{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:58:05Z","timestamp":1791928685074,"version":"4.3.4"},"reference-count":65,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"15","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"DOI":"10.1167\/iovs.18-23789","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T17:23:33Z","timestamp":1544117013000},"page":"5785","source":"Crossref","is-referenced-by-count":39,"title":["Epithelial-Mesenchymal Transdifferentiation in Pediatric Lens Epithelial Cells"],"prefix":"10.1167","volume":"59","author":[{"given":"Laura","family":"Wernecke","sequence":"first","affiliation":[{"name":"Experimental Ophthalmology, Department of Ophthalmology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"},{"name":"Department of Ophthalmology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Keckeis","sequence":"additional","affiliation":[{"name":"Experimental Ophthalmology, Department of Ophthalmology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Reichhart","sequence":"additional","affiliation":[{"name":"Experimental Ophthalmology, Department of Ophthalmology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Strau\u00df","sequence":"additional","affiliation":[{"name":"Experimental Ophthalmology, Department of Ophthalmology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Salchow","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","published-online":{"date-parts":[[2018,12,1]]},"reference":[{"key":"i1552-5783-59-15-5785-b01","doi-asserted-by":"crossref","unstructured":"Zetterstr\u00f6m\n\t\t\t\t\t\t\tC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLundvall\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKugelberg\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tCataracts in children.\n\t\t\t\t\tJ Cataract Refract Surg.\n\t\t\t\t\t2005;\n\t\t\t\t\t31:\n\t\t\t\t\t824\u2013840.","DOI":"10.1016\/j.jcrs.2005.01.012"},{"key":"i1552-5783-59-15-5785-b02","doi-asserted-by":"crossref","unstructured":"Trumler\n\t\t\t\t\t\t\tAA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tEvaluation of pediatric cataracts and systemic disorders.\n\t\t\t\t\tCurr Opin Ophthalmol.\n\t\t\t\t\t2011;\n\t\t\t\t\t22:\n\t\t\t\t\t365\u2013379.","DOI":"10.1097\/ICU.0b013e32834994dc"},{"key":"i1552-5783-59-15-5785-b03","doi-asserted-by":"crossref","unstructured":"Zetterstr\u00f6m\n\t\t\t\t\t\t\tC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKugelberg\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tPaediatric cataract surgery.\n\t\t\t\t\tActa Ophthalmol Scand.\n\t\t\t\t\t2007;\n\t\t\t\t\t85:\n\t\t\t\t\t698\u2013710.","DOI":"10.1111\/j.1600-0420.2007.01007.x"},{"key":"i1552-5783-59-15-5785-b04","doi-asserted-by":"crossref","unstructured":"Wirth\n\t\t\t\t\t\t\tMG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRussell-Eggitt\n\t\t\t\t\t\t\tIM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCraig\n\t\t\t\t\t\t\tJE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tElder\n\t\t\t\t\t\t\tJE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMackey\n\t\t\t\t\t\t\tDA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAetiology of congenital and paediatric cataract in an Australian population.\n\t\t\t\t\tBr J Ophthalmol.\n\t\t\t\t\t2002;\n\t\t\t\t\t86:\n\t\t\t\t\t782\u2013786.","DOI":"10.1136\/bjo.86.7.782"},{"key":"i1552-5783-59-15-5785-b05","doi-asserted-by":"crossref","unstructured":"Lim\n\t\t\t\t\t\t\tME,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBuckley\n\t\t\t\t\t\t\tEG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPrakalapakorn\n\t\t\t\t\t\t\tSG.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tUpdate on congenital cataract surgery management.\n\t\t\t\t\tCurr Opin Ophthalmol.\n\t\t\t\t\t2017;\n\t\t\t\t\t28:\n\t\t\t\t\t87\u201392.","DOI":"10.1097\/ICU.0000000000000324"},{"key":"i1552-5783-59-15-5785-b06","doi-asserted-by":"crossref","unstructured":"Apple\n\t\t\t\t\t\t\tDJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSolomon\n\t\t\t\t\t\t\tKD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTetz\n\t\t\t\t\t\t\tMR,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tPosterior capsule opacification.\n\t\t\t\t\tSurv Ophthalmol.\n\t\t\t\t\t1992;\n\t\t\t\t\t37:\n\t\t\t\t\t73\u2013116.","DOI":"10.1016\/0039-6257(92)90073-3"},{"key":"i1552-5783-59-15-5785-b07","doi-asserted-by":"crossref","unstructured":"Jensen\n\t\t\t\t\t\t\tAA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBasti\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGreenwald\n\t\t\t\t\t\t\tMJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMets\n\t\t\t\t\t\t\tMB.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tWhen may the posterior capsule be preserved in pediatric intraocular lens surgery?\n\t\t\t\t\tOphthalmology.\n\t\t\t\t\t2002;\n\t\t\t\t\t109:\n\t\t\t\t\t324\u2013327;\n\t\t\t\t\tdiscussion 328.","DOI":"10.1016\/S0161-6420(01)00950-2"},{"key":"i1552-5783-59-15-5785-b08","doi-asserted-by":"crossref","unstructured":"Plager\n\t\t\t\t\t\t\tDA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLynn\n\t\t\t\t\t\t\tMJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBuckley\n\t\t\t\t\t\t\tEG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWilson\n\t\t\t\t\t\t\tME,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLambert\n\t\t\t\t\t\t\tSR;\n\t\t\t\t\t\t\n\t\t\t\t\t\tInfant Aphakia Treatment Study Group.\n\t\t\t\t\t\n\t\t\t\t\tComplications, adverse events, and additional intraocular surgery 1 year after cataract surgery in the infant Aphakia Treatment Study.\n\t\t\t\t\tOphthalmology.\n\t\t\t\t\t2011;\n\t\t\t\t\t118:\n\t\t\t\t\t2330\u20132334.","DOI":"10.1016\/j.ophtha.2011.06.017"},{"key":"i1552-5783-59-15-5785-b09","doi-asserted-by":"crossref","unstructured":"Hager\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSchirra\n\t\t\t\t\t\t\tF,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSeitz\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tK\u00e4smann-Kellner\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tTreatment of pediatric cataracts. Part 2: IOL implantation, postoperative complications, aphakia management and postoperative development [in German].\n\t\t\t\t\tOphthalmologe.\n\t\t\t\t\t2013;\n\t\t\t\t\t110:\n\t\t\t\t\t179\u2013190.","DOI":"10.1007\/s00347-012-2755-0"},{"key":"i1552-5783-59-15-5785-b10","doi-asserted-by":"crossref","unstructured":"Whitman\n\t\t\t\t\t\t\tMC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVanderveen\n\t\t\t\t\t\t\tDK.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tComplications of pediatric cataract surgery.\n\t\t\t\t\tSemin Ophthalmol.\n\t\t\t\t\t2014;\n\t\t\t\t\t29:\n\t\t\t\t\t414\u2013420.","DOI":"10.3109\/08820538.2014.959192"},{"key":"i1552-5783-59-15-5785-b11","unstructured":"Medsinge\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNischal\n\t\t\t\t\t\t\tKK.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tPediatric cataract: challenges and future directions.\n\t\t\t\t\tClin Ophthalmol.\n\t\t\t\t\t2015;\n\t\t\t\t\t9:\n\t\t\t\t\t77\u201390."},{"key":"i1552-5783-59-15-5785-b12","doi-asserted-by":"crossref","unstructured":"Vasavada\n\t\t\t\t\t\t\tAR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPraveen\n\t\t\t\t\t\t\tMR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTassignon\n\t\t\t\t\t\t\tMJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tPosterior capsule management in congenital cataract surgery.\n\t\t\t\t\tJ Cataract Refract Surg.\n\t\t\t\t\t2011;\n\t\t\t\t\t37:\n\t\t\t\t\t173\u2013193.","DOI":"10.1016\/j.jcrs.2010.10.036"},{"key":"i1552-5783-59-15-5785-b13","doi-asserted-by":"crossref","unstructured":"Martinez\n\t\t\t\t\t\t\tG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tde Iongh\n\t\t\t\t\t\t\tRU.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tThe lens epithelium in ocular health and disease.\n\t\t\t\t\tInt J Biochem Cell Biol.\n\t\t\t\t\t2010;\n\t\t\t\t\t42:\n\t\t\t\t\t1945\u20131963.","DOI":"10.1016\/j.biocel.2010.09.012"},{"key":"i1552-5783-59-15-5785-b14","doi-asserted-by":"crossref","unstructured":"Nibourg\n\t\t\t\t\t\t\tLM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGelens\n\t\t\t\t\t\t\tE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKuijer\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHooymans\n\t\t\t\t\t\t\tJM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tvan Kooten\n\t\t\t\t\t\t\tTG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKoopmans\n\t\t\t\t\t\t\tSA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tPrevention of posterior capsular opacification.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2015;\n\t\t\t\t\t136:\n\t\t\t\t\t100\u2013115.","DOI":"10.1016\/j.exer.2015.03.011"},{"key":"i1552-5783-59-15-5785-b15","doi-asserted-by":"crossref","unstructured":"Wormstone\n\t\t\t\t\t\t\tIM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWang\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLiu\n\t\t\t\t\t\t\tCS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tPosterior capsule opacification.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2009;\n\t\t\t\t\t88:\n\t\t\t\t\t257\u2013269.","DOI":"10.1016\/j.exer.2008.10.016"},{"key":"i1552-5783-59-15-5785-b16","doi-asserted-by":"crossref","unstructured":"de Iongh\n\t\t\t\t\t\t\tRU,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWederell\n\t\t\t\t\t\t\tE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLovicu\n\t\t\t\t\t\t\tFJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMcAvoy\n\t\t\t\t\t\t\tJW.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tTransforming growth factor-beta-induced epithelial-mesenchymal transition in the lens: a model for cataract formation.\n\t\t\t\t\tCells Tissues Organs.\n\t\t\t\t\t2005;\n\t\t\t\t\t179:\n\t\t\t\t\t43\u201355.","DOI":"10.1159\/000084508"},{"key":"i1552-5783-59-15-5785-b17","doi-asserted-by":"crossref","unstructured":"Saika\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tTGFbeta pathobiology in the eye.\n\t\t\t\t\tLab Invest.\n\t\t\t\t\t2006;\n\t\t\t\t\t86:\n\t\t\t\t\t106\u2013115.","DOI":"10.1038\/labinvest.3700375"},{"key":"i1552-5783-59-15-5785-b18","unstructured":"Gordon-Thomson\n\t\t\t\t\t\t\tC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tde Iongh\n\t\t\t\t\t\t\tRU,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHales\n\t\t\t\t\t\t\tAM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChamberlain\n\t\t\t\t\t\t\tCG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMcAvoy\n\t\t\t\t\t\t\tJW.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tDifferential cataractogenic potency of TGF-beta1, -beta2, and -beta3 and their expression in the postnatal rat eye.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t1998;\n\t\t\t\t\t39:\n\t\t\t\t\t1399\u20131409."},{"key":"i1552-5783-59-15-5785-b19","doi-asserted-by":"crossref","unstructured":"Saika\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYamanaka\n\t\t\t\t\t\t\tO,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSumioka\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tFibrotic disorders in the eye: targets of gene therapy.\n\t\t\t\t\tProg Retin Eye Res.\n\t\t\t\t\t2008;\n\t\t\t\t\t27:\n\t\t\t\t\t177\u2013196.","DOI":"10.1016\/j.preteyeres.2007.12.002"},{"key":"i1552-5783-59-15-5785-b20","doi-asserted-by":"crossref","unstructured":"Walker\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMenko\n\t\t\t\t\t\t\tAS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tIntegrins in lens development and disease.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2009;\n\t\t\t\t\t88:\n\t\t\t\t\t216\u2013225.","DOI":"10.1016\/j.exer.2008.06.020"},{"key":"i1552-5783-59-15-5785-b21","doi-asserted-by":"crossref","unstructured":"Sponer\n\t\t\t\t\t\t\tU,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPieh\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSoleiman\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSkorpik\n\t\t\t\t\t\t\tC.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tUpregulation of alphavbeta6 integrin, a potent TGF-beta1 activator, and posterior capsule opacification.\n\t\t\t\t\tJ Cataract Refract Surg.\n\t\t\t\t\t2005;\n\t\t\t\t\t31:\n\t\t\t\t\t595\u2013606.","DOI":"10.1016\/j.jcrs.2004.05.058"},{"key":"i1552-5783-59-15-5785-b22","doi-asserted-by":"crossref","unstructured":"Todorovic\n\t\t\t\t\t\t\tV,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJurukovski\n\t\t\t\t\t\t\tV,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChen\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFontana\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDabovic\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRifkin\n\t\t\t\t\t\t\tDB.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tLatent TGF-beta binding proteins.\n\t\t\t\t\tInt J Biochem Cell Biol.\n\t\t\t\t\t2005;\n\t\t\t\t\t37:\n\t\t\t\t\t38\u201341.","DOI":"10.1016\/j.biocel.2004.03.011"},{"key":"i1552-5783-59-15-5785-b23","unstructured":"Liu\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHales\n\t\t\t\t\t\t\tAM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChamberlain\n\t\t\t\t\t\t\tCG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMcAvoy\n\t\t\t\t\t\t\tJW.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tInduction of cataract-like changes in rat lens epithelial explants by transforming growth factor beta.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t1994;\n\t\t\t\t\t35:\n\t\t\t\t\t388\u2013401."},{"key":"i1552-5783-59-15-5785-b24","unstructured":"Hales\n\t\t\t\t\t\t\tAM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChamberlain\n\t\t\t\t\t\t\tCG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMcAvoy\n\t\t\t\t\t\t\tJW.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tSusceptibility to TGFbeta2-induced cataract increases with aging in the rat.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2000;\n\t\t\t\t\t41:\n\t\t\t\t\t3544\u20133551."},{"key":"i1552-5783-59-15-5785-b25","unstructured":"Wormstone\n\t\t\t\t\t\t\tIM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTamiya\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAnderson\n\t\t\t\t\t\t\tI,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDuncan\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tTGF-beta2-induced matrix modification and cell transdifferentiation in the human lens capsular bag.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2002;\n\t\t\t\t\t43:\n\t\t\t\t\t2301\u20132308."},{"key":"i1552-5783-59-15-5785-b26","doi-asserted-by":"crossref","unstructured":"Wormstone\n\t\t\t\t\t\t\tIM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTamiya\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEldred\n\t\t\t\t\t\t\tJA,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tCharacterisation of TGF-beta2 signalling and function in a human lens cell line.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2004;\n\t\t\t\t\t78:\n\t\t\t\t\t705\u2013714.","DOI":"10.1016\/j.exer.2003.08.006"},{"key":"i1552-5783-59-15-5785-b27","doi-asserted-by":"crossref","unstructured":"Li\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTang\n\t\t\t\t\t\t\tX,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChen\n\t\t\t\t\t\t\tX.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tComparative effects of TGF-\u00df2\/Smad2 and TGF-\u00df2\/Smad3 signaling pathways on proliferation, migration, and extracellular matrix production in a human lens cell line.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2011;\n\t\t\t\t\t92:\n\t\t\t\t\t173\u2013179.","DOI":"10.1016\/j.exer.2011.01.009"},{"key":"i1552-5783-59-15-5785-b28","doi-asserted-by":"crossref","unstructured":"Lin\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOuyang\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZhu\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tLens regeneration using endogenous stem cells with gain of visual function.\n\t\t\t\t\tNature.\n\t\t\t\t\t2016;\n\t\t\t\t\t531:\n\t\t\t\t\t323\u2013328.","DOI":"10.1038\/nature17181"},{"key":"i1552-5783-59-15-5785-b29","doi-asserted-by":"crossref","unstructured":"Ibaraki\n\t\t\t\t\t\t\tN.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tHuman lens epithelial cell culture.\n\t\t\t\t\tMethods Mol Biol.\n\t\t\t\t\t2002;\n\t\t\t\t\t188:\n\t\t\t\t\t1\u20136.","DOI":"10.1385\/1-59259-185-X:01"},{"key":"i1552-5783-59-15-5785-b30","unstructured":"Andley\n\t\t\t\t\t\t\tUP,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRhim\n\t\t\t\t\t\t\tJS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChylack\n\t\t\t\t\t\t\tLT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFleming\n\t\t\t\t\t\t\tTP.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tPropagation and immortalization of human lens epithelial cells in culture.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t1994;\n\t\t\t\t\t35:\n\t\t\t\t\t3094\u20133102."},{"key":"i1552-5783-59-15-5785-b31","unstructured":"Ibaraki\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLin\n\t\t\t\t\t\t\tLR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tReddy\n\t\t\t\t\t\t\tVN.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tEffects of growth factors on proliferation and differentiation in human lens epithelial cells in early subculture.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t1995;\n\t\t\t\t\t36:\n\t\t\t\t\t2304\u20132312."},{"key":"i1552-5783-59-15-5785-b32","doi-asserted-by":"crossref","unstructured":"Power\n\t\t\t\t\t\t\tW,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNeylan\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCollum\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tGrowth characteristics of human lens epithelial cells in culture. Effect of media and donor age.\n\t\t\t\t\tDoc Ophthalmol.\n\t\t\t\t\t1993;\n\t\t\t\t\t84:\n\t\t\t\t\t365\u2013372.","DOI":"10.1007\/BF01215450"},{"key":"i1552-5783-59-15-5785-b33","unstructured":"Liu\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFeng\n\t\t\t\t\t\t\tG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWu\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tThe effects of rapamycin on lens epithelial cell proliferation, migration, and matrix formation: an in vitro study.\n\t\t\t\t\tMol Vis.\n\t\t\t\t\t2010;\n\t\t\t\t\t16:\n\t\t\t\t\t1646\u20131653."},{"key":"i1552-5783-59-15-5785-b34","unstructured":"Liu\n\t\t\t\t\t\t\tCS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWormstone\n\t\t\t\t\t\t\tIM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDuncan\n\t\t\t\t\t\t\tG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMarcantonio\n\t\t\t\t\t\t\tJM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWebb\n\t\t\t\t\t\t\tSF,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDavies\n\t\t\t\t\t\t\tPD.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tA study of human lens cell growth in vitro. A model for posterior capsule opacification.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t1996;\n\t\t\t\t\t37:\n\t\t\t\t\t906\u2013914."},{"key":"i1552-5783-59-15-5785-b35","doi-asserted-by":"crossref","unstructured":"Kubo\n\t\t\t\t\t\t\tE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tShibata\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tShibata\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKiyokawa\n\t\t\t\t\t\t\tE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSasaki\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSingh\n\t\t\t\t\t\t\tDP.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tFGF2 antagonizes aberrant TGF\u00df regulation of tropomyosin: role for posterior capsule opacity.\n\t\t\t\t\tJ Cell Mol Med.\n\t\t\t\t\t2017;\n\t\t\t\t\t21:\n\t\t\t\t\t916\u2013928.","DOI":"10.1111\/jcmm.13030"},{"key":"i1552-5783-59-15-5785-b36","doi-asserted-by":"crossref","unstructured":"Schmittgen\n\t\t\t\t\t\t\tTD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLivak\n\t\t\t\t\t\t\tKJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAnalyzing real-time PCR data by the comparative C(T) method.\n\t\t\t\t\tNat Protoc.\n\t\t\t\t\t2008;\n\t\t\t\t\t3:\n\t\t\t\t\t1101\u20131108.","DOI":"10.1038\/nprot.2008.73"},{"key":"i1552-5783-59-15-5785-b37","doi-asserted-by":"crossref","unstructured":"McCloy\n\t\t\t\t\t\t\tRA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRogers\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCaldon\n\t\t\t\t\t\t\tCE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLorca\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCastro\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBurgess\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tPartial inhibition of Cdk1 in G 2 phase overrides the SAC and decouples mitotic events.\n\t\t\t\t\tCell Cycle.\n\t\t\t\t\t2014;\n\t\t\t\t\t13:\n\t\t\t\t\t1400\u20131412.","DOI":"10.4161\/cc.28401"},{"key":"i1552-5783-59-15-5785-b38","doi-asserted-by":"crossref","unstructured":"Rueden\n\t\t\t\t\t\t\tCT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSchindelin\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHiner\n\t\t\t\t\t\t\tMC,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tImageJ2: ImageJ for the next generation of scientific image data.\n\t\t\t\t\tBMC Bioinformatics.\n\t\t\t\t\t2017;\n\t\t\t\t\t18:\n\t\t\t\t\t529.","DOI":"10.1186\/s12859-017-1934-z"},{"key":"i1552-5783-59-15-5785-b39","doi-asserted-by":"crossref","unstructured":"Lambert\n\t\t\t\t\t\t\tSR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDrack\n\t\t\t\t\t\t\tAV.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tInfantile cataracts.\n\t\t\t\t\tSurv Ophthalmol.\n\t\t\t\t\t1996;\n\t\t\t\t\t40:\n\t\t\t\t\t427\u2013458.","DOI":"10.1016\/S0039-6257(96)82011-X"},{"key":"i1552-5783-59-15-5785-b40","doi-asserted-by":"crossref","unstructured":"Wormstone\n\t\t\t\t\t\t\tIM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEldred\n\t\t\t\t\t\t\tJA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tExperimental models for posterior capsule opacification research.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2016;\n\t\t\t\t\t142:\n\t\t\t\t\t2\u201312.","DOI":"10.1016\/j.exer.2015.04.021"},{"key":"i1552-5783-59-15-5785-b41","doi-asserted-by":"crossref","unstructured":"Xu\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLamouille\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDerynck\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tTGF-beta-induced epithelial to mesenchymal transition.\n\t\t\t\t\tCell Res.\n\t\t\t\t\t2009;\n\t\t\t\t\t19:\n\t\t\t\t\t156\u2013172.","DOI":"10.1038\/cr.2009.5"},{"key":"i1552-5783-59-15-5785-b42","doi-asserted-by":"crossref","unstructured":"Lamouille\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tXu\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDerynck\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tMolecular mechanisms of epithelial-mesenchymal transition.\n\t\t\t\t\tNat Rev Mol Cell Biol.\n\t\t\t\t\t2014;\n\t\t\t\t\t15:\n\t\t\t\t\t178\u2013196.","DOI":"10.1038\/nrm3758"},{"key":"i1552-5783-59-15-5785-b43","doi-asserted-by":"crossref","unstructured":"Zhang\n\t\t\t\t\t\t\tYE.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tNon-Smad pathways in TGF-beta signaling.\n\t\t\t\t\tCell Res.\n\t\t\t\t\t2009;\n\t\t\t\t\t19:\n\t\t\t\t\t128\u2013139.","DOI":"10.1038\/cr.2008.328"},{"key":"i1552-5783-59-15-5785-b44","doi-asserted-by":"crossref","unstructured":"Lovicu\n\t\t\t\t\t\t\tFJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSchulz\n\t\t\t\t\t\t\tMW,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHales\n\t\t\t\t\t\t\tAM,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tTGFbeta induces morphological and molecular changes similar to human anterior subcapsular cataract.\n\t\t\t\t\tBr J Ophthalmol.\n\t\t\t\t\t2002;\n\t\t\t\t\t86:\n\t\t\t\t\t220\u2013226.","DOI":"10.1136\/bjo.86.2.220"},{"key":"i1552-5783-59-15-5785-b45","doi-asserted-by":"crossref","unstructured":"Gotoh\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPerdue\n\t\t\t\t\t\t\tNR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMatsushima\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSage\n\t\t\t\t\t\t\tEH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYan\n\t\t\t\t\t\t\tQ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tClark\n\t\t\t\t\t\t\tJI.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAn in vitro model of posterior capsular opacity: SPARC and TGF-beta2 minimize epithelial-to-mesenchymal transition in lens epithelium.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2007;\n\t\t\t\t\t48:\n\t\t\t\t\t4679\u20134687.","DOI":"10.1167\/iovs.07-0091"},{"key":"i1552-5783-59-15-5785-b46","unstructured":"Lee\n\t\t\t\t\t\t\tEH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJoo\n\t\t\t\t\t\t\tCK.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tRole of transforming growth factor-beta in transdifferentiation and fibrosis of lens epithelial cells.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t1999;\n\t\t\t\t\t40:\n\t\t\t\t\t2025\u20132032."},{"key":"i1552-5783-59-15-5785-b47","doi-asserted-by":"crossref","unstructured":"Fontana\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChen\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPrijatelj\n\t\t\t\t\t\t\tP,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tFibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1.\n\t\t\t\t\tFASEB J.\n\t\t\t\t\t2005;\n\t\t\t\t\t19:\n\t\t\t\t\t1798\u20131808.","DOI":"10.1096\/fj.05-4134com"},{"key":"i1552-5783-59-15-5785-b48","unstructured":"Olivero\n\t\t\t\t\t\t\tDK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFurcht\n\t\t\t\t\t\t\tLT.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tType IV collagen, laminin, and fibronectin promote the adhesion and migration of rabbit lens epithelial cells in vitro.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t1993;\n\t\t\t\t\t34:\n\t\t\t\t\t2825\u20132834."},{"key":"i1552-5783-59-15-5785-b49","doi-asserted-by":"crossref","unstructured":"Johar\n\t\t\t\t\t\t\tK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVasavada\n\t\t\t\t\t\t\tAR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTatsumi\n\t\t\t\t\t\t\tK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDholakia\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNihalani\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRao\n\t\t\t\t\t\t\tSS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAnterior capsular plaque in congenital cataract: occurrence, morphology, immunofluorescence, and ultrastructure.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2007;\n\t\t\t\t\t48:\n\t\t\t\t\t4209\u20134214.","DOI":"10.1167\/iovs.07-0312"},{"key":"i1552-5783-59-15-5785-b50","doi-asserted-by":"crossref","unstructured":"Asano\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tIhn\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYamane\n\t\t\t\t\t\t\tK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJinnin\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMimura\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTamaki\n\t\t\t\t\t\t\tK.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tPhosphatidylinositol 3-kinase is involved in alpha2(I) collagen gene expression in normal and scleroderma fibroblasts.\n\t\t\t\t\tJ Immunol.\n\t\t\t\t\t2004;\n\t\t\t\t\t172:\n\t\t\t\t\t7123\u20137135.","DOI":"10.4049\/jimmunol.172.11.7123"},{"key":"i1552-5783-59-15-5785-b51","doi-asserted-by":"crossref","unstructured":"Ramirez\n\t\t\t\t\t\t\tF,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTanaka\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBou-Gharios\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tTranscriptional regulation of the human alpha2(I) collagen gene (COL1A2), an informative model system to study fibrotic diseases.\n\t\t\t\t\tMatrix Biol.\n\t\t\t\t\t2006;\n\t\t\t\t\t25:\n\t\t\t\t\t365\u2013372.","DOI":"10.1016\/j.matbio.2006.05.002"},{"key":"i1552-5783-59-15-5785-b52","doi-asserted-by":"crossref","unstructured":"Raghavan\n\t\t\t\t\t\t\tCT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSmuda\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSmith\n\t\t\t\t\t\t\tAJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tAGEs in human lens capsule promote the TGF\u00df2-mediated EMT of lens epithelial cells: implications for age-associated fibrosis.\n\t\t\t\t\tAging Cell.\n\t\t\t\t\t2016;\n\t\t\t\t\t15:\n\t\t\t\t\t465\u2013476.","DOI":"10.1111\/acel.12450"},{"key":"i1552-5783-59-15-5785-b53","unstructured":"Nagamoto\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEguchi\n\t\t\t\t\t\t\tG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBeebe\n\t\t\t\t\t\t\tDC.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAlpha-smooth muscle actin expression in cultured lens epithelial cells.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2000;\n\t\t\t\t\t41:\n\t\t\t\t\t1122\u20131129."},{"key":"i1552-5783-59-15-5785-b54","unstructured":"Jong-Hesse\n\t\t\t\t\t\t\tYD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLang\n\t\t\t\t\t\t\tGK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKampmeier\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLang\n\t\t\t\t\t\t\tGE.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tEffect of growth factors on the differentiation of porcine lens epithelial cells [in German].\n\t\t\t\t\tKlin Monbl Augenheilkd.\n\t\t\t\t\t2004;\n\t\t\t\t\t221:\n\t\t\t\t\t175\u2013179."},{"key":"i1552-5783-59-15-5785-b55","doi-asserted-by":"crossref","unstructured":"Xiao\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZhao\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGao\n\t\t\t\t\t\t\tZ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPan\n\t\t\t\t\t\t\tQ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tOveraccumulation of transforming growth factor-beta1 and basic fibroblast growth factor in lens epithelial cells of congenital cataract.\n\t\t\t\t\tCan J Ophthalmol.\n\t\t\t\t\t2009;\n\t\t\t\t\t44:\n\t\t\t\t\t189\u2013192.","DOI":"10.3129\/i09-006"},{"key":"i1552-5783-59-15-5785-b56","unstructured":"Banasiak\n\t\t\t\t\t\t\tP,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tStrzalka-Mrozik\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tForminska-Kapuscik\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tQuantitative relationships between transforming growth factor beta mRNA isoforms in congenital and traumatic cataracts.\n\t\t\t\t\tMol Vis.\n\t\t\t\t\t2011;\n\t\t\t\t\t17:\n\t\t\t\t\t3025\u20133033."},{"key":"i1552-5783-59-15-5785-b57","doi-asserted-by":"crossref","unstructured":"Saika\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMiyamoto\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tIshida\n\t\t\t\t\t\t\tI,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tTGFbeta-Smad signalling in postoperative human lens epithelial cells.\n\t\t\t\t\tBr J Ophthalmol.\n\t\t\t\t\t2002;\n\t\t\t\t\t86:\n\t\t\t\t\t1428\u20131433.","DOI":"10.1136\/bjo.86.12.1428"},{"key":"i1552-5783-59-15-5785-b58","doi-asserted-by":"crossref","unstructured":"Bustin\n\t\t\t\t\t\t\tSA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tQuantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems.\n\t\t\t\t\tJ Mol Endocrinol.\n\t\t\t\t\t2002;\n\t\t\t\t\t29:\n\t\t\t\t\t23\u201339.","DOI":"10.1677\/jme.0.0290023"},{"key":"i1552-5783-59-15-5785-b59","doi-asserted-by":"crossref","unstructured":"Valasek\n\t\t\t\t\t\t\tMA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRepa\n\t\t\t\t\t\t\tJJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tThe power of real-time PCR.\n\t\t\t\t\tAdv Physiol Educ.\n\t\t\t\t\t2005;\n\t\t\t\t\t29:\n\t\t\t\t\t151\u2013159.","DOI":"10.1152\/advan.00019.2005"},{"key":"i1552-5783-59-15-5785-b60","doi-asserted-by":"crossref","unstructured":"Andley\n\t\t\t\t\t\t\tUP.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tEffects of alpha-crystallin on lens cell function and cataract pathology.\n\t\t\t\t\tCurr Mol Med.\n\t\t\t\t\t2009;\n\t\t\t\t\t9:\n\t\t\t\t\t887\u2013892.","DOI":"10.2174\/156652409789105598"},{"key":"i1552-5783-59-15-5785-b61","doi-asserted-by":"crossref","unstructured":"Horwitz\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBova\n\t\t\t\t\t\t\tMP,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDing\n\t\t\t\t\t\t\tLL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHaley\n\t\t\t\t\t\t\tDA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tStewart\n\t\t\t\t\t\t\tPL.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tLens alpha-crystallin: function and structure.\n\t\t\t\t\tEye (Lond).\n\t\t\t\t\t1999;\n\t\t\t\t\t13:\n\t\t\t\t\t403\u2013408.","DOI":"10.1038\/eye.1999.114"},{"key":"i1552-5783-59-15-5785-b62","doi-asserted-by":"crossref","unstructured":"Nahomi\n\t\t\t\t\t\t\tRB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPantcheva\n\t\t\t\t\t\t\tMB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNagaraj\n\t\t\t\t\t\t\tRH.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\taB-crystallin is essential for the TGF-\u00df2-mediated epithelial to mesenchymal transition of lens epithelial cells.\n\t\t\t\t\tBiochem J.\n\t\t\t\t\t2016;\n\t\t\t\t\t473:\n\t\t\t\t\t1455\u20131469.","DOI":"10.1042\/BCJ20160128"},{"key":"i1552-5783-59-15-5785-b63","doi-asserted-by":"crossref","unstructured":"Liu\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKe\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWang\n\t\t\t\t\t\t\tZ,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tIdentification of a CRYAB mutation associated with autosomal dominant posterior polar cataract in a Chinese family.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2006;\n\t\t\t\t\t47:\n\t\t\t\t\t3461\u20133466.","DOI":"10.1167\/iovs.05-1438"},{"key":"i1552-5783-59-15-5785-b64","doi-asserted-by":"crossref","unstructured":"Bellaye\n\t\t\t\t\t\t\tPS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWettstein\n\t\t\t\t\t\t\tG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBurgy\n\t\t\t\t\t\t\tO,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tThe small heat-shock protein aB-crystallin is essential for the nuclear localization of Smad4: impact on pulmonary fibrosis.\n\t\t\t\t\tJ Pathol.\n\t\t\t\t\t2014;\n\t\t\t\t\t232:\n\t\t\t\t\t458\u2013472.","DOI":"10.1002\/path.4314"},{"key":"i1552-5783-59-15-5785-b65","doi-asserted-by":"crossref","unstructured":"Andley\n\t\t\t\t\t\t\tUP.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tCrystallins in the eye: function and pathology.\n\t\t\t\t\tProg Retin Eye Res.\n\t\t\t\t\t2007;\n\t\t\t\t\t26:\n\t\t\t\t\t78\u201398.","DOI":"10.1016\/j.preteyeres.2006.10.003"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2718276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:00Z","timestamp":1791927060000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.18-23789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,1]]},"references-count":65,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2018,12,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.18-23789","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12,1]]}}}