{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:46:48Z","timestamp":1762508808944,"version":"3.41.2"},"reference-count":28,"publisher":"American Scientific Publishers","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j biomed nanotechnol"],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:p>Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused significant death, economic crisis, and the world to almost completely shut down. This present study focused on targeting the novel SARS-CoV-2 envelope protein, which has\n not been frequently mutating, and the S protein with a much larger peptide capable of inhibiting virus-mammalian cell attraction. In doing so, molecular dynamics software was used here to model six peptides including: NapFFTLUFLTUTE, NapFFSLAFLTATE, NapFFSLUFLSUTE, NapFFTLAFLTATE, NapFFSLUFLSUSE,\n and NapFFMLUFLMUME. Results showed that two of these completely hydrophobic peptides (NapFFTLUFLTUTE and NapFFMLUFLMUME) had a strong ability to bind to the virus, preventing its binding to a mammalian cell membrane, entering the cell, and replicating by covering many cell attachment sites\n on SARS-CoV-2. Further cell modeling results demonstrated the low toxicity and suitable pharmacokinetic properties of both peptides making them ideal for additional <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> investigation. In this manner, these two peptides should be further explored for a wide range\n of present and future COVID-19 therapeutic and prophylactic applications.<\/jats:p>","DOI":"10.1166\/jbn.2022.3307","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:42:42Z","timestamp":1658277762000},"page":"1121-1130","source":"Crossref","is-referenced-by-count":2,"title":["Inhibiting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants: Targeting the Spike and Envelope Proteins Using Nanomaterial Like Peptides"],"prefix":"10.1166","volume":"18","author":[{"given":"Alaa F.","family":"Nahhas","sequence":"first","affiliation":[{"name":"Biochemistry Department, College of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alrayan F.","family":"Nahhas","sequence":"additional","affiliation":[{"name":"Biochemistry Department, College of Science, King Abdulaziz University, Jeddah 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