{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:49:17Z","timestamp":1792651757246,"version":"4.5.0"},"reference-count":28,"publisher":"American Scientific Publishers","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j biomed nanotechnol"],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:p>Cervical spondylosis is a disease that occurs with age and affects the discs and joints in the cervical spine located in the neck. The hydroxyapatite (HA) bone graft substitutes can used as a potential bone-forming agent, however, the efficacy of using HA is challenging in cervical\n reconstruction. In this regard, nano-based HA was used in this study to explore its sagittal parameters and clinical potency in relative to titanium (TiO<jats:sub>2<\/jats:sub>) cage in patient with cervical spondylosis. 50 patients suffering from cervical spondylosis were divided in two groups and were\n grafted with either TiO<jats:sub>2<\/jats:sub> cage or nano-HA. The sagittal parameters, including cervical spine lateral radiographs (C<jats:sub>0\u22122<\/jats:sub>Coob and C<jats:sub>2\u22127<\/jats:sub>Coob) were taken pre- and post-operation (3-month, one-year and two-year). The clinical potency was also done based\n on the JOA scores. Angle analysis indicated that the C<jats:sub>0\u22122<\/jats:sub>Cobb and C<jats:sub>2\u22127<\/jats:sub>Cobb angles were significantly changed after the operation in both TiO<jats:sub>2<\/jats:sub> cage and nano-HA groups, whereas no significant changes was determined in nano-HA relative to TiO<jats:sub>2<\/jats:sub>\n cage condition. Also, it was shown that JOA scores were significantly higher after the operation than pre-operation, indicating a potential cervical reconstruction after surgery in both groups which slightly were higher for nano-HA groups.<\/jats:p>","DOI":"10.1166\/jbn.2021.3121","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T04:34:25Z","timestamp":1630038865000},"page":"1448-1452","source":"Crossref","is-referenced-by-count":4,"title":["Titanium Cage in Comparison with Nano-Hydroxyapatite Bone Graft Substitutes in Cervical Reconstruction"],"prefix":"10.1166","volume":"17","author":[{"given":"Tao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Fourth Affiliated Hospital of Harbin Medical University, Nangang District, Harbin 150001, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Guo","sequence":"additional","affiliation":[{"name":"Central Catheterization Room, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Fourth Affiliated Hospital of Harbin Medical University, Nangang District, Harbin 150001, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runze","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Fourth Affiliated Hospital of Harbin Medical University, Nangang District, Harbin 150001, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naiwu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Fourth Affiliated Hospital of Harbin Medical University, Nangang District, Harbin 150001, Heilongjiang Province, 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