{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:58:16Z","timestamp":1791928696897,"version":"4.3.4"},"reference-count":127,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"14","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2018,11,27]]},"DOI":"10.1167\/iovs.17-23750","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T18:09:28Z","timestamp":1543342168000},"page":"DES71","source":"Crossref","is-referenced-by-count":51,"title":["Sj\u00f6gren's Syndrome, Non-Sj\u00f6gren's Syndrome, and Graft-Versus-Host Disease Related Dry Eye"],"prefix":"10.1167","volume":"59","author":[{"given":"Yoko","family":"Ogawa","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-59-14-DES71-b01","doi-asserted-by":"crossref","unstructured":"Craig JP, Nichols KK, Akpek EK, et al. TFOS DEWS II definition and classification report. Ocul Surf. 2017; 15: 276\u2013283.","DOI":"10.1016\/j.jtos.2017.05.008"},{"key":"i1552-5783-59-14-DES71-b02","doi-asserted-by":"crossref","unstructured":"Tsubota K, Yokoi N, Shimazaki J, et al. New perspectives on dry eye definition and diagnosis: a consensus report by the Asia Dry Eye Society. Ocul Surf. 2017; 15: 65\u201376.","DOI":"10.1016\/j.jtos.2016.09.003"},{"key":"i1552-5783-59-14-DES71-b03","doi-asserted-by":"crossref","unstructured":"Stern ME, Gao J, Siemasko KF, Beuerman RW, Pflugfelder SC. The role of the lacrimal functional unit in the pathophysiology of dry eye. Exp Eye Res. 2004; 78: 409\u2013416.","DOI":"10.1016\/j.exer.2003.09.003"},{"key":"i1552-5783-59-14-DES71-b04","doi-asserted-by":"crossref","unstructured":"Tsuboi H, Asashima H, Takai C, et al. Primary and secondary surveys on epidemiology of Sj\u00f6gren's syndrome in Japan. Mod Rheumatol. 2014; 24: 464\u2013470.","DOI":"10.3109\/14397595.2013.843765"},{"key":"i1552-5783-59-14-DES71-b05","doi-asserted-by":"crossref","unstructured":"Ciurtin C, Ostas A, Cojocaru VM, Walsh SB, Isenberg DA. Advances in the treatment of ocular dryness associated with Sj\u00f6grens syndrome. Semin Arthritis Rheum. 2015; 45: 321\u2013327.","DOI":"10.1016\/j.semarthrit.2015.06.007"},{"key":"i1552-5783-59-14-DES71-b06","doi-asserted-by":"crossref","unstructured":"Tsuboi H, Hagiwara S, Asashima H, et al. Comparison of performance of the 2016 ACR-EULAR classification criteria for primary Sj\u00f6gren's syndrome with other sets of criteria in Japanese patients. Ann Rheum Dis. 2017; 76: 1980\u20131985.","DOI":"10.1136\/annrheumdis-2016-210758"},{"key":"i1552-5783-59-14-DES71-b07","doi-asserted-by":"crossref","unstructured":"Kuklinski E, Asbell PA. Sj\u00f6gren's syndrome from the perspective of ophthalmology. Clin Immunol. 2017; 182: 55\u201361.","DOI":"10.1016\/j.clim.2017.04.017"},{"key":"i1552-5783-59-14-DES71-b08","doi-asserted-by":"crossref","unstructured":"Sakane Y, Yamaguchi M, Yokoi N, et al. Development and validation of the Dry Eye-Related Quality-of-Life Score questionnaire. JAMA Ophthalmol. 2013; 131: 1331\u20131338.","DOI":"10.1001\/jamaophthalmol.2013.4503"},{"key":"i1552-5783-59-14-DES71-b09","doi-asserted-by":"crossref","unstructured":"Jones L, Downie LE, Korb D, et al. TFOS DEWS II management and therapy report. Ocul Surf. 2017; 15: 575\u2013628.","DOI":"10.1016\/j.jtos.2017.05.006"},{"key":"i1552-5783-59-14-DES71-b10","doi-asserted-by":"crossref","unstructured":"Bron AJ, de Paiva CS, Chauhan SK, et al. TFOS DEWS II pathophysiology report. Ocul Surf. 2017; 15: 438\u2013510.","DOI":"10.1016\/j.jtos.2017.05.011"},{"key":"i1552-5783-59-14-DES71-b11","doi-asserted-by":"crossref","unstructured":"Wang H, Wang PB, Chen T, et al. Analysis of clinical characteristics of immune-related dry eye. J Ophthalmol. 2017; 2017: 8532397.","DOI":"10.1155\/2017\/8532397"},{"key":"i1552-5783-59-14-DES71-b12","doi-asserted-by":"crossref","unstructured":"Shiboski SC, Shiboski CH, Criswell L, et al. American College of Rheumatology classification criteria for Sj\u00f6gren's syndrome: a data-driven, expert consensus approach in the Sj\u00f6gren's International Collaborative Clinical Alliance cohort. Arthritis Care Res. 2012; 64: 475\u2013487.","DOI":"10.1002\/acr.21591"},{"key":"i1552-5783-59-14-DES71-b13","doi-asserted-by":"crossref","unstructured":"Tomiita M, Saito K, Kohno Y, Shimojo N, Fujikawa S, Niimi H. The clinical features of Sj\u00f6gren's syndrome in Japanese children. Acta Paediatr Jpn. 1997; 39: 268\u2013272.","DOI":"10.1111\/j.1442-200X.1997.tb03597.x"},{"key":"i1552-5783-59-14-DES71-b14","doi-asserted-by":"crossref","unstructured":"Means C, Aldape MA, King E. Pediatric primary Sj\u00f6gren's syndrome presenting with bilateral ranulas: A case report and systematic review of the literature. Int J Pediatr Otorhinolaryngol. 2017; 101: 11\u201319.","DOI":"10.1016\/j.ijporl.2017.07.019"},{"key":"i1552-5783-59-14-DES71-b15","doi-asserted-by":"crossref","unstructured":"Tomiita M, Takei S, Kuwada N, et al. Efficacy and safety of orally administered pilocarpine hydrochloride for patients with juvenile-onset Sj\u00f6gren's s syndrome. Mod Rheumatol. 2010; 20: 486\u2013490.","DOI":"10.3109\/s10165-010-0313-7"},{"key":"i1552-5783-59-14-DES71-b16","unstructured":"Tsubota K, Xu KP, Fujihara T, Katagiri S, Takeuchi T. Decreased reflex tearing is associated with lymphocytic infiltration in lacrimal glands. J Rheumatol. 1996; 23: 313\u2013320."},{"key":"i1552-5783-59-14-DES71-b17","doi-asserted-by":"crossref","unstructured":"Tsubota K. The importance of the Schirmer test with nasal stimulation. J Ophthalmol. 1991; 111: 106\u2013108.","DOI":"10.1016\/S0002-9394(14)76908-9"},{"key":"i1552-5783-59-14-DES71-b18","doi-asserted-by":"crossref","unstructured":"Yokoi N, Georgiev GA, Kato H, et al. Classification of fluorescein breakup patterns: a novel method of differential diagnosis for dry eye. J Ophthalmol. 2017; 180: 72\u201385.","DOI":"10.1016\/j.ajo.2017.05.022"},{"key":"i1552-5783-59-14-DES71-b19","doi-asserted-by":"crossref","unstructured":"Shimazaki J, Goto E, Ono M, Shimmura S, Tsubota K. Meibomian gland dysfunction in patients with Sj\u00f6gren's syndrome. Ophthalmology. 1998; 105: 1485\u20131488.","DOI":"10.1016\/S0161-6420(98)98033-2"},{"key":"i1552-5783-59-14-DES71-b20","doi-asserted-by":"crossref","unstructured":"Koufakis DI, Karabatsas CH, Sakkas LI, Alvanou A, Manthos AK, Chatzoulis DZ. Conjunctival surface changes in patients with Sj\u00f6gren's syndrome: a transmission electron microscopy study. Invest Ophthalmol Vis Sci. 2006; 47: 541\u2013544.","DOI":"10.1167\/iovs.05-0804"},{"key":"i1552-5783-59-14-DES71-b21","doi-asserted-by":"crossref","unstructured":"Sugai S. Sj\u00f6gren's syndrome associated with liver and neurological disorders, and malignant lymphoma. Intern Med. 2000; 39: 193\u2013194.","DOI":"10.2169\/internalmedicine.39.193"},{"key":"i1552-5783-59-14-DES71-b22","doi-asserted-by":"crossref","unstructured":"Foulks GN, Forstot SL, Donshik PC, et al. Clinical guidelines for management of dry eye associated with Sj\u00f6gren's disease. Ocul Surf. 2015; 13: 118\u2013132.","DOI":"10.1016\/j.jtos.2014.12.001"},{"key":"i1552-5783-59-14-DES71-b23","doi-asserted-by":"crossref","unstructured":"Sullivan DA, Rocha EM, Aragona P, et al. TFOS DEWS II sex, gender, and hormones report. Ocul Surf. 2017; 15: 284\u2013333.","DOI":"10.1016\/j.jtos.2017.04.001"},{"key":"i1552-5783-59-14-DES71-b24","doi-asserted-by":"crossref","unstructured":"Rosenthal P, Borsook D. The corneal pain system. Part I: the missing piece of the dry eye puzzle. Ocul Surf. 2012; 10: 2\u201314.","DOI":"10.1016\/j.jtos.2012.01.002"},{"key":"i1552-5783-59-14-DES71-b25","doi-asserted-by":"crossref","unstructured":"Galor A, Covington D, Levitt AE, et al. Neuropathic ocular pain due to dry eye is associated with multiple comorbid chronic pain syndromes. J Pain. 2016; 17: 310\u2013318.","DOI":"10.1016\/j.jpain.2015.10.019"},{"key":"i1552-5783-59-14-DES71-b26","doi-asserted-by":"crossref","unstructured":"Villani E, Galimberti D, Viola F, Mapelli C, Ratiglia R. The cornea in Sj\u00f6gren's syndrome: an in vivo confocal study. Invest Ophthalmol Vis Sci. 2007; 48: 2017\u20132022.","DOI":"10.1167\/iovs.06-1129"},{"key":"i1552-5783-59-14-DES71-b27","doi-asserted-by":"crossref","unstructured":"Parra A, Madrid R, Echevarria D, et al. Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea. Nat Med. 2010; 16: 1396\u20131399.","DOI":"10.1038\/nm.2264"},{"key":"i1552-5783-59-14-DES71-b28","doi-asserted-by":"crossref","unstructured":"Yokoi N, Kato H, Kinoshita S. Facilitation of tear fluid secretion by 3% diquafosol ophthalmic solution in normal human eyes. J Ophthalmol. 2014; 157: 85\u201392.e81.","DOI":"10.1016\/j.ajo.2013.09.009"},{"key":"i1552-5783-59-14-DES71-b29","doi-asserted-by":"crossref","unstructured":"Kinoshita S, Awamura S, Nakamichi N, et al. A multicenter, open-label, 52-week study of 2% rebamipide (OPC-12759) ophthalmic suspension in patients with dry eye. J Ophthalmol. 2014; 157: 576\u2013583.e571.","DOI":"10.1016\/j.ajo.2013.11.010"},{"key":"i1552-5783-59-14-DES71-b30","doi-asserted-by":"crossref","unstructured":"Yokoi N, Sonomura Y, Kato H, Komuro A, Kinoshita S. Three percent diquafosol ophthalmic solution as an additional therapy to existing artificial tears with steroids for dry-eye patients with Sj\u00f6gren's syndrome. Eye. 2015; 29: 1204\u20131212.","DOI":"10.1038\/eye.2015.125"},{"key":"i1552-5783-59-14-DES71-b31","doi-asserted-by":"crossref","unstructured":"Koh S, Maeda N, Ikeda C, et al. Effect of diquafosol ophthalmic solution on the optical quality of the eyes in patients with aqueous-deficient dry eye. Acta Ophthalmologica. 2014; 92: e671\u2013e675.","DOI":"10.1111\/aos.12443"},{"key":"i1552-5783-59-14-DES71-b32","doi-asserted-by":"crossref","unstructured":"Cowlen MS, Zhang VZ, Warnock L, Moyer CF, Peterson WM, Yerxa BR. Localization of ocular P2Y2 receptor gene expression by in situ hybridization. Exp Eye Res. 2003; 77: 77\u201384.","DOI":"10.1016\/S0014-4835(03)00068-X"},{"key":"i1552-5783-59-14-DES71-b33","doi-asserted-by":"crossref","unstructured":"Jumblatt JE, Jumblatt MM. Regulation of ocular mucin secretion by P2Y2 nucleotide receptors in rabbit and human conjunctiva. Exp Eye Res. 1998; 67: 341\u2013346.","DOI":"10.1006\/exer.1998.0520"},{"key":"i1552-5783-59-14-DES71-b34","doi-asserted-by":"crossref","unstructured":"Li Y, Kuang K, Yerxa B, Wen Q, Rosskothen H, Fischbarg J. Rabbit conjunctival epithelium transports fluid, and P2Y2 receptor agonists stimulate Cl(-) and fluid secretion. Am J Physiol Cell Physiol. 2001; 281: C595\u2013C602.","DOI":"10.1152\/ajpcell.2001.281.2.C595"},{"key":"i1552-5783-59-14-DES71-b35","doi-asserted-by":"crossref","unstructured":"Nakamura M, Imanaka T, Sakamoto A. Diquafosol ophthalmic solution for dry eye treatment. Adv Ther. 2012; 29: 579\u2013589.","DOI":"10.1007\/s12325-012-0033-9"},{"key":"i1552-5783-59-14-DES71-b36","doi-asserted-by":"crossref","unstructured":"Kinoshita S, Oshiden K, Awamura S, et al. A randomized, multicenter phase 3 study comparing 2% rebamipide (OPC-12759) with 0.1% sodium hyaluronate in the treatment of dry eye. Ophthalmology. 2013; 120: 1158\u20131165.","DOI":"10.1016\/j.ophtha.2012.12.022"},{"key":"i1552-5783-59-14-DES71-b37","doi-asserted-by":"crossref","unstructured":"Kinoshita S, Awamura S, Oshiden K, Suzuki H, Nakamichi N, Yokoi N; Rebamipide Ophthalmic Suspension Phase 3 Study Group. Rebamipide (OPC-12759) in the treatment of dry eye: a randomized, double-masked, multicenter, placebo-controlled phase II study. Ophthalmology. 2012; 119: 2471\u20132478.","DOI":"10.1016\/j.ophtha.2012.06.052"},{"key":"i1552-5783-59-14-DES71-b38","doi-asserted-by":"crossref","unstructured":"Arimoto A, Kitagawa K, Mita N, Takahashi Y, Shibuya E, Sasaki H. Effect of rebamipide ophthalmic suspension on signs and symptoms of keratoconjunctivitis sicca in Sj\u00f6gren's syndrome patients with or without punctal occlusions. Cornea. 2014; 33: 806\u2013811.","DOI":"10.1097\/ICO.0000000000000155"},{"key":"i1552-5783-59-14-DES71-b39","doi-asserted-by":"crossref","unstructured":"Sumida T, Azuma N, Moriyama M, et al. Clinical practice guideline for Sj\u00f6rgren's syndrome 2017. Mod Rheumatol. 2017; 28: 383\u2013408.","DOI":"10.1080\/14397595.2018.1438093"},{"key":"i1552-5783-59-14-DES71-b40","doi-asserted-by":"crossref","unstructured":"McDonald CC, Kaye SB, Figueiredo FC, Macintosh G, Lockett C. A randomised, crossover, multicentre study to compare the performance of 0.1% (w\/v) sodium hyaluronate with 1.4% (w\/v) polyvinyl alcohol in the alleviation of symptoms associated with dry eye syndrome. Eye. 2002; 16: 601\u2013607.","DOI":"10.1038\/sj.eye.6700169"},{"key":"i1552-5783-59-14-DES71-b41","unstructured":"Fox PC, Datiles M, Atkinson JC, et al. Prednisone and piroxicam for treatment of primary Sj\u00f6gren's syndrome. Clin Exp Rheumatol. 1993; 11: 149\u2013156."},{"key":"i1552-5783-59-14-DES71-b42","doi-asserted-by":"crossref","unstructured":"Baudouin C, de la Maza MS, Amrane M, et al. One-year efficacy and safety of 0.1% cyclosporine A cationic emulsion in the treatment of severe dry eye disease [published online ahead of print 2017]. Eur J Ophthalmol. doi:10.5301\/ejo.5001002.","DOI":"10.5301\/ejo.5001002"},{"key":"i1552-5783-59-14-DES71-b43","doi-asserted-by":"crossref","unstructured":"Lallemand F, Schmitt M, Bourges JL, Gurny R, Benita S, Garrigue JS. Cyclosporine A delivery to the eye: a comprehensive review of academic and industrial efforts. Eur J Pharm Biopharm. 2017; 117: 14\u201328.","DOI":"10.1016\/j.ejpb.2017.03.006"},{"key":"i1552-5783-59-14-DES71-b44","doi-asserted-by":"crossref","unstructured":"Lifitegrast (Xiidra) for dry eye disease. JAMA. 2017; 317: 1473\u20131474.","DOI":"10.1001\/jama.2016.12872"},{"key":"i1552-5783-59-14-DES71-b45","doi-asserted-by":"crossref","unstructured":"Geerling G, Tauber J, Baudouin C, et al. The International Workshop on Meibomian Gland Dysfunction: report of the subcommittee on management and treatment of meibomian gland dysfunction. Invest Ophthalmol Vis Sci. 2011; 52: 2050\u20132064.","DOI":"10.1167\/iovs.10-6997g"},{"key":"i1552-5783-59-14-DES71-b46","doi-asserted-by":"crossref","unstructured":"Tsubota K, Toda I, Yagi Y, Ogawa Y, Ono M, Yoshino K. Three different types of dry eye syndrome. Cornea. 1994; 13: 202\u2013209.","DOI":"10.1097\/00003226-199405000-00002"},{"key":"i1552-5783-59-14-DES71-b47","doi-asserted-by":"crossref","unstructured":"Kovtonyuk LV, Fritsch K, Feng X, Manz MG, Takizawa H. Inflamm-aging of hematopoiesis, hematopoietic stem cells, and the bone marrow microenvironment. Front Immunol. 2016; 7: 502.","DOI":"10.3389\/fimmu.2016.00502"},{"key":"i1552-5783-59-14-DES71-b48","doi-asserted-by":"crossref","unstructured":"Obata H, Yamamoto S, Horiuchi H, Machinami R. Histopathologic study of human lacrimal gland. Statistical analysis with special reference to aging. Ophthalmology. 1995; 102: 678\u2013686.","DOI":"10.1016\/S0161-6420(95)30971-2"},{"key":"i1552-5783-59-14-DES71-b49","doi-asserted-by":"crossref","unstructured":"Coursey TG, Bian F, Zaheer M, Pflugfelder SC, Volpe EA, de Paiva CS. Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells. Mucosal Immunol. 2017; 10: 743\u2013756.","DOI":"10.1038\/mi.2016.83"},{"key":"i1552-5783-59-14-DES71-b50","doi-asserted-by":"crossref","unstructured":"Kojima T, Wakamatsu TH, Dogru M, et al. Age-related dysfunction of the lacrimal gland and oxidative stress: evidence from the Cu, Zn-superoxide dismutase-1 (Sod1) knockout mice. Am J Pathol. 2012; 180: 1879\u20131896.","DOI":"10.1016\/j.ajpath.2012.01.019"},{"key":"i1552-5783-59-14-DES71-b51","doi-asserted-by":"crossref","unstructured":"McClellan AJ, Volpe EA, Zhang X, et al. Ocular surface disease and dacryoadenitis in aging C57BL\/6 mice. Am J Pathol. 2014; 184: 631\u2013643.","DOI":"10.1016\/j.ajpath.2013.11.019"},{"key":"i1552-5783-59-14-DES71-b52","doi-asserted-by":"crossref","unstructured":"Rocha EM, Alves M, Rios JD, Dartt DA. The aging lacrimal gland: changes in structure and function. Ocul Surf. 2008; 6: 162\u2013174.","DOI":"10.1016\/S1542-0124(12)70177-5"},{"key":"i1552-5783-59-14-DES71-b53","doi-asserted-by":"crossref","unstructured":"Shah A, Santhiago MR, Espana EM. Cataract surgery in patients with chronic severe graft-versus-host disease. J Cataract Refract Surg. 2016; 42: 833\u2013839.","DOI":"10.1016\/j.jcrs.2016.02.046"},{"key":"i1552-5783-59-14-DES71-b54","doi-asserted-by":"crossref","unstructured":"Stone JH, Chan JK, Deshpande V, Okazaki K, Umehara H, Zen Y. IgG4-Related disease. Int J Rheumatol. 2013; 2013: 532612.","DOI":"10.1155\/2013\/532612"},{"key":"i1552-5783-59-14-DES71-b55","doi-asserted-by":"crossref","unstructured":"Khosroshahi A, Wallace ZS, Crowe JL, et al. International Consensus Guidance Statement on the management and treatment of IgG4-related disease. Arthritis Rheumatol. 2015; 67: 1688\u20131699.","DOI":"10.1002\/art.39132"},{"key":"i1552-5783-59-14-DES71-b56","unstructured":"Goto H, Takahira M, Azumi A; Japanese Study Group for IgG4-Related Ophthalmic Disease. Diagnostic criteria for IgG4-related ophthalmic disease. J Ophthalmol. 2015; 59: 1\u20137."},{"key":"i1552-5783-59-14-DES71-b57","doi-asserted-by":"crossref","unstructured":"Fukui M, Ogawa Y, Shimmura S, et al. Possible involvement of epithelial-mesenchymal transition in fibrosis associated with IgG4-related Mikulicz's disease. Mod Rheumatol. 2015; 25: 737\u2013743.","DOI":"10.3109\/14397595.2014.1002968"},{"key":"i1552-5783-59-14-DES71-b58","doi-asserted-by":"crossref","unstructured":"Kang YS, Lee HS, Li Y, Choi W, Yoon KC. Manifestation of meibomian gland dysfunction in patients with Sj\u00f6gren's syndrome, non-Sj\u00f6gren's dry eye, and non-dry eye controls. Int Ophthalmol. 2017; 38: 1161\u20131167.","DOI":"10.1007\/s10792-017-0577-4"},{"key":"i1552-5783-59-14-DES71-b59","doi-asserted-by":"crossref","unstructured":"Ayaki M, Kawashima M, Negishi K, Tsubota K. High prevalence of sleep and mood disorders in dry eye patients: survey of 1, 000 eye clinic visitors. Neuropsychiatr Dis Treat. 2015; 11: 889\u2013894.","DOI":"10.2147\/NDT.S81515"},{"key":"i1552-5783-59-14-DES71-b60","doi-asserted-by":"crossref","unstructured":"Kawashima M, Uchino M, Yokoi N, et al. The association of sleep quality with dry eye disease: the Osaka study. Clin Ophthalmol. 2016; 10: 1015\u20131021.","DOI":"10.2147\/OPTH.S99620"},{"key":"i1552-5783-59-14-DES71-b61","doi-asserted-by":"crossref","unstructured":"Lee W, Lim SS, Won JU, et al. The association between sleep duration and dry eye syndrome among Korean adults. Sleep Med. 2015; 16: 1327\u20131331.","DOI":"10.1016\/j.sleep.2015.06.021"},{"key":"i1552-5783-59-14-DES71-b62","doi-asserted-by":"crossref","unstructured":"Jagasia MH, Greinix HT, Arora M, et al. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report. Biol Blood Marrow Transplant. 2015; 21: 389\u2013401.e381.","DOI":"10.1016\/j.bbmt.2014.12.001"},{"key":"i1552-5783-59-14-DES71-b63","doi-asserted-by":"crossref","unstructured":"Inamoto Y, Martin PJ, Storer BE, et al. Association of severity of organ involvement with mortality and recurrent malignancy in patients with chronic graft-versus-host disease. Haematologica. 2014; 99: 1618\u20131623.","DOI":"10.3324\/haematol.2014.109611"},{"key":"i1552-5783-59-14-DES71-b64","doi-asserted-by":"crossref","unstructured":"Shikari H, Antin JH, Dana R. Ocular graft-versus-host disease: a review. Surv Ophthalmol. 2013; 58: 233\u2013251.","DOI":"10.1016\/j.survophthal.2012.08.004"},{"key":"i1552-5783-59-14-DES71-b65","doi-asserted-by":"crossref","unstructured":"Ogawa Y, Kim SK, Dana R, et al. International Chronic Ocular Graft-vs-Host-Disease (GVHD) Consensus Group: proposed diagnostic criteria for chronic GVHD (Part I). Sci Rep. 2013; 3: 3419.","DOI":"10.1038\/srep03419"},{"key":"i1552-5783-59-14-DES71-b66","doi-asserted-by":"crossref","unstructured":"Nassar A, Tabbara KF, Aljurf M. Ocular manifestations of graft-versus-host disease. Saudi J Ophthalmol. 2013; 27: 215\u2013222.","DOI":"10.1016\/j.sjopt.2013.06.007"},{"key":"i1552-5783-59-14-DES71-b67","doi-asserted-by":"crossref","unstructured":"Espana EM, Shah S, Santhiago MR, Singh AD. Graft versus host disease: clinical evaluation, diagnosis and management. Graefes Arch Clin Exp Ophthalmol. 2013; 251: 1257\u20131266.","DOI":"10.1007\/s00417-013-2301-z"},{"key":"i1552-5783-59-14-DES71-b68","doi-asserted-by":"crossref","unstructured":"Dietrich-Ntoukas T, Cursiefen C, Westekemper H, et al. Diagnosis and treatment of ocular chronic graft-versus-host disease: report from the German-Austrian-Swiss Consensus Conference on clinical practice in chronic GVHD. Cornea. 2012; 31: 299\u2013310.","DOI":"10.1097\/ICO.0b013e318226bf97"},{"key":"i1552-5783-59-14-DES71-b69","doi-asserted-by":"crossref","unstructured":"Stevenson W, Shikari H, Saboo US, Amparo F, Dana R. Bilateral corneal ulceration in ocular graft-versus-host disease. Clin Ophthalmol. 2013; 7: 2153\u20132158.","DOI":"10.2147\/OPTH.S51180"},{"key":"i1552-5783-59-14-DES71-b70","unstructured":"Inagaki E, Ogawa Y, Matsumoto Y, Kawakita T, Shimmura S, Tsubota K. Four cases of corneal perforation in patients with chronic graft-versus-host disease. Mol Vis. 2011; 17: 598\u2013606."},{"key":"i1552-5783-59-14-DES71-b71","doi-asserted-by":"crossref","unstructured":"Saboo US, Amparo F, Abud TB, Schaumberg DA, Dana R. Vision-related quality of life in patients with ocular graft-versus-host disease. Ophthalmology. 2015; 122: 1669\u20131674.","DOI":"10.1016\/j.ophtha.2015.04.011"},{"key":"i1552-5783-59-14-DES71-b72","doi-asserted-by":"crossref","unstructured":"Riemens A, Te Boome LC, Kalinina Ayuso V, et al. Impact of ocular graft-versus-host disease on visual quality of life in patients after allogeneic stem cell transplantation: questionnaire study. Acta Ophthalmol. 2014; 92: 82\u201387.","DOI":"10.1111\/aos.12047"},{"key":"i1552-5783-59-14-DES71-b73","doi-asserted-by":"crossref","unstructured":"Ogawa Y, Okamoto S, Wakui M, et al. Dry eye after haematopoietic stem cell transplantation. J Ophthalmol. 1999; 83: 1125\u20131130.","DOI":"10.1136\/bjo.83.10.1125"},{"key":"i1552-5783-59-14-DES71-b74","doi-asserted-by":"crossref","unstructured":"Kim SK. Ocular graft vs. host disease. Ocul Surf. 2005; 3 (suppl 4): S177\u2013S179.","DOI":"10.1016\/S1542-0124(12)70250-1"},{"key":"i1552-5783-59-14-DES71-b75","doi-asserted-by":"crossref","unstructured":"Uchino M, Ogawa Y, Kawai M, et al. Ocular complications in a child with acute graft-versus-host disease following cord blood stem cell transplantation: therapeutic challenges. Acta Ophthalmol Scand. 2006; 84: 545\u2013548.","DOI":"10.1111\/j.1600-0420.2006.00658.x"},{"key":"i1552-5783-59-14-DES71-b76","doi-asserted-by":"crossref","unstructured":"Phillips RJ, Burdick MD, Hong K, et al. Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest. 2004; 114: 438\u2013446.","DOI":"10.1172\/JCI200420997"},{"key":"i1552-5783-59-14-DES71-b77","unstructured":"Ogawa Y, Yamazaki K, Kuwana M, et al. A significant role of stromal fibroblasts in rapidly progressive dry eye in patients with chronic GVHD. Invest Ophthalmol Vis Sci. 2001; 42: 111\u2013119."},{"key":"i1552-5783-59-14-DES71-b78","doi-asserted-by":"crossref","unstructured":"Ogawa Y, Okamoto S, Mori T, et al. Autologous serum eyedrops for the treatment of severe dry eye in patients with chronic graft-versus-host disease. Bone Marrow Transplant. 2003; 31: 579\u2013583.","DOI":"10.1038\/sj.bmt.1703862"},{"key":"i1552-5783-59-14-DES71-b79","doi-asserted-by":"crossref","unstructured":"Robinson MR, Lee SS, Rubin BI, et al. Topical corticosteroid therapy for cicatricial conjunctivitis associated with chronic graft-versus-host disease. Bone Marrow Transplant. 2004; 33: 1031\u20131035.","DOI":"10.1038\/sj.bmt.1704453"},{"key":"i1552-5783-59-14-DES71-b80","doi-asserted-by":"crossref","unstructured":"Jabs DA, Wingard J, Green WR, Farmer ER, Vogelsang G, Saral R. The eye in bone marrow transplant. III. Conjunctival graft-vs-host disease. Arch Ophthalmol. 1989; 107: 1343\u20131348.","DOI":"10.1001\/archopht.1989.01070020413046"},{"key":"i1552-5783-59-14-DES71-b81","doi-asserted-by":"crossref","unstructured":"Franklin RM, Kenyon KR, Tutschka PJ, et al. Ocular manifestations of graft-vs-host disease. Ophthalmology. 1983; 90: 4\u201313.","DOI":"10.1016\/S0161-6420(83)34604-2"},{"key":"i1552-5783-59-14-DES71-b82","unstructured":"Jack MK, Hicks JD. Ocular complications in high-dose chemoradiotherapy and marrow transplantation. Ann Ophthalmol. 1981; 13: 709\u2013711."},{"key":"i1552-5783-59-14-DES71-b83","doi-asserted-by":"crossref","unstructured":"Kamoi M, Ogawa Y, Uchino M, et al. Donor-recipient gender difference affects severity of dry eye after hematopoietic stem cell transplantation. Eye. 2011; 25: 860\u2013865.","DOI":"10.1038\/eye.2011.73"},{"key":"i1552-5783-59-14-DES71-b84","doi-asserted-by":"crossref","unstructured":"Shikari H, Amparo F, Saboo U, Dana R. Onset of ocular graft-versus-host disease symptoms after allogeneic hematopoietic stem cell transplantation. Cornea. 2015; 34: 243\u2013247.","DOI":"10.1097\/ICO.0000000000000340"},{"key":"i1552-5783-59-14-DES71-b85","doi-asserted-by":"crossref","unstructured":"Giannaccare G, Bonifazi F, Sessa M, et al. Ocular surface analysis in hematological patients before and after allogeneic hematopoietic stem cell transplantation: implication for daily clinical practice. Eye. 2017; 31: 1417\u20131426.","DOI":"10.1038\/eye.2017.78"},{"key":"i1552-5783-59-14-DES71-b86","doi-asserted-by":"crossref","unstructured":"Jacobs R, Tran U, Chen H, et al. Prevalence and risk factors associated with development of ocular GVHD defined by NIH consensus criteria. Bone Marrow Transplant. 2012; 47: 1470\u20131473.","DOI":"10.1038\/bmt.2012.56"},{"key":"i1552-5783-59-14-DES71-b87","doi-asserted-by":"crossref","unstructured":"Kamoi M, Ogawa Y, Dogru M, et al. Spontaneous lacrimal punctal occlusion associated with ocular chronic graft-versus-host disease. Curr Eye Res. 2007; 32: 837\u2013842.","DOI":"10.1080\/02713680701586409"},{"key":"i1552-5783-59-14-DES71-b88","doi-asserted-by":"crossref","unstructured":"Uchino M, Ogawa Y, Uchino Y, Mori T, Okamoto S, Tsubota K. Comparison of stem cell sources in the severity of dry eye after allogeneic haematopoietic stem cell transplantation. J Ophthalmol. 2012; 96: 34\u201337.","DOI":"10.1136\/bjophthalmol-2011-300514"},{"key":"i1552-5783-59-14-DES71-b89","doi-asserted-by":"crossref","unstructured":"Saboo US, Amparo F, Shikari H, Dana R. Prevalence of ocular hypertension and glaucoma in patients with chronic ocular graft-versus-host disease. Graefes Arch Clin Exp Ophthalmol. 2016; 254: 923\u2013928.","DOI":"10.1007\/s00417-016-3312-3"},{"key":"i1552-5783-59-14-DES71-b90","unstructured":"Ban Y, Ogawa Y, Ibrahim OM, et al. Morphologic evaluation of meibomian glands in chronic graft-versus-host disease using in vivo laser confocal microscopy. Mol Vis. 2011; 17: 2533\u20132543."},{"key":"i1552-5783-59-14-DES71-b91","doi-asserted-by":"crossref","unstructured":"Kusne Y, Temkit M, Khera N, Patel DR, Shen JF. Conjunctival subepithelial fibrosis and meibomian gland atrophy in ocular graft-versus-host disease. Ocul Surf. 2017; 15: 784\u2013788.","DOI":"10.1016\/j.jtos.2017.08.002"},{"key":"i1552-5783-59-14-DES71-b92","doi-asserted-by":"crossref","unstructured":"Kim S, Yoo YS, Kim HS, Joo CK, Na KS. Changes of meibomian glands in the early stage of post hematopoietic stem cell transplantation. Exp Eye Res. 2017; 163: 85\u201390.","DOI":"10.1016\/j.exer.2017.07.013"},{"key":"i1552-5783-59-14-DES71-b93","doi-asserted-by":"crossref","unstructured":"Engel LA, Wittig S, Bock F, et al. Meibography and meibomian gland measurements in ocular graft-versus-host disease. Bone Marrow Transplant. 2015; 50: 961\u2013967.","DOI":"10.1038\/bmt.2015.72"},{"key":"i1552-5783-59-14-DES71-b94","doi-asserted-by":"crossref","unstructured":"Berchicci L, Iuliano L, Miserocchi E, Bandello F, Modorati G. Tear osmolarity in ocular graft-versus-host disease. Cornea. 2014; 33: 1252\u20131256.","DOI":"10.1097\/ICO.0000000000000283"},{"key":"i1552-5783-59-14-DES71-b95","doi-asserted-by":"crossref","unstructured":"Rapoport Y, Freeman T, Koyama T, et al. Validation of International Chronic Ocular Graft-Versus-Host Disease (GVHD) Group diagnostic criteria as a chronic ocular GVHD-specific metric. Cornea. 2017; 36: 258\u2013263.","DOI":"10.1097\/ICO.0000000000001109"},{"key":"i1552-5783-59-14-DES71-b96","doi-asserted-by":"crossref","unstructured":"He J, Ogawa Y, Mukai S, et al. In vivo confocal microscopy evaluation of ocular surface with graft-versus-host disease-related dry eye disease. Sci Rep. 2017; 7: 10720.","DOI":"10.1038\/s41598-017-10237-w"},{"key":"i1552-5783-59-14-DES71-b97","doi-asserted-by":"crossref","unstructured":"Tung CI. Current approaches to treatment of ocular graft-versus-host disease. Int Ophthalmol Clin. 2017; 57: 65\u201388.","DOI":"10.1097\/IIO.0000000000000167"},{"key":"i1552-5783-59-14-DES71-b98","doi-asserted-by":"crossref","unstructured":"Tepelus TC, Chiu GB, Maram J, et al. Corneal features in ocular graft-versus-host disease by in vivo confocal microscopy. Graefes Arch Clin Exp Ophthalmol. 2017; 255: 2389\u20132397.","DOI":"10.1007\/s00417-017-3759-x"},{"key":"i1552-5783-59-14-DES71-b99","doi-asserted-by":"crossref","unstructured":"Kheirkhah A, Qazi Y, Arnoldner MA, Suri K, Dana R. In vivo confocal microscopy in dry eye disease associated with chronic graft-versus-host disease. Invest Ophthalmol Vis Sci. 2016; 57: 4686\u20134691.","DOI":"10.1167\/iovs.16-20013"},{"key":"i1552-5783-59-14-DES71-b100","doi-asserted-by":"crossref","unstructured":"Inamoto Y, Sun YC, Flowers ME, et al. Bandage soft contact lenses for ocular graft-versus-host disease. Biol Blood Marrow Transplant. 2015; 21: 2002\u20132007.","DOI":"10.1016\/j.bbmt.2015.07.013"},{"key":"i1552-5783-59-14-DES71-b101","doi-asserted-by":"crossref","unstructured":"Hessen M, Akpek EK. Ocular graft-versus-host disease. Curr Opin Allergy Clin Immunol. 2012; 12: 540\u2013547.","DOI":"10.1097\/ACI.0b013e328357b4b9"},{"key":"i1552-5783-59-14-DES71-b102","doi-asserted-by":"crossref","unstructured":"Yamane M, Ogawa Y, Tsubota K. Long-term topical diquafosol tetrasodium treatment of dry eye disease caused by chronic graft-versus-host-disease: a retrospective study [ published ahead of print 12 26, 2017]. Eye Contact Lens. doi:10.1097\/ICL.0000000000000455.","DOI":"10.1097\/ICL.0000000000000455"},{"key":"i1552-5783-59-14-DES71-b103","doi-asserted-by":"crossref","unstructured":"Yaguchi S, Ogawa Y, Kamoi M, et al. Surgical management of lacrimal punctal cauterization in chronic GVHD-related dry eye with recurrent punctal plug extrusion. Bone Marrow Transplant. 2012; 47: 1465\u20131469.","DOI":"10.1038\/bmt.2012.50"},{"key":"i1552-5783-59-14-DES71-b104","doi-asserted-by":"crossref","unstructured":"Abud TB, Amparo F, Saboo US, et al. A clinical trial comparing the safety and efficacy of topical tacrolimus versus methylprednisolone in ocular graft-versus-host disease. Ophthalmology. 2016; 123: 1449\u20131457.","DOI":"10.1016\/j.ophtha.2016.02.044"},{"key":"i1552-5783-59-14-DES71-b105","doi-asserted-by":"crossref","unstructured":"Pflugfelder SC, de Paiva CS. The pathophysiology of dry eye disease: what we know and future directions for research. Ophthalmology. 2017; 124: S4\u2013S13.","DOI":"10.1016\/j.ophtha.2017.07.010"},{"key":"i1552-5783-59-14-DES71-b106","doi-asserted-by":"crossref","unstructured":"Amparo F, Dastjerdi MH, Okanobo A, et al. Topical interleukin 1 receptor antagonist for treatment of dry eye disease: a randomized clinical trial. JAMA Ophthalmol. 2013; 131: 715\u2013723.","DOI":"10.1001\/jamaophthalmol.2013.195"},{"key":"i1552-5783-59-14-DES71-b107","doi-asserted-by":"crossref","unstructured":"Darakhshan S, Pour AB. Tranilast: a review of its therapeutic applications. Pharmacol Res. 2015; 91: 15\u201328.","DOI":"10.1016\/j.phrs.2014.10.009"},{"key":"i1552-5783-59-14-DES71-b108","doi-asserted-by":"crossref","unstructured":"Hertenstein A, Schumacher T, Litzenburger U, et al. Suppression of human CD4+ T cell activation by 3, 4-dimethoxycinnamonyl-anthranilic acid (tranilast) is mediated by CXCL9 and CXCL10. Biochem Pharmacol. 2011; 82: 632\u2013641.","DOI":"10.1016\/j.bcp.2011.06.013"},{"key":"i1552-5783-59-14-DES71-b109","doi-asserted-by":"crossref","unstructured":"Suzawa H, Kikuchi S, Arai N, Koda A. The mechanism involved in the inhibitory action of tranilast on collagen biosynthesis of keloid fibroblasts. Jpn J Pharmacol. 1992; 60: 91\u201396.","DOI":"10.1254\/jjp.60.91"},{"key":"i1552-5783-59-14-DES71-b110","doi-asserted-by":"crossref","unstructured":"Suzawa H, Kikuchi S, Ichikawa K, Koda A. Inhibitory action of tranilast, an anti-allergic drug, on the release of cytokines and PGE2 from human monocytes-macrophages. Jpn J Pharmacol. 1992; 60: 85\u201390.","DOI":"10.1254\/jjp.60.85"},{"key":"i1552-5783-59-14-DES71-b111","doi-asserted-by":"crossref","unstructured":"Tan SM, Zhang Y, Cox AJ, Kelly DJ, Qi W. Tranilast attenuates the up-regulation of thioredoxin-interacting protein and oxidative stress in an experimental model of diabetic nephropathy. Nephrol Dial Transplant. 2011; 26: 100\u2013110.","DOI":"10.1093\/ndt\/gfq355"},{"key":"i1552-5783-59-14-DES71-b112","doi-asserted-by":"crossref","unstructured":"Ogawa Y, Dogru M, Uchino M, et al. Topical tranilast for treatment of the early stage of mild dry eye associated with chronic GVHD. Bone Marrow Transplant. 2010; 45: 565\u2013569.","DOI":"10.1038\/bmt.2009.173"},{"key":"i1552-5783-59-14-DES71-b113","doi-asserted-by":"crossref","unstructured":"Yamada H, Tajima S, Nishikawa T. Tranilast inhibits collagen synthesis in normal, scleroderma and keloid fibroblasts at a late passage culture but not at an early passage culture. J Dermatol Sci. 1995; 9: 45\u201347.","DOI":"10.1016\/0923-1811(94)00355-I"},{"key":"i1552-5783-59-14-DES71-b114","doi-asserted-by":"crossref","unstructured":"Yamane M, Ogawa Y, Fukui M, et al. Long-term rebamipide and diquafosol in two cases of immune-mediated dry eye. Optom Vis Sci. 2015; 92 (suppl 1): S25\u2013S32.","DOI":"10.1097\/OPX.0000000000000523"},{"key":"i1552-5783-59-14-DES71-b115","doi-asserted-by":"crossref","unstructured":"Kojima T, Higuchi A, Goto E, Matsumoto Y, Dogru M, Tsubota K. Autologous serum eyedrops for the treatment of dry eye diseases. Cornea. 2008; (suppl 1): S25\u201330.","DOI":"10.1097\/ICO.0b013e31817f3a0e"},{"key":"i1552-5783-59-14-DES71-b116","doi-asserted-by":"crossref","unstructured":"Rocha EM, Pelegrino FS, de Paiva CS, Vigorito AC, de Souza CA. GVHD dry eyes treated with autologous serum tears. Bone Marrow Transplant. 2000; 25: 1101\u20131103.","DOI":"10.1038\/sj.bmt.1702334"},{"key":"i1552-5783-59-14-DES71-b117","doi-asserted-by":"crossref","unstructured":"Chiang CC, Lin JM, Chen WL, et al. Allogeneic serum eyedrops for the treatment of severe dry eye in patients with chronic graft-versus-host disease. Cornea. 2007; 26: 861\u2013863.","DOI":"10.1097\/ICO.0b013e3180645cd7"},{"key":"i1552-5783-59-14-DES71-b118","doi-asserted-by":"crossref","unstructured":"Pezzotta S, Del Fante C, Scudeller L, et al. Long-term safety and efficacy of autologous platelet lysate drops for treatment of ocular GvHD. Bone Marrow Transplant. 2017; 52: 101\u2013106.","DOI":"10.1038\/bmt.2016.221"},{"key":"i1552-5783-59-14-DES71-b119","doi-asserted-by":"crossref","unstructured":"Miklos D, Cutler CS, Arora M, et al. Ibrutinib for chronic graft-versus-host disease after failure of prior therapy. Blood. 2017.","DOI":"10.1182\/blood-2017-07-793786"},{"key":"i1552-5783-59-14-DES71-b120","doi-asserted-by":"crossref","unstructured":"Perez RL, Perez-Simon JA, Caballero-Velazquez T, et al. Limbus damage in ocular graft-versus-host disease. Biol Blood Marrow Transplant. 2011; 17: 270\u2013273.","DOI":"10.1016\/j.bbmt.2010.08.008"},{"key":"i1552-5783-59-14-DES71-b121","doi-asserted-by":"crossref","unstructured":"Martinez-Carrasco R, Sanchez-Abarca LI, Nieto-Gomez C, et al. Assessment of dry eye in a GVHD murine model: approximation through tear osmolarity measurement. Exp Eye Res. 2017; 154: 64\u201369.","DOI":"10.1016\/j.exer.2016.11.004"},{"key":"i1552-5783-59-14-DES71-b122","doi-asserted-by":"crossref","unstructured":"Herretes S, Ross DB, Duffort S, et al. Recruitment of donor T cells to the eyes during ocular GVHD in recipients of MHC-matched allogeneic hematopoietic stem cell transplants. Invest Ophthalmol Vis Sci. 2015; 56: 2348\u20132357.","DOI":"10.1167\/iovs.14-15630"},{"key":"i1552-5783-59-14-DES71-b123","doi-asserted-by":"crossref","unstructured":"He J, Yamane M, Shibata S, et al. Ocular surface and tear film characteristics in a sclerodermatous chronic graft-versus-host disease mouse model. Cornea. 2018; 37: 486\u2013494.","DOI":"10.1097\/ICO.0000000000001487"},{"key":"i1552-5783-59-14-DES71-b124","doi-asserted-by":"crossref","unstructured":"Tseng SC. HC-HA\/PTX3 purified from amniotic membrane as novel regenerative matrix: insight into relationship between inflammation and regeneration. Invest Ophthalmol Vis Sci. 2016; 57: ORSFh1\u2013ORSFh8.","DOI":"10.1167\/iovs.15-17637"},{"key":"i1552-5783-59-14-DES71-b125","doi-asserted-by":"crossref","unstructured":"Mukai S, Ogawa Y, Urano F, Kudo-Saito C, Kawakami Y, Tsubota K. Novel treatment of chronic graft-versus-host disease in mice using the ER Stress reducer 4-phenylbutyric acid. Sci Rep. 2017; 7: 41939.","DOI":"10.1038\/srep41939"},{"key":"i1552-5783-59-14-DES71-b126","doi-asserted-by":"crossref","unstructured":"Mukai S, Ogawa Y, Kawakami Y, Mashima Y, Tsubota K. Inhibition of vascular adhesion protein-1 for treatment of graft-versus-host disease in mice. FASEB J. 2018; 2: 4085\u20134095.","DOI":"10.1096\/fj.201700176R"},{"key":"i1552-5783-59-14-DES71-b127","doi-asserted-by":"crossref","unstructured":"Yaguchi S, Ogawa Y, Shimmura S, et al. Angiotensin II type 1 receptor antagonist attenuates lacrimal gland, lung, and liver fibrosis in a murine model of chronic graft-versus-host disease. PLoS One. 2013; 8: e64724.","DOI":"10.1371\/journal.pone.0064724"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2717215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:01Z","timestamp":1791927061000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.17-23750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,27]]},"references-count":127,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2018,11,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.17-23750","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11,27]]}}}