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The International ARM Epidemiological Study Group.\n\t\t\t\t\tSurv Ophthalmol.\n\t\t\t\t\t1995;\n\t\t\t\t\t39:\n\t\t\t\t\t367\u2013374.","DOI":"10.1016\/S0039-6257(05)80092-X"},{"key":"i1552-5783-59-4-AMD202-b03","doi-asserted-by":"crossref","unstructured":"Ferris\n\t\t\t\t\t\t\tFL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDavis\n\t\t\t\t\t\t\tMD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tClemons\n\t\t\t\t\t\t\tTE,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tA simplified severity scale for age-related macular degeneration: AREDS Report No. 18.\n\t\t\t\t\tArch Ophthalmol.\n\t\t\t\t\t2005;\n\t\t\t\t\t123:\n\t\t\t\t\t1570\u20131574.","DOI":"10.1001\/archopht.123.11.1570"},{"key":"i1552-5783-59-4-AMD202-b04","doi-asserted-by":"crossref","unstructured":"Klein\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDavis\n\t\t\t\t\t\t\tMD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMagli\n\t\t\t\t\t\t\tYL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSegal\n\t\t\t\t\t\t\tP,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKlein\n\t\t\t\t\t\t\tBE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHubbard\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tThe Wisconsin age-related maculopathy grading system.\n\t\t\t\t\tOphthalmology.\n\t\t\t\t\t1991;\n\t\t\t\t\t98:\n\t\t\t\t\t1128\u20131134.","DOI":"10.1016\/S0161-6420(91)32186-9"},{"key":"i1552-5783-59-4-AMD202-b05","doi-asserted-by":"crossref","unstructured":"Age-Related Eye Disease Study Research Group.\n\t\t\t\t\tThe Age-Related Eye Disease Study system for classifying age-related macular 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