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Recent studies have shown that, extracellular EVs can effectively cross the blood\u2013 brain barrier (BBB) through endocytosis and they transmit molecular signals in cell-to-cell communication. Abnormal EVs produced in the lesion portion transport pathogenic factors, including miRNAs, proteins, and virions into the CNS. These pathogenic factors participate in cellular pathways to interfere with homeostasis or are themselves pathogens that directly damage CNS. In addition, different or specific pathological molecules in EVs are potential disease markers. We herein reviewed pathways through which the abnormal EVs cross BBB and adverse effects of abnormal exosomes. We also and summarized their existing detection techniques, so as to provide basis for prevention and early diagnosis of secondary diseases.<\/jats:p>","DOI":"10.1166\/jbn.2022.3293","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T04:42:13Z","timestamp":1655527333000},"page":"640-659","source":"Crossref","is-referenced-by-count":5,"title":["Circulating Abnormal Extracellular Vesicles: Their Mechanism for Crossing Blood\u2013Brain Barrier, Effects on Central Nervous System and Detection Methods"],"prefix":"10.1166","volume":"18","author":[{"given":"Boyue","family":"Fan","sequence":"first","affiliation":[{"name":"Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing, 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Gu","sequence":"additional","affiliation":[{"name":"Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing, 210008, 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