{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:58:11Z","timestamp":1791928691709,"version":"4.3.4"},"reference-count":65,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"8","license":[{"start":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T00:00:00Z","timestamp":1531094400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2018,7,9]]},"DOI":"10.1167\/iovs.17-22232","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T18:02:49Z","timestamp":1532109769000},"page":"3394","source":"Crossref","is-referenced-by-count":7,"title":["Selective Early Glial Reactivity in the Visual Pathway Precedes Axonal Loss, Following Short-Term Cerebrospinal Fluid Pressure Reduction"],"prefix":"10.1167","volume":"59","author":[{"given":"Xiao Xia","family":"Li","sequence":"first","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China"},{"name":"Beijing Institute of Ophthalmology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui Yang","family":"Zeng","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China"},{"name":"Beijing Institute of Ophthalmology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Wu","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China"},{"name":"Beijing Institute of Ophthalmology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China"},{"name":"Beijing Institute of Ophthalmology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing Xue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China"},{"name":"Beijing Institute of Ophthalmology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China"},{"name":"Beijing Institute of Ophthalmology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di Ya","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China"},{"name":"Beijing Institute of Ophthalmology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-59-8-3394-b01","doi-asserted-by":"crossref","unstructured":"Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006; 90: 262\u2013267.","DOI":"10.1136\/bjo.2005.081224"},{"key":"i1552-5783-59-8-3394-b02","doi-asserted-by":"crossref","unstructured":"Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology. 2014; 121: 2081\u20132090.","DOI":"10.1016\/j.ophtha.2014.05.013"},{"key":"i1552-5783-59-8-3394-b03","doi-asserted-by":"crossref","unstructured":"Mitchell P, Smith W, Attebo K, Healey PR. Prevalence of open-angle glaucoma in Australia. The Blue Mountains Eye Study. Ophthalmology. 1996; 103: 1661\u20131669.","DOI":"10.1016\/S0161-6420(96)30449-1"},{"key":"i1552-5783-59-8-3394-b04","doi-asserted-by":"crossref","unstructured":"Iwase A, Suzuki Y, Araie M, et al. The prevalence of primary open-angle glaucoma in Japanese: the Tajimi Study. Ophthalmology. 2004; 111: 1641\u20131648.","DOI":"10.1016\/S0161-6420(04)00665-7"},{"key":"i1552-5783-59-8-3394-b05","unstructured":"Werner EB. Treatment of progressive normal-tension glaucoma. J Glaucoma 1997; 6: 408\u2013411."},{"key":"i1552-5783-59-8-3394-b06","doi-asserted-by":"crossref","unstructured":"Ren R, Jonas JB, Tian G, et al. Cerebrospinal fluid pressure in glaucoma: a prospective study. Ophthalmology. 2010; 117: 259\u2013266.","DOI":"10.1016\/j.ophtha.2009.06.058"},{"key":"i1552-5783-59-8-3394-b07","doi-asserted-by":"crossref","unstructured":"De Moraes CG, Demirel S, Gardiner SK, et al. Effect of treatment on the rate of visual field change in the ocular hypertension treatment study observation group. Invest Ophthalmol Vis Sci. 2012; 53: 1704\u20131709.","DOI":"10.1167\/iovs.11-8186"},{"key":"i1552-5783-59-8-3394-b08","doi-asserted-by":"crossref","unstructured":"Chakravarti T. Assessing precision of Hodapp-Parrish-Anderson Criteria for staging early glaucomatous damage in an ocular hypertension cohort: a retrospective study. Asia Pac J Ophthalmol (Phila). 2017; 6: 21\u201327.","DOI":"10.1097\/APO.0000000000000201"},{"key":"i1552-5783-59-8-3394-b09","doi-asserted-by":"crossref","unstructured":"Ren R, Zhang X, Wang N, Li B, Tian G, Jonas JB. Cerebrospinal fluid pressure in ocular hypertension. Acta Ophthalmol. 2011; 89: e142\u2013e148.","DOI":"10.1111\/j.1755-3768.2010.02015.x"},{"key":"i1552-5783-59-8-3394-b10","unstructured":"Volkov VV. Essential element of the glaucomatous process neglected in clinical practice [in Russian]. Oftalmologicheskii zhurnal. 1976; 31: 500\u2013504."},{"key":"i1552-5783-59-8-3394-b11","unstructured":"Morgan WH, Yu DY, Cooper RL, Alder VA, Cringle SJ, Constable IJ. The influence of cerebrospinal fluid pressure on the lamina cribrosa tissue pressure gradient. Invest Ophthalmol Vis Sci. 1995; 36: 1163\u20131172."},{"key":"i1552-5783-59-8-3394-b12","doi-asserted-by":"crossref","unstructured":"Berdahl JP, Fautsch MP, Stinnett SS, Allingham RR. Intracranial pressure in primary open angle glaucoma, normal tension glaucoma, and ocular hypertension: a case-control study. Invest Ophthalmol Vis Sci. 2008; 49: 5412\u20135418.","DOI":"10.1167\/iovs.08-2228"},{"key":"i1552-5783-59-8-3394-b13","doi-asserted-by":"crossref","unstructured":"Jonas JB, Wang N, Yang D, Ritch R, Panda-Jonas S. Facts and myths of cerebrospinal fluid pressure for the physiology of the eye. Prog Retin Eye Res. 2015; 46: 67\u201383.","DOI":"10.1016\/j.preteyeres.2015.01.002"},{"key":"i1552-5783-59-8-3394-b14","doi-asserted-by":"crossref","unstructured":"Dongqi H, Zeqin R. A biomathematical model for pressure-dependent lamina cribrosa behavior. J Biomech. 1999; 32: 579\u2013584.","DOI":"10.1016\/S0021-9290(99)00025-1"},{"key":"i1552-5783-59-8-3394-b15","doi-asserted-by":"crossref","unstructured":"Chen BH, Drucker MD, Louis KM, Richards DW. Progression of normal-tension glaucoma after ventriculoperitoneal shunt to decrease cerebrospinal fluid pressure. J Glaucoma 2016; 25: e50\u201352.","DOI":"10.1097\/IJG.0000000000000186"},{"key":"i1552-5783-59-8-3394-b16","doi-asserted-by":"crossref","unstructured":"Jaggi GP, Harlev M, Ziegler U, Dotan S, Miller NR, Killer HE. Cerebrospinal fluid segregation optic neuropathy: an experimental model and a hypothesis. Br J Ophthalmol. 2010; 94: 1088\u20131093.","DOI":"10.1136\/bjo.2009.171660"},{"key":"i1552-5783-59-8-3394-b17","doi-asserted-by":"crossref","unstructured":"Yang D, Fu J, Hou R, et al. Optic neuropathy induced by experimentally reduced cerebrospinal fluid pressure in monkeys. Invest Ophthalmol Vis Sci. 2014; 55: 3067\u20133073.","DOI":"10.1167\/iovs.13-13657"},{"key":"i1552-5783-59-8-3394-b18","doi-asserted-by":"crossref","unstructured":"Zhao D, He Z, Vingrys AJ, Bui BV, Nguyen CT. The effect of intraocular and intracranial pressure on retinal structure and function in rats. Physiol Rep. 2015; 3: e12507.","DOI":"10.14814\/phy2.12507"},{"key":"i1552-5783-59-8-3394-b19","doi-asserted-by":"crossref","unstructured":"Zhang Z, Wu S, Jonas JB, et al. Dynein, kinesin and morphological changes in optic nerve axons in a rat model with cerebrospinal fluid pressure reduction: the Beijing Intracranial and Intraocular Pressure (iCOP) study. Acta Ophthalmol. 2016; 94: 266\u2013275.","DOI":"10.1111\/aos.12768"},{"key":"i1552-5783-59-8-3394-b20","doi-asserted-by":"crossref","unstructured":"Zhang Z, Liu D, Jonas JB, et al. Axonal transport in the rat optic nerve following short-term reduction in cerebrospinal fluid pressure or elevation in intraocular pressure. Invest Ophthalmol Vis Sci. 2015; 56: 4257\u20134266.","DOI":"10.1167\/iovs.14-16045"},{"key":"i1552-5783-59-8-3394-b21","doi-asserted-by":"crossref","unstructured":"Killer HE, Laeng HR, Flammer J, Groscurth P. Architecture of arachnoid trabeculae, pillars, and septa in the subarachnoid space of the human optic nerve: anatomy and clinical considerations. Br J Ophthalmol. 2003; 87: 777\u2013781.","DOI":"10.1136\/bjo.87.6.777"},{"key":"i1552-5783-59-8-3394-b22","doi-asserted-by":"crossref","unstructured":"Killer HE, Jaggi GP, Flammer J, Miller NR, Huber AR, Mironov A. Cerebrospinal fluid dynamics between the intracranial and the subarachnoid space of the optic nerve. Is it always bidirectional? Brain. 2007; 130: 514\u2013520.","DOI":"10.1093\/brain\/awl324"},{"key":"i1552-5783-59-8-3394-b23","doi-asserted-by":"crossref","unstructured":"Wostyn P, De Groot V, Van Dam D, Audenaert K, Killer HE, De Deyn PP. Fast circulation of cerebrospinal fluid: an alternative perspective on the protective role of high intracranial pressure in ocular hypertension. Clin Exp Optom. 2016; 99: 213\u2013218.","DOI":"10.1111\/cxo.12332"},{"key":"i1552-5783-59-8-3394-b24","doi-asserted-by":"crossref","unstructured":"Wostyn P, De Groot V, Van Dam D, Audenaert K, Killer HE, De Deyn PP. Glaucoma and the role of cerebrospinal fluid dynamics. Invest Ophthalmol Vis Sci. 2015; 56: 6630\u20136631.","DOI":"10.1167\/iovs.15-18016"},{"key":"i1552-5783-59-8-3394-b25","doi-asserted-by":"crossref","unstructured":"Killer HE, Jaggi GP, Miller NR, et al. Cerebrospinal fluid dynamics between the basal cisterns and the subarachnoid space of the optic nerve in patients with papilloedema. Br J Ophthalmol. 2011; 95: 822\u2013827.","DOI":"10.1136\/bjo.2010.189324"},{"key":"i1552-5783-59-8-3394-b26","doi-asserted-by":"crossref","unstructured":"Skytt DM, Toft-Kehler AK, Braendstrup CT, et al. Glia-neuron interactions in the retina can be studied in cocultures of M\u00fcller cells and retinal ganglion cells. Biomed Res Int. 2016; 2016: 1087647.","DOI":"10.1155\/2016\/1087647"},{"key":"i1552-5783-59-8-3394-b27","doi-asserted-by":"crossref","unstructured":"Vecino E, Rodriguez FD, Ruzafa N, Pereiro X, Sharma SC. Glia-neuron interactions in the mammalian retina. Prog Retin Eye Res. 2016; 51: 1\u201340.","DOI":"10.1016\/j.preteyeres.2015.06.003"},{"key":"i1552-5783-59-8-3394-b28","doi-asserted-by":"crossref","unstructured":"Hayakawa K, Esposito E, Wang X, et al. Transfer of mitochondria from astrocytes to neurons after stroke. Nature. 2016; 535: 551\u2013555.","DOI":"10.1038\/nature18928"},{"key":"i1552-5783-59-8-3394-b29","doi-asserted-by":"crossref","unstructured":"Sapienza A, Raveu AL, Reboussin E, et al. Bilateral neuroinflammatory processes in visual pathways induced by unilateral ocular hypertension in the rat. J Neuroinflamm. 2016; 13: 44.","DOI":"10.1186\/s12974-016-0509-7"},{"key":"i1552-5783-59-8-3394-b30","doi-asserted-by":"crossref","unstructured":"Mac Nair CE, Schlamp CL, Montgomery AD, Shestopalov VI, Nickells RW. Retinal glial responses to optic nerve crush are attenuated in Bax-deficient mice and modulated by purinergic signaling pathways. J Neuroinflamm. 2016; 13: 93.","DOI":"10.1186\/s12974-016-0558-y"},{"key":"i1552-5783-59-8-3394-b31","doi-asserted-by":"crossref","unstructured":"Zeng HY, Zhu XA, Zhang C, Yang LP, Wu LM, Tso MO. Identification of sequential events and factors associated with microglial activation, migration, and cytotoxicity in retinal degeneration in rd mice. Invest Ophthalmol Vis Sci. 2005; 46: 2992\u20132999.","DOI":"10.1167\/iovs.05-0118"},{"key":"i1552-5783-59-8-3394-b32","doi-asserted-by":"crossref","unstructured":"Ramirez AI, Salazar JJ, de Hoz R, et al. Macro- and microglial responses in the fellow eyes contralateral to glaucomatous eyes. Prog Brain Res. 2015; 220: 155\u2013172.","DOI":"10.1016\/bs.pbr.2015.05.003"},{"key":"i1552-5783-59-8-3394-b33","doi-asserted-by":"crossref","unstructured":"Zhang S, Wang H, Lu Q, et al. Detection of early neuron degeneration and accompanying glial responses in the visual pathway in a rat model of acute intraocular hypertension. Brain Res. 2009; 1303: 131\u2013143.","DOI":"10.1016\/j.brainres.2009.09.029"},{"key":"i1552-5783-59-8-3394-b34","doi-asserted-by":"crossref","unstructured":"Sun D, Qu J, Jakobs TC. Reversible reactivity by optic nerve astrocytes. Glia. 2013; 61: 1218\u20131235.","DOI":"10.1002\/glia.22507"},{"key":"i1552-5783-59-8-3394-b35","doi-asserted-by":"crossref","unstructured":"Fujishiro T, Kawasaki H, Aihara M, et al. Establishment of an experimental ferret ocular hypertension model for the analysis of central visual pathway damage. Sci Rep. 2014; 4: 6501.","DOI":"10.1038\/srep06501"},{"key":"i1552-5783-59-8-3394-b36","doi-asserted-by":"crossref","unstructured":"Pircher A, Montali M, Berberat J, Remonda L, Killer HE. Relationship between the optic nerve sheath diameter and lumbar cerebrospinal fluid pressure in patients with normal tension glaucoma. Eye. 2017; 31: 1365\u20131372.","DOI":"10.1038\/eye.2017.70"},{"key":"i1552-5783-59-8-3394-b37","doi-asserted-by":"crossref","unstructured":"Linden C, Qvarlander S, Johannesson G, et al. Normal-tension glaucoma has normal intracranial pressure: a prospective study of intracranial pressure and intraocular pressure in different body positions. Ophthalmology. 2018; 125: 361\u2013368.","DOI":"10.1016\/j.ophtha.2017.09.022"},{"key":"i1552-5783-59-8-3394-b38","doi-asserted-by":"crossref","unstructured":"Roy Chowdhury U, Holman BH, Fautsch MP. A novel rat model to study the role of intracranial pressure modulation on optic neuropathies. PLoS One. 2013; 8: e82151.","DOI":"10.1371\/journal.pone.0082151"},{"key":"i1552-5783-59-8-3394-b39","doi-asserted-by":"crossref","unstructured":"Uldall M, Juhler M, Skjolding AD, Kruuse C, Jansen-Olesen I, Jensen R. A novel method for long-term monitoring of intracranial pressure in rats. J Neurosci Methods. 2014; 227: 1\u20139.","DOI":"10.1016\/j.jneumeth.2014.01.036"},{"key":"i1552-5783-59-8-3394-b40","doi-asserted-by":"crossref","unstructured":"Zwienenberg M, Gong QZ, Lee LL, Berman RF, Lyeth BG. ICP monitoring in the rat: comparison of monitoring in the ventricle, brain parenchyma, and cisterna magna. J Neurotrauma. 1999; 16: 1095\u20131102.","DOI":"10.1089\/neu.1999.16.1095"},{"key":"i1552-5783-59-8-3394-b41","doi-asserted-by":"crossref","unstructured":"Mandell EC, Zimmermann E. Continuous measurement of cerebrospinal fluid pressure in unrestrained rats. Physiol Behav. 1980; 24: 399\u2013402.","DOI":"10.1016\/0031-9384(80)90105-5"},{"key":"i1552-5783-59-8-3394-b42","doi-asserted-by":"crossref","unstructured":"Chou CH, Doong ML, Fuh JL, Wu JC, Wang SJ. Queckenstedt's test affects more than jugular venous congestion in rat. PLoS One. 2013; 8: e59409.","DOI":"10.1371\/journal.pone.0059409"},{"key":"i1552-5783-59-8-3394-b43","doi-asserted-by":"crossref","unstructured":"Verlooy J, Selosse P, Van Reempts J, Haseldonckx M, Borgers M. Fiberoptic intracranial pressure monitoring in rats. J Neurosci Methods. 1990; 31: 1\u20136.","DOI":"10.1016\/0165-0270(90)90002-W"},{"key":"i1552-5783-59-8-3394-b44","doi-asserted-by":"crossref","unstructured":"Williamson MR, John RD, Colbourne F. Measurement of intracranial pressure in freely moving rats. Methods Mol Biol. 2018; 1717: 17\u201325.","DOI":"10.1007\/978-1-4939-7526-6_2"},{"key":"i1552-5783-59-8-3394-b45","unstructured":"Lundberg N. Continuous recording and control of ventricular fluid pressure in neurosurgical practice. Acta Psychiatr Scand Suppl. 1960; 36: 1\u2013193."},{"key":"i1552-5783-59-8-3394-b46","doi-asserted-by":"crossref","unstructured":"Yang H, Downs JC, Burgoyne CF. Physiologic intereye differences in monkey optic nerve head architecture and their relation to changes in early experimental glaucoma. Invest Ophthalmol Vis Sci. 2009; 50: 224\u2013234.","DOI":"10.1167\/iovs.08-2464"},{"key":"i1552-5783-59-8-3394-b47","doi-asserted-by":"crossref","unstructured":"Burgoyne CF. A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma. Exp Eye Res. 2011; 93: 120\u2013132.","DOI":"10.1016\/j.exer.2010.09.005"},{"key":"i1552-5783-59-8-3394-b48","doi-asserted-by":"crossref","unstructured":"Burgoyne CF, Downs JC, Bellezza AJ, Hart RT. Three-dimensional reconstruction of normal and early glaucoma monkey optic nerve head connective tissues. Invest Ophthalmol Vis Sci. 2004; 45: 4388\u20134399.","DOI":"10.1167\/iovs.04-0022"},{"key":"i1552-5783-59-8-3394-b49","unstructured":"Morgan WH, Chauhan BC, Yu DY, Cringle SJ, Alder VA, House PH. Optic disc movement with variations in intraocular and cerebrospinal fluid pressure. Invest Ophthalmol Vis Sci. 2002; 43: 3236\u20133242."},{"key":"i1552-5783-59-8-3394-b50","doi-asserted-by":"crossref","unstructured":"Sigal IA, Yang H, Roberts MD, et al. IOP-induced lamina cribrosa deformation and scleral canal expansion: independent or related? Invest Ophthalmol Vis Sci. 2011; 52: 9023\u20139032.","DOI":"10.1167\/iovs.11-8183"},{"key":"i1552-5783-59-8-3394-b51","unstructured":"Ochs S. Energy metabolism and supply of ~ P to the fast axoplasmic transport mechanism in nerve. Fed Proc. 1974; 33: 1049\u20131058."},{"key":"i1552-5783-59-8-3394-b52","doi-asserted-by":"crossref","unstructured":"Hahnenberger RW. Inhibition of fast anterograde axoplasmic transport by a pressure barrier. The effect of pressure gradient and maximal pressure. Acta Physiol Scand. 1980; 109: 117\u2013121.","DOI":"10.1111\/j.1748-1716.1980.tb06575.x"},{"key":"i1552-5783-59-8-3394-b53","doi-asserted-by":"crossref","unstructured":"Hayreh SS. Pathogenesis of oedema of the optic disc. Doc Ophthalmol. 1968; 24: 289\u2013411.","DOI":"10.1007\/BF02550944"},{"key":"i1552-5783-59-8-3394-b54","doi-asserted-by":"crossref","unstructured":"Hayreh SS. Pathogenesis of optic disc edema in raised intracranial pressure. Prog Retin Eye Res. 2016; 50: 108\u2013144.","DOI":"10.1016\/j.preteyeres.2015.10.001"},{"key":"i1552-5783-59-8-3394-b55","doi-asserted-by":"crossref","unstructured":"Kanamori A, Nakamura M, Nakanishi Y, Yamada Y, Negi A. Long-term glial reactivity in rat retinas ipsilateral and contralateral to experimental glaucoma. Exp Eye Res. 2005; 81: 48\u201356.","DOI":"10.1016\/j.exer.2005.01.012"},{"key":"i1552-5783-59-8-3394-b56","doi-asserted-by":"crossref","unstructured":"Chen H, Weber AJ. Expression of glial fibrillary acidic protein and glutamine synthetase by M\u00fcller cells after optic nerve damage and intravitreal application of brain-derived neurotrophic factor. Glia. 2002; 38: 115\u2013125.","DOI":"10.1002\/glia.10061"},{"key":"i1552-5783-59-8-3394-b57","doi-asserted-by":"crossref","unstructured":"Danbolt NC. Glutamate uptake. Prog Neurobiol. 2001; 65: 1\u2013105.","DOI":"10.1016\/S0301-0082(00)00067-8"},{"key":"i1552-5783-59-8-3394-b58","doi-asserted-by":"crossref","unstructured":"Mizutani M, Gerhardinger C, Lorenzi M. M\u00fcller cell changes in human diabetic retinopathy. Diabetes. 1998; 47: 445\u2013449.","DOI":"10.2337\/diabetes.47.3.445"},{"key":"i1552-5783-59-8-3394-b59","unstructured":"Morgan WH, Yu DY, Alder VA, et al. The correlation between cerebrospinal fluid pressure and retrolaminar tissue pressure. Invest Ophthalmol Vis Sci. 1998; 39: 1419\u20131428."},{"key":"i1552-5783-59-8-3394-b60","doi-asserted-by":"crossref","unstructured":"Hou R, Zhang Z, Yang D, et al. Pressure balance and imbalance in the optic nerve chamber: The Beijing Intracranial and Intraocular Pressure (iCOP) Study. Sci China Life Sci. 2016; 59: 495\u2013503.","DOI":"10.1007\/s11427-016-5022-9"},{"key":"i1552-5783-59-8-3394-b61","doi-asserted-by":"crossref","unstructured":"Takeuchi N, Horikoshi T, Kinouchi H, et al. Diagnostic value of the optic nerve sheath subarachnoid space in patients with intracranial hypotension syndrome. J Neurosurg. 2012; 117: 372\u2013377.","DOI":"10.3171\/2012.5.JNS1271"},{"key":"i1552-5783-59-8-3394-b62","doi-asserted-by":"crossref","unstructured":"Kim EJ, Pellman B, Kim JJ. Stress effects on the hippocampus: a critical review. Learn Mem. 2015; 22: 411\u2013416.","DOI":"10.1101\/lm.037291.114"},{"key":"i1552-5783-59-8-3394-b63","doi-asserted-by":"crossref","unstructured":"Butenko O, Dzamba D, Benesova J, et al. The increased activity of TRPV4 channel in the astrocytes of the adult rat hippocampus after cerebral hypoxia\/ischemia. PLoS One 2012; 7: e39959.","DOI":"10.1371\/journal.pone.0039959"},{"key":"i1552-5783-59-8-3394-b64","doi-asserted-by":"crossref","unstructured":"Yu DY, Cringle SJ, Balaratnasingam C, Morgan WH, Yu PK, Su EN. Retinal ganglion cells: energetics, compartmentation, axonal transport, cytoskeletons and vulnerability. Prog Retin Eye Res. 2013; 36: 217\u2013246.","DOI":"10.1016\/j.preteyeres.2013.07.001"},{"key":"i1552-5783-59-8-3394-b65","unstructured":"Davson H. Physiology of the Cerebrospinal Fluid. London: Churchill; 1967."}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2687706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:30:55Z","timestamp":1791927055000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.17-22232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,9]]},"references-count":65,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,7,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.17-22232","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7,9]]}}}