{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:57:56Z","timestamp":1791928676307,"version":"4.3.4"},"reference-count":62,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"10","license":[{"start":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T00:00:00Z","timestamp":1534809600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2018,8,21]]},"DOI":"10.1167\/iovs.18-24037","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T12:32:23Z","timestamp":1533904343000},"page":"4082","source":"Crossref","is-referenced-by-count":19,"title":["Differential Distribution of Laminin N-Terminus \u03b131 Across the Ocular Surface: Implications for Corneal Wound Repair"],"prefix":"10.1167","volume":"59","author":[{"given":"Valentina","family":"Barrera","sequence":"first","affiliation":[{"name":"Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee D.","family":"Troughton","sequence":"additional","affiliation":[{"name":"Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Iorio","sequence":"additional","affiliation":[{"name":"Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olutobi","family":"Oyewole","sequence":"additional","affiliation":[{"name":"Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl M.","family":"Sheridan","sequence":"additional","affiliation":[{"name":"Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Hamill","sequence":"additional","affiliation":[{"name":"Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-59-10-4082-b01","doi-asserted-by":"crossref","unstructured":"Hamill KJ, Langbein L, Jones JC, McLean WH. Identification of a novel family of laminin N-terminal alternate splice isoforms: structural and functional characterization. J Biol Chem. 2009; 284: 35588\u201335596.","DOI":"10.1074\/jbc.M109.052811"},{"key":"i1552-5783-59-10-4082-b02","doi-asserted-by":"crossref","unstructured":"Bystrom B, Virtanen I, Rousselle P, Gullberg D, Pedrosa-Domellof F. Distribution of laminins in the developing human eye. Invest Ophthalmol Vis Sci. 2006; 47: 777\u2013785.","DOI":"10.1167\/iovs.05-0367"},{"key":"i1552-5783-59-10-4082-b03","doi-asserted-by":"crossref","unstructured":"Kabosova A, Azar DT, Bannikov GA, et al. Compositional differences between infant and adult human corneal basement membranes. Invest Ophthalmol Vis Sci. 2007; 48: 4989\u20134999.","DOI":"10.1167\/iovs.07-0654"},{"key":"i1552-5783-59-10-4082-b04","doi-asserted-by":"crossref","unstructured":"Ljubimov AV, Burgeson RE, Butkowski RJ, et al. Basement membrane abnormalities in human eyes with diabetic retinopathy. J Histochem Cytochem. 1996; 44: 1469\u20131479.","DOI":"10.1177\/44.12.8985139"},{"key":"i1552-5783-59-10-4082-b05","unstructured":"Ljubimov AV, Burgeson RE, Butkowski RJ, Michael AF, Sun TT, Kenney MC. Human corneal basement membrane heterogeneity: topographical differences in the expression of type IV collagen and laminin isoforms. Lab Invest. 1995; 72: 461\u2013473."},{"key":"i1552-5783-59-10-4082-b06","doi-asserted-by":"crossref","unstructured":"Pal-Ghosh S, Pajoohesh-Ganji A, Tadvalkar G, Stepp MA. Removal of the basement membrane enhances corneal wound healing. Exp Eye Res. 2011; 93: 927\u2013936.","DOI":"10.1016\/j.exer.2011.10.012"},{"key":"i1552-5783-59-10-4082-b07","doi-asserted-by":"crossref","unstructured":"Schlotzer-Schrehardt U, Dietrich T, Saito K, et al. Characterization of extracellular matrix components in the limbal epithelial stem cell compartment. Exp Eye Res. 2007; 85: 845\u2013860.","DOI":"10.1016\/j.exer.2007.08.020"},{"key":"i1552-5783-59-10-4082-b08","doi-asserted-by":"crossref","unstructured":"Hamill KJ, Kligys K, Hopkinson SB, Jones JC. Laminin deposition in the extracellular matrix: a complex picture emerges. J Cell Sci. 2009; 122: 4409\u20134417.","DOI":"10.1242\/jcs.041095"},{"key":"i1552-5783-59-10-4082-b09","doi-asserted-by":"crossref","unstructured":"Aumailley M. The laminin family. Cell Adh Migr. 2013; 7: 48\u201355.","DOI":"10.4161\/cam.22826"},{"key":"i1552-5783-59-10-4082-b10","doi-asserted-by":"crossref","unstructured":"Hohenester E, Yurchenco PD. Laminins in basement membrane assembly. Cell Adh Migr. 2013; 7: 56\u201363.","DOI":"10.4161\/cam.21831"},{"key":"i1552-5783-59-10-4082-b11","doi-asserted-by":"crossref","unstructured":"Radisky DC. Function following form: functional differentiation of mammary epithelial cells requires laminin-induced polarization of PI3-kinase. Cell Cycle. 2011; 10: 15.","DOI":"10.4161\/cc.10.1.14218"},{"key":"i1552-5783-59-10-4082-b12","doi-asserted-by":"crossref","unstructured":"Kikkawa Y, Kataoka A, Matsuda Y, et al. Maintenance of hepatic differentiation by hepatocyte attachment peptides derived from laminin chains. J Biomed Mater Res A. 2011; 99: 203\u2013210.","DOI":"10.1002\/jbm.a.33176"},{"key":"i1552-5783-59-10-4082-b13","doi-asserted-by":"crossref","unstructured":"Akerlund M, Carmignac V, Scheele S, Durbeej M. Laminin alpha1 domains LG4-5 are essential for the complete differentiation of visceral endoderm. Cell Tissue Res. 2009; 338: 129\u2013137.","DOI":"10.1007\/s00441-009-0845-3"},{"key":"i1552-5783-59-10-4082-b14","doi-asserted-by":"crossref","unstructured":"van Dijk A, Niessen HW, Zandieh Doulabi B, Visser FC, van Milligen FJ. Differentiation of human adipose-derived stem cells towards cardiomyocytes is facilitated by laminin. Cell Tissue Res. 2008; 334: 457\u2013467.","DOI":"10.1007\/s00441-008-0713-6"},{"key":"i1552-5783-59-10-4082-b15","doi-asserted-by":"crossref","unstructured":"Hashimoto J, Ogawa T, Tsubota Y, Miyazaki K. Laminin-5 suppresses chondrogenic differentiation of murine teratocarcinoma cell line ATDC5. Exp Cell Res. 2005; 310: 256\u2013269.","DOI":"10.1016\/j.yexcr.2005.07.025"},{"key":"i1552-5783-59-10-4082-b16","doi-asserted-by":"crossref","unstructured":"Chen ZL, Strickland S. Laminin gamma1 is critical for Schwann cell differentiation, axon myelination, and regeneration in the peripheral nerve. J Cell Biol. 2003; 163: 889\u2013899.","DOI":"10.1083\/jcb.200307068"},{"key":"i1552-5783-59-10-4082-b17","doi-asserted-by":"crossref","unstructured":"Okumura N, Kakutani K, Numata R, et al. Laminin-511 and -521 enable efficient in vitro expansion of human corneal endothelial cells. Invest Ophthalmol Vis Sci. 2015; 56: 2933\u20132942.","DOI":"10.1167\/iovs.14-15163"},{"key":"i1552-5783-59-10-4082-b18","doi-asserted-by":"crossref","unstructured":"Polisetti N, Sorokin L, Okumura N, et al. Laminin-511 and -521-based matrices for efficient ex vivo-expansion of human limbal epithelial progenitor cells. Sci Rep. 2017; 7: 5152.","DOI":"10.1038\/s41598-017-04916-x"},{"key":"i1552-5783-59-10-4082-b19","doi-asserted-by":"crossref","unstructured":"Ryan MC, Tizard R, VanDevanter DR, Carter WG. Cloning of the LamA3 gene encoding the alpha 3 chain of the adhesive ligand epiligrin. Expression in wound repair. J Biol Chem. 1994; 269: 22779\u201322787.","DOI":"10.1016\/S0021-9258(17)31713-1"},{"key":"i1552-5783-59-10-4082-b20","doi-asserted-by":"crossref","unstructured":"Ferrigno O, Virolle T, Galliano MF, et al. Murine laminin alpha3A and alpha3B isoform chains are generated by usage of two promoters and alternative splicing. J Biol Chem. 1997; 272: 20502\u201320507.","DOI":"10.1074\/jbc.272.33.20502"},{"key":"i1552-5783-59-10-4082-b21","doi-asserted-by":"crossref","unstructured":"Figueira EC, Murrell DF, Coroneo MT. Ophthalmic involvement in inherited epidermolysis bullosa. Dermatol Clin. 2010; 28: 143\u2013152.","DOI":"10.1016\/j.det.2009.10.021"},{"key":"i1552-5783-59-10-4082-b22","doi-asserted-by":"crossref","unstructured":"Hammerton ME, Turner TW, Pyne RJ. A case of junctional epidermolysis bullosa (Herlitz-Pearson) with corneal bullae. Aust J Ophthalmol. 1984; 12: 45\u201348.","DOI":"10.1111\/j.1442-9071.1984.tb01123.x"},{"key":"i1552-5783-59-10-4082-b23","doi-asserted-by":"crossref","unstructured":"Kirtschig G, Marinkovich MP, Burgeson RE, Yancey KB. Anti-basement membrane autoantibodies in patients with anti-epiligrin cicatricial pemphigoid bind the alpha subunit of laminin 5. J Invest Dermatol. 1995; 105: 543\u2013548.","DOI":"10.1111\/1523-1747.ep12323431"},{"key":"i1552-5783-59-10-4082-b24","doi-asserted-by":"crossref","unstructured":"Lazarova Z, Yee C, Lazar J, Yancey KB. IgG autoantibodies in patients with anti-epiligrin cicatricial pemphigoid recognize the G domain of the laminin 5 alpha-subunit. Clin Immunol. 2001; 101: 100\u2013105.","DOI":"10.1006\/clim.2001.5091"},{"key":"i1552-5783-59-10-4082-b25","doi-asserted-by":"crossref","unstructured":"Fukuchi O, Suko A, Matsuzaki H, et al. Anti-laminin-332 mucous membrane pemphigoid with autoantibodies to alpha3, beta3 and gamma2 subunits of laminin-332 as well as to BP230 and periplakin associated with adenocarcinoma from an unknown primary site. J Dermatol. 2013; 40: 61\u201362.","DOI":"10.1111\/j.1346-8138.2012.01645.x"},{"key":"i1552-5783-59-10-4082-b26","doi-asserted-by":"crossref","unstructured":"McLean WH, Irvine AD, Hamill KJ, et al. An unusual N-terminal deletion of the laminin alpha3a isoform leads to the chronic granulation tissue disorder laryngo-onycho-cutaneous syndrome. Hum Mol Genet. 2003; 12: 2395\u20132409.","DOI":"10.1093\/hmg\/ddg234"},{"key":"i1552-5783-59-10-4082-b27","doi-asserted-by":"crossref","unstructured":"Oliver VF, van Bysterveldt KA, Cadzow M, et al. A COL17A1 splice-altering mutation is prevalent in inherited recurrent corneal erosions. Ophthalmology. 2016; 123: 23.","DOI":"10.1016\/j.ophtha.2015.12.008"},{"key":"i1552-5783-59-10-4082-b28","doi-asserted-by":"crossref","unstructured":"Pal-Ghosh S, Blanco T, Tadvalkar G, et al. MMP9 cleavage of the beta4 integrin ectodomain leads to recurrent epithelial erosions in mice. J Cell Sci. 2011; 124: 2666\u20132675.","DOI":"10.1242\/jcs.085480"},{"key":"i1552-5783-59-10-4082-b29","doi-asserted-by":"crossref","unstructured":"Ebihara N, Watanabe Y, Nakayasu K, Kanai A. The expression of laminin-5 and ultrastructure of the interface between basal cells and underlying stroma in the keratoconus cornea. Jpn J Ophthalmol. 2001; 45: 209\u2013215.","DOI":"10.1016\/S0021-5155(01)00328-8"},{"key":"i1552-5783-59-10-4082-b30","doi-asserted-by":"crossref","unstructured":"Kenney MC, Nesburn AB, Burgeson RE, Butkowski RJ, Ljubimov AV. Abnormalities of the extracellular matrix in keratoconus corneas. Cornea. 1997; 16: 345\u2013351.","DOI":"10.1097\/00003226-199705000-00016"},{"key":"i1552-5783-59-10-4082-b31","doi-asserted-by":"crossref","unstructured":"Nielsen PK, Gho YS, Hoffman MP, et al. Identification of a major heparin and cell binding site in the LG4 module of the laminin alpha 5 chain. J Biol Chem. 2000; 275: 14517\u201314523.","DOI":"10.1074\/jbc.275.19.14517"},{"key":"i1552-5783-59-10-4082-b32","doi-asserted-by":"crossref","unstructured":"Timpl R, Tisi D, Talts JF, Andac Z, Sasaki T, Hohenester E. Structure and function of laminin LG modules. Matrix Biol. 2000; 19: 309\u2013317.","DOI":"10.1016\/S0945-053X(00)00072-X"},{"key":"i1552-5783-59-10-4082-b33","doi-asserted-by":"crossref","unstructured":"Shang M, Koshikawa N, Schenk S, Quaranta V. The LG3 module of laminin-5 harbors a binding site for integrin alpha3beta1 that promotes cell adhesion, spreading, and migration. J Biol Chem. 2001; 276: 33045\u201333053.","DOI":"10.1074\/jbc.M100798200"},{"key":"i1552-5783-59-10-4082-b34","doi-asserted-by":"crossref","unstructured":"Kadoya Y, Mochizuki M, Nomizu M, Sorokin L, Yamashina S. Role for laminin-alpha5 chain LG4 module in epithelial branching morphogenesis. Dev Biol. 2003; 263: 153\u2013164.","DOI":"10.1016\/S0012-1606(03)00446-9"},{"key":"i1552-5783-59-10-4082-b35","doi-asserted-by":"crossref","unstructured":"Okamoto O, Bachy S, Odenthal U, et al. Normal human keratinocytes bind to the alpha3LG4\/5 domain of unprocessed laminin-5 through the receptor syndecan-1. J Biol Chem. 2003; 278: 44168\u201344177.","DOI":"10.1074\/jbc.M300726200"},{"key":"i1552-5783-59-10-4082-b36","doi-asserted-by":"crossref","unstructured":"Cheng YS, Champliaud MF, Burgeson RE, Marinkovich MP, Yurchenco PD. Self-assembly of laminin isoforms. J Biol Chem. 1997; 272: 31525\u201331532.","DOI":"10.1074\/jbc.272.50.31525"},{"key":"i1552-5783-59-10-4082-b37","doi-asserted-by":"crossref","unstructured":"Yurchenco PD, Cheng YS. Self-assembly and calcium-binding sites in laminin. A three-arm interaction model. J Biol Chem. 1993; 268: 17286\u201317299.","DOI":"10.1016\/S0021-9258(19)85334-6"},{"key":"i1552-5783-59-10-4082-b38","doi-asserted-by":"crossref","unstructured":"Yurchenco PD, Tsilibary EC, Charonis AS, Furthmayr H. Laminin polymerization in vitro. Evidence for a two-step assembly with domain specificity. J Biol Chem. 1985; 260: 7636\u20137644.","DOI":"10.1016\/S0021-9258(17)39656-4"},{"key":"i1552-5783-59-10-4082-b39","doi-asserted-by":"crossref","unstructured":"Schneiders FI, Maertens B, Bose K, et al. Binding of netrin-4 to laminin short arms regulates basement membrane assembly. J Biol Chem. 2007; 282: 23750\u201323758.","DOI":"10.1074\/jbc.M703137200"},{"key":"i1552-5783-59-10-4082-b40","doi-asserted-by":"crossref","unstructured":"Reuten R, Patel TR, McDougall M, et al. Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes. Nat Commun. 2016; 7: 13515.","DOI":"10.1038\/ncomms13515"},{"key":"i1552-5783-59-10-4082-b41","doi-asserted-by":"crossref","unstructured":"Maier AB, Klein S, Kociok N, et al. Netrin-4 mediates corneal hemangiogenesis but hot lymphangiogenesis in the mouse-model of suture-induced neovascularization. Invest Ophthalmol Vis Sci. 2017; 58: 1387\u20131396.","DOI":"10.1167\/iovs.16-19249"},{"key":"i1552-5783-59-10-4082-b42","doi-asserted-by":"crossref","unstructured":"Han Y, Shao Y, Liu T, Qu YL, Li W, Liu Z. Therapeutic effects of topical netrin-4 inhibits corneal neovascularization in alkali-burn rats. PLoS One. 2015; 10: e0122951.","DOI":"10.1371\/journal.pone.0122951"},{"key":"i1552-5783-59-10-4082-b43","doi-asserted-by":"crossref","unstructured":"Han Y, Shao Y, Lin Z, et al. Netrin-1 simultaneously suppresses corneal inflammation and neovascularization. Invest Ophthalmol Vis Sci. 2012; 53: 1285\u20131295.","DOI":"10.1167\/iovs.11-8722"},{"key":"i1552-5783-59-10-4082-b44","doi-asserted-by":"crossref","unstructured":"Li YN, Pinzon-Duarte G, Dattilo M, Claudepierre T, Koch M, Brunken WJ. The expression and function of netrin-4 in murine ocular tissues. Exp Eye Res. 2012; 96: 24\u201335.","DOI":"10.1016\/j.exer.2012.01.007"},{"key":"i1552-5783-59-10-4082-b45","doi-asserted-by":"crossref","unstructured":"Torricelli AA, Singh V, Santhiago MR, Wilson SE. The corneal epithelial basement membrane: structure, function, and disease. Invest Ophthalmol Vis Sci. 2013; 54: 6390\u20136400.","DOI":"10.1167\/iovs.13-12547"},{"key":"i1552-5783-59-10-4082-b46","unstructured":"Kurpakus MA, Stock EL, Jones JC. Expression of the 55-kD\/64-kD corneal keratins in ocular surface epithelium. Invest Ophthalmol Vis Sci. 1990; 31: 448\u2013456."},{"key":"i1552-5783-59-10-4082-b47","doi-asserted-by":"crossref","unstructured":"Langhofer M, Hopkinson SB, Jones JC. The matrix secreted by 804G cells contains laminin-related components that participate in hemidesmosome assembly in vitro. J Cell Sci. 1993; 105 (pt 3): 753\u2013764.","DOI":"10.1242\/jcs.105.3.753"},{"key":"i1552-5783-59-10-4082-b48","doi-asserted-by":"crossref","unstructured":"Gonzales M, Haan K, Baker SE, et al. A cell signal pathway involving laminin-5, alpha3beta1 integrin, and mitogen-activated protein kinase can regulate epithelial cell proliferation. Mol Biol Cell. 1999; 10: 259\u2013270.","DOI":"10.1091\/mbc.10.2.259"},{"key":"i1552-5783-59-10-4082-b49","doi-asserted-by":"crossref","unstructured":"Galfre G, Milstein C. Preparation of monoclonal antibodies: strategies and procedures. Methods Enzymol. 1981; 73: 3\u201346.","DOI":"10.1016\/0076-6879(81)73054-4"},{"key":"i1552-5783-59-10-4082-b50","unstructured":"Boukamp P, Stanbridge EJ, Foo DY, Cerutti PA, Fusenig NE. c-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy. Cancer Res. 1990; 50: 2840\u20132847."},{"key":"i1552-5783-59-10-4082-b51","doi-asserted-by":"crossref","unstructured":"Anderson C, Zhou Q, Wang S. An alkali-burn injury model of corneal neovascularization in the mouse. J Vis Exp. 2014; 86","DOI":"10.3791\/51159"},{"key":"i1552-5783-59-10-4082-b52","doi-asserted-by":"crossref","unstructured":"Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol. 1988; 106: 761\u2013771.","DOI":"10.1083\/jcb.106.3.761"},{"key":"i1552-5783-59-10-4082-b53","doi-asserted-by":"crossref","unstructured":"Kariya Y, Mori T, Yasuda C, et al. Localization of laminin alpha3B chain in vascular and epithelial basement membranes of normal human tissues and its down-regulation in skin cancers. J Mol Histol. 2008; 39: 435\u2013446.","DOI":"10.1007\/s10735-008-9183-0"},{"key":"i1552-5783-59-10-4082-b54","doi-asserted-by":"crossref","unstructured":"Yoshida S, Shimmura S, Kawakita T, et al. Cytokeratin 15 can be used to identify the limbal phenotype in normal and diseased ocular surfaces. Invest Ophthalmol Vis Sci. 2006; 47: 4780\u20134786.","DOI":"10.1167\/iovs.06-0574"},{"key":"i1552-5783-59-10-4082-b55","unstructured":"Morita S, Shirakata Y, Shiraishi A, et al. Human corneal epithelial cell proliferation by epiregulin and its cross-induction by other EGF family members. Mol Vis. 2007; 13: 2119\u20132128."},{"key":"i1552-5783-59-10-4082-b56","doi-asserted-by":"crossref","unstructured":"Chen Z, de Paiva CS, Luo L, Kretzer FL, Pflugfelder SC, Li DQ. Characterization of putative stem cell phenotype in human limbal epithelia. Stem Cells. 2004; 22: 355\u2013366.","DOI":"10.1634\/stemcells.22-3-355"},{"key":"i1552-5783-59-10-4082-b57","unstructured":"Zieske JD, Takahashi H, Hutcheon AE, Dalbone AC. Activation of epidermal growth factor receptor during corneal epithelial migration. Invest Ophthalmol Vis Sci. 2000; 41: 1346\u20131355."},{"key":"i1552-5783-59-10-4082-b58","doi-asserted-by":"crossref","unstructured":"Kalha S, Shrestha B, Sanz Navarro M, Jones KB, Klein OD, Michon F. Bmi1+ progenitor cell dynamics in murine cornea during homeostasis and wound healing. Stem Cells. 2018; 36: 562\u2013573.","DOI":"10.1002\/stem.2767"},{"key":"i1552-5783-59-10-4082-b59","doi-asserted-by":"crossref","unstructured":"Levis HJ, Daniels JT. Recreating the human limbal epithelial stem cell niche with bioengineered limbal crypts. Curr Eye Res. 2016; 41: 1153\u20131160.","DOI":"10.3109\/02713683.2015.1095932"},{"key":"i1552-5783-59-10-4082-b60","doi-asserted-by":"crossref","unstructured":"Stasi K, Goings D, Huang J, et al. Optimal isolation and xeno-free culture conditions for limbal stem cell function. Invest Ophthalmol Vis Sci. 2014; 55: 375\u2013386.","DOI":"10.1167\/iovs.13-12517"},{"key":"i1552-5783-59-10-4082-b61","doi-asserted-by":"crossref","unstructured":"Han Y, Shao Y, Lin Z, et al. Netrin-1 simultaneously suppresses corneal inflammation and neovascularization. Invest Ophthalmol Vis Sci. 2012; 53: 1285\u20131295.","DOI":"10.1167\/iovs.11-8722"},{"key":"i1552-5783-59-10-4082-b62","doi-asserted-by":"crossref","unstructured":"Li YN, Pinzon-Duarte G, Dattilo M, Claudepierre T, Koch M, Brunken WJ. The expression and function of netrin-4 in murine ocular tissues. Exp Eye Res. 2012; 96: 24\u201335.","DOI":"10.1016\/j.exer.2012.01.007"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2697349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:30:56Z","timestamp":1791927056000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.18-24037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,21]]},"references-count":62,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,8,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.18-24037","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8,21]]}}}