{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:08:00Z","timestamp":1791540480455,"version":"4.3.4"},"reference-count":23,"publisher":"American Scientific Publishers","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j biomed nanotechnol"],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:p>Poly-ether-ether-ketone (PEEK) has become the spinal implant material of choice due to its radiolucency, low elastic modulus, manufacturability, and mechanical durability. However, studies have highlighted less that optimal cytocompatibility properties of conventional PEEK leading to\n decreased bone growth and\/or extensive bacteria infection. In order to improve the surface properties of PEEK for orthopedic applications, here, Accelerated Neutral Atom Beam (ANAB) technology was used to modify PEEK and such samples were tested <jats:italic>In Vitro<\/jats:italic> for osteoblast (bone-forming\n cell) functions and bacterial colonization. Results showed significantly improved osteoblast responses (such as deposition of calcium containing mineral as well as alkaline phosphatase, osteocalcin, osteopontin, and osteonectin synthesis) on ANAB modified PEEK compared to controls due to optimized\n surface energy from nanostructured features and greater exposure of PEEK chemistry. ANAB treatment enhanced protein absorption (specifically, mucin, casein, and lubricin) to the PEEK surface and consequently significantly reduced bacterial (including methicillin resistant <jats:italic>Staph. aureus<\/jats:italic>\n (or MRSA), <jats:italic>E. coli<\/jats:italic>, and <jats:italic>Staph. epidermidis<\/jats:italic>) colonization. Collectively, this study introduces ANAB treated PEEK as a novel material that should be further studied for a wide range of improved orthopedic applications.<\/jats:p>","DOI":"10.1166\/jbn.2022.3247","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T04:42:13Z","timestamp":1655527333000},"page":"788-795","source":"Crossref","is-referenced-by-count":9,"title":["Accelerated Neutral Atom Beam (ANAB) Modified Poly-Ether-Ether-Ketone for Increasing <i>In Vitro<\/i> Bone Cell Functions and Reducing Bacteria Colonization Without Drugs or Antibiotics"],"prefix":"10.1166","volume":"18","author":[{"given":"Thomas J.","family":"Webster","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Shallenberger","sequence":"additional","affiliation":[{"name":"Materials Characterization Laboratory, Pennsylvania 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