{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:00:19Z","timestamp":1756310419130},"reference-count":7,"publisher":"American Scientific Publishers","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j nanosci nanotechnol"],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:p>Lupus nephritis (LN) is a common, frequently-occurring and refractory renal medical disease. With the progress of society, the improvement of people\u2019s living standards, changes in lifestyles, and drug abuse, the incidence rate is increasing year by year. The effect of treatment\n on it is currently unsatisfactory clinically, and the recurrence rate is relatively high, which seriously affects People\u2019s quality of life. Therefore, the disease has become a hot and difficult point of research. In recent years, the pathogenesis and treatment of this disease have been\n thoroughly studied at home and abroad, especially the application of hormones and cyclophosphamide, which have achieved relatively good clinical effects. In this paper, nanostructured lipid carriers were prepared and their pharmacodynamics were studied in the treatment of mice with immunological\n lupus nephritis. The main experimental methods and results show that the nanostructured lipid carrier TWHF-NLC prepared by the high-pressure microjet method is characterized by transmission electron microscopy, and the TP-NLC has a uniform particle size, and the nanoparticles are spherical\n or short rod-shaped. Animal experiments show that TWHF-NLC has obvious therapeutic effect on mice with immune lupus nephritis. Pathological sections of the kidney showed that TWHF-NLC can effectively reduce the collagen content of the renal interstitial cells, and remove MCP-1 deposited in\n the kidney, and inhibit its expression.<\/jats:p>","DOI":"10.1166\/jnn.2021.18671","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T04:53:47Z","timestamp":1605243227000},"page":"1099-1106","source":"Crossref","is-referenced-by-count":3,"title":["Experimental Study of Nanostructured Lipid Carrier in the Treatment of Immune Lupus Nephritis"],"prefix":"10.1166","volume":"21","author":[{"given":"Yuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Tianjin First Central Hospital, Tianjin 300192, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wufang","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Tianjin First Central Hospital, Tianjin 300192, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17","reference":[{"issue":"(1)","key":"r1","first-page":"pp.1","article-title":"Regulation of inflammatory response of macrophages and induction of regulatory T cells by using retinoic acid-loaded nanostructured lipid carrier.","volume":"30","author":"Zai","year":"2019","journal-title":"Jour nal of Biomaterials Science, Polymer Edition"},{"issue":"(11)","key":"r2","doi-asserted-by":"crossref","first-page":"pp.1239","DOI":"10.2217\/nnm-2017-0318","article-title":"Nanostructured lipid carriers-based thermosensitive eye drops for enhanced, sustained delivery of dexamethasone.","volume":"13","author":"Mo","year":"2018","journal-title":"Nanomedicine"},{"issue":"(2)","key":"r3","doi-asserted-by":"crossref","first-page":"pp.257","DOI":"10.15171\/apb.2018.030","article-title":"Enhanced lymphatic uptake of leflunomide loaded nanolipid carrier via chylomicron formation for the treatment of rheumatoid arthritis.","volume":"8","author":"Krishnan","year":"2018","journal-title":"Advanced Pharmaceutical Bulletin"},{"issue":"(1)","key":"r4","doi-asserted-by":"crossref","first-page":"pp.42","DOI":"10.3390\/nano8010042","article-title":"Lipid-based nanopar-ticles as a potential delivery approach in the treatment of rheumatoid arthritis.","volume":"8","author":"Chuang","year":"2018","journal-title":"Nanomaterials"},{"issue":"(14)","key":"r5","doi-asserted-by":"crossref","first-page":"pp.1540039","DOI":"10.1142\/S0218127415400398","article-title":"A traffic motion object extraction algorithm.","volume":"25","author":"Wu","year":"2015","journal-title":"International Journal of Bifurcation and Chaos"},{"issue":"(2)","key":"r6","doi-asserted-by":"crossref","first-page":"pp.385","DOI":"10.1002\/9781118592403.ch14","article-title":"Peptide nanostructured conjugates for therapeutics: The example of P140 peptide for the treatment of systemic lupus erythematosus.","volume":"3","author":"Fr\u00e8re","year":"2013","journal-title":"Peptide Materials: From Nanostructures to Applications"},{"issue":"(15)","key":"r7","doi-asserted-by":"crossref","first-page":"pp.1412","DOI":"10.1016\/j.addr.2009.09.005","article-title":"Squalene: A natural triterpene for use in disease management and therapy.","volume":"61","author":"Reddy","year":"2009","journal-title":"Advanced Drug Delivery Reviews"}],"container-title":["Journal of Nanoscience and Nanotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/asp\/jnn\/2021\/00000021\/00000002\/art00040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T04:49:47Z","timestamp":1608785387000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.1166\/jnn.2021.18671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,1]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2,1]]}},"alternative-id":["1533-4880(20210201)21:2L.1099;1-"],"URL":"https:\/\/doi.org\/10.1166\/jnn.2021.18671","relation":{},"ISSN":["1533-4880"],"issn-type":[{"value":"1533-4880","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2,1]]}}}