{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T21:45:23Z","timestamp":1787607923162,"version":"build-2736575974"},"reference-count":36,"publisher":"American Scientific Publishers","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j biomed nanotechnol"],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:p>Occlusal trauma (OT), by causing periodontal tissue damage, can activate and enhance the activity of the peripheral and central nervous system (CNS) neuropeptides. The brain-derived neurotrophic factor (BDNF) gene is activity-dependent and exhibits marked alterations, characterized by protection against injury and repair. Our results show the possible molecular mechanism through which noxious environmental stimuli induce alterations in BDNF activity in the local periodontal tissue, the primary sensory neurons-Vc, and the hippocampus, suggesting systemic impairment. BDNF serves a more positive and enduring trauma protection and repair function in Vc compared to that in local dental tissue.<\/jats:p>","DOI":"10.1166\/jbn.2021.3112","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T04:34:25Z","timestamp":1630038865000},"page":"1371-1379","source":"Crossref","is-referenced-by-count":2,"title":["Brain-Derived Neurotrophic Factor Systemic Response in the Periodontium, Trigeminal Nucleus Caudalis, and Hippocampus Induced by Occlusal Trauma"],"prefix":"10.1166","volume":"17","author":[{"given":"Di","family":"Liu","sequence":"first","affiliation":[{"name":"School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinnan, Shandong, 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Qilu Hospital of Shandong University, 250012, 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