{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:22:58Z","timestamp":1778872978675,"version":"3.51.4"},"reference-count":14,"publisher":"American Scientific Publishers","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j nanosci nanotechnol"],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:p>At present, surgical suture treatment can be performed for spinal patients after nerve injury, but nerve regeneration and functional recovery require comprehensive treatment including drug treatment. However, there is still a lack of adjuvant therapeutic drugs that can effectively promote\n nerve regeneration and functional recovery. Drug treatment after nerve injury is the basis of nerve injury treatment and an important supplement to surgical treatment. Finding an effective method for treating spinal nerve injury and studying its mechanism of action may have important basic\n and clinical significance. The nanofiber catheter material simulates the nano\/sub-micron level collagen fiber bundle structure of cells in the body, so it has been more and more widely used in the field of tissue engineering. Therefore, in this study, PHBV nanofiber catheter was successfully\n prepared by electrostatic spinning method, and the nanofiber catheter was characterized by SEM and DSC tests. The PHBV nanofiber catheter prepared by this research method has excellent characteristics such as porosity, large specific surface area, stable structure, thermal stability, and good\n mechanical properties. At the same time, adult male SD rats were selected to establish an animal model of cervical spine injury in this experiment. The expressions of three inflammation-related factors (IL-1<jats:italic>\u03b1<\/jats:italic>, IL-10 and TNF-1) were analyzed by ELISA. The results showed that in\n the spinal injury group, the expression of the three inflammatory factors all showed a significant increase over time and then reached a peak, then decreased and stabilized. This showed that the PHBV nanofiber catheter repairs cervical spine injury by affecting the inflammatory response, which\n is conducive to repairing cervical spine injury. RT-PCR was used to detect the expression of CNTF, GAP-43, and Tubulin-related proteins. During the neural regeneration process in rats, the expressions of both backbone proteins continued to be expressed, and they were first up-regulated and\n then flattened. This indicated that in the early stage of neural regeneration, a large number of skeletal proteins are synthesized, and they continue to be expressed at low levels over time, laying a foundation for the axon skeleton reconstruction.<\/jats:p>","DOI":"10.1166\/jnn.2021.18639","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T04:53:47Z","timestamp":1605243227000},"page":"1259-1265","source":"Crossref","is-referenced-by-count":2,"title":["Preparation of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Nanofiber Catheter and Its Mechanism of Nerve Injury in Patients with Cervical Spine Injury"],"prefix":"10.1166","volume":"21","author":[{"given":"Xuan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun City, 130033, Jilin Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun City, 130033, Jilin Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun City, 130033, Jilin Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17","reference":[{"key":"r1","doi-asserted-by":"crossref","first-page":"pp.66","DOI":"10.1016\/j.biomaterials.2015.04.047","article-title":"In vivo studies of silk based gold nano-composite conduits for functional peripheral nerve regeneration.","volume":"62","author":"Das","year":"2015","journal-title":"Biomaterials"},{"issue":"(6)","key":"r2","doi-asserted-by":"crossref","first-page":"pp.651","DOI":"10.1097\/MAT.0b013e3182a79151","article-title":"Chitosan-cross-linked nanofibrous PHBV nerve guide for rat sciatic nerve regeneration across a defect bridge.","volume":"59","author":"Biazar","year":"2013","journal-title":"Asaio Journal"},{"key":"r3","doi-asserted-by":"crossref","first-page":"pp.315","DOI":"10.1016\/j.dib.2015.05.020","article-title":"Data in support of in vivo studies of silk based gold nano-composite conduits for functional peripheral nerve regeneration.","volume":"4","author":"Das","year":"2015","journal-title":"Data in Brief"},{"issue":"(5)","key":"r4","doi-asserted-by":"crossref","first-page":"pp.2867","DOI":"10.2298\/TSCI190104201W","article-title":"Study and evaluation of clustering algorithm for solubility and thermodynamic data of glycerol 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and Bioengineering"},{"key":"r8","doi-asserted-by":"crossref","first-page":"pp.1295","DOI":"10.1002\/jnr.23881","article-title":"Neuropathic pain following traumatic spinal cord injury: Models, measurement, and mechanisms.","volume":"956","author":"Kramer","year":"2017","journal-title":"Journal of Neu-roscience Research"},{"key":"r9","doi-asserted-by":"crossref","first-page":"pp.57","DOI":"10.1016\/j.bbrc.2019.07.003","article-title":"A novel activation mechanism of cellular factor XIII in zebrafish retina after optic nerve injury.","volume":"5171","author":"Sugitani","year":"2019","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"(2)","key":"r10","doi-asserted-by":"crossref","first-page":"pp.41","DOI":"10.3109\/15419061.2013.774378","article-title":"A nanofibrous PHBV tube dwith Schwann cell as artificial nerve graft contributing to rat sciatic nerve regeneration across a 30-mm defect bridge.","volume":"201","author":"Biazar","year":"2013","journal-title":"Cell Communication & Adhesion"},{"key":"r11","doi-asserted-by":"crossref","first-page":"pp.486","DOI":"10.1111\/jnc.14001","article-title":"Neuronal and microglial mechanisms for neuropathic pain in the spinal dorsal horn and anterior cingulate cortex.","volume":"1414","author":"Tsuda","year":"2017","journal-title":"Journal of Neurochemistry"},{"issue":"(1)","key":"r12","doi-asserted-by":"crossref","first-page":"p.7761","DOI":"10.1038\/s41598-018-26219-5","article-title":"Protective effects of intraoperative nerve monitoring (ionm) for recurrent laryngeal nerve injury in thyroidectomy: Meta-analysis.","volume":"8","author":"Bai","year":"2018","journal-title":"Scientific Reports"},{"issue":"(2016)","key":"r13","first-page":"pp.929","article-title":"Reliable MRI and MRN signs of nerve and muscle injury following trauma to the shoulder with EMG and clinical correlation.","volume":"47","author":"Dawoud","year":"2018","journal-title":"Egyptian Journal of Radiology & Nuclear Medicine"},{"issue":"(9)","key":"r14","first-page":"pp.419","article-title":"Preoperative risk factors of c5 nerve root palsy after laminec-tomy and fusion in patients with cervical myelopathy: Analysis of 70 consecutive patients.","volume":"30","author":"Suk","year":"2017","journal-title":"Clinical Spine Surgery"}],"container-title":["Journal of Nanoscience and 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