{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T15:20:15Z","timestamp":1772205615994,"version":"3.50.1"},"reference-count":0,"publisher":"American Scientific Publishers","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j nanosci nanotechnol"],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:p>Quantum dots (QDs) are semiconducting materials which have a wide array of applications starting from semiconducting devices, in humidity and pressure sensors and in medical imaging including cancer therapy. In the present study, cadmium telluride (CdTe) QDs were synthesized by a biological\n method using yeast cells, <jats:italic>Saccharomyces cerevisiae<\/jats:italic> in modified Czapek\u2019s medium. QDs were characterized by transmission electron microscopy and X-ray diffraction. Cancer cells were treated with 2, 4, 8 and 16 <jats:italic>\u03bc<\/jats:italic>M concentrations of CdTe QDs for 24 h. The anti-proliferative\n activity was determined by using MTT assay, by evaluating the production of reactive oxygen species (ROS), and also by nuclear apoptosis and cell cycle analysis using a flow cytometer against human prostate carcinoma cell line PC-3. The size of the CdTe QDs was approximately 2 nm. <jats:italic>In vitro<\/jats:italic>\n anti-proliferative study showed that CdTe QDs induced cell death and nuclear apoptosis in a dosedependent manner. CdTe QDs induced significant increase in ROS level in PC-3 cells which was dose-dependent. Moreover, CdTe also arrested growth of PC-3 cells in the G2\/M phase of the cell cycle.\n This study elucidates the apoptotic activity of CdTe QDs on prostate carcinoma which could provide useful insights to researchers for its clinical application.<\/jats:p>","DOI":"10.1166\/jnn.2020.17316","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T04:46:18Z","timestamp":1574311578000},"page":"3398-3403","source":"Crossref","is-referenced-by-count":21,"title":["Biological Synthesis of CdTe Quantum Dots and Their Anti-Proliferative Assessment Against Prostate Cancer Cell Line"],"prefix":"10.1166","volume":"20","author":[{"given":"Aditya Kumar","family":"Jigyasu","sequence":"first","affiliation":[{"name":"Department of Physics, Integral University, Lucknow 226002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahabjada","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Era\u2019s Lucknow Medical College & Hospital, Era University, Lucknow 226003, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asif","family":"Jafri","sequence":"additional","affiliation":[{"name":"Molecular Endocrinology Laboratory, Department of Zoology, University of Lucknow, Lucknow 226007, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md","family":"Arshad","sequence":"additional","affiliation":[{"name":"Molecular Endocrinology Laboratory, Department of Zoology, University of Lucknow, Lucknow 226007, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohatashim","family":"Lohani","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Integral University, Lucknow 226026, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irfan Ali","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Physics, Integral University, Lucknow 226002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17","container-title":["Journal of Nanoscience and Nanotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/asp\/jnn\/2020\/00000020\/00000006\/art00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T04:32:08Z","timestamp":1574656328000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.1166\/jnn.2020.17316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6,1]]}},"alternative-id":["1533-4880(20200601)20:6L.3398;1-"],"URL":"https:\/\/doi.org\/10.1166\/jnn.2020.17316","relation":{},"ISSN":["1533-4880"],"issn-type":[{"value":"1533-4880","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6,1]]}}}