{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T05:12:12Z","timestamp":1652073132515},"reference-count":33,"publisher":"American Scientific Publishers","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j biomed nanotechnol"],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:p>Microwave (MW) hyperthermia has been widely studied in tumor therapy, while the lack of specificity, and the potential toxicity induced by instability or difficulty in degradation of existed MW thermal sensitizers still limits the application. Herein, a new biocompatible Poly(lactic-co-glycolic\n acid) (PLGA)-based nanosensitizer of Dtxl-Gd@PLGA-PEG-TPP (DGPPT) with capacities of magnetic resonance (MR) imaging and mitochondrial targeting for MW hyperthermia combined with chemotherapy was constructed via a double emulsion solvent evaporation method. The modified TPP significantly enhanced\n the specificity of sensitizer for targeting mitochondria, a heat-sensitive energy supply plant in cells. Thus the MW thermal damage induced by the loaded Gd in PLGA nanospheres was also strengthened. Together, the system could also achieve MR imaging due to the existence of Gd. In addition,\n the encapsulated Dtxl performed the chemotherapy of inhibiting mitochondrial function for assisting with MW hyperthermia. <jats:italic>In vivo<\/jats:italic> experiments demonstrated that PLGA had high biocompatibility that no obvious damage occurred even the dose was up to 200 mg\/kg. Meanwhile, DGPPT+MW representing\n the combination of mitochondrial targeting and MW hyperthermia-chemotherapy has also been proved to shrink tumor size effectively. This study provides a new direction for building biosafe and multifunctional MW sensitizer with active targeting ability to impede tumor growth.<\/jats:p>","DOI":"10.1166\/jbn.2022.3259","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T04:35:58Z","timestamp":1651206958000},"page":"369-380","source":"Crossref","is-referenced-by-count":0,"title":["High Biocompatible Poly(lactic-co-glycolic acid)-Based Nanosensitizer With Magnetic Resonance Imaging Capacity for Tumor Targeted Microwave Hyperthermia and Chemotherapy"],"prefix":"10.1166","volume":"18","author":[{"given":"Shimei","family":"Li","sequence":"first","affiliation":[{"name":"Laboratory of Controllable Preparation and Application of Nanomaterials, Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 29 Zhongguancun East Road, Beijing, 100190, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xudong","family":"Lan","sequence":"additional","affiliation":[{"name":"Laboratory of Controllable Preparation and Application of Nanomaterials, Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 29 Zhongguancun East Road, Beijing, 100190, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longfei","family":"Tan","sequence":"additional","affiliation":[{"name":"Laboratory of Controllable Preparation and Application of Nanomaterials, Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 29 Zhongguancun East Road, Beijing, 100190, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xudong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, Guangdong, P. R.\n China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kong-Peng","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, Guangdong, P. R.\n China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongbing","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Biomedical Engineering, Sichuan University, Chengdu, 610065, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Gou","sequence":"additional","affiliation":[{"name":"College of Biomedical Engineering, Sichuan University, Chengdu, 610065, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wan","sequence":"additional","affiliation":[{"name":"College of Chemistry & Environment, Southwest Minzu University, Chengdu, 610041, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianwei","family":"Meng","sequence":"additional","affiliation":[{"name":"Laboratory of Controllable Preparation and Application of Nanomaterials, Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 29 Zhongguancun East Road, Beijing, 100190, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17","reference":[{"key":"R87_444_744","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.7150\/thno.42818","volume":"10","journal-title":"Theranostics"},{"key":"R87_418_693","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1039\/C8NR08498J","volume":"11","journal-title":"Nanoscale"},{"key":"R87_440_653","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1021\/acs.nanolett.9b01735","volume":"19","journal-title":"Nano Letters","ISSN":"http:\/\/id.crossref.org\/issn\/1530-6984","issn-type":"print"},{"key":"R87_370_510","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1166\/jbn.2021.3158","volume":"17","journal-title":"Journal of Biomedical Nanotechnology","ISSN":"http:\/\/id.crossref.org\/issn\/1550-7033","issn-type":"print"},{"key":"R87_465_460","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41568-020-00308-y","volume":"21","journal-title":"Nature Reviews Cancer","ISSN":"http:\/\/id.crossref.org\/issn\/1474-175X","issn-type":"print"},{"key":"R87_493_429","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1007\/s00018-020-03536-5","volume":"77","journal-title":"Cellular and Molecular Life Sciences","ISSN":"http:\/\/id.crossref.org\/issn\/1420-682X","issn-type":"print"},{"key":"R87_527_399","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/ijc.31947","volume":"144","journal-title":"International Journal of Cancer","ISSN":"http:\/\/id.crossref.org\/issn\/0020-7136","issn-type":"print"},{"key":"R87_485_348","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.bioactmat.2020.04.002","volume":"5","journal-title":"Bioactive Materials"},{"key":"R87_449_298","doi-asserted-by":"crossref","first-page":"7166","DOI":"10.1039\/D0TB01175D","volume":"8","journal-title":"Journal of Materials Chemistry B"},{"key":"R87_436_257","first-page":"2175","volume":"80","journal-title":"Cancer Research","ISSN":"http:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"key":"R87_460_612","first-page":"0","volume":"1","journal-title":"Frontiers in Oncology"},{"key":"R87_376_581","first-page":"5","volume":"24","journal-title":"Biomaterials","ISSN":"http:\/\/id.crossref.org\/issn\/0142-9612","issn-type":"print"},{"key":"R87_417_541","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.actbio.2019.09.009","volume":"101","journal-title":"Acta Biomaterialia"},{"key":"R87_348_186","first-page":"8","volume":"10","journal-title":"Materials Science & Engineering C-Materials for Biological Appli- cations"},{"key":"R87_492_155","first-page":"2","volume":"1","journal-title":"Cancers"},{"key":"R88_554_262","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1080\/10717544.2021.1938756","volume":"28","journal-title":"Drug Delivery","ISSN":"http:\/\/id.crossref.org\/issn\/1071-7544","issn-type":"print"},{"key":"R88_485_222","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1021\/acsami.9b19435","volume":"12","journal-title":"Acs Applied Materials & Interfaces"},{"key":"R88_459_162","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cclet.2018.06.016","volume":"30","journal-title":"Chinese Chemical Letters","ISSN":"http:\/\/id.crossref.org\/issn\/1001-8417","issn-type":"print"},{"key":"R88_189_441","doi-asserted-by":"crossref","first-page":"9264","DOI":"10.1002\/anie.202010951","volume":"60","journal-title":"Angewandte Chemie-International Edi- tion","ISSN":"http:\/\/id.crossref.org\/issn\/1521-3773","issn-type":"print"},{"key":"R88_124_371","doi-asserted-by":"crossref","first-page":"5180","DOI":"10.1021\/acsbiomaterials.9b01233","volume":"5","journal-title":"Acs Biomaterials Science & Engineering"},{"key":"R88_283_272","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1021\/acsnano.7b08868","volume":"12","journal-title":"Acs Nano"},{"key":"R88_126_232","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1039\/C9CS00309F","volume":"48","journal-title":"Chemical Society Reviews","ISSN":"http:\/\/id.crossref.org\/issn\/0306-0012","issn-type":"print"},{"key":"R88_216_192","doi-asserted-by":"crossref","first-page":"7921","DOI":"10.7150\/thno.49577","volume":"10","journal-title":"Theranostics"},{"key":"R88_133_162","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1016\/j.cclet.2020.06.024","volume":"31","journal-title":"Chinese Chemical Letters","ISSN":"http:\/\/id.crossref.org\/issn\/1001-8417","issn-type":"print"},{"key":"R88_471_441","first-page":"2","volume":"3","journal-title":"Advanced Materials"},{"key":"R88_462_391","first-page":"0","volume":"3","journal-title":"Advanced Functional Materials","ISSN":"http:\/\/id.crossref.org\/issn\/1616-301X","issn-type":"print"},{"key":"R88_349_351","first-page":"2","volume":"1","journal-title":"Cancers"},{"key":"R88_495_291","first-page":"1","volume":"1","journal-title":"Frontiers in Oncology"},{"key":"R88_433_112","first-page":"0","volume":"1","journal-title":"Advanced Healthcare Materials"},{"key":"R88_95_411","first-page":"1","volume":"3","journal-title":"Advanced Materials"},{"key":"R88_292_311","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.apmt.2015.11.002","volume":"2","journal-title":"Applied Materials Today"},{"key":"R88_210_122","first-page":"4","volume":"23","journal-title":"Biomaterials","ISSN":"http:\/\/id.crossref.org\/issn\/0142-9612","issn-type":"print"},{"key":"R88_541_68","first-page":"6","volume":"1","journal-title":"Li et al."}],"container-title":["Journal of Biomedical Nanotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/asp\/jbn\/2022\/00000018\/00000002\/art00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T04:42:37Z","timestamp":1652071357000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.1166\/jbn.2022.3259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,1]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2,1]]}},"alternative-id":["1550-7033(20220201)18:2L.369;1-"],"URL":"https:\/\/doi.org\/10.1166\/jbn.2022.3259","relation":{},"ISSN":["1550-7033"],"issn-type":[{"value":"1550-7033","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,1]]}}}