{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:23:05Z","timestamp":1761718985401},"reference-count":17,"publisher":"American Scientific Publishers","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j nanosci nanotechnol"],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:p>As a first-line drug widely used in the treatment of leukemia, 6-MP has obvious effects on leukemia. However, 6-MP disadvantages such as poor solubility in water, easy binding with serum proteins, short circulation time, and large toxic and side effects greatly limit the application\n of 6-MP. For this reason, various 6-MP nano drug-loading systems have been designed to increase the water solubility of 6-MP, extend the circulation time, and increase the bioavailability of 6-MP to a certain extent, reducing its toxic and side effects. However, its therapeutic effect <jats:italic>in\n vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> is still far from expectations, and there is a lot of room for improvement. In order to solve the above problems encountered in the clinical application of 6-MP, we have tried two ways of polymer prodrugs and drug-loaded vesicles to achieve efficient targeted delivery\n and treatment of 6-MP. We designed hyaluronic acid (HA)-based gluteal-skin-responsive 6-MP polymer prodrug (HA-GS-MP) for highly effective targeted therapy of acute myeloid leukemia. Hyaluronic acid is a natural polysaccharide, which has excellent biocompatibility and biodegradability, and\n has a good ability to actively target malignant tumor cells overexpressing the CD<jats:sub>44<\/jats:sub> receptor. 6-MP is connected to the HA chain through a vinyl sulfide bond, which is stable under physiological conditions (no drug release), and under intracellular reducing conditions, the connection\n bond is broken and 6-MP is quickly released. HA-GS-MP has a simple preparation process, good water solubility, long cycle time, and strong targeting ability. This GSH-responsive CD<jats:sub>44<\/jats:sub> targeted 6-MP polymer prodrug is expected to improve the therapeutic effect on acute myeloid leukemia\n cells.<\/jats:p>","DOI":"10.1166\/jnn.2021.18695","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T04:53:47Z","timestamp":1605243227000},"page":"1001-1007","source":"Crossref","is-referenced-by-count":8,"title":["Application and Analysis of 6-Mercaptopurine Nanomedicine in the Treatment of Leukemia"],"prefix":"10.1166","volume":"21","author":[{"given":"Xueying","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Hematology, The Affiliated Huaian No.1 People\u2019s Hospital of Nanjing Medical University, Huai\u2019an City, 223001, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yandong","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Brain Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou City, 221006, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Central Hospital of Zibo, Zibo, 255036, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17","reference":[{"issue":"(10)","key":"r1","doi-asserted-by":"crossref","first-page":"pp.3207","DOI":"10.1021\/acs.biomac.7b00846","article-title":"Glutathione\u2014Sensitive hyaluronic acid\u2014Mercaptopurine pro-drug linked via carbonyl vinyl sulfide: A robust and CD44-targeted nanomedicine for leukemia.","volume":"18","author":"Qiu","year":"2017","journal-title":"Biomacromolecules"},{"issue":"(2)","key":"r2","doi-asserted-by":"crossref","first-page":"pp.568","DOI":"10.1021\/la702782k","article-title":"Gold nanoparticles enhance the anti-leukemia action of a 6-mercaptopurine chemotherapeutic 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