{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T18:10:11Z","timestamp":1730139011264,"version":"3.28.0"},"reference-count":67,"publisher":"American Scientific Publishers","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["mat express"],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:p>The objective of this research was to perform a genomics study of five cerium oxide particles, 4 nano and one micrometer-sized particles which have been studied previously by our group with respect to cytotoxicity, biochemistry and metabolomics. Human liver carcinoma HepG2 cells were exposed to between 0.3 to 300 ug\/ml of CeO<jats:sub>2<\/jats:sub>particles for 72 hours and then total RNA was harvested. Fatty acid accumulation was observed with W4, X5, Z7 and less with Q but not Y6.The gene expression changes in the fatty acid metabolism genes correlated the fatty acid accumulation we detected in the prior metabolomics study for the CeO<jats:sub>2<\/jats:sub>particles named W4, Y6, Z7 and Q, but not for X5. In particular, the observed genomics effects on fatty acid uptake and fatty acid oxidation offer a possible explanation of why many CeO<jats:sub>2<\/jats:sub>particles increase cellular free fatty acid concentrations in HepG2 cells. The major genomic changes observed in this study were sirtuin, ubiquitination signaling pathways, NRF2-mediated stress response and mitochondrial dysfunction. The sirtuin pathway was affected by many CeO<jats:sub>2<\/jats:sub>particle treatments. Sirtuin signaling itself is sensitive to oxidative stress state of the cells and may be an important contributor in CeO<jats:sub>2<\/jats:sub>particle induced fatty acid accumulation. Ubiquitination pathway regulates many protein functions in the cells, including sirtuin signaling, NRF2 mediated stress, and mitochondrial dysfunction pathways. NRF2-mediated stress response and mitochondrial were reported to be altered in many nanoparticles treated cells. All these pathways may contribute to the fatty acid accumulation in the CeO<jats:sub>2<\/jats:sub>particle treated cells.<\/jats:p>","DOI":"10.1166\/mex.2023.2527","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T04:35:36Z","timestamp":1695357336000},"page":"1799-1811","source":"Crossref","is-referenced-by-count":0,"title":["Differential genomic effects of four nano-sized and one micro-sized CeO<sub>2<\/sub>particles on HepG2 cells"],"prefix":"10.1166","volume":"13","author":[{"given":"Sheau-Fung","family":"Thai","sequence":"first","affiliation":[{"name":"Center for Computational Toxicology and Exposure, US Environmental Protection Agency, 109 TW Alexander Dr., Durham, NC, 27709, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlton P.","family":"Jones","sequence":"additional","affiliation":[{"name":"Center for Computational Toxicology and Exposure, US Environmental Protection Agency, 109 TW Alexander Dr., Durham, NC, 27709, 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