{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:57:42Z","timestamp":1791928662093,"version":"4.3.4"},"reference-count":58,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"14","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2018,11,27]]},"DOI":"10.1167\/iovs.17-23538","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T18:06:50Z","timestamp":1543342010000},"page":"DES109","source":"Crossref","is-referenced-by-count":134,"title":["Dry Eye After LASIK"],"prefix":"10.1167","volume":"59","author":[{"given":"Ikuko","family":"Toda","sequence":"first","affiliation":[{"name":"Minamiaoyama Eye Clinic, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-59-14-DES109-b01","doi-asserted-by":"crossref","unstructured":"Li XM, Hu L, Hu J, Wang W. Investigation of dry eye disease and analysis of the pathogenic factors in patients after cataract surgery. Cornea. 2007; 26: S16\u2013S20.","DOI":"10.1097\/ICO.0b013e31812f67ca"},{"key":"i1552-5783-59-14-DES109-b02","doi-asserted-by":"crossref","unstructured":"Jeon S, Park SH, Choi JS, Shin SY. Ocular surface changes after lateral rectus muscle recession. Ophthalmic Surg Lasers Imaging. 20; 42: 428\u2013433.","DOI":"10.3928\/15428877-20110630-02"},{"key":"i1552-5783-59-14-DES109-b03","doi-asserted-by":"crossref","unstructured":"Dailey RA, Saulny SM, Sullivan SA. M\u00fcller muscle-conjunctival resection: effect on tear production. Ophthalmic Plast Reconstr Surg. 2002; 18: 421\u2013425.","DOI":"10.1097\/00002341-200211000-00006"},{"key":"i1552-5783-59-14-DES109-b04","doi-asserted-by":"crossref","unstructured":"Hong JW, Kim HM. The changes of tear break up time after myopic excimer laser photorefractive keratectomy. Korean J Ophthalmol. 1997; 11: 89\u201393.","DOI":"10.3341\/kjo.1997.11.2.89"},{"key":"i1552-5783-59-14-DES109-b05","doi-asserted-by":"crossref","unstructured":"Battat L, Macri A, Dursun D, Pflugfelder SC. Effects of laser in situ keratomileusis on tear production, clearance, and the ocular surface. Ophthalmology. 2001; 108: 1230\u20131235.","DOI":"10.1016\/S0161-6420(01)00623-6"},{"key":"i1552-5783-59-14-DES109-b06","doi-asserted-by":"crossref","unstructured":"Toda I, Asano-Kato N, Hori-Komai Y, Tsubota K. Dry eye following laser in situ keratomileusis. Am J Ophthalmol. 2001; 132: 1\u20137.","DOI":"10.1016\/S0002-9394(01)00959-X"},{"key":"i1552-5783-59-14-DES109-b07","doi-asserted-by":"crossref","unstructured":"Shrestha GS, Wagh S, Darak A. Evaluation of tear film stability before and after laser in situ keratomileusis. Nepal J Ophthalmol. 2011; 3: 140\u2013145.","DOI":"10.3126\/nepjoph.v3i2.5266"},{"key":"i1552-5783-59-14-DES109-b08","doi-asserted-by":"crossref","unstructured":"Sandoval HP, Donnenfeld ED, Kohnen T, et al. Modern laser in situ keratomileusis outcomes. J Cataract Refract Surg. 2016; 42: 1224\u20131234.","DOI":"10.1016\/j.jcrs.2016.07.012"},{"key":"i1552-5783-59-14-DES109-b09","doi-asserted-by":"crossref","unstructured":"De Paiva CS, Chen Z, Koch DD, et al. The incidence and risk factors for developing dry eye after myopic LASIK. Am J Ophthalmol. 2006; 141: 438\u2013445.","DOI":"10.1016\/j.ajo.2005.10.006"},{"key":"i1552-5783-59-14-DES109-b10","doi-asserted-by":"crossref","unstructured":"Shoja MR, Besharati MR. Dry eye after LASIK for myopia: incidence and risk factors. Eur J Ophthalmol. 2007; 17: 1\u20136.","DOI":"10.1177\/112067210701700101"},{"key":"i1552-5783-59-14-DES109-b11","doi-asserted-by":"crossref","unstructured":"Wilson S. Laser in situ keratomileusis-induced (presumed) neurotrophic epitheliopathy. Ophthalmology. 2001; 108: 1082\u20131087.","DOI":"10.1016\/S0161-6420(01)00587-5"},{"key":"i1552-5783-59-14-DES109-b12","doi-asserted-by":"crossref","unstructured":"Lee JB, Ryu CH, Kim J, Kim EK, Kim HB. Comparison of tear secretion and tear film instability after photorefractive keratectomy and laser in situ keratomileusis. J Cataract Refract Surg. 2000; 26: 1326\u20131331.","DOI":"10.1016\/S0886-3350(00)00566-6"},{"key":"i1552-5783-59-14-DES109-b13","doi-asserted-by":"crossref","unstructured":"Yu EY, Leung A, Rao S, Lam DS. Effect of laser in situ keratomileusis on tear stability. Ophthalmology. 2000; 107: 2131\u20132135.","DOI":"10.1016\/S0161-6420(00)00388-2"},{"key":"i1552-5783-59-14-DES109-b14","doi-asserted-by":"crossref","unstructured":"Albietz JM, Lenton LM, McLennan SG. Chronic dry eye and regression after laser in situ keratomileusis for myopia. J Cataract Refract Surg. 2004; 30: 675\u2013684.","DOI":"10.1016\/j.jcrs.2003.07.003"},{"key":"i1552-5783-59-14-DES109-b15","doi-asserted-by":"crossref","unstructured":"Tanaka K, Takano Y, Dogru Y, et al. Effect of preoperative tear function on early functional visual acuity after laser in situ keratomileusis. J Cataract Refract Surg. 2004; 30: 2311\u20132315.","DOI":"10.1016\/j.jcrs.2004.02.086"},{"key":"i1552-5783-59-14-DES109-b16","doi-asserted-by":"crossref","unstructured":"Nettune GR, Pflugfelder SC. Post-LASIK tear dysfunction and dysesthesia. Ocul Surf. 2010; 8: 135\u2013145.","DOI":"10.1016\/S1542-0124(12)70224-0"},{"key":"i1552-5783-59-14-DES109-b17","doi-asserted-by":"crossref","unstructured":"Bower KS, Sia RK, Ryan DS, et al. Chronic dry eye in photorefractive keratectomy and laser in situ keratomileusis: Manifestations, incidence, and predictive factors. J Cataract Refract Surg. 2015; 41: 2624\u20132634.","DOI":"10.1016\/j.jcrs.2015.06.037"},{"key":"i1552-5783-59-14-DES109-b18","doi-asserted-by":"crossref","unstructured":"Toda I, Hori-Komai Y, Asano-Kato N, Tsubota K. Laser-assisted in situ keratomileusis for patients with dry eye. Arch Ophthalmol. 2002; 120: 1024\u20131028.","DOI":"10.1001\/archopht.120.8.1024"},{"key":"i1552-5783-59-14-DES109-b19","doi-asserted-by":"crossref","unstructured":"Albietz JM, Lenton LM, McLennan SG. Dry eye after LASIK: comparison of outcomes for Asian and Caucasian eyes. Clin Exp Optom. 2005; 88: 89\u201396.","DOI":"10.1111\/j.1444-0938.2005.tb06673.x"},{"key":"i1552-5783-59-14-DES109-b20","doi-asserted-by":"crossref","unstructured":"Donnenfeld ED, Solomon K, Perry HD, et al. The effect of hinge position on corneal sensation and dry eye after LASIK. Ophthalmology. 2003; 110: 1023\u20131029.","DOI":"10.1016\/S0161-6420(03)00100-3"},{"key":"i1552-5783-59-14-DES109-b21","doi-asserted-by":"crossref","unstructured":"Donnenfeld ED, Ehrenhaus M, Solomon R, Mazurek J, Rozell JC, Perry HD. Effect of hinge width on corneal sensation and dry eye after laser in situ keratomileusis. J Cataract Refract Surg. 2004; 30: 790\u2013797.","DOI":"10.1016\/j.jcrs.2003.09.043"},{"key":"i1552-5783-59-14-DES109-b22","unstructured":"Lee B, Mclaren J, Eric J, Hodge D, Bourne W. Reinnervation in the cornea after LASIK. Invest Ophthalmol Vis Sci. 2002; 43: 3660\u20133664."},{"key":"i1552-5783-59-14-DES109-b23","doi-asserted-by":"crossref","unstructured":"Di Pascuale MA, Liu TS, Trattler W, Tseng SCG. Lipid tear deficiency in persistent dry eye after laser in situ keratomileusis and treatment results of new eye-warming device. J Cataract Refract Surg. 2005; 31: 1741\u20131749.","DOI":"10.1016\/j.jcrs.2005.02.041"},{"key":"i1552-5783-59-14-DES109-b24","doi-asserted-by":"crossref","unstructured":"Savini G, Barboni P, Zanini M, Tseng SCG. Ocular surface changes in laser in situ keratomileusis-induced neurotrophic epitheliopathy. J Refract Surg. 2004; 20: 803\u2013809.","DOI":"10.3928\/1081-597X-20041101-08"},{"key":"i1552-5783-59-14-DES109-b25","doi-asserted-by":"crossref","unstructured":"Ablamowicz AF, Nichols JJ. Ocular surface membrane-associated mucins. Ocul Surf. 2016; 14: 331\u2013341.","DOI":"10.1016\/j.jtos.2016.03.003"},{"key":"i1552-5783-59-14-DES109-b26","doi-asserted-by":"crossref","unstructured":"Song XJ, Li DQ, Farley W, et al. Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 2003; 44: 4223\u20134229.","DOI":"10.1167\/iovs.02-1319"},{"key":"i1552-5783-59-14-DES109-b27","doi-asserted-by":"crossref","unstructured":"Moshirfar M, McCaughey MV, Reinstein DZ, et al. Small-incision lenticule extraction. J Cataract Refract Surg. 2015; 41: 652\u2013665.","DOI":"10.1016\/j.jcrs.2015.02.006"},{"key":"i1552-5783-59-14-DES109-b28","doi-asserted-by":"crossref","unstructured":"Kobashi H, Kamiya K, Shimizu K. Dry eye after small incision lenticule extraction and femtosecond laser-assisted LASIK: meta-analysis. Cornea. 2017; 36: 85\u201391.","DOI":"10.1097\/ICO.0000000000000999"},{"key":"i1552-5783-59-14-DES109-b29","doi-asserted-by":"crossref","unstructured":"Shen Z, Zhu Y, Song X, et al. Dry eye after small incision lenticule extraction (SMILE) versus femtosecond laser-assisted in situ keratomileusis (FS-LASIK) for myopia: a meta-analysis. PLoS One. 2016; 11: e0168081.","DOI":"10.1371\/journal.pone.0168081"},{"key":"i1552-5783-59-14-DES109-b30","doi-asserted-by":"crossref","unstructured":"Cai WT, Liu QY, Ren CD, et al. Dry eye and corneal sensitivity after small incision lenticule extraction and femtosecond laser-assisted in situ keratomileusis: a meta-analysis. Int J Ophthalmol. 2017;18; 10: 632\u2013638.","DOI":"10.18240\/ijo.2017.04.21"},{"key":"i1552-5783-59-14-DES109-b31","doi-asserted-by":"crossref","unstructured":"Li M, Zhao J, Shen Y, et al. Comparison of dry eye and corneal sensitivity between small incision lenticule extraction and femtosecond LASIK for myopia. PLoS One. 2013; 8: e77797.","DOI":"10.1371\/journal.pone.0077797"},{"key":"i1552-5783-59-14-DES109-b32","doi-asserted-by":"crossref","unstructured":"Zhang H, Wang Y. Dry eye evaluation and correlation analysis between tear film stability and corneal surface regularity after small incision lenticule extraction [published online ahead of print September 22, 2017]. Int Ophthalmol. https:\/\/doi.org\/10.1007\/s10792-017-0717-x","DOI":"10.1007\/s10792-017-0717-x"},{"key":"i1552-5783-59-14-DES109-b33","doi-asserted-by":"crossref","unstructured":"Zhang C, Ding H, He M, et al. Comparison of early changes in ocular surface and inflammatory mediators between femtosecond lenticule extraction and small-incision lenticule extraction. PLoS One. 2016; 11: e0149503.","DOI":"10.1371\/journal.pone.0149503"},{"key":"i1552-5783-59-14-DES109-b34","doi-asserted-by":"crossref","unstructured":"Gao S, Li S, Liu L, et al. Early changes in ocular surface and tear inflammatory mediators after small-incision lenticule extraction and femtosecond laser-assisted laser in situ keratomileusis. PLoS One. 2014; 9: e107370.","DOI":"10.1371\/journal.pone.0107370"},{"key":"i1552-5783-59-14-DES109-b35","doi-asserted-by":"crossref","unstructured":"Xu Y, Yang Y. Dry eye after small incision lenticule extraction and LASIK for myopia. J Refract Surg. 2014; 30: 186\u2013190.","DOI":"10.3928\/1081597X-20140219-02"},{"key":"i1552-5783-59-14-DES109-b36","doi-asserted-by":"crossref","unstructured":"Li M, Niu L, Qin B, et al. Confocal comparison of corneal reinnervation after small incision lenticule extraction (SMILE) and femtosecond laser in situ keratomileusis (FS-LASIK). PLoS One. 2013; 8: e81435.","DOI":"10.1371\/journal.pone.0081435"},{"key":"i1552-5783-59-14-DES109-b37","doi-asserted-by":"crossref","unstructured":"Szczesna DH, Kulas Z, Kasprzak HT, et al. Examination of tear film smoothness on corneae after refractive surgeries using a noninvasive interferometric method. J Biomed Opt. 2009; 14: 064029.","DOI":"10.1117\/1.3275850"},{"key":"i1552-5783-59-14-DES109-b38","doi-asserted-by":"crossref","unstructured":"Konomi K, Chen LL, Tarko RS, et al. Preoperative characteristics and a potential mechanism of chronic dry eye after LASIK. Invest Ophthalmol Vis Sci. 2008; 49: 168\u2013174.","DOI":"10.1167\/iovs.07-0337"},{"key":"i1552-5783-59-14-DES109-b39","doi-asserted-by":"crossref","unstructured":"Shin SY, Lee YJ. Conjunctival changes induced by LASIK suction ring in a rabbit model. Ophthalmic Res. 2006; 38: 343\u2013349.","DOI":"10.1159\/000096229"},{"key":"i1552-5783-59-14-DES109-b40","doi-asserted-by":"crossref","unstructured":"Nettune GR, Pflugfelder SC. Post-LASIK tear dysfunction and dysesthesia. Ocul Surf. 2010; 8: 135\u2013145.","DOI":"10.1016\/S1542-0124(12)70224-0"},{"key":"i1552-5783-59-14-DES109-b41","doi-asserted-by":"crossref","unstructured":"Levitt AE, Galor A, Weiss JS, et al. Chronic dry eye symptoms after LASIK: parallels and lessons to be learned from other persistent post-operative pain disorders. Mol Pain. 2015; 11: 21.","DOI":"10.1186\/s12990-015-0020-7"},{"key":"i1552-5783-59-14-DES109-b42","doi-asserted-by":"crossref","unstructured":"Toda I, Asano-Kato N, Hori-Komai Y, Tusbota K. Dry eye enhancement by flap-lifting in laser in situ keratomiluesis. J Refract Surg. 2006; 22: 358\u2013362.","DOI":"10.3928\/1081-597X-20060401-11"},{"key":"i1552-5783-59-14-DES109-b43","doi-asserted-by":"crossref","unstructured":"Calvillo MP, Mclaren JW, Hodge DO, Bourne WM. Corneal reinnervation after LASIK: prospective 3-year longitudinal study. Invest Ophthalmol Vis Sci. 2004; 45: 3991\u20133996.","DOI":"10.1167\/iovs.04-0561"},{"key":"i1552-5783-59-14-DES109-b44","unstructured":"Shimazaki J. Definition and criteria of dry eye. Ganka. 1995; 37: 765\u2013767."},{"key":"i1552-5783-59-14-DES109-b45","doi-asserted-by":"crossref","unstructured":"Yu EY, Leung A, Rao S, Lam DS. Effect of laser in situ keratomileusis on tear stability. Ophthalmology. 2000; 107: 2131\u20132135.","DOI":"10.1016\/S0161-6420(00)00388-2"},{"key":"i1552-5783-59-14-DES109-b46","doi-asserted-by":"crossref","unstructured":"Liang L, Zhang M, Zou W, et al. Aggravated dry eye after laser in situ keratomileusis in patients with Sj\u00f6gren syndrome. Cornea. 2008; 27: 120\u2013123.","DOI":"10.1097\/ICO.0b013e318158312f"},{"key":"i1552-5783-59-14-DES109-b47","unstructured":"Astakhov YS, Astakhov SY, Lisochkina AB. Assessment of dry eye signs and symptoms and ocular tolerance of a preservative-free lacrimal substitute (Hylabak\u00ae) versus a preserved lacrimal substitute (Systane\u00ae) used for 3 months in patients after LASIK. Clin Ophthalmol. 2013; 7: 2289\u20132297."},{"key":"i1552-5783-59-14-DES109-b48","doi-asserted-by":"crossref","unstructured":"Toda I, Ide T, Fukumoto T, Ichihashi Y, Tsubota K. Combination therapy with diquafosol tetrasodium and sodium hyaluronate in patients with dry eye after laser in situ keratomileusis. Am J Ophthalmol. 2014; 157: 616\u2013622.","DOI":"10.1016\/j.ajo.2013.11.017"},{"key":"i1552-5783-59-14-DES109-b49","doi-asserted-by":"crossref","unstructured":"Mori Y, Nejima R, Masuda A, et al. Effect of diquafosol tetrasodium eye drop for persistent dry eye after laser in situ keratomileusis. Cornea. 2014; 33: 659\u2013662.","DOI":"10.1097\/ICO.0000000000000136"},{"key":"i1552-5783-59-14-DES109-b50","doi-asserted-by":"crossref","unstructured":"Keating GM. Diquafosol ophthalmic solution 3%: a review of its use in dry eye. Drugs. 2015; 75: 911\u2013922.","DOI":"10.1007\/s40265-015-0409-7"},{"key":"i1552-5783-59-14-DES109-b51","doi-asserted-by":"crossref","unstructured":"Kinoshita S, Oshiden K, Awamura S, et al. A randomized, multicenter phase 3 study comparing 2% rebamipide (OPC-12759) with 0.1% sodium hyaluronate in the treatment of dry eye. Ophthalmology. 2013; 120: 1158\u20131165.","DOI":"10.1016\/j.ophtha.2012.12.022"},{"key":"i1552-5783-59-14-DES109-b52","doi-asserted-by":"crossref","unstructured":"Igarashi A, Kamiya K, Kobashi H, et al. Effect of rebamipide ophthalmic suspension on intraocular light scattering for dry eye after corneal refractive surgery. Cornea. 2015; 34: 895\u2013900.","DOI":"10.1097\/ICO.0000000000000456"},{"key":"i1552-5783-59-14-DES109-b53","doi-asserted-by":"crossref","unstructured":"Salib GM, McDonald MB, Smolek M. Safety and efficacy of cyclosporine 0.05% drops versus unpreserved artificial tears in dry-eye patients having laser in situ keratomileusis. J Cataract Refract Surg. 2006; 32: 772\u2013778.","DOI":"10.1016\/j.jcrs.2005.10.034"},{"key":"i1552-5783-59-14-DES109-b54","doi-asserted-by":"crossref","unstructured":"Ohguchi T, Kojima T, Ibrahim OM, et al. The effects of 2% rebamipide ophthalmic solution on the tear functions and ocular surface of the superoxide dismutase-1 (sod1) knockout mice. Invest Ophthalmol Vis Sci. 2013; 21; 54: 7793\u20137802.","DOI":"10.1167\/iovs.13-13128"},{"key":"i1552-5783-59-14-DES109-b55","doi-asserted-by":"crossref","unstructured":"Matsumoto Y, Dogru M, Goto E, et al. Efficacy of a new warm moist air device on tear functions of patients with simple meibomian gland dysfunction. Cornea. 2006; 25: 644\u2013650.","DOI":"10.1097\/01.ico.0000208822.70732.25"},{"key":"i1552-5783-59-14-DES109-b56","doi-asserted-by":"crossref","unstructured":"Schallhorn CS, Schallhorn JM, Hannan S, Schallhorn SC. Effectiveness of an eyelid thermal pulsation procedure to treat recalcitrant dry eye symptoms after laser vision correction. J Refract Surg. 2017; 33: 30\u201336.","DOI":"10.3928\/1081597X-20161006-05"},{"key":"i1552-5783-59-14-DES109-b57","doi-asserted-by":"crossref","unstructured":"Toyos R, McGill W, Briscoe D. Intense pulsed light treatment for dry eye disease due to meibomian gland dysfunction; a 3-year retrospective study. Photomed Laser Surg. 2015; 33: 41\u201346.","DOI":"10.1089\/pho.2014.3819"},{"key":"i1552-5783-59-14-DES109-b58","doi-asserted-by":"crossref","unstructured":"Noda-Tsuruya T, Asano-Kato N, Toda I, Tsubota K. Autologous serum eye drops are effective for dry eye after laser in situ keratomileusis. J Refract Surg. 2006; 22: 358\u2013362.","DOI":"10.3928\/1081-597X-20060101-13"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2717220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:30:49Z","timestamp":1791927049000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.17-23538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,27]]},"references-count":58,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2018,11,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.17-23538","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11,27]]}}}