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diagnosis of meibomian gland dysfunction.\n\t\t\t\t\tOphthalmology.\n\t\t\t\t\t2010;\n\t\t\t\t\t117:\n\t\t\t\t\t665\u2013672.","DOI":"10.1016\/j.ophtha.2009.12.029"},{"key":"i1552-5783-59-14-DES87-b13","doi-asserted-by":"crossref","unstructured":"Matsumoto\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tShigeno\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSato\n\t\t\t\t\t\t\tEA,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tThe evaluation of the treatment response in obstructive meibomian gland disease by in vivo laser confocal microscopy.\n\t\t\t\t\tGraefes Arch Clin Exp 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Ophthalmol.\n\t\t\t\t\t2017;\n\t\t\t\t\t17:\n\t\t\t\t\t84.","DOI":"10.1186\/s12886-017-0482-7"},{"key":"i1552-5783-59-14-DES87-b59","doi-asserted-by":"crossref","unstructured":"Arita\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMorishige\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKoh\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tIncreased tear fluid production as a compensatory response to meibomian gland loss: a multicenter cross-sectional study.\n\t\t\t\t\tOphthalmology.\n\t\t\t\t\t2015;\n\t\t\t\t\t122:\n\t\t\t\t\t925\u2013933.","DOI":"10.1016\/j.ophtha.2014.12.018"},{"key":"i1552-5783-59-14-DES87-b60","doi-asserted-by":"crossref","unstructured":"Matsumoto\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDogru\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSato\n\t\t\t\t\t\t\tEA,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tS-1 induces meibomian gland dysfunction.\n\t\t\t\t\tOphthalmology.\n\t\t\t\t\t2010;\n\t\t\t\t\t117:\n\t\t\t\t\t1275.","DOI":"10.1016\/j.ophtha.2010.01.048"},{"key":"i1552-5783-59-14-DES87-b61","doi-asserted-by":"crossref","unstructured":"Ban\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOgawa\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGoto\n\t\t\t\t\t\t\tE,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tTear function and lipid layer alterations in dry eye patients with chronic graft-vs-host disease.\n\t\t\t\t\tEye (Lond).\n\t\t\t\t\t2009;\n\t\t\t\t\t23:\n\t\t\t\t\t202\u2013208.","DOI":"10.1038\/eye.2008.340"}],"container-title":["Investigative Opthalmology &amp; Visual 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