{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T00:33:59Z","timestamp":1793666039274,"version":"4.5.1"},"reference-count":54,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"14","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2018,11,27]]},"DOI":"10.1167\/iovs.17-23537","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T18:00:43Z","timestamp":1543341643000},"page":"DES183","source":"Crossref","is-referenced-by-count":35,"title":["Results of Detailed Investigations Into Stevens-Johnson Syndrome With Severe Ocular Complications"],"prefix":"10.1167","volume":"59","author":[{"given":"Mayumi","family":"Ueta","sequence":"first","affiliation":[{"name":"Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-59-14-DES183-b01","doi-asserted-by":"crossref","unstructured":"Sotozono C, Ueta M, Nakatani E, et al. Predictive factors associated with acute ocular involvement in Stevens-Johnson syndrome and toxic epidermal necrolysis. Am J Ophthalmol. 2015; 160: 228\u2013 237 e222.","DOI":"10.1016\/j.ajo.2015.05.002"},{"key":"i1552-5783-59-14-DES183-b02","doi-asserted-by":"crossref","unstructured":"Ueta M, Kinoshita S. Ocular surface inflammation is regulated by innate immunity. Prog Retin Eye Res. 2012; 31: 551\u2013 575.","DOI":"10.1016\/j.preteyeres.2012.05.003"},{"key":"i1552-5783-59-14-DES183-b03","doi-asserted-by":"crossref","unstructured":"Ueta M, Sotozono C, Tokunaga K, Yabe T, Kinoshita S. Strong association between HLA-A*0206 and Stevens-Johnson syndrome in the Japanese. Am J Ophthalmol. 2007; 143: 367\u2013 368.","DOI":"10.1016\/j.ajo.2006.09.029"},{"key":"i1552-5783-59-14-DES183-b04","doi-asserted-by":"crossref","unstructured":"Ueta M, Sotozono C, Inatomi T, et al. Toll-like receptor 3 gene polymorphisms in Japanese patients with Stevens-Johnson syndrome. Br J Ophthalmol. 2007; 91: 962\u2013 965.","DOI":"10.1136\/bjo.2006.113449"},{"key":"i1552-5783-59-14-DES183-b05","doi-asserted-by":"crossref","unstructured":"Ueta M, Sawai H, Sotozono C, et al. IKZF1, a new susceptibility gene for cold medicine-related Stevens-Johnson syndrome\/toxic epidermal necrolysis with severe mucosal involvement. J Allergy Clin Immunol. 2015; 135: 1538\u2013 1545 e1517.","DOI":"10.1016\/j.jaci.2014.12.1916"},{"key":"i1552-5783-59-14-DES183-b06","doi-asserted-by":"crossref","unstructured":"Ueta M, Sawai H, Shingaki R, et al. Genome-wide association study using the ethnicity-specific Japonica array: identification of new susceptibility loci for cold medicine-related Stevens-Johnson syndrome with severe ocular complications. J Hum Genet. 2017; 62: 485\u2013 489.","DOI":"10.1038\/jhg.2016.160"},{"key":"i1552-5783-59-14-DES183-b07","doi-asserted-by":"crossref","unstructured":"Ueta M, Kannabiran C, Wakamatsu TH, et al. Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications. Sci Rep. 2014; 4: 5981.","DOI":"10.1038\/srep05981"},{"key":"i1552-5783-59-14-DES183-b08","doi-asserted-by":"crossref","unstructured":"Ueta M, Kaniwa N, Sotozono C, et al. Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement. Sci Rep. 2014; 4: 4862.","DOI":"10.1038\/srep04862"},{"key":"i1552-5783-59-14-DES183-b09","doi-asserted-by":"crossref","unstructured":"Sotozono C, Ang LP, Koizumi N, et al. New grading system for the evaluation of chronic ocular manifestations in patients with Stevens-Johnson syndrome. Ophthalmology. 2007; 114: 1294\u2013 1302.","DOI":"10.1016\/j.ophtha.2006.10.029"},{"key":"i1552-5783-59-14-DES183-b10","doi-asserted-by":"crossref","unstructured":"Sotozono C, Ueta M, Koizumi N, et al. Diagnosis and treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis with ocular complications. Ophthalmology. 2009; 116: 685\u2013 690.","DOI":"10.1016\/j.ophtha.2008.12.048"},{"key":"i1552-5783-59-14-DES183-b11","doi-asserted-by":"crossref","unstructured":"Sotozono C, Inagaki K, Fujita A, et al. Methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis infections in the cornea. Cornea. 2002; 21: S94\u2013 S101.","DOI":"10.1097\/01.ico.0000263127.84015.3f"},{"key":"i1552-5783-59-14-DES183-b12","doi-asserted-by":"crossref","unstructured":"Ueta M, Iida T, Sakamoto M, et al. Polyclonality of Staphylococcus epidermidis residing on the healthy ocular surface. J Med Microbiol. 2007; 56: 77\u2013 82.","DOI":"10.1099\/jmm.0.46810-0"},{"key":"i1552-5783-59-14-DES183-b13","doi-asserted-by":"crossref","unstructured":"Chan HL, Stern RS, Arndt KA, et al. The incidence of erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis: a population-based study with particular reference to reactions caused by drugs among outpatients. Arch Dermatol. 1990; 126: 43\u2013 47.","DOI":"10.1001\/archderm.1990.01670250049006"},{"key":"i1552-5783-59-14-DES183-b14","doi-asserted-by":"crossref","unstructured":"Yetiv JZ, Bianchine JR, Owen JA Jr. Etiologic factors of the Stevens-Johnson syndrome. South Med J. 1980; 73: 599\u2013 602.","DOI":"10.1097\/00007611-198005000-00015"},{"key":"i1552-5783-59-14-DES183-b15","doi-asserted-by":"crossref","unstructured":"Power WJ, Ghoraishi M, Merayo-Lloves J, Neves RA, Foster CS. Analysis of the acute ophthalmic manifestations of the erythema multiforme\/Stevens-Johnson syndrome\/toxic epidermal necrolysis disease spectrum. Ophthalmology. 1995; 102: 1669\u2013 1676.","DOI":"10.1016\/S0161-6420(95)30811-1"},{"key":"i1552-5783-59-14-DES183-b16","doi-asserted-by":"crossref","unstructured":"Yamane Y, Aihara M, Ikezawa Z. Analysis of Stevens-Johnson syndrome and toxic epidermal necrolysis in Japan from 2000 to 2006. Allergol Int. 2007; 56: 419\u2013 425.","DOI":"10.2332\/allergolint.O-07-483"},{"key":"i1552-5783-59-14-DES183-b17","doi-asserted-by":"crossref","unstructured":"Mockenhaupt M, Viboud C, Dunant A, et al. Stevens-Johnson syndrome and toxic epidermal necrolysis: assessment of medication risks with emphasis on recently marketed drugs. The EuroSCAR-study. J Invest Dermatol. 2008; 128: 35\u2013 44.","DOI":"10.1038\/sj.jid.5701033"},{"key":"i1552-5783-59-14-DES183-b18","doi-asserted-by":"crossref","unstructured":"Roujeau JC, Kelly JP, Naldi L, et al. Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. N Engl J Med. 1995; 333: 1600\u2013 1607.","DOI":"10.1056\/NEJM199512143332404"},{"key":"i1552-5783-59-14-DES183-b19","doi-asserted-by":"crossref","unstructured":"Ueta M. Ethnic differences in the association between human leukocyte antigen and Stevens-Johnson syndrome. Eur Ophthalmic Rev. 2009; 3: 15\u2013 18.","DOI":"10.17925\/EOR.2009.03.01.15"},{"key":"i1552-5783-59-14-DES183-b20","doi-asserted-by":"crossref","unstructured":"Ueta M, Sotozono C, Nakano M, et al. Association between prostaglandin E receptor 3 polymorphisms and Stevens-Johnson syndrome identified by means of a genome-wide association study. J Allergy Clin Immunol. 2010; 126: 1218\u2013 1225 e1210.","DOI":"10.1016\/j.jaci.2010.08.007"},{"key":"i1552-5783-59-14-DES183-b21","doi-asserted-by":"crossref","unstructured":"Wakamatsu TH, Ueta M, Tokunaga K, et al. Human leukocyte antigen class i genes associated with Stevens-Johnson syndrome and severe ocular complications following use of cold medicine in a Brazilian population. JAMA Ophthalmol. 2017; 135: 355\u2013 360.","DOI":"10.1001\/jamaophthalmol.2017.0074"},{"key":"i1552-5783-59-14-DES183-b22","unstructured":"Jongkhajornpong P, Lekhanont K, Pisuchpen P, et al. Association between HLA-B*44:03-HLA-C*07:01 haplotype and cold medicine-related Stevens-Johnson syndrome with severe ocular complications in Thailand [published online ahead of print April 29, 2018]. Br J Ophthalmol. Available at: https:\/\/bjo.bmj.com\/content\/102\/9\/1303. Accessed October 9, 2018."},{"key":"i1552-5783-59-14-DES183-b23","doi-asserted-by":"crossref","unstructured":"Lee HK, Yoon KC, Seo KY, Ueta M, Kim MK. Chronic ocular complications of Stevens-Johnson syndrome associated with causative medications in Korea. J Allergy Clin Immunol Pract. 2018; 6: 700\u2013 702.","DOI":"10.1016\/j.jaip.2017.09.001"},{"key":"i1552-5783-59-14-DES183-b24","doi-asserted-by":"crossref","unstructured":"Ueta M. Cold medicine-related Stevens-Johnson syndrome\/toxic epidermal necrolysis with severe ocular complications-phenotypes and genetic predispositions. Taiwan J Opthalmol. 2016; 6: 108\u2013 118.","DOI":"10.1016\/j.tjo.2016.06.001"},{"key":"i1552-5783-59-14-DES183-b25","doi-asserted-by":"crossref","unstructured":"Lee HS, Ueta M, Kim MK, et al. Analysis of ocular manifestation and genetic association of allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in South Korea. Cornea. 2016; 35: 199\u2013 204.","DOI":"10.1097\/ICO.0000000000000708"},{"key":"i1552-5783-59-14-DES183-b26","doi-asserted-by":"crossref","unstructured":"Hung SI, Chung WH, Liou LB, et al. HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc Natl Acad Sci U S A. 2005; 102: 4134\u2013 4139.","DOI":"10.1073\/pnas.0409500102"},{"key":"i1552-5783-59-14-DES183-b27","doi-asserted-by":"crossref","unstructured":"Lonjou C, Borot N, Sekula P, et al. A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs. Pharmacogenet Genomics. 2008; 18: 99\u2013 107.","DOI":"10.1097\/FPC.0b013e3282f3ef9c"},{"key":"i1552-5783-59-14-DES183-b28","doi-asserted-by":"crossref","unstructured":"Kaniwa N, Sugiyama E, Saito Y, et al. Specific HLA types are associated with antiepileptic drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese subjects. Pharmacogenomics. 2013; 14: 1821\u2013 1831.","DOI":"10.2217\/pgs.13.180"},{"key":"i1552-5783-59-14-DES183-b29","doi-asserted-by":"crossref","unstructured":"Chung WH, Hung SI, Hong HS, et al. Medical genetics: a marker for Stevens-Johnson syndrome. Nature. 2004; 428: 486.","DOI":"10.1038\/428486a"},{"key":"i1552-5783-59-14-DES183-b30","doi-asserted-by":"crossref","unstructured":"Ozeki T, Mushiroda T, Yowang A, et al. Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population. Hum Mol Genet. 2011; 20: 1034\u2013 1041.","DOI":"10.1093\/hmg\/ddq537"},{"key":"i1552-5783-59-14-DES183-b31","doi-asserted-by":"crossref","unstructured":"McCormack M, Alfirevic A, Bourgeois S, et al. HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med. 2011; 364: 1134\u2013 1143.","DOI":"10.1056\/NEJMoa1013297"},{"key":"i1552-5783-59-14-DES183-b32","doi-asserted-by":"crossref","unstructured":"Kaniwa N, Saito Y, Aihara M, et al. HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis. Pharmacogenomics. 2008; 9: 1617\u2013 1622.","DOI":"10.2217\/14622416.9.11.1617"},{"key":"i1552-5783-59-14-DES183-b33","doi-asserted-by":"crossref","unstructured":"Mondino BJ, Brown SI, Biglan AW. HLA antigens in Stevens-Johnson syndrome with ocular involvement. Arch Ophthalmol. 1982; 100: 1453\u2013 1454.","DOI":"10.1001\/archopht.1982.01030040431012"},{"key":"i1552-5783-59-14-DES183-b34","doi-asserted-by":"crossref","unstructured":"Roujeau JC, Bracq C, Huyn NT, Chaussalet E, Raffin C, Duedari N. HLA phenotypes and bullous cutaneous reactions to drugs. Tissue Antigens. 1986; 28: 251\u2013 254.","DOI":"10.1111\/j.1399-0039.1986.tb00491.x"},{"key":"i1552-5783-59-14-DES183-b35","doi-asserted-by":"crossref","unstructured":"Ueta M, Kinoshita S. Innate immunity of the ocular surface. Brain Res Bull. 2010; 81: 219\u2013 228.","DOI":"10.1016\/j.brainresbull.2009.10.001"},{"key":"i1552-5783-59-14-DES183-b36","doi-asserted-by":"crossref","unstructured":"Ueta M, Mizushima K, Yokoi N, Naito Y, Kinoshita S. Gene-expression analysis of polyI:C-stimulated primary human conjunctival epithelial cells. Br J Ophthalmol. 2010; 94: 1528\u2013 1532.","DOI":"10.1136\/bjo.2010.180554"},{"key":"i1552-5783-59-14-DES183-b37","doi-asserted-by":"crossref","unstructured":"Ueta M, Hamuro J, Kiyono H, Kinoshita S. Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines. Biochem Biophys Res Commun. 2005; 331: 285\u2013 294.","DOI":"10.1016\/j.bbrc.2005.02.196"},{"key":"i1552-5783-59-14-DES183-b38","doi-asserted-by":"crossref","unstructured":"Ueta M. Cold medicine-related Stevens-Johnson syndrome\/toxic epidermal necrolysis with severe ocular complications-phenotypes and genetic predispositions. Taiwan J Ophthalmol. 2016; 6: 108\u2013 118.","DOI":"10.1016\/j.tjo.2016.06.001"},{"key":"i1552-5783-59-14-DES183-b39","doi-asserted-by":"crossref","unstructured":"Ueta M, Uematsu S, Akira S, Kinoshita S. Toll-like receptor 3 enhances late-phase reaction of experimental allergic conjunctivitis. J Allergy Clin Immunol. 2009; 123: 1187\u2013 1189.","DOI":"10.1016\/j.jaci.2009.03.008"},{"key":"i1552-5783-59-14-DES183-b40","doi-asserted-by":"crossref","unstructured":"Yasuike R, Tamagawa-Mineoka R, Ueta M, Nakamura N, Kinoshita S, Katoh N. The role of toll-like receptor 3 in chronic contact hypersensitivity induced by repeated elicitation. J Dermatol Sci. 2017; 88: 184\u2013 191.","DOI":"10.1016\/j.jdermsci.2017.07.017"},{"key":"i1552-5783-59-14-DES183-b41","doi-asserted-by":"crossref","unstructured":"Nakamura N, Tamagawa-Mineoka R, Ueta M, Kinoshita S, Katoh N. Toll-like receptor 3 increases allergic and irritant contact dermatitis. J Invest Dermatol. 2015; 135: 411\u2013 417.","DOI":"10.1038\/jid.2014.402"},{"key":"i1552-5783-59-14-DES183-b42","doi-asserted-by":"crossref","unstructured":"Ueta M, Tamiya G, Tokunaga K, et al. Epistatic interaction between Toll-like receptor 3 (TLR3) and prostaglandin E receptor 3 (PTGER3) genes. J Allergy Clin Immunol. 2012; 129: 1413\u2013 1416 e1411.","DOI":"10.1038\/hgv.2015.23"},{"key":"i1552-5783-59-14-DES183-b43","doi-asserted-by":"crossref","unstructured":"Ueta M, Tokunaga K, Sotozono C, et al. HLA-A*02:06 and PTGER3 polymorphism exerts additive effects in cold medicine-related Stevens-Johnson syndrome with severe ocular complications. Human Genome Variation. 2015; 2: 15023.","DOI":"10.1038\/hgv.2015.23"},{"key":"i1552-5783-59-14-DES183-b44","doi-asserted-by":"crossref","unstructured":"Kunikata T, Yamane H, Segi E, et al. Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3. Nat Immunol. 2005; 6: 524\u2013 531.","DOI":"10.1371\/journal.pone.0025209"},{"key":"i1552-5783-59-14-DES183-b45","doi-asserted-by":"crossref","unstructured":"Ueta M, Matsuoka T, Narumiya S, Kinoshita S. Prostaglandin E receptor subtype EP3 in conjunctival epithelium regulates late-phase reaction of experimental allergic conjunctivitis. J Allergy Clin Immunol. 2009; 123: 466\u2013 471.","DOI":"10.1136\/bjo.2010.199679"},{"key":"i1552-5783-59-14-DES183-b46","doi-asserted-by":"crossref","unstructured":"Honda T, Matsuoka T, Ueta M, Kabashima K, Miyachi Y, Narumiya S. Prostaglandin E(2)-EP(3) signaling suppresses skin inflammation in murine contact hypersensitivity. J Allergy Clin Immunol. 2009; 124: 809\u2013 818 e802.","DOI":"10.1001\/archopthalmol.2011.1472"},{"key":"i1552-5783-59-14-DES183-b47","doi-asserted-by":"crossref","unstructured":"Ueta M, Sotozono C, Yokoi N, Inatomi T, Kinoshita S. Prostaglandin E receptor subtype EP3 expression in human conjunctival epithelium and its changes in various ocular surface disorders. PLoS One. 2011; 6: e25209.","DOI":"10.1136\/bjo.2007.128322"},{"key":"i1552-5783-59-14-DES183-b48","doi-asserted-by":"crossref","unstructured":"Ueta M, Matsuoka T, Yokoi N, Kinoshita S. Prostaglandin E2 suppresses polyinosine-polycytidylic acid (polyI:C)-stimulated cytokine production via prostaglandin E2 receptor (EP) 2 and 3 in human conjunctival epithelial cells. Br J Ophthalmol. 2011; 95: 859\u2013 863.","DOI":"10.1111\/all.13308"},{"key":"i1552-5783-59-14-DES183-b49","doi-asserted-by":"crossref","unstructured":"Ueta M, Sotozono C, Yokoi N, Kinoshita S. Downregulation of monocyte chemoattractant protein 1 expression by prostaglandin E(2) in human ocular surface epithelium. Arch Ophthalmol. 2012; 130: 249\u2013 251.","DOI":"10.1371\/journal.pone.0043650"},{"key":"i1552-5783-59-14-DES183-b50","doi-asserted-by":"crossref","unstructured":"Kojima K, Ueta M, Hamuro J, et al. Human conjunctival epithelial cells express functional Toll-like receptor 5. Br J Ophthalmol. 2008; 92: 411\u2013 416.","DOI":"10.1136\/bjo.2010.188748"},{"key":"i1552-5783-59-14-DES183-b51","doi-asserted-by":"crossref","unstructured":"Ueta M, Hamuro J, Nishigaki H, et al. Mucocutaneous inflammation in the Ikaros Family Zinc Finger 1-keratin 5-specific transgenic mice. Allergy. 2018; 73: 395\u2013 404.","DOI":"10.1111\/all.13308"},{"key":"i1552-5783-59-14-DES183-b52","doi-asserted-by":"crossref","unstructured":"Ueta M, Tokunaga K, Sotozono C, et al. HLA-A*0206 with TLR3 polymorphisms exerts more than additive effects in Stevens-Johnson syndrome with severe ocular surface complications. PLoS One. 2012; 7: e43650.","DOI":"10.1371\/journal.pone.0043650"},{"key":"i1552-5783-59-14-DES183-b53","doi-asserted-by":"crossref","unstructured":"Ueta M, Mizushima K, Naito Y, Narumiya S, Shinomiya K, Kinoshita S. Suppression of polyI:C-inducible gene expression by EP3 in murine conjunctival epithelium. Immunol Lett. 2014; 159: 73\u2013 75.","DOI":"10.1016\/j.imlet.2013.08.010"},{"key":"i1552-5783-59-14-DES183-b54","doi-asserted-by":"crossref","unstructured":"Ueta M, Matsuoka T, Yokoi N, Kinoshita S. Prostaglandin E receptor subtype EP3 downregulates TSLP expression in human conjunctival epithelium. Br J Ophthalmol. 2011; 95: 742\u2013 743.","DOI":"10.1136\/bjo.2010.188748"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2717239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:30:51Z","timestamp":1791927051000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.17-23537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,27]]},"references-count":54,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2018,11,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.17-23537","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11,27]]}}}