{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T03:36:30Z","timestamp":1782704190837,"version":"3.54.5"},"reference-count":6,"publisher":"American Scientific Publishers","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j nanosci nanotechnol"],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:p>In order to explore the influence of nanoparticle-loaded edaravone on postoperative effects in patients with cerebral hemorrhage, a total of 120 patients who were diagnosed as cerebral hemorrhage and underwent minimally invasive hematoma removal at the designated hospital by the study\n from December 2014 to December 2018 were selected as research objects and divided into three groups according to the random number table method: edaravone treatment (ET) group, nanoparticle-loaded edaravone treatment (NET) group, and combined treatment (CT) group with 40 patients in each group.\n Three groups of patients underwent routine treatments based on their conditions, including regulating blood sugar, regulating blood pressure, anti-infection, nutritional support, and managing complications, in which 25 mg edaravone injection and 100 ml saline were added for patients in NET\n and CT group on the basis of the routine treatment of patients in ET group. The results showed that, after 15 days of standard treatment, the 40 patients in NET group had significantly improved neurological function than that before the treatment; the secretion of inflammatory factors in peripheral\n serum increased on the 7th day of treatment and decreased on the 14th day of treatment; there was no statistically significant difference in edema volume before treatment and the edema volume in the NET group was (11.56\u00b10.44) mL after treatment, which was significantly smaller than\n that in ET group of (14.63\u00b11.15) mL and the difference between the three groups was statistically significant (<jats:italic>P<\/jats:italic> &lt;0.05). Therefore, it is believed that nanoparticle-loaded edaravone has an important effect on the postoperative effect of patients with cerebral hemorrhage; it\n can significantly improve the neurological function of patients with cerebral hemorrhage after minimally invasive drainage, and obviously reduce the production and release of interleukin and tumor necrosis factor, which is beneficial to protect healthy brain tissue and other organs throughout\n the body, and is conducive to the recovery and healing of cerebral hemorrhage. The results of this study provide a reference for further research on the influence of nanoparticle-loaded edaravone on postoperative effects in patients with cerebral hemorrhage.<\/jats:p>","DOI":"10.1166\/jnn.2021.18668","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T04:53:47Z","timestamp":1605243227000},"page":"1202-1211","source":"Crossref","is-referenced-by-count":12,"title":["Influence of Nanoparticle-Loaded Edaravone on Postoperative Effects in Patients with Cerebral Hemorrhage"],"prefix":"10.1166","volume":"21","author":[{"given":"Lianfeng","family":"Dang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Nuclear Industry 215 Hospital of Shaanxi Province, 712000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xianyang Hospital of Yan\u2019an University, 712000, China; Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, 14155-6455, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nuclear Industry 215 Hospital of Shaanxi Province, 712000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"17","reference":[{"issue":"(4)","key":"r1","doi-asserted-by":"crossref","first-page":"pp.264","DOI":"10.1272\/jnms.81.264","article-title":"Atypical radiological and intraoperative findings of acute cerebral hemorrhage caused by ruptured cerebral aneurysm in a patient with severe chronic anemia.","volume":"81","author":"Matano","year":"2014","journal-title":"Journal of Nippon Medical School"},{"issue":"(7)","key":"r2","doi-asserted-by":"crossref","first-page":"pp.1029","DOI":"10.2217\/nnm.12.2","article-title":"Redox nanoparticle treatment protects against neurological deficit in focused ultrasound-induced intracerebral hemorrhage.","volume":"7","author":"Chonpathompikunlert","year":"2012","journal-title":"Nanomedicine"},{"issue":"(2)","key":"r3","first-page":"pp.106","article-title":"Beneficial effects of edaravone on the expression of serum matrix metalloproteinase-9 after cerebral hemorrhage.","volume":"19","author":"Zhao","year":"2014","journal-title":"Neurosciences"},{"issue":"(10)","key":"r4","doi-asserted-by":"crossref","first-page":"pp.824","DOI":"10.1111\/cns.12584","article-title":"Stereotactic administration of edaravone ameliorates collagenase-induced intracerebral hemorrhage in rat.","volume":"22","author":"Zhang","year":"2016","journal-title":"CNS Neuroscience & Therapeutics"},{"issue":"(1)","key":"r5","first-page":"pp.27","article-title":"Intracerebral hemorrhage caused by cerebral hyperperfusion after superficial temporal artery to middle cerebral artery bypass for atherosclerotic occlusive cerebrovascular disease.","volume":"4","author":"Matano","year":"2016","journal-title":"NMC Case Report Journal"},{"issue":"(6)","key":"r6","first-page":"pp.843","article-title":"Current therapeutic drugs against cerebral vasospasm after subarachnoid hemorrhage: A comprehensive review of basic and clinical studies.","volume":"14","author":"Hasegawa","year":"2017","journal-title":"Current Drug Delivery"}],"container-title":["Journal of Nanoscience and Nanotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/asp\/jnn\/2021\/00000021\/00000002\/art00054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T04:50:59Z","timestamp":1608785459000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.1166\/jnn.2021.18668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,1]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2,1]]}},"alternative-id":["1533-4880(20210201)21:2L.1202;1-"],"URL":"https:\/\/doi.org\/10.1166\/jnn.2021.18668","relation":{},"ISSN":["1533-4880"],"issn-type":[{"value":"1533-4880","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2,1]]}}}