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A rat model of common carotid artery thrombosis was used for anti-thrombus experiments <jats:italic>in vivo<\/jats:italic>. P1Cm-SPIO-Cy5.5 remains stable <jats:italic>in vitro<\/jats:italic>\n and has good anticoagulation capacity. It can bind specifically to activated platelets and thrombi. In rats that underwent bypass surgery, P1Cm-SPIO-Cy5.5 could detect and label thrombi over a long period, and prevent thrombosis in grafted vessels. P1Cm-SPIO-Cy5.5 improved cardiac function\n in rats following CABG surgery. P1Cm-SPIO-Cy5.5 is a potential sensor for use in MRI for the early diagnosis and prevention of thrombosis after CABG surgery.<\/jats:p>","DOI":"10.1166\/jbn.2021.3164","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T04:38:09Z","timestamp":1635395889000},"page":"1951-1959","source":"Crossref","is-referenced-by-count":1,"title":["A Nano-Based P1Cminimum Probe to Monitor Thrombosis in Grafts and Improve Cardiac Function After Coronary Artery Bypass Grafting Surgery"],"prefix":"10.1166","volume":"17","author":[{"given":"Qiyong","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiac Surgery, The Affiliated Changzhou No. 2 People\u2019s Hospital of Nanjing Medical University, Changzhou, 213164, Jiangsu, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqiang","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Affiliated Changzhou No. 2 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