{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:33:57Z","timestamp":1790620437893,"version":"4.1.0"},"reference-count":0,"publisher":"American Scientific Publishers","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j nanosci nanotechnol"],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:p>Intestinal metaplasia (IM) refers to the replacement of gastric epithelial cells by intestinal epithelial cells. This is often accompanied by chronic atrophic gastritis (CAG), which is a precancerous lesion of gastric cancer. The incidence rates of CAG and IM are increasing gradually,\n which generates an enormous economic burden to individuals and society. To explore the pathogenesis of CAG with IM, we screened out the differentially expressed gene olfactomedin 4 (OLFM4) by bioinformatics and constructed OLFM4-shRNA plasmid chitosan magnetic nanoparticles to knockdown this\n gene. This caused a downregulation of caudal type homeobox 2 (CDX2), a marker of IM, suggesting that knocking down OLFM4 may slow the pathological process of IM, thus providing putative relevant targets for the treatment of CAG with IM.<\/jats:p>","DOI":"10.1166\/jnn.2020.18892","type":"journal-article","created":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T04:35:53Z","timestamp":1595738153000},"page":"7324-7332","source":"Crossref","is-referenced-by-count":7,"title":["Study on the Mechanism of Olfactomedin 4-shRNA Plasmid Chitosan Magnetic Nanoparticles in Intestinal Metaplasia of Chronic Atrophic Gastritis"],"prefix":"10.1166","volume":"20","author":[{"given":"Haiwen","family":"Li","sequence":"first","affiliation":[{"name":"Shenzhen Traditional Chinese Medicine Hospital, Spleen and Stomach Department, Shenzhen 518000, Guangdong, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Li","sequence":"additional","affiliation":[{"name":"Shenzhen Traditional Chinese Medicine Hospital, Spleen and Stomach Department, Shenzhen 518000, Guangdong, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiwu","family":"Li","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangzhou, University of Chinese Medicine, Spleen and Stomach Department, Guangzhou 510000, Guangdong, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijian","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Spleen and Stomach Department, Shenzhen 518000, Guangdong, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqin","family":"Yang","sequence":"additional","affiliation":[{"name":"The Eighth Affiliated Hospital, Sun Yat-Sen University, Chinese Medicine Department, Shenzhen 518000, Guangdong, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Xu","sequence":"additional","affiliation":[{"name":"Shenzhen Traditional Chinese Medicine Hospital, Spleen and Stomach Department, Shenzhen 518000, Guangdong, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyuan","family":"Kang","sequence":"additional","affiliation":[{"name":"Shenzhen Traditional Chinese Medicine Hospital, Spleen and Stomach Department, Shenzhen 518000, Guangdong, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingchao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shenzhen Traditional Chinese Medicine Hospital, Spleen and Stomach Department, Shenzhen 518000, Guangdong, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yabin","family":"Wu","sequence":"additional","affiliation":[{"name":"Shenzhen Traditional Chinese Medicine Hospital, Spleen and Stomach Department, Shenzhen 518000, Guangdong, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafeng","family":"Pan","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoju","family":"Guo","sequence":"additional","affiliation":[{"name":"Shenzhen Traditional Chinese Medicine Hospital, Spleen and Stomach Department, Shenzhen 518000, Guangdong, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"17","container-title":["Journal of Nanoscience and Nanotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/asp\/jnn\/2020\/00000020\/00000012\/art00012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T11:39:13Z","timestamp":1596541153000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.1166\/jnn.2020.18892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12,1]]}},"alternative-id":["1533-4880(20201201)20:12L.7324;1-"],"URL":"https:\/\/doi.org\/10.1166\/jnn.2020.18892","relation":{},"ISSN":["1533-4880"],"issn-type":[{"value":"1533-4880","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12,1]]}}}