{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:11:57Z","timestamp":1761948717703},"reference-count":0,"publisher":"American Scientific Publishers","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["j nanosci nanotechnol"],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:p>Inflammation mediated by the innate immune system is the organism\u2019s protective mechanism against infectious environmental risk factors. Uncontrolled acute inflammation can become chronic, contributing to various chronic inflammatory diseases such as arthritis, asthma, autoimmune\n diseases, and atherosclerosis. Although microalgae are increasingly receiving attention as a source of bioactive molecules with therapeutic potential for various human diseases, the underlying mechanisms are not yet well understood. In the present study, we investigated the molecular mechanisms\n underlying the anti-inflammatory and anti-aging activities of ethanol extracts of Antarctic freshwater microalga <jats:italic>Micractinium simplicissimum.<\/jats:italic> Using RAW 264.7 macrophages, microalgal extracts exerted anti-inflammatory activity by regulating the major inflammatory indicators including\n cyclooxy-genase (COX)-2, interleukin (IL)-6, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-\u03b1 and nitric oxide (NO). Besides, we observed the anti-aging activity of the microalgal extract by suppressing MMP-1 production in human dermal fibroblast. Taken together,\n these data suggest that anti-inflammatory and anti-aging activities of Antarctic freshwater microalga, <jats:italic>Micractinium simplicissimum,<\/jats:italic> can provide new clues to understanding the molecular link between inflammation and diseases, and be a potential anti-inflammatory agent.<\/jats:p>","DOI":"10.1166\/jnn.2021.19158","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T04:31:27Z","timestamp":1615782687000},"page":"4098-4103","source":"Crossref","is-referenced-by-count":6,"title":["Antarctic Freshwater Microalga, <i>Micractinium simplicissimum,<\/i> Suppresses Inflammation"],"prefix":"10.1166","volume":"21","author":[{"given":"Hae-Jung","family":"Chae","sequence":"first","affiliation":[{"name":"Department of Biosciences, Mokpo National University, Muan, 58554, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Bae","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Mokpo National University, Muan, 58554, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Hak","family":"Kim","sequence":"additional","affiliation":[{"name":"Lab of Animal Molecular Biochemistry, Chonnam National University, Gwangju, 61186, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ei Joung","family":"Youn","sequence":"additional","affiliation":[{"name":"Division of Polar Life Sciences, Korea Polar Research Institute, Incheon, 21990, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanghee","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Polar Life Sciences, Korea Polar Research Institute, Incheon, 21990, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Suk","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Mokpo National University, Muan, 58554, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17","container-title":["Journal of Nanoscience and Nanotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/asp\/jnn\/2021\/00000021\/00000007\/art00086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T04:41:57Z","timestamp":1625805717000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.1166\/jnn.2021.19158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,1]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7,1]]}},"alternative-id":["1533-4880(20210701)21:7L.4098;1-"],"URL":"https:\/\/doi.org\/10.1166\/jnn.2021.19158","relation":{},"ISSN":["1533-4880"],"issn-type":[{"value":"1533-4880","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7,1]]}}}