{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T03:24:12Z","timestamp":1778556252815,"version":"3.51.4"},"reference-count":35,"publisher":"American Scientific Publishers","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j biomed nanotechnol"],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:p>To date, the possibility of drug-resistant bacterial infections in hospitals and intensive care units comprises a significant concern especially for immunocompromised cancer patients. In the current study, violacein and superparamagnetic iron oxide nanoparticles were co-encapsulated\n in polylactic acid nanoparticles (vio-Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>-PLA) and tested for their antimicrobial and anticancer activity. The loaded nanoparticles presented efficient saturation magnetization that rendered this nanosystem a promising candidate for magnetic targeting. Moreover, violacein\n released from the nanoparticles at 500 <jats:italic>\u03bc<\/jats:italic>g\/mL successfully inhibited the growth of the \u201csuperbug\u201d methicillin-resistant Staphylococcus aureus (MRSA) with an IC<jats:sub>50<\/jats:sub> value of 595.8 <jats:italic>\u03bc<\/jats:italic>g\/mL, while it did not prove effective against multi-drug-resistant Escherichia\n coli at concentrations of 10\u20131000 <jats:italic>\u03bc<\/jats:italic>g\/mL. Finally, a concentration of 500 <jats:italic>\u03bc<\/jats:italic>g\/mL of drug loaded magnetic nanoparticles induced an over 80% growth inhibition of glioblastoma and melanoma cancer cell lines with IC<jats:sub>50<\/jats:sub> values of 221.30 and 201.60 <jats:italic>\u03bc<\/jats:italic>g\/mL,\n respectively. Since bacterial infections are a key clinical problem for cancer patients due to their compromised immune systems, the presented results suggest that our system should be further studied for its simultaneous anti-bacterial and anti-cancer properties, as it comprises a promising\n strategy for combating bacterial infections and providing anticancer activity through magnetic-targeted delivery.<\/jats:p>","DOI":"10.1166\/jbn.2022.3305","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T04:42:13Z","timestamp":1655527333000},"page":"729-739","source":"Crossref","is-referenced-by-count":8,"title":["Co-Encapsulation of Violacein and Iron Oxide in Poly(lactic acid) Nanoparticles for Simultaneous Antibacterial and Anticancer Applications"],"prefix":"10.1166","volume":"18","author":[{"given":"Maria","family":"Kanelli","sequence":"first","affiliation":[{"name":"IndBioCat Group, Biotechnology Laboratory, School of Chemical Engineering, National Technical 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