{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:55:28Z","timestamp":1784606128314,"version":"3.55.0"},"reference-count":12,"publisher":"American Scientific Publishers","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j nanosci nanotechnol"],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:p>Dyslipidemia and oxidative stress injury of blood vessel walls play important roles in the formation of atherosclerosis (AS) and plaque progression. This is also the main pathological basis for atherosclerosis. Statins, as inhibitors of HMG-CoA reductase in the process of cholesterol\n biosynthesis, have become key drugs for lipid-lowering treatment. Many studies have found the anti-atherosclerotic effect of atorvastatin is far beyond the lipid-lowering effect. Its lipid-lowering effects are also involved, such as anti-inflammatory, inhibiting endothelial cell ROS production,\n and improving endothelial cell damage. Nano selenium (Nano-Se) shows stronger anti-oxidation ability, lower toxicity, high efficiency absorption and strong immune regulation ability. Because of the unique biological effects of Nano-Se, it has broad prospects in the field of human health care.\n Therefore, in this study, by constructing a rat model of abnormal lipid metabolism, we observed changes in parameters such as serum peroxidase (MPO), propylene glycol (MDA), superoxide dismutase (SOD), and blood lipid levels in atherosclerotic rats Happening, furthermore, the effects of atorvastatin+nano-selenium\n on lipid metabolism disorders and the protective effects and mechanisms of oxidative stress injury in rats were investigated and with a view to providing new targets for the treatment of arteriosclerosis. The results of this study demonstrated that contrast to the AS rat, the combined use\n of atorvastatin+nano-selenium group could significantly reduce serum TC, TG, and LDL-C contents, and declined tissue lesions such as aortic arch and liver; Significantly enhanced the activities of GPx-1 and SOD in serum, decreased MDA content, and increased the SOD activity in rat aorta. These\n results suggested that the combined use of atorvastatin+nano-selenium has good protection against oxidative stress caused by disorders of lipid metabolism.<\/jats:p>","DOI":"10.1166\/jnn.2021.18633","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T04:53:47Z","timestamp":1605243227000},"page":"1331-1337","source":"Crossref","is-referenced-by-count":18,"title":["Effects of Atorvastatin Combined with Nano-Selenium on Blood Lipids and Oxidative Stress in Atherosclerotic Rats"],"prefix":"10.1166","volume":"21","author":[{"given":"Zhe","family":"Han","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Affiliated Hospital of Hebei University, Baoding City, 071000, Hebei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Affiliated Hospital of Hebei University, Baoding City, 071000, Hebei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Department of Cardiology, Affiliated Hospital of Hebei University, Baoding City, 071000, Hebei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"17","reference":[{"key":"r1","first-page":"pp.152","article-title":"Effects of atorvastatin on the hypertension-induced oxidative stress in the rat brain.","volume":"173","author":"Mohammadi","year":"2013","journal-title":"Iranian Biomedical Journal"},{"key":"r2","first-page":"pp.368","article-title":"Antioxidant and lipid-regulating effects of probu-col combined with atorvastatin in patients with acute coronary syndrome.","volume":"73","author":"Guo","year":"2015","journal-title":"Journal of Thoracic Disease"},{"key":"r3","doi-asserted-by":"crossref","first-page":"pp.133","DOI":"10.1007\/s00380-005-0833-9","article-title":"Effects of atorvastatin on inflammation and oxidative stress.","volume":"204","author":"Sugiyama","year":"2005","journal-title":"Heart and Vessels"},{"key":"r4","doi-asserted-by":"crossref","first-page":"pp.697","DOI":"10.1111\/nep.12502","article-title":"Effects of atorvastatin on oxidative stress in chronic kidney disease.","volume":"2010","author":"Fassett","year":"2015","journal-title":"Nephrology"},{"key":"r5","doi-asserted-by":"crossref","first-page":"pp.9","DOI":"10.1016\/j.exger.2014.01.015","article-title":"Long-term atorvastatin improves age-related endothelial dysfunction by ameliorating oxidative stress and normalizing eNOS\/iNOS imbalance in rat aorta.","volume":"52","author":"Gong","year":"2014","journal-title":"Experimental Gerontology"},{"issue":"(5)","key":"r6","doi-asserted-by":"crossref","first-page":"pp.2857","DOI":"10.2298\/TSCI190104200W","article-title":"Construction of visual 3-D fabric reinforced composite thermal performance prediction system.","volume":"23","author":"Wu","year":"2019","journal-title":"Thermal Science"},{"key":"r7","doi-asserted-by":"crossref","first-page":"pp.330","DOI":"10.1016\/j.livsci.2015.05.004","article-title":"Effects of organic, inorganic, and nano-Se on growth performance, antioxidant capacity, cellular and humoral immune responses in broiler chickens exposed to oxidative stress.","volume":"178","author":"Boostani","year":"2015","journal-title":"Livestock Science"},{"key":"r8","doi-asserted-by":"crossref","first-page":"pp.160","DOI":"10.1097\/FJC.0b013e318294998d","article-title":"Atorvastatin active metabolite inhibits oxidative modification of small dense low-density lipoprotein.","volume":"622","author":"Jacob","year":"2013","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"r9","doi-asserted-by":"crossref","first-page":"pp.225","DOI":"10.1007\/s10517-015-2928-3","article-title":"Lipid peroxidation-antioxidant defense system during toxic liver damage and its correction with a composite substance containing selenium and arabinogalactan.","volume":"1592","author":"Kolesnikova","year":"2015","journal-title":"Bulletin of Experimental Biology and Medicine"},{"issue":"(2)","key":"r10","first-page":"pp.187","article-title":"Effect of nano-selenium on plasma antioxidant status and reproductive system function of female rats exposed to oxidative stress induced by doxorubicin.","volume":"7","author":"Rastgoo","year":"2015","journal-title":"Biological Forum."},{"issue":"(2)","key":"r11","doi-asserted-by":"crossref","first-page":"pp.243","DOI":"10.1007\/s11010-015-2415-1","article-title":"Nano-Se attenuates cyclophosphamide-induced pulmonary injury through modulation of oxidative stress and DNA damage in Swiss albino mice.","volume":"40","author":"Bhattacharjee","year":"2015","journal-title":"Molecular and Cellular Biochemistry"},{"issue":"(1)","key":"r12","doi-asserted-by":"crossref","first-page":"pp.105","DOI":"10.1186\/s12967-018-1481-z","article-title":"Endoplasmic reticulum stress in perivascular adipose tissue promotes destabilization of atherosclerotic plaque by regulating gm-csf paracrine.","volume":"16","author":"Ying","year":"2018","journal-title":"Journal of Translational Medicine"}],"container-title":["Journal of Nanoscience and Nanotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/asp\/jnn\/2021\/00000021\/00000002\/art00071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T04:49:34Z","timestamp":1608785374000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.1166\/jnn.2021.18633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,1]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2,1]]}},"alternative-id":["1533-4880(20210201)21:2L.1331;1-"],"URL":"https:\/\/doi.org\/10.1166\/jnn.2021.18633","relation":{},"ISSN":["1533-4880"],"issn-type":[{"value":"1533-4880","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2,1]]}}}