{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T04:47:19Z","timestamp":1787460439989,"version":"build-2736575974"},"reference-count":8,"publisher":"American Scientific Publishers","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j nanosci nanotechnol"],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:p>Cancer is a serious threat to human health and longevity, and is an important cause of disease death. At present, cancer is mainly treated by surgery, radiotherapy, chemotherapy, etc. The existing various methods of treating tumors have their limitations. Although there are immune,\n genetic and other treatment methods, they are still immature. Therefore, tumor-targeted drug delivery systems have attracted more and more attention in cancer treatment. Targeted nano-drugs are selectively targeted to the tumor surface to achieve targeted drug delivery. New nano-drugs have\n created new hotspots in medical research. It could be a new strategy for treating cancer. Carboxymethyl chitosan (CMC) is formed by the carboxylation of chitosan. It has good water solubility and biodegradability, biocompatibility and antibacterial properties, so CMC is the best choice as\n a nanomaterial. Isorhamnetin (Iso) is an important anticancer drug. This article uses nanomedicine technology to construct CMC as a carrier, Iso as an antitumor drug, and using polydopamine (PDA) to modify the surface of the particles. Through <jats:italic>in vitro<\/jats:italic> and in vivo experiments, the Iso\/CMC-PDA\n nanosphere Targeting and Growth Inhibition of Cervical Cancer Cells.<\/jats:p>","DOI":"10.1166\/jnn.2021.18690","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T04:53:47Z","timestamp":1605243227000},"page":"1293-1299","source":"Crossref","is-referenced-by-count":8,"title":["Preparation of Isorhamnetin Nanoparticles and Their Targeting Efficiency to Nasopharynx Cancer"],"prefix":"10.1166","volume":"21","author":[{"given":"Bo","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"17","reference":[{"issue":"(4)","key":"r1","doi-asserted-by":"crossref","first-page":"pp.582","DOI":"10.1158\/1940-6207.CAPR-11-0032","article-title":"Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K.","volume":"4","author":"Kim","year":"2011","journal-title":"Cancer Prevention Research"},{"issue":"(17)","key":"r2","doi-asserted-by":"crossref","first-page":"pp.5473","DOI":"10.1158\/0008-5472.CAN-13-0525","article-title":"Chemopreven-tive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and \/3-catenin.","volume":"73","author":"Saud","year":"2013","journal-title":"Cancer Research"},{"issue":"(45)","key":"r3","doi-asserted-by":"crossref","first-page":"pp.38028","DOI":"10.1074\/jbc.M112.388702","article-title":"Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated 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Nanotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/asp\/jnn\/2021\/00000021\/00000002\/art00066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T04:50:45Z","timestamp":1608785445000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.1166\/jnn.2021.18690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,1]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2,1]]}},"alternative-id":["1533-4880(20210201)21:2L.1293;1-"],"URL":"https:\/\/doi.org\/10.1166\/jnn.2021.18690","relation":{},"ISSN":["1533-4880"],"issn-type":[{"value":"1533-4880","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2,1]]}}}