{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:57:16Z","timestamp":1791928636193,"version":"4.3.4"},"reference-count":0,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"6","license":[{"start":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T00:00:00Z","timestamp":1508371200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2017,10,19]]},"DOI":"10.1167\/iovs.17-21773","type":"journal-article","created":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T15:31:52Z","timestamp":1508427112000},"page":"BIO300","source":"Crossref","is-referenced-by-count":31,"title":["The Photopic Negative Response: An Objective Measure of Retinal Ganglion Cell Function in Patients With Leber's Hereditary Optic Neuropathy"],"prefix":"10.1167","volume":"58","author":[{"given":"Rustum","family":"Karanjia","sequence":"first","affiliation":[{"name":"Doheny Eye Institute, Los Angeles, California, United States 2Doheny Eye Centers of UCLA, Department of Ophthalmology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, United States 3Ottawa Eye Institute, University of Ottawa, Ottawa, Ontario, Canada 4Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Berezovsky","sequence":"additional","affiliation":[{"name":"Departamento de Oftalmologia e Ci\u00eancias Visuais, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Yuri","family":"Sacai","sequence":"additional","affiliation":[{"name":"Departamento de Oftalmologia e Ci\u00eancias Visuais, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nivea Nunes","family":"Cavascan","sequence":"additional","affiliation":[{"name":"Departamento de Oftalmologia e Ci\u00eancias Visuais, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry Yuheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Ottawa Eye Institute, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Nazarali","sequence":"additional","affiliation":[{"name":"Ottawa Eye Institute, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton Nunes","family":"Moraes-Filho","sequence":"additional","affiliation":[{"name":"Instituto de Olhos de Colatina, Colatina, ES, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Anderson","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute, Los Angeles, California, United States 2Doheny Eye Centers of UCLA, Department of Ophthalmology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey Show","family":"Tran","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute, Los Angeles, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung EunSong","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Departamento de Oftalmologia e Ci\u00eancias Visuais, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton Nunes","family":"Moraes","sequence":"additional","affiliation":[{"name":"Instituto de Olhos de Colatina, Colatina, ES, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Sadun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ospedale Parodi Delfino, Colleferro, Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"DeNegri","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera San Camillo-Forlanini, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Barboni","sequence":"additional","affiliation":[{"name":"Studio Oculistico d'Azeglio, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"do Val Ferreira Ramos","sequence":"additional","affiliation":[{"name":"Hospital Federal da Lagoa, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"La Morgia","sequence":"additional","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Institute of Neurological Sciences of Bologna, Bellaria Hospital, Bologna, Italy 12Unit of Neurology, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Carelli","sequence":"additional","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Institute of Neurological Sciences of Bologna, Bellaria Hospital, Bologna, Italy 12Unit of Neurology, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Rubens","family":"Belfort","sequence":"additional","affiliation":[{"name":"Departamento de Oftalmologia e Ci\u00eancias Visuais, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart Glenn","family":"Coupland","sequence":"additional","affiliation":[{"name":"Ottawa Eye Institute, University of Ottawa, Ottawa, Ontario, Canada 4Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solange Rios","family":"Salomao","sequence":"additional","affiliation":[{"name":"Departamento de Oftalmologia e Ci\u00eancias Visuais, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo A.","family":"Sadun","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute, Los Angeles, California, United States 2Doheny Eye Centers of UCLA, Department of Ophthalmology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.17-21773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:30:40Z","timestamp":1791927040000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.17-21773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,19]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,5,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.17-21773","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10,19]]}}}