{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:41:02Z","timestamp":1787913662389,"version":"build-2784847793"},"reference-count":34,"publisher":"American Scientific Publishers","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j biomed nanotechnol"],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:p>As a severe neurological disease of trauma, traumatic brain injury (TBI) leads to other disorders, such as depression, dementia and epilepsy. This study investigated whether poly d,l-(lactic-co-glycolic) acid (PLGA) PEGylated isoliquiritigenin could alleviate TBI. One hundred and eighty-three patients with clinical brain trauma were divided into two groups with or without intracranial injury in magnetic resonance imaging. The clinical results showed that serum cyclooxygenase 2 (COX-2) levels were obviously increased in the TBI patients compared to the patients with head trauma only or healthy individuals. Intracranial injection of isoliquiritigenin in TBI rats reversed TBI induced increase of COX-2 level, significantly reduced water content and contusion volume. Our findings suggest that PLGA PEG nanoparticles loaded with isoliquiritigenin can achieve the same effects as intracranial administration of isoliquiritigenin in reducing serum COX-2 level.<\/jats:p>","DOI":"10.1166\/jbn.2022.3284","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T04:42:13Z","timestamp":1655527333000},"page":"909-916","source":"Crossref","is-referenced-by-count":5,"title":["Poly d,l-(lactic-co-glycolic) Acid PEGylated Isoliquiritigenin Alleviates Traumatic Brain Injury by Reversing Cyclooxygenase 2 Level"],"prefix":"10.1166","volume":"18","author":[{"given":"Zhengyang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiology, Cangzhou Central Hospital, No. 16 Xinhua West Road, Cangzhou, 061001, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cangzhou Central Hospital, No. 16 Xinhua West Road, Cangzhou, 061001, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cangzhou Central Hospital, No. 16 Xinhua West Road, Cangzhou, 061001, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"17","reference":[{"key":"R296_334_366","first-page":"001","volume":"0","journal-title":"p <"},{"key":"R296_334_330","first-page":"01","volume":"0","journal-title":"p <"},{"key":"R296_368_173","first-page":"001","volume":"0","journal-title":"p <"},{"key":"R299_544_733","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1089\/089771502760341965","volume":"19","journal-title":"Journal of Neurotrauma","ISSN":"https:\/\/id.crossref.org\/issn\/0897-7151","issn-type":"print"},{"key":"R299_510_713","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1089\/neu.2000.17.69","volume":"17","journal-title":"Journal of Neuro- trauma","ISSN":"https:\/\/id.crossref.org\/issn\/0897-7151","issn-type":"print"},{"key":"R299_481_692","first-page":"0","volume":"6","journal-title":"Archives of Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0003-9942","issn-type":"print"},{"key":"R299_498_671","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1038\/labinvest.2012.118","volume":"92","journal-title":"Laboratory Investiga- tion","ISSN":"https:\/\/id.crossref.org\/issn\/0023-6837","issn-type":"print"},{"key":"R299_503_640","first-page":"3","volume":"1","journal-title":"Journal of Neuroin- flammation"},{"key":"R299_544_609","doi-asserted-by":"crossref","first-page":"15210","DOI":"10.1523\/JNEUROSCI.3950-10.2010","volume":"30","journal-title":"Journal of Neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/0270-6474","issn-type":"print"},{"key":"R299_369_568","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbr.2014.10.053","volume":"279","journal-title":"Behavioural Brain Research","ISSN":"https:\/\/id.crossref.org\/issn\/0166-4328","issn-type":"print"},{"key":"R299_505_537","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.cbi.2018.02.028","volume":"286","journal-title":"Chemico-Biological Interactions","ISSN":"https:\/\/id.crossref.org\/issn\/0009-2797","issn-type":"print"},{"key":"R300_385_361","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s13346-019-00694-3","volume":"10","journal-title":"Drug Delivery and Translational Research"},{"key":"R300_349_341","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.addr.2015.09.012","volume":"99","journal-title":"Advanced Drug Delivery Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/0169-409X","issn-type":"print"},{"key":"R300_412_321","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1007\/s11064-018-2671-z","volume":"43","journal-title":"Neurochemical Research","ISSN":"https:\/\/id.crossref.org\/issn\/0364-3190","issn-type":"print"},{"key":"R300_519_282","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1081\/PDT-120017517","volume":"8","journal-title":"Pharmaceutical Development and Technology","ISSN":"https:\/\/id.crossref.org\/issn\/1083-7450","issn-type":"print"},{"key":"R300_542_262","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1203\/PDR.0b013e3180db2902","volume":"62","journal-title":"Pediatric Research","ISSN":"https:\/\/id.crossref.org\/issn\/0031-3998","issn-type":"print"},{"key":"R300_349_242","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1016\/S0140-6736(15)00386-4","volume":"386","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"key":"R300_370_192","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.brainresbull.2010.11.015","volume":"84","journal-title":"Brain Research Bulletin","ISSN":"https:\/\/id.crossref.org\/issn\/0361-9230","issn-type":"print"},{"key":"R300_528_162","doi-asserted-by":"crossref","first-page":"31","DOI":"10.47102\/annals-acadmedsg.V36N1p31","volume":"36","journal-title":"Annals of the Academy of Medicine, Singapore","ISSN":"https:\/\/id.crossref.org\/issn\/0304-4602","issn-type":"print"},{"key":"R300_510_142","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.expneurol.2015.08.020","volume":"273","journal-title":"Experimental Neu- rology","ISSN":"https:\/\/id.crossref.org\/issn\/0014-4886","issn-type":"print"},{"key":"R300_431_132","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1477-3155-1-6","volume":"1","journal-title":"Journal of Nanobiotechnology"},{"key":"R300_537_92","first-page":"4","volume":"18","journal-title":"Journal of Surgical Research","ISSN":"https:\/\/id.crossref.org\/issn\/0022-4804","issn-type":"print"},{"key":"R300_128_371","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jconrel.2015.12.029","volume":"223","journal-title":"Journal of Controlled Release","ISSN":"https:\/\/id.crossref.org\/issn\/0168-3659","issn-type":"print"},{"key":"R300_131_331","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1016\/j.ejso.2018.09.007","volume":"44","journal-title":"European Journal of Surgical Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0748-7983","issn-type":"print"},{"key":"R300_198_301","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s10787-018-0503-z","volume":"27","journal-title":"Inflammopharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0925-4692","issn-type":"print"},{"key":"R300_285_272","first-page":"8","volume":"201","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"R300_200_242","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1742-2094-1-4","volume":"1","journal-title":"Journal of Neuroinflammation"},{"key":"R300_266_212","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jnutbio.2017.05.001","volume":"47","journal-title":"The Journal of Nutritional Biochemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0955-2863","issn-type":"print"},{"key":"R300_161_202","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1002\/ptr.5348","volume":"29","journal-title":"Phytotherapy Research","ISSN":"https:\/\/id.crossref.org\/issn\/0951-418X","issn-type":"print"},{"key":"R300_160_172","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejps.2014.06.024","volume":"63","journal-title":"European Journal of Pharmaceutical Sciences","ISSN":"https:\/\/id.crossref.org\/issn\/0928-0987","issn-type":"print"},{"key":"R300_95_152","first-page":"749","volume":"8","journal-title":"American Journal of Translational Research"},{"key":"R300_168_132","doi-asserted-by":"crossref","first-page":"12076","DOI":"10.1039\/C5NR03474D","volume":"7","journal-title":"Nanoscale"},{"key":"R300_282_92","first-page":"5","volume":"10","journal-title":"Journal of Biomedical Materials Research Part B Applied Biomaterials"},{"key":"R300_541_68","first-page":"0","volume":"1","journal-title":"Li et al."}],"container-title":["Journal of Biomedical Nanotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/asp\/jbn\/2022\/00000018\/00000003\/art00027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T19:19:52Z","timestamp":1675883992000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.1166\/jbn.2022.3284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3,1]]}},"alternative-id":["1550-7033(20220301)18:3L.909;1-"],"URL":"https:\/\/doi.org\/10.1166\/jbn.2022.3284","relation":{},"ISSN":["1550-7033"],"issn-type":[{"value":"1550-7033","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3,1]]}}}