{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:53:30Z","timestamp":1775742810886,"version":"3.50.1"},"reference-count":17,"publisher":"American Scientific Publishers","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j biomed nanotechnol"],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:p>The present investigation undertakes the formulation of nanoparticulate suspension of Riboflavin to treat keratoconus disease by applying it to the infected mice corneas. The nanoparticles of Riboflavin were prepared using single solvent evaporation method and later formulated as suspension\n using continuous probe sonication method. Then, both riboflavin nanoparticles and suspension were evaluated for various parameters. The nanoparticles showed smooth and spherical surface with <jats:italic>in vitro<\/jats:italic> drug release up to 77.89%. The drug content was found to be 97.23%\u201398.89%. The\n suspension was found to be visually clear with pH ranging from 6 to 7. The drug entrapment was found to be from 76.37% to 97.34%. Since there was no hemolytic activity, this formulation was suitable for ophthalmic administration. The Draize test confirmed the non-irritant, non-itchy nature\n of formulation. The prepared formulations, such as nanoparticulate gel and suspension, were found to be significantly efficacious in experimental animals.<\/jats:p>","DOI":"10.1166\/jbn.2021.3156","type":"journal-article","created":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T04:35:17Z","timestamp":1635050117000},"page":"1866-1873","source":"Crossref","is-referenced-by-count":1,"title":["Ophthalmic Delivery of Riboflavin Loaded Nanoparticulate Suspension in Keratoconus: A Preclinical Study in Rabbit Model"],"prefix":"10.1166","volume":"17","author":[{"given":"Ling","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The Second Hospital of Chifeng, Inner Mongolia, 024000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunlai","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Forth Hospital of Harbin Medical University, 150001, Heilongjiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Wu","sequence":"additional","affiliation":[{"name":"3Department of Ophthalmology, Xi\u2019an Fourth Hospital, No.21, Jiefang Road, Xincheng District, Xi\u2019an, 710004, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17","reference":[{"issue":"(4)","key":"r1","doi-asserted-by":"crossref","first-page":"pp.297","DOI":"10.1016\/S0039-6257(97)00119-7","article-title":"Keratoconus.","volume":"42","author":"Rabinowitz","year":"1998","journal-title":"Survey of Ophthalmology"},{"issue":"(2)","key":"r2","first-page":"pp.131","article-title":"Epikeratoplasty for keratoconus: A clinicopathologic case report.","volume":"6","author":"Jaeger","year":"1987.","journal-title":"Cornea"},{"issue":"(3)","key":"r3","doi-asserted-by":"crossref","first-page":"pp.439","DOI":"10.1016\/S0161-6420(94)31313-3","article-title":"Prognostic factors for the progression of 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