{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:57:57Z","timestamp":1791928677673,"version":"4.3.4"},"reference-count":57,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"6","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2018,5,24]]},"DOI":"10.1167\/iovs.17-22578","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T15:32:09Z","timestamp":1527694329000},"page":"2623","source":"Crossref","is-referenced-by-count":36,"title":["Dopamine D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice"],"prefix":"10.1167","volume":"59","author":[{"given":"Furong","family":"Huang","sequence":"first","affiliation":[{"name":"School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishuai","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongsi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangfan","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Qu","sequence":"additional","affiliation":[{"name":"School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangtian","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"State Key Laboratory of Optometry, Ophthalmology and Vision Science, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-59-6-2623-b01","doi-asserted-by":"crossref","unstructured":"Dolgin E. The myopia boom. Nature. 2015; 519: 276\u2013278.","DOI":"10.1038\/519276a"},{"key":"i1552-5783-59-6-2623-b02","doi-asserted-by":"crossref","unstructured":"Holden BA, Fricke TR, Wilson DA, et al. Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050. Ophthalmology. 2016; 123: 1036\u20131042.","DOI":"10.1016\/j.ophtha.2016.01.006"},{"key":"i1552-5783-59-6-2623-b03","doi-asserted-by":"crossref","unstructured":"Feldkaemper M, Schaeffel F. An updated view on the role of dopamine in myopia. Exp Eye Res. 2013; 114: 106\u2013119.","DOI":"10.1016\/j.exer.2013.02.007"},{"key":"i1552-5783-59-6-2623-b04","doi-asserted-by":"crossref","unstructured":"Zhou X, Pardue MT, Iuvone PM, Qu J. Dopamine signaling and myopia development: What are the key challenges. Prog Retin Eye Res. 2017; 61: 60\u201371.","DOI":"10.1016\/j.preteyeres.2017.06.003"},{"key":"i1552-5783-59-6-2623-b05","doi-asserted-by":"crossref","unstructured":"Papastergiou GI, Schmid GF, Laties AM, Pendrak K, Lin T, Stone RA. Induction of axial eye elongation and myopic refractive shift in one-year-old chickens. Vision Res. 1998; 38: 1883\u20131888.","DOI":"10.1016\/S0042-6989(97)00347-7"},{"key":"i1552-5783-59-6-2623-b06","doi-asserted-by":"crossref","unstructured":"Stone RA, Lin T, Laties AM, Iuvone PM. Retinal dopamine and form-deprivation myopia. Proc Natl Acad Sci U S A. 1989; 86: 704\u2013706.","DOI":"10.1073\/pnas.86.2.704"},{"key":"i1552-5783-59-6-2623-b07","doi-asserted-by":"crossref","unstructured":"Iuvone PM, Tigges M, Fernandes A, Tigges J. Dopamine synthesis and metabolism in rhesus monkey retina: development, aging, and the effects of monocular visual deprivation. Vis Neurosci. 1989; 2: 465\u2013471.","DOI":"10.1017\/S0952523800012360"},{"key":"i1552-5783-59-6-2623-b08","unstructured":"Dong F, Zhi Z, Pan M, et al. Inhibition of experimental myopia by a dopamine agonist: different effectiveness between form deprivation and hyperopic defocus in guinea pigs. Mol Vis. 2011; 17: 2824\u20132834."},{"key":"i1552-5783-59-6-2623-b09","doi-asserted-by":"crossref","unstructured":"Ohngemach S, Hagel G, Schaeffel F. Concentrations of biogenic amines in fundal layers in chickens with normal visual experience, deprivation, and after reserpine application. Vis Neurosci. 1997; 14: 493\u2013505.","DOI":"10.1017\/S0952523800012153"},{"key":"i1552-5783-59-6-2623-b10","doi-asserted-by":"crossref","unstructured":"Stone RA, Pendrak K, Sugimoto R, et al. Local patterns of image degradation differentially affect refraction and eye shape in chick. Curr Eye Res. 2006; 31: 91\u2013105.","DOI":"10.1080\/02713680500479517"},{"key":"i1552-5783-59-6-2623-b11","doi-asserted-by":"crossref","unstructured":"Pendrak K, Nguyen T, Lin T, Capehart C, Zhu X, Stone RA. Retinal dopamine in the recovery from experimental myopia. Curr Eye Res. 1997; 16: 152\u2013157.","DOI":"10.1076\/ceyr.16.2.152.5090"},{"key":"i1552-5783-59-6-2623-b12","doi-asserted-by":"crossref","unstructured":"Wu XH, Li YY, Zhang PP, et al. Unaltered retinal dopamine levels in a C57BL\/6 mouse model of form-deprivation myopia. Invest Ophthalmol Vis Sci. 2015; 56: 967\u2013977.","DOI":"10.1167\/iovs.13-13362"},{"key":"i1552-5783-59-6-2623-b13","doi-asserted-by":"crossref","unstructured":"Park H, Jabbar SB, Tan CC, et al. Visually-driven ocular growth in mice requires functional rod photoreceptors. Invest Ophthalmol Vis Sci. 2014; 55: 6272\u20136279.","DOI":"10.1167\/iovs.14-14648"},{"key":"i1552-5783-59-6-2623-b14","unstructured":"Chakraborty R, Park H, Aung MH, et al. Comparison of refractive development and retinal dopamine in OFF pathway mutant and C57BL\/6J wild-type mice. Mol Vis. 2014; 20: 1318\u20131327."},{"key":"i1552-5783-59-6-2623-b15","doi-asserted-by":"crossref","unstructured":"Wu XH, Qian KW, Xu GZ, et al. The role of retinal dopamine in C57BL\/6 mouse refractive development as revealed by intravitreal administration of 6-hydroxydopamine. Invest Ophthalmol Vis Sci. 2016; 57: 5393\u20135404.","DOI":"10.1167\/iovs.16-19543"},{"key":"i1552-5783-59-6-2623-b16","doi-asserted-by":"crossref","unstructured":"Bergen MA, Park HN, Chakraborty R, et al. Altered refractive development in mice with reduced levels of retinal dopamine. Invest Ophthalmol Vis Sci. 2016; 57: 4412\u20134419.","DOI":"10.1167\/iovs.15-17784"},{"key":"i1552-5783-59-6-2623-b17","doi-asserted-by":"crossref","unstructured":"Rohrer B, Spira AW, Stell WK. Apomorphine blocks form-deprivation myopia in chickens by a dopamine D2-receptor mechanism acting in retina or pigmented epithelium. Vis Neurosci. 1993; 10: 447\u2013453.","DOI":"10.1017\/S0952523800004673"},{"key":"i1552-5783-59-6-2623-b18","doi-asserted-by":"crossref","unstructured":"Schmid KL, Wildsoet CF. Inhibitory effects of apomorphine and atropine and their combination on myopia in chicks. Optom Vis Sci. 2004; 81: 137\u2013147.","DOI":"10.1097\/00006324-200402000-00012"},{"key":"i1552-5783-59-6-2623-b19","doi-asserted-by":"crossref","unstructured":"Gao Q, Liu Q, Ma P, Zhong X, Wu J, Ge J. Effects of direct intravitreal dopamine injections on the development of lid-suture induced myopia in rabbits. Graefes Arch Clin Exp Ophthalmol. 2006; 244: 1329\u20131335.","DOI":"10.1007\/s00417-006-0254-1"},{"key":"i1552-5783-59-6-2623-b20","unstructured":"Iuvone PM, Tigges M, Stone RA, Lambert S, Laties AM. Effects of apomorphine, a dopamine receptor agonist, on ocular refraction and axial elongation in a primate model of myopia. Invest Ophthalmol Vis Sci. 1991; 32: 1674\u20131677."},{"key":"i1552-5783-59-6-2623-b21","doi-asserted-by":"crossref","unstructured":"Mao J, Liu S, Qin W, Li F, Wu X, Tan Q. Levodopa inhibits the development of form-deprivation myopia in guinea pigs. Optom Vis Sci. 2010; 87: 53\u201360.","DOI":"10.1097\/OPX.0b013e3181c12b3d"},{"key":"i1552-5783-59-6-2623-b22","doi-asserted-by":"crossref","unstructured":"Yan T, Xiong W, Huang F, et al. Daily injection but not continuous infusion of apomorphine inhibits form-deprivation myopia in mice. Invest Ophthalmol Vis Sci. 2015; 56: 2475\u20132485.","DOI":"10.1167\/iovs.13-12361"},{"key":"i1552-5783-59-6-2623-b23","doi-asserted-by":"crossref","unstructured":"Auffret M, Drapier S, Verin M. Pharmacological insights into the use of apomorphine in Parkinsoni's disease: clinical relevance. Clin Drug Investig. 2018; 38: 287\u2013312.","DOI":"10.1007\/s40261-018-0619-3"},{"key":"i1552-5783-59-6-2623-b24","doi-asserted-by":"crossref","unstructured":"LeWitt PA. Subcutaneously administered apomorphine: pharmacokinetics and metabolism. Neurology. 2004; 62: S8\u201311.","DOI":"10.1212\/WNL.62.6_suppl_4.S8"},{"key":"i1552-5783-59-6-2623-b25","doi-asserted-by":"crossref","unstructured":"Beaulieu JM, Gainetdinov RR. The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev. 2011; 63: 182\u2013217.","DOI":"10.1124\/pr.110.002642"},{"key":"i1552-5783-59-6-2623-b26","doi-asserted-by":"crossref","unstructured":"Popova E. Role of dopamine in distal retina. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2014; 200: 333\u2013358.","DOI":"10.1007\/s00359-014-0906-2"},{"key":"i1552-5783-59-6-2623-b27","doi-asserted-by":"crossref","unstructured":"Gao YG, Ram VJ, Campbell A, Kula NS, Baldessarini RJ, Neumeyer JL. Synthesis and structural requirements of N-substituted norapomorphines for affinity and activity at dopamine D-1, D-2, and agonist receptor sites in rat brain. J Med Chem. 1990; 33: 39\u201344.","DOI":"10.1021\/jm00163a007"},{"key":"i1552-5783-59-6-2623-b28","doi-asserted-by":"crossref","unstructured":"Huang F, Yan T, Shi F, et al. Activation of dopamine d2 receptor is critical for the development of form-deprivation myopia in the C57BL\/6 mouse. Invest Ophthalmol Vis Sci. 2014; 55: 5537\u20135544.","DOI":"10.1167\/iovs.13-13211"},{"key":"i1552-5783-59-6-2623-b29","doi-asserted-by":"crossref","unstructured":"Jiang L, Long K, Schaeffel F, et al. Effects of dopaminergic agents on progression of naturally occurring myopia in albino guinea pigs (Cavia porcellus). Invest Ophthalmol Vis Sci. 2014; 55: 7508\u20137519.","DOI":"10.1167\/iovs.14-14294"},{"key":"i1552-5783-59-6-2623-b30","doi-asserted-by":"crossref","unstructured":"Chen S, Zhi Z, Ruan Q, et al. Bright light suppresses form-deprivation myopia development with activation of dopamine D1 receptor signaling in the ON pathway in retina. Invest Ophthalmol Vis Sci. 2017; 58: 2306\u20132316.","DOI":"10.1167\/iovs.16-20402"},{"key":"i1552-5783-59-6-2623-b31","doi-asserted-by":"crossref","unstructured":"Kelly MA, Rubinstein M, Asa SL, et al. Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice. Neuron. 1997; 19: 103\u2013113.","DOI":"10.1016\/S0896-6273(00)80351-7"},{"key":"i1552-5783-59-6-2623-b32","doi-asserted-by":"crossref","unstructured":"Asa SL, Kelly MA, Grandy DK, Low MJ. Pituitary lactotroph adenomas develop after prolonged lactotroph hyperplasia in dopamine D2 receptor-deficient mice. Endocrinology. 1999; 140: 5348\u20135355.","DOI":"10.1210\/endo.140.11.7118"},{"key":"i1552-5783-59-6-2623-b33","doi-asserted-by":"crossref","unstructured":"Schaeffel F, Burkhardt E, Howland HC, Williams RW. Measurement of refractive state and deprivation myopia in two strains of mice. Optom Vis Sci. 2004; 81: 99\u2013110.","DOI":"10.1097\/00006324-200402000-00008"},{"key":"i1552-5783-59-6-2623-b34","doi-asserted-by":"crossref","unstructured":"Bronstein DM, Hong JS. Effects of sulpiride and SCH 23390 on methamphetamine-induced changes in body temperature and lethality. J Pharmacol Exp Ther. 1995; 274: 943\u2013950.","DOI":"10.1016\/S0022-3565(25)10672-1"},{"key":"i1552-5783-59-6-2623-b35","doi-asserted-by":"crossref","unstructured":"Chausmer AL, Ettenberg A. A role for D2, but not D1, dopamine receptors in the response-reinstating effects of food reinforcement. Pharmacol Biochem Behav. 1997; 57: 681\u2013685.","DOI":"10.1016\/S0091-3057(96)00388-7"},{"key":"i1552-5783-59-6-2623-b36","doi-asserted-by":"crossref","unstructured":"Dysli C, Enzmann V, Sznitman R, Zinkernagel MS. Quantitative analysis of mouse retinal layers using automated segmentation of spectral domain optical coherence tomography images. Trans Vis Sci Tech. 2015; 4(4): 9.","DOI":"10.1167\/tvst.4.4.9"},{"key":"i1552-5783-59-6-2623-b37","doi-asserted-by":"crossref","unstructured":"Schaeffel F. Test systems for measuring ocular parameters and visual function in mice. Front Biosci. 2008; 13: 4904\u20134911.","DOI":"10.2741\/3049"},{"key":"i1552-5783-59-6-2623-b38","doi-asserted-by":"crossref","unstructured":"Yuan Y, Chen F, Shen M, Lu F, Wang J. Repeated measurements of the anterior segment during accommodation using long scan depth optical coherence tomography. Eye Contact Lens. 2012; 38: 102\u2013108.","DOI":"10.1097\/ICL.0b013e318243e795"},{"key":"i1552-5783-59-6-2623-b39","doi-asserted-by":"crossref","unstructured":"Shen M, Wang MR, Yuan Y, et al. SD-OCT with prolonged scan depth for imaging the anterior segment of the eye. Ophthalmic Surg Lasers Imaging. 2010; (suppl 41): S65\u201369.","DOI":"10.3928\/15428877-20101031-18"},{"key":"i1552-5783-59-6-2623-b40","doi-asserted-by":"crossref","unstructured":"Witkovsky P. Dopamine and retinal function. Doc Ophthalmol. 2004; 108: 17\u201340.","DOI":"10.1023\/B:DOOP.0000019487.88486.0a"},{"key":"i1552-5783-59-6-2623-b41","doi-asserted-by":"crossref","unstructured":"Kim DY, Jung CS. Gap junction contributions to the goldfish electroretinogram at the photopic illumination level. Korean J Physiol Pharmacol. 2012; 16: 219\u2013224.","DOI":"10.4196\/kjpp.2012.16.3.219"},{"key":"i1552-5783-59-6-2623-b42","doi-asserted-by":"crossref","unstructured":"Schneider T, Zrenner E. Effects of D-1 and D-2 dopamine antagonists on ERG and optic nerve response of the cat. Exp Eye Res. 1991; 52: 425\u2013430.","DOI":"10.1016\/0014-4835(91)90038-G"},{"key":"i1552-5783-59-6-2623-b43","doi-asserted-by":"crossref","unstructured":"Tian N, Xu HP, Wang P. Dopamine D2 receptors preferentially regulate the development of light responses of the inner retina. Eur J Neurosci. 2015; 41: 17\u201330.","DOI":"10.1111\/ejn.12783"},{"key":"i1552-5783-59-6-2623-b44","doi-asserted-by":"crossref","unstructured":"Lavoie J, Illiano P, Sotnikova TD, Gainetdinov RR, Beaulieu JM, Hebert M. The electroretinogram as a biomarker of central dopamine and serotonin: potential relevance to psychiatric disorders. Biol Psychiatry. 2014; 75: 479\u2013486.","DOI":"10.1016\/j.biopsych.2012.11.024"},{"key":"i1552-5783-59-6-2623-b45","doi-asserted-by":"crossref","unstructured":"Huppe-Gourgues F, Coude G, Lachapelle P, Casanova C. Effects of the intravitreal administration of dopaminergic ligands on the b-wave amplitude of the rabbit electroretinogram. Vision Res. 2005; 45: 137\u2013145.","DOI":"10.1016\/j.visres.2004.08.001"},{"key":"i1552-5783-59-6-2623-b46","doi-asserted-by":"crossref","unstructured":"Jackson CR, Ruan GX, Aseem F, et al. Retinal dopamine mediates multiple dimensions of light-adapted vision. J Neurosci. 2012; 32: 9359\u20139368.","DOI":"10.1523\/JNEUROSCI.0711-12.2012"},{"key":"i1552-5783-59-6-2623-b47","doi-asserted-by":"crossref","unstructured":"He Q, Xu HP, Wang P, Tian N. Dopamine D1 receptors regulate the light dependent development of retinal synaptic responses. PLoS One. 2013; 8: e79625.","DOI":"10.1371\/journal.pone.0079625"},{"key":"i1552-5783-59-6-2623-b48","doi-asserted-by":"crossref","unstructured":"Popova E, Kupenova P. Effects of dopamine receptor blockade on the intensity-response function of ERG b- and d-waves in dark adapted eyes. Vision Res. 2013; 88: 22\u201329.","DOI":"10.1016\/j.visres.2013.06.004"},{"key":"i1552-5783-59-6-2623-b49","doi-asserted-by":"crossref","unstructured":"Schaeffel F, Bartmann M, Hagel G, Zrenner E. Studies on the role of the retinal dopamine\/melatonin system in experimental refractive errors in chickens. Vision Res. 1995; 35: 1247\u20131264.","DOI":"10.1016\/0042-6989(94)00221-7"},{"key":"i1552-5783-59-6-2623-b50","doi-asserted-by":"crossref","unstructured":"Cottriall CL, Brew J, Vessey KA, McBrien NA. Diisopropylfluorophosphate alters retinal neurotransmitter levels and reduces experimentally-induced myopia. Naunyn Schmiedebergs Arch Pharmacol. 2001; 364: 372\u2013382.","DOI":"10.1007\/s002100100460"},{"key":"i1552-5783-59-6-2623-b51","doi-asserted-by":"crossref","unstructured":"Ward AH, Siegwart JT, Frost MR, Norton TT. Intravitreally-administered dopamine D2-like (and D4), but not D1-like, receptor agonists reduce form-deprivation myopia in tree shrews. Vis Neurosci. 2017; 34: E003.","DOI":"10.1017\/S0952523816000195"},{"key":"i1552-5783-59-6-2623-b52","doi-asserted-by":"crossref","unstructured":"McNamara FN, Clifford JJ, Tighe O, et al. Congenic D1A dopamine receptor mutants: ethologically based resolution of behavioural topography indicates genetic background as a determinant of knockout phenotype. Neuropsychopharmacology. 2003; 28: 86\u201399.","DOI":"10.1038\/sj.npp.1300008"},{"key":"i1552-5783-59-6-2623-b53","doi-asserted-by":"crossref","unstructured":"Cohen Y, Belkin M, Yehezkel O, Solomon AS, Polat U. Dependency between light intensity and refractive development under light-dark cycles. Exp Eye Res. 2011; 92: 40\u201346.","DOI":"10.1016\/j.exer.2010.10.012"},{"key":"i1552-5783-59-6-2623-b54","doi-asserted-by":"crossref","unstructured":"Calabrese EJ. Dopamine: biphasic dose responses. Crit Rev Toxicol. 2001; 31: 563\u2013583.","DOI":"10.1080\/20014091111839"},{"key":"i1552-5783-59-6-2623-b55","doi-asserted-by":"crossref","unstructured":"Ko F, Seeman P, Sun WS, Kapur S. Dopamine D2 receptors internalize in their low-affinity state. Neuroreport. 2002; 13: 1017\u20131020.","DOI":"10.1097\/00001756-200206120-00007"},{"key":"i1552-5783-59-6-2623-b56","doi-asserted-by":"crossref","unstructured":"Nowak JZ, Sek B, Schorderet M. Dark-induced supersensitivity of dopamine D-1 and D-2 receptors in rat retina. Neuroreport. 1991; 2: 429\u2013432.","DOI":"10.1097\/00001756-199108000-00004"},{"key":"i1552-5783-59-6-2623-b57","doi-asserted-by":"crossref","unstructured":"Pardue MT, Stone RA, Iuvone PM. Investigating mechanisms of myopia in mice. Exp Eye Res. 2013; 114: 96\u2013105.","DOI":"10.1016\/j.exer.2012.12.014"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2683049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:30:53Z","timestamp":1791927053000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.17-22578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,24]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,5,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.17-22578","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5,24]]}}}