{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T21:13:49Z","timestamp":1781298829700,"version":"3.54.1"},"reference-count":0,"publisher":"American Scientific Publishers","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j nanosci nanotechnol"],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:p>Emergence of multidrug resistance (MDR), extensively drug resistance (XDR) and pandrug resistance (PDR) strains of bacteria in communicable diseases of zoonotic and reverse zoonotic importance is the major hurdle of one health concept. Increasing level of resistance against antibiotics\n among bacterial population throughout the world, slow pace of new antibacterial drug discovery and enhanced pace of resistance development by pathogenic bacteria possess major challenges for human and animal health as well as life in future. Alternative management strategy in terms of improved\n prophylactic vaccine; early, easy and effective diagnostics and therapeutic drugs against those resistant bacteria is the need of the hour. In this context nanomedicine can fit into the multifaceted demands as an effective prophylactic and theranostic alternative to control the communicable\n diseases in a cost effective manner in the era of microbial resistance. The current review is focused towards delineating the application of nanomaterials as vaccine or drug delivery system, diagnostics and directly acting antimicrobial therapeutic agents in combating the important zoonotic\n and reverse zoonotic bacterial diseases in recent scenario along with their potential benefits, limitations and future prospects to formulate successful eradication strategies.<\/jats:p>","DOI":"10.1166\/jnn.2021.18999","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T23:06:18Z","timestamp":1636153578000},"page":"3404-3452","source":"Crossref","is-referenced-by-count":18,"title":["The Importance of Nanomedicine in Prophylactic and Theranostic Intervention of Bacterial Zoonoses and Reverse Zoonoses in the Era of Microbial Resistance"],"prefix":"10.1166","volume":"21","author":[{"given":"Minakshi","family":"Prasad","sequence":"first","affiliation":[{"name":"Department of Animal Biotechnology, Lala Lajpar Rai University of Veterinary and Animal Sciences, Hisar 125004, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayukh","family":"Ghosh","sequence":"additional","affiliation":[{"name":"APR Division, Indian Council of Agricultural Research-Central Research Institute on Buffaloes, Hisar 125001, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology & Biochem, LLR University of Veterinary and Animal Sciences, Hisar 125004, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basanti","family":"Brar","sequence":"additional","affiliation":[{"name":"Department of Animal Biotechnology, Lala Lajpar Rai University of Veterinary and Animal Sciences, Hisar 125004, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. P.","family":"Surjith","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy & Histology, College of Veterinary & Animal Sciences Pookode, Wayanad 673576, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upendra P.","family":"Lambe","sequence":"additional","affiliation":[{"name":"Department of Animal Biotechnology, Lala Lajpar Rai University of Veterinary and Animal Sciences, Hisar 125004, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koushlesh","family":"Ranjan","sequence":"additional","affiliation":[{"name":"Sardar Vallabh Bhai Patel University of Agriculture and Technology, Meerut 250110, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somesh","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology, Immunology Section, Lajpar Rai University of Veterinary and Animal Sciences, Hisar 125004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaya","family":"Prasad","sequence":"additional","affiliation":[{"name":"Sardar Vallabh Bhai Patel University of Agriculture and Technology, Meerut 250110, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandip","family":"Kumar Khurana","sequence":"additional","affiliation":[{"name":"Indian Council of Agricultural Research-Central Institute for Research on Buffaloes, Hisar 125001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pushpa","family":"Kharb","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Biotechnology and Bioinformatcs, Chaudhary Charan Singh Haryana Agricultural University, Hisar 125004, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"17","container-title":["Journal of Nanoscience and Nanotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/asp\/jnn\/2021\/00000021\/00000006\/art00028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T23:06:38Z","timestamp":1636153598000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.1166\/jnn.2021.18999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6,1]]}},"alternative-id":["1533-4880(20210601)21:6L.3404;1-"],"URL":"https:\/\/doi.org\/10.1166\/jnn.2021.18999","relation":{},"ISSN":["1533-4880"],"issn-type":[{"value":"1533-4880","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6,1]]}}}