub> and AUC<jats:sub>0\u2192t<\/jats:sub>) of NGN, accelerated NGN transepithelial\n transport in MDCK cells and intestinal absorption in the jejunum and ileum, and reduced hepatic lipid accumulation in an oleic acid (OA) plus lipopolysaccharide (LPS)-induced lipid deposition cell model in primary hepatocytes and in a methionine\/choline deficient (MCD) diet-induced NAFLD mouse\n model. A detailed study of the mechanism showed that this NLC formulation elevated the drug release rate in simulated intestinal solutions <jats:italic>in vitro,<\/jats:italic> the transepithelial transport in MDCK cells, the oral absorption in mice and the <jats:italic>ex vivo<\/jats:italic> intestinal absorption of NGN. Thus, NGN-NLCs\n significantly enhanced the inhibitory effects of NGN on MCD diet induced mouse NAFLD.<\/jats:p>","DOI":"10.1166\/jbn.2021.3077","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T04:32:32Z","timestamp":1622781152000},"page":"942-951","source":"Crossref","is-referenced-by-count":9,"title":["Study on the Inhibitory Effects of Naringenin-Loaded Nanostructured Lipid Carriers Against Nonalcoholic Fatty Liver Disease"],"prefix":"10.1166","volume":"17","author":[{"given":"Rui","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanli","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yini","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigui","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"17","reference":[{"key":"r1","doi-asserted-by":"crossref","first-page":"pp.846","DOI":"10.1002\/hep.21496","article-title":"The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD.","volume":"45","author":"Makar","year":"2007.","journal-title":"Hepatology"},{"key":"r2","doi-asserted-by":"crossref","first-page":"pp.S47","DOI":"10.1016\/j.jhep.2014.12.012","article-title":"NAFLD: A multisystem disease.","volume":"62","author":"Byrne","year":"2015.","journal-title":"Journal of Hepatology"},{"issue":"(7)","key":"r3","doi-asserted-by":"crossref","first-page":"pp.908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies.","volume":"24","author":"Friedman","year":"2018.","journal-title":"Nature Medicine"},{"issue":"(1)","key":"r4","doi-asserted-by":"crossref","first-page":"pp.73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease\u2014Meta-analytic assessment of prevalence, incidence, and outcomes.","volume":"64","author":"Younossi","year":"2016.","journal-title":"Hepatology"},{"issue":"(11)","key":"r5","doi-asserted-by":"crossref","first-page":"pp.686","DOI":"10.1038\/nrgastro.2013.171","article-title":"The global NAFLD epidemic.","volume":"10","author":"Loomba","year":"2013.","journal-title":"Nature Reviews Gastroenterology & Hepatology"},{"issue":"(4)","key":"r6","doi-asserted-by":"crossref","first-page":"pp.404","DOI":"10.3945\/an.113.005603","article-title":"Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action.","volume":"5","author":"Alam","year":"2014.","journal-title":"Advances in Nutrition (Bethesda. 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