{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T20:40:07Z","timestamp":1773434407865,"version":"3.50.1"},"reference-count":0,"publisher":"American Scientific Publishers","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j nanosci nanotechnol"],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:p>Tenofovir disoproxil (TD) has narrow absorption site mostly in upper intestinal tract where tenofovir rapidly decomposes. The aim of this work was to prepare and evaluate tenofovir disoproxil-loaded enteric microparticles (TDEMs) for the enhanced duodenal delivery. TDEMs were composed\n of TD, eudragit L-100 (EL) and ethyl cellulose (EC) as release-controlling polymers. For the physicochemical characterization, TDEMs were evaluated in terms of encapsulation efficiency (EE%), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR). The dissolution\n test was also performed while continuously changing the medium pH. The EE% of TD in TDEMs was good and more than 90%. The EC and EL formed a physically mixed structure and maintained their respective properties in TDEMs as confirmed by SEM image and FT-IR analysis. Combination of EL and EC\n gave higher enteric properties to TDEMs than the single use of EL or EC. The optimized TDEM (TD\/EL\/EC = 0.2\/1\/1, w\/w\/w ratio) yielded mean dissolution rate less than 10% in 1 h at pH 1.2, but completed dissolution with a dissolution more than 85% within 1 h at pH 6.5. Thus, the suggested TDEM\n would be promising enteric microparticles for the intensive delivery of TD to the duodenum.<\/jats:p>","DOI":"10.1166\/jnn.2020.17641","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T04:36:38Z","timestamp":1587098198000},"page":"5796-5799","source":"Crossref","is-referenced-by-count":3,"title":["Preparation and Characterization of Tenofovir Disoproxil-Loaded Enteric Microparticle"],"prefix":"10.1166","volume":"20","author":[{"given":"Young Hoon","family":"Kim","sequence":"first","affiliation":[{"name":"College of Pharmacy, Inje Institute of Pharmaceutical Sciences and Research, Inje University, Gimhae 50834, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, Inje University, Gimhae 50834, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Yeol","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Inje Institute of Pharmaceutical Sciences and Research, Inje University, Gimhae 50834, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimi","family":"Byeon","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, Inje University, Gimhae 50834, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-Joo","family":"Maeng","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Tae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, Inje University, Gimhae 50834, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoung Ah","family":"Min","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Inje Institute of Pharmaceutical Sciences and Research, Inje University, Gimhae 50834, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Jin","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, Inje University, Gimhae 50834, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwan Hyung","family":"Cho","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Inje Institute of Pharmaceutical Sciences and Research, Inje University, Gimhae 50834, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17","container-title":["Journal of Nanoscience and Nanotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/asp\/jnn\/2020\/00000020\/00000009\/art00089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T04:40:19Z","timestamp":1587703219000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.1166\/jnn.2020.17641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,1]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9,1]]}},"alternative-id":["1533-4880(20200901)20:9L.5796;1-"],"URL":"https:\/\/doi.org\/10.1166\/jnn.2020.17641","relation":{},"ISSN":["1533-4880"],"issn-type":[{"value":"1533-4880","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9,1]]}}}