{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:13:48Z","timestamp":1792653228524,"version":"4.5.0"},"reference-count":38,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"4","license":[{"start":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2019,3,29]]},"DOI":"10.1167\/iovs.18-24166","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T11:36:15Z","timestamp":1553859375000},"page":"1265","source":"Crossref","is-referenced-by-count":34,"title":["Deletion of miR-182 Leads to Retinal Dysfunction in Mice"],"prefix":"10.1167","volume":"60","author":[{"given":"Kun-Chao","family":"Wu","sequence":"first","affiliation":[{"name":"Lab for Stem Cell & Retinal Regeneration, Institute of Stem Cell Research, State Key Laboratory of Ophthalmology, Optometry and Vision Science, National Center for International Research in Regenerative Medicine and Neurogenetics, Wenzhou Medical University, Wenzhou, China"},{"name":"Division of Ophthalmic Genetics, The Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Jiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Lab for Stem Cell & Retinal Regeneration, Institute of Stem Cell Research, State Key Laboratory of Ophthalmology, Optometry and Vision Science, National Center for International Research in Regenerative Medicine and Neurogenetics, Wenzhou Medical University, Wenzhou, China"},{"name":"Division of Ophthalmic Genetics, The Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Hui","family":"Jin","sequence":"additional","affiliation":[{"name":"Lab for Stem Cell & Retinal Regeneration, Institute of Stem Cell Research, State Key Laboratory of Ophthalmology, Optometry and Vision Science, National Center for International Research in Regenerative Medicine and Neurogenetics, Wenzhou Medical University, Wenzhou, China"},{"name":"Division of Ophthalmic Genetics, The Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Lab for Stem Cell & Retinal Regeneration, Institute of Stem Cell Research, State Key Laboratory of Ophthalmology, Optometry and Vision Science, National Center for International Research in Regenerative Medicine and Neurogenetics, Wenzhou Medical University, Wenzhou, China"},{"name":"Division of Ophthalmic Genetics, The Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-Dan","family":"Yang","sequence":"additional","affiliation":[{"name":"Lab for Stem Cell & Retinal Regeneration, Institute of Stem Cell Research, State Key Laboratory of Ophthalmology, Optometry and Vision Science, National Center for International Research in Regenerative Medicine and Neurogenetics, Wenzhou Medical University, Wenzhou, China"},{"name":"Division of Ophthalmic Genetics, The Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Lab for Stem Cell & Retinal Regeneration, Institute of Stem Cell Research, State Key Laboratory of Ophthalmology, Optometry and Vision Science, National Center for International Research in Regenerative Medicine and Neurogenetics, Wenzhou Medical University, Wenzhou, China"},{"name":"Division of Ophthalmic Genetics, The Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lue","family":"Xiang","sequence":"additional","affiliation":[{"name":"Lab for Stem Cell & Retinal Regeneration, Institute of Stem Cell Research, State Key Laboratory of Ophthalmology, Optometry and Vision Science, National Center for International Research in Regenerative Medicine and Neurogenetics, Wenzhou Medical University, Wenzhou, China"},{"name":"Division of Ophthalmic Genetics, The Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Lab for Stem Cell & Retinal Regeneration, Institute of Stem Cell Research, State Key Laboratory of Ophthalmology, Optometry and Vision Science, National Center for International Research in Regenerative Medicine and Neurogenetics, Wenzhou Medical University, Wenzhou, China"},{"name":"Division of Ophthalmic Genetics, The Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao-Hui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Lab for Stem Cell & Retinal Regeneration, Institute of Stem Cell Research, State Key Laboratory of Ophthalmology, Optometry and Vision Science, National Center for International Research in Regenerative Medicine and Neurogenetics, Wenzhou Medical University, Wenzhou, China"},{"name":"Division of Ophthalmic Genetics, The Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Lab for Stem Cell & Retinal Regeneration, Institute of Stem Cell Research, State Key Laboratory of Ophthalmology, Optometry and Vision Science, National Center for International Research in Regenerative Medicine and Neurogenetics, Wenzhou Medical University, Wenzhou, China"},{"name":"Division of Ophthalmic Genetics, The Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Bing","family":"Jin","sequence":"additional","affiliation":[{"name":"Lab for Stem Cell & Retinal Regeneration, Institute of Stem Cell Research, State Key Laboratory of Ophthalmology, Optometry and Vision Science, National Center for International Research in Regenerative Medicine and Neurogenetics, Wenzhou Medical University, Wenzhou, China"},{"name":"Division of Ophthalmic Genetics, The Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-60-4-1265-b01","doi-asserted-by":"crossref","unstructured":"Ebert MS, Neilson JR, Sharp PA. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat Methods. 2007; 4: 721\u2013726.","DOI":"10.1038\/nmeth1079"},{"key":"i1552-5783-60-4-1265-b02","doi-asserted-by":"crossref","unstructured":"Tanzer A, Stadler PF. Molecular evolution of a microRNA cluster. J Mol Biol. 2004; 339: 327\u2013335.","DOI":"10.1016\/j.jmb.2004.03.065"},{"key":"i1552-5783-60-4-1265-b03","doi-asserted-by":"crossref","unstructured":"Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009; 136: 215\u2013233.","DOI":"10.1016\/j.cell.2009.01.002"},{"key":"i1552-5783-60-4-1265-b04","doi-asserted-by":"crossref","unstructured":"Lee Y, Ahn C, Han J, et al. The nuclear RNase III Drosha initiates microRNA processing. Nature. 2003; 425: 415\u2013419.","DOI":"10.1038\/nature01957"},{"key":"i1552-5783-60-4-1265-b05","doi-asserted-by":"crossref","unstructured":"Lee YS, Nakahara K, Pham JW, et al. Distinct roles for drosophila dicer-1 and dicer-2 in the siRNA\/miRNA silencing pathways. Cell. 2004; 117: 69\u201381.","DOI":"10.1016\/S0092-8674(04)00261-2"},{"key":"i1552-5783-60-4-1265-b06","doi-asserted-by":"crossref","unstructured":"Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet. 2010; 11: 597\u2013610.","DOI":"10.1038\/nrg2843"},{"key":"i1552-5783-60-4-1265-b07","doi-asserted-by":"crossref","unstructured":"Sundermeier TR, Palczewski K. The physiological impact of microRNA gene regulation in the retina. Cell Mol Life Sci. 2012; 69: 2739\u20132750.","DOI":"10.1007\/s00018-012-0976-7"},{"key":"i1552-5783-60-4-1265-b08","doi-asserted-by":"crossref","unstructured":"Damiani D, Alexander JJ, O'Rourke JR, et al. Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci. 2008; 28: 4878\u20134887.","DOI":"10.1523\/JNEUROSCI.0828-08.2008"},{"key":"i1552-5783-60-4-1265-b09","doi-asserted-by":"crossref","unstructured":"Sundermeier TR, Palczewski K. The impact of microRNA gene regulation on the survival and function of mature cell types in the eye. FASEB J. 2016; 30: 23\u201333.","DOI":"10.1096\/fj.15-279745"},{"key":"i1552-5783-60-4-1265-b10","doi-asserted-by":"crossref","unstructured":"Krol J, Krol I, Alvarez CP, et al. A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture. Nat Commun. 2015; 6: 7305.","DOI":"10.1038\/ncomms8305"},{"key":"i1552-5783-60-4-1265-b11","doi-asserted-by":"crossref","unstructured":"Huang XF, Huang ZQ, Fang XL, Chen ZJ, Cheng W, Jin ZB. Retinal miRNAs variations in a large cohort of inherited retinal disease. Ophthalmic Genet. 2018; 39: 175\u2013179.","DOI":"10.1080\/13816810.2017.1329448"},{"key":"i1552-5783-60-4-1265-b12","doi-asserted-by":"crossref","unstructured":"Ran X, Cai WJ, Huang XF, et al. \u201cRetinoGenetics\u201d: a comprehensive mutation database for genes related to inherited retinal degeneration. Database. 2014; 2014: bau047.","DOI":"10.1093\/database\/bau047"},{"key":"i1552-5783-60-4-1265-b13","doi-asserted-by":"crossref","unstructured":"Xu S. microRNAs and inherited retinal dystrophies. Proc Natl Acad Sci U S A. 2015; 112: 8805\u20138806.","DOI":"10.1073\/pnas.1511019112"},{"key":"i1552-5783-60-4-1265-b14","doi-asserted-by":"crossref","unstructured":"Huang XF, Huang F, Wu KC, et al. Genotype-phenotype correlation and mutation spectrum in a large cohort of patients with inherited retinal dystrophy revealed by next-generation sequencing. Genet Med. 2015; 17: 271\u2013278.","DOI":"10.1038\/gim.2014.138"},{"key":"i1552-5783-60-4-1265-b15","doi-asserted-by":"crossref","unstructured":"Sundermeier TR, Zhang N, Vinberg F, et al. DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice. FASEB J. 2014; 28: 3780\u20133791.","DOI":"10.1096\/fj.14-254292"},{"key":"i1552-5783-60-4-1265-b16","doi-asserted-by":"crossref","unstructured":"Busskamp V, Krol J, Nelidova D, et al. miRNAs 182 and 183 are necessary to maintain adult cone photoreceptor outer segments and visual function. Neuron. 2014; 83: 586\u2013600.","DOI":"10.1016\/j.neuron.2014.06.020"},{"key":"i1552-5783-60-4-1265-b17","doi-asserted-by":"crossref","unstructured":"Zhu Q, Sun W, Okano K, et al. Sponge transgenic mouse model reveals important roles for the microRNA-183 (miR-183)\/96\/182 cluster in postmitotic photoreceptors of the retina. J Biol Chem. 2011; 286: 31749\u201331760.","DOI":"10.1074\/jbc.M111.259028"},{"key":"i1552-5783-60-4-1265-b18","doi-asserted-by":"crossref","unstructured":"Lumayag S, Haldin CE, Corbett NJ, et al. Inactivation of the microRNA-183\/96\/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013; 110: E507\u2013E516.","DOI":"10.1073\/pnas.1212655110"},{"key":"i1552-5783-60-4-1265-b19","doi-asserted-by":"crossref","unstructured":"Xiang L, Chen XJ, Wu KC, et al. miR-183\/96 plays a pivotal regulatory role in mouse photoreceptor maturation and maintenance. Proc Natl Acad Sci U S A. 2017; 114: 6376\u20136381.","DOI":"10.1073\/pnas.1618757114"},{"key":"i1552-5783-60-4-1265-b20","doi-asserted-by":"crossref","unstructured":"Fan J, Jia L, Li Y, et al. Maturation arrest in early postnatal sensory receptors by deletion of the miR-183\/96\/182 cluster in mouse. Proc Natl Acad Sci U S A. 2017; 114: E4271\u2013E4280.","DOI":"10.1073\/pnas.1619442114"},{"key":"i1552-5783-60-4-1265-b21","doi-asserted-by":"crossref","unstructured":"Xu S, Witmer PD, Lumayag S, Kovacs B, Valle D. MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster. J Biol Chem. 2007; 282: 25053\u201325066.","DOI":"10.1074\/jbc.M700501200"},{"key":"i1552-5783-60-4-1265-b22","doi-asserted-by":"crossref","unstructured":"Karali M, Persico M, Mutarelli M, et al. High-resolution analysis of the human retina miRNome reveals isomiR variations and novel microRNAs. Nucleic Acids Res. 2016; 44: 1525\u20131540.","DOI":"10.1093\/nar\/gkw039"},{"key":"i1552-5783-60-4-1265-b23","unstructured":"Jin ZB, Hirokawa G, Gui L, et al. Targeted deletion of miR-182, an abundant retinal microRNA. Mol Vis. 2009; 15: 523\u2013533."},{"key":"i1552-5783-60-4-1265-b24","doi-asserted-by":"crossref","unstructured":"Jin ZB, Huang XF, Lv JN, et al. SLC7A14 linked to autosomal recessive retinitis pigmentosa. Nat Commun. 2014; 5: 3517.","DOI":"10.1038\/ncomms4517"},{"key":"i1552-5783-60-4-1265-b25","doi-asserted-by":"crossref","unstructured":"Zeitz C, van Genderen M, Neidhardt J, et al. Mutations in GRM6 cause autosomal recessive congenital stationary night blindness with a distinctive scotopic 15-Hz flicker electroretinogram. Invest Ophthalmol Vis Sci. 2005; 46: 4328\u20134335.","DOI":"10.1167\/iovs.05-0526"},{"key":"i1552-5783-60-4-1265-b26","doi-asserted-by":"crossref","unstructured":"Bech-Hansen NT, Naylor MJ, Maybaum TA, et al. Mutations in NYX, encoding the leucine-rich proteoglycan nyctalopin, cause X-linked complete congenital stationary night blindness. Nat Genet. 2000; 26: 319\u2013323.","DOI":"10.1038\/81619"},{"key":"i1552-5783-60-4-1265-b27","doi-asserted-by":"crossref","unstructured":"Audo I, Kohl S, Leroy BP, et al. TRPM1 is mutated in patients with autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet. 2009; 85: 720\u2013729.","DOI":"10.1016\/j.ajhg.2009.10.013"},{"key":"i1552-5783-60-4-1265-b28","doi-asserted-by":"crossref","unstructured":"Sprecher E, Bergman R, Richard G, et al. Hypotrichosis with juvenile macular dystrophy is caused by a mutation in CDH3, encoding P-cadherin. Nat Genet. 2001; 29: 134\u2013136.","DOI":"10.1038\/ng716"},{"key":"i1552-5783-60-4-1265-b29","doi-asserted-by":"crossref","unstructured":"Hageman GS, Anderson DH, Johnson LV, et al. A common haplotype in the complement regulatory gene factor H (HF1\/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A. 2005; 102: 7227\u20137232.","DOI":"10.1073\/pnas.0501536102"},{"key":"i1552-5783-60-4-1265-b30","doi-asserted-by":"crossref","unstructured":"Katsanis N, Beales PL, Woods MO, et al. Mutations in MKKS cause obesity, retinal dystrophy and renal malformations associated with Bardet-Biedl syndrome. Nat Genet. 2000; 26: 67\u201370.","DOI":"10.1038\/79201"},{"key":"i1552-5783-60-4-1265-b31","unstructured":"Ayala-Ramirez R, Graue-Wiechers F, Robredo V, Amato-Almanza M, Horta-Diez I, Zenteno JC. A new autosomal recessive syndrome consisting of posterior microphthalmos, retinitis pigmentosa, foveoschisis, and optic disc drusen is caused by a MFRP gene mutation. Mol Vis. 2006; 12: 1483\u20131489."},{"key":"i1552-5783-60-4-1265-b32","doi-asserted-by":"crossref","unstructured":"Morimura H, Saindelle-Ribeaudeau F, Berson EL, Dryja TP. Mutations in RGR, encoding a light-sensitive opsin homologue, in patients with retinitis pigmentosa. Nat Genet. 1999; 23: 393\u2013394.","DOI":"10.1038\/70496"},{"key":"i1552-5783-60-4-1265-b33","doi-asserted-by":"crossref","unstructured":"Huang DW, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009; 4: 44\u201357.","DOI":"10.1038\/nprot.2008.211"},{"key":"i1552-5783-60-4-1265-b34","doi-asserted-by":"crossref","unstructured":"Nabhan JF, Pan H, Lu QA. Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta 2-adrenergic receptor. EMBO Rep. 2010; 11: 605\u2013611.","DOI":"10.1038\/embor.2010.80"},{"key":"i1552-5783-60-4-1265-b35","doi-asserted-by":"crossref","unstructured":"Murad N, Kokkinaki M, Gunawardena N, et al. miR-184 regulates ezrin, LAMP-1 expression, affects phagocytosis in human retinal pigment epithelium and is downregulated in age-related macular degeneration. FEBS J. 2014; 281: 5251\u20135264.","DOI":"10.1111\/febs.13066"},{"key":"i1552-5783-60-4-1265-b36","doi-asserted-by":"crossref","unstructured":"Saxena K, Rutar MV, Provis JM, Natoli RC. Identification of miRNAs in a model of retinal degenerations. Invest Ophthalmol Vis Sci. 2015; 56: 1820\u20131829.","DOI":"10.1167\/iovs.14-15449"},{"key":"i1552-5783-60-4-1265-b37","doi-asserted-by":"crossref","unstructured":"Krol J, Busskamp V, Markiewicz I, et al. Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs. Cell. 2010; 141: 618\u2013631.","DOI":"10.1016\/j.cell.2010.03.039"},{"key":"i1552-5783-60-4-1265-b38","doi-asserted-by":"crossref","unstructured":"Wang X, Zhao L, Zhang J, et al. Requirement for microglia for the maintenance of synaptic function and integrity in the mature retina. J Neurosci. 2016; 36: 2827\u20132842.","DOI":"10.1523\/JNEUROSCI.3575-15.2016"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2729849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:02Z","timestamp":1791927062000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.18-24166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,29]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,3,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.18-24166","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3,29]]}}}