{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:58:11Z","timestamp":1793051891310,"version":"4.5.0"},"reference-count":67,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"7","license":[{"start":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T00:00:00Z","timestamp":1529366400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2018,6,19]]},"DOI":"10.1167\/iovs.18-24258","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T18:43:51Z","timestamp":1532112231000},"page":"3069","source":"Crossref","is-referenced-by-count":82,"title":["YAP\/TAZ Are Essential for TGF-\u03b22\u2013Mediated Conjunctival Fibrosis"],"prefix":"10.1167","volume":"59","author":[{"given":"Akiko","family":"Futakuchi","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan-Yan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Inoue-Mochita","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomokazu","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhito","family":"Tomizawa","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenobu","family":"Tanihara","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-59-7-3069-b01","doi-asserted-by":"crossref","unstructured":"Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006; 90: 262\u2013267.","DOI":"10.1136\/bjo.2005.081224"},{"key":"i1552-5783-59-7-3069-b02","doi-asserted-by":"crossref","unstructured":"Weinreb RN, Aung T, Medeiros FA. The pathophysiology and treatment of glaucoma: a review. JAMA. 2014; 311: 1901\u20131911.","DOI":"10.1001\/jama.2014.3192"},{"key":"i1552-5783-59-7-3069-b03","doi-asserted-by":"crossref","unstructured":"Skuta GL, Parrish RK II. Wound healing in glaucoma filtering surgery. Surv Ophthalmol. 1987; 32: 149\u2013170.","DOI":"10.1016\/0039-6257(87)90091-9"},{"key":"i1552-5783-59-7-3069-b04","doi-asserted-by":"crossref","unstructured":"Chang L, Crowston JG, Cordeiro MF, Akbar AN, Khaw PT. The role of the immune system in conjunctival wound healing after glaucoma surgery. Surv Ophthalmol. 2000; 45: 49\u201368.","DOI":"10.1016\/S0039-6257(00)00135-1"},{"key":"i1552-5783-59-7-3069-b05","doi-asserted-by":"crossref","unstructured":"Seibold LK, Sherwood MB, Kahook MY. Wound modulation after filtration surgery. Surv Ophthalmol. 2012; 57: 530\u2013550.","DOI":"10.1016\/j.survophthal.2012.01.008"},{"key":"i1552-5783-59-7-3069-b06","doi-asserted-by":"crossref","unstructured":"Razzaque MS, Ahmed BS, Foster CS, Ahmed AR. Effects of IL-4 on conjunctival fibroblasts: possible role in ocular cicatricial pemphigoid. Invest Ophthalmol Vis Sci. 2003; 44: 3417\u20133423.","DOI":"10.1167\/iovs.02-1084"},{"key":"i1552-5783-59-7-3069-b07","unstructured":"Razzaque MS, Foster CS, Ahmed AR. Role of enhanced expression of m-CSF in conjunctiva affected by cicatricial pemphigoid. Invest Ophthalmol Vis Sci. 2002; 43: 2977\u20132983."},{"key":"i1552-5783-59-7-3069-b08","unstructured":"Razzaque MS, Foster CS, Ahmed AR. Tissue and molecular events in human conjunctival scarring in ocular cicatricial pemphigoid. Histol Histopathol. 2001; 16: 1203\u20131212."},{"key":"i1552-5783-59-7-3069-b09","doi-asserted-by":"crossref","unstructured":"Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol. 2002; 3: 349\u2013363.","DOI":"10.1038\/nrm809"},{"key":"i1552-5783-59-7-3069-b10","doi-asserted-by":"crossref","unstructured":"Liu F, Mih JD, Shea BS, et al. Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression. J Cell Biol. 2010; 190: 693\u2013706.","DOI":"10.1083\/jcb.201004082"},{"key":"i1552-5783-59-7-3069-b11","doi-asserted-by":"crossref","unstructured":"Dokukina IV, Gracheva ME. A model of fibroblast motility on substrates with different rigidities. Biophys J. 2010; 98: 2794\u20132803.","DOI":"10.1016\/j.bpj.2010.03.026"},{"key":"i1552-5783-59-7-3069-b12","doi-asserted-by":"crossref","unstructured":"Discher DE, Janmey P, Wang YL. Tissue cells feel and respond to the stiffness of their substrate. Science. 2005; 310: 1139\u20131143.","DOI":"10.1126\/science.1116995"},{"key":"i1552-5783-59-7-3069-b13","doi-asserted-by":"crossref","unstructured":"Georges PC, Hui JJ, Gombos Z, et al. Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis. Am J Physiol Gastrointest Liver Physiol. 2007; 293: G1147\u2013G1154.","DOI":"10.1152\/ajpgi.00032.2007"},{"key":"i1552-5783-59-7-3069-b14","doi-asserted-by":"crossref","unstructured":"Janmey PA, Wells RG, Assoian RK, McCulloch CA. From tissue mechanics to transcription factors. Differentiation. 2013; 86: 112\u2013120.","DOI":"10.1016\/j.diff.2013.07.004"},{"key":"i1552-5783-59-7-3069-b15","doi-asserted-by":"crossref","unstructured":"Mannaerts I, Leite SB, Verhulst S, et al. The Hippo pathway effector YAP controls mouse hepatic stellate cell activation. J Hepatol. 2015; 63: 679\u2013688.","DOI":"10.1016\/j.jhep.2015.04.011"},{"key":"i1552-5783-59-7-3069-b16","doi-asserted-by":"crossref","unstructured":"Caliari SR, Perepelyuk M, Cosgrove BD, et al. Stiffening hydrogels for investigating the dynamics of hepatic stellate cell mechanotransduction during myofibroblast activation. Sci Rep. 2016; 6: 21387.","DOI":"10.1038\/srep21387"},{"key":"i1552-5783-59-7-3069-b17","doi-asserted-by":"crossref","unstructured":"Liu F, Lagares D, Choi KM, et al. Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis. Am J Physiol Lung Cell Mol Physiol. 2015; 308: L344\u2013L357.","DOI":"10.1152\/ajplung.00300.2014"},{"key":"i1552-5783-59-7-3069-b18","doi-asserted-by":"crossref","unstructured":"Jorgenson AJ, Choi KM, Sicard D, et al. TAZ activation drives fibroblast spheroid growth, expression of profibrotic paracrine signals, and context-dependent ECM gene expression. Am J Physiol Cell Physiol. 2017; 312: C277\u2013C285.","DOI":"10.1152\/ajpcell.00205.2016"},{"key":"i1552-5783-59-7-3069-b19","doi-asserted-by":"crossref","unstructured":"Noguchi S, Saito A, Mikami Y, et al. TAZ contributes to pulmonary fibrosis by activating profibrotic functions of lung fibroblasts. Sci Rep. 2017; 7: 42595.","DOI":"10.1038\/srep42595"},{"key":"i1552-5783-59-7-3069-b20","doi-asserted-by":"crossref","unstructured":"Szeto SG, Narimatsu M, Lu M, et al. YAP\/TAZ are mechanoregulators of TGF-\u00df-Smad signaling and renal fibrogenesis. J Am Soc Nephrol. 2016; 27: 3117\u20133128.","DOI":"10.1681\/ASN.2015050499"},{"key":"i1552-5783-59-7-3069-b21","doi-asserted-by":"crossref","unstructured":"Panciera T, Azzolin L, Cordenonsi M, Piccolo S. Mechanobiology of YAP and TAZ in physiology and disease. Nat Rev Mol Cell Biol. 2017; 18: 758\u2013770.","DOI":"10.1038\/nrm.2017.87"},{"key":"i1552-5783-59-7-3069-b22","doi-asserted-by":"crossref","unstructured":"Dupont S, Morsut L, Aragona M, et al. Role of YAP\/TAZ in mechanotransduction. Nature. 2011; 474: 179\u2013183.","DOI":"10.1038\/nature10137"},{"key":"i1552-5783-59-7-3069-b23","doi-asserted-by":"crossref","unstructured":"Wada K, Itoga K, Okano T, Yonemura S, Sasaki H. Hippo pathway regulation by cell morphology and stress fibers. Development. 2011; 138: 3907\u20133914.","DOI":"10.1242\/dev.070987"},{"key":"i1552-5783-59-7-3069-b24","doi-asserted-by":"crossref","unstructured":"Codelia VA, Sun G, Irvine KD. Regulation of YAP by mechanical strain through Jnk and Hippo signaling. Curr Biol. 2014; 24: 2012\u20132017.","DOI":"10.1016\/j.cub.2014.07.034"},{"key":"i1552-5783-59-7-3069-b25","doi-asserted-by":"crossref","unstructured":"Meng Z, Moroishi T, Guan KL. Mechanisms of Hippo pathway regulation. Genes Dev. 2016; 30: 1\u201317.","DOI":"10.1101\/gad.274027.115"},{"key":"i1552-5783-59-7-3069-b26","doi-asserted-by":"crossref","unstructured":"Zhao B, Ye X, Yu J, et al. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev. 2008; 22: 1962\u20131971.","DOI":"10.1101\/gad.1664408"},{"key":"i1552-5783-59-7-3069-b27","doi-asserted-by":"crossref","unstructured":"Zhang H, Pasolli HA, Fuchs E. Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin. Proc Natl Acad Sci U S A. 2011; 108: 2270\u20132275.","DOI":"10.1073\/pnas.1019603108"},{"key":"i1552-5783-59-7-3069-b28","doi-asserted-by":"crossref","unstructured":"Rosenbluh J, Nijhawan D, Cox AG, et al. \u00df-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. Cell. 2012; 151: 1457\u20131473.","DOI":"10.1016\/j.cell.2012.11.026"},{"key":"i1552-5783-59-7-3069-b29","doi-asserted-by":"crossref","unstructured":"Zhang J, Ji JY, Yu M, et al. YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway. Nat Cell Biol. 2009; 11: 1444\u20131450.","DOI":"10.1038\/ncb1993"},{"key":"i1552-5783-59-7-3069-b30","doi-asserted-by":"crossref","unstructured":"Xu MZ, Chan SW, Liu AM, et al. AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma. Oncogene. 2011; 30: 1229\u20131240.","DOI":"10.1038\/onc.2010.504"},{"key":"i1552-5783-59-7-3069-b31","doi-asserted-by":"crossref","unstructured":"Zhu C, Li L, Zhao B. The regulation and function of YAP transcription co-activator. Acta Biochim Biophys Sin (Shanghai). 2015; 47: 16\u201328.","DOI":"10.1093\/abbs\/gmu110"},{"key":"i1552-5783-59-7-3069-b32","doi-asserted-by":"crossref","unstructured":"Tripathi RC, Li J, Chan WF, Tripathi BJ. Aqueous humor in glaucomatous eyes contains an increased level of TGF-beta 2. Exp Eye Res. 1994; 59: 723\u2013727.","DOI":"10.1006\/exer.1994.1158"},{"key":"i1552-5783-59-7-3069-b33","doi-asserted-by":"crossref","unstructured":"Jampel HD, Roche N, Stark WJ, Roberts AB. Transforming growth factor-beta in human aqueous humor. Curr Eye Res. 1990; 9: 963\u2013969.","DOI":"10.3109\/02713689009069932"},{"key":"i1552-5783-59-7-3069-b34","doi-asserted-by":"crossref","unstructured":"Chen WS, Cao Z, Krishnan C, Panjwani N. Verteporfin without light stimulation inhibits YAP activation in trabecular meshwork cells: implications for glaucoma treatment. Biochem Biophys Res Commun. 2015; 466: 221\u2013225.","DOI":"10.1016\/j.bbrc.2015.09.012"},{"key":"i1552-5783-59-7-3069-b35","doi-asserted-by":"crossref","unstructured":"Kimura TE, Duggirala A, Smith MC, et al. The Hippo pathway mediates inhibition of vascular smooth muscle cell proliferation by cAMP. J Mol Cell Cardiol. 2016; 90: 1\u201310.","DOI":"10.1016\/j.yjmcc.2015.11.024"},{"key":"i1552-5783-59-7-3069-b36","doi-asserted-by":"crossref","unstructured":"Futakuchi A, Inoue T, Fujimoto T, Inoue-Mochita M, Kawai M, Tanihara H. The effects of ripasudil (K-115), a Rho kinase inhibitor, on activation of human conjunctival fibroblasts. Exp Eye Res. 2016; 149: 107\u2013115.","DOI":"10.1016\/j.exer.2016.07.001"},{"key":"i1552-5783-59-7-3069-b37","doi-asserted-by":"crossref","unstructured":"Fujimoto T, Inoue T, Kameda T, et al. Involvement of RhoA\/Rho-associated kinase signal transduction pathway in dexamethasone-induced alterations in aqueous outflow. Invest Ophthalmol Vis Sci. 2012; 53: 7097\u20137108.","DOI":"10.1167\/iovs.12-9989"},{"key":"i1552-5783-59-7-3069-b38","unstructured":"Nakamura Y, Hirano S, Suzuki K, Seki K, Sagara T, Nishida T. Signaling mechanism of TGF-beta1-induced collagen contraction mediated by bovine trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2002; 43: 3465\u20133472."},{"key":"i1552-5783-59-7-3069-b39","doi-asserted-by":"crossref","unstructured":"Hamel W, Dazin P, Israel MA. Adaptation of a simple flow cytometric assay to identify different stages during apoptosis. Cytometry. 1996; 25: 173\u2013181.","DOI":"10.1002\/(SICI)1097-0320(19961001)25:2<173::AID-CYTO6>3.0.CO;2-I"},{"key":"i1552-5783-59-7-3069-b40","doi-asserted-by":"crossref","unstructured":"Futakuchi A, Inoue T, Fujimoto T, et al. Molecular mechanisms underlying the filtration bleb-maintaining effects of suberoylanilide hydroxamic acid (SAHA). Invest Ophthalmol Vis Sci. 2017; 58: 2421\u20132429.","DOI":"10.1167\/iovs.16-21403"},{"key":"i1552-5783-59-7-3069-b41","doi-asserted-by":"crossref","unstructured":"Whitman M. Smads and early developmental signaling by the TGFbeta superfamily. Genes Dev. 1998; 12: 2445\u20132462.","DOI":"10.1101\/gad.12.16.2445"},{"key":"i1552-5783-59-7-3069-b42","doi-asserted-by":"crossref","unstructured":"Grannas K, Arng\u00e5rden L, L\u00f6nn P, et al. Crosstalk between Hippo and TGF\u00df: subcellular localization of YAP\/TAZ\/Smad complexes. J Mol Biol. 2015; 427: 3407\u20133415.","DOI":"10.1016\/j.jmb.2015.04.015"},{"key":"i1552-5783-59-7-3069-b43","doi-asserted-by":"crossref","unstructured":"Wallace DM, Murphy-Ullrich JE, Downs JC, O'Brien CJ. The role of matricellular proteins in glaucoma. Matrix Biol. 2014; 37: 174\u2013182.","DOI":"10.1016\/j.matbio.2014.03.007"},{"key":"i1552-5783-59-7-3069-b44","unstructured":"Granville DJ, Hunt DW. Porphyrin-mediated photosensitization\u2014taking the apoptosis fast lane. Curr Opin Drug Discov Devel. 2000; 3: 232\u2013243."},{"key":"i1552-5783-59-7-3069-b45","doi-asserted-by":"crossref","unstructured":"Meng XM, Nikolic-Paterson DJ, Lan HY. TGF-\u00df: the master regulator of fibrosis. Nat Rev Nephrol. 2016; 12: 325\u2013338.","DOI":"10.1038\/nrneph.2016.48"},{"key":"i1552-5783-59-7-3069-b46","doi-asserted-by":"crossref","unstructured":"Razzaque MS, Foster CS, Ahmed AR. Role of collagen-binding heat shock protein and transforming growth factor-beta1 in conjunctival scarring in ocular cicatricial pemphigoid. Invest Ophthalmol Vis Sci. 2003; 44: 1616\u20131621.","DOI":"10.1167\/iovs.02-0644"},{"key":"i1552-5783-59-7-3069-b47","doi-asserted-by":"crossref","unstructured":"Razzaque MS, Foster CS, Ahmed AR. Role of connective tissue growth factor in the pathogenesis of conjunctival scarring in ocular cicatricial pemphigoid. Invest Ophthalmol Vis Sci. 2003; 44: 1998\u20132003.","DOI":"10.1167\/iovs.02-0967"},{"key":"i1552-5783-59-7-3069-b48","unstructured":"Pasquale LR, Dorman-Pease ME, Lutty GA, Quigley HA, Jampel HD. Immunolocalization of TGF-beta 1, TGF-beta 2, and TGF-beta 3 in the anterior segment of the human eye. Invest Ophthalmol Vis Sci. 1993; 34: 23\u201330."},{"key":"i1552-5783-59-7-3069-b49","doi-asserted-by":"crossref","unstructured":"Hinz B. Tissue stiffness, latent TGF-beta1 activation, and mechanical signal transduction: implications for the pathogenesis and treatment of fibrosis. Curr Rheumatol Rep. 2009; 11: 120\u2013126.","DOI":"10.1007\/s11926-009-0017-1"},{"key":"i1552-5783-59-7-3069-b50","doi-asserted-by":"crossref","unstructured":"Lai CF, Lin SL, Chiang WC, et al. Blockade of cysteine-rich protein 61 attenuates renal inflammation and fibrosis after ischemic kidney injury. Am J Physiol Renal Physiol. 2014; 307: F581\u2013F592.","DOI":"10.1152\/ajprenal.00670.2013"},{"key":"i1552-5783-59-7-3069-b51","doi-asserted-by":"crossref","unstructured":"Leask A, Holmes A, Abraham DJ. Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis. Curr Rheumatol Rep. 2002; 4: 136\u2013142.","DOI":"10.1007\/s11926-002-0009-x"},{"key":"i1552-5783-59-7-3069-b52","doi-asserted-by":"crossref","unstructured":"Hong JH, Hwang ES, McManus MT, et al. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science. 2005; 309: 1074\u20131078.","DOI":"10.1126\/science.1110955"},{"key":"i1552-5783-59-7-3069-b53","doi-asserted-by":"crossref","unstructured":"Hayashi H, Higashi T, Yokoyama N, et al. An imbalance in TAZ and YAP expression in hepatocellular carcinoma confers cancer stem cell-like behaviors contributing to disease progression. Cancer Res. 2015; 75: 4985\u20134997.","DOI":"10.1158\/0008-5472.CAN-15-0291"},{"key":"i1552-5783-59-7-3069-b54","doi-asserted-by":"crossref","unstructured":"Morin-Kensicki EM, Boone BN, Howell M, et al. Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65. Mol Cell Biol. 2006; 26: 77\u201387.","DOI":"10.1128\/MCB.26.1.77-87.2006"},{"key":"i1552-5783-59-7-3069-b55","doi-asserted-by":"crossref","unstructured":"Makita R, Uchijima Y, Nishiyama K, et al . Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ. Am J Physiol Renal Physiol. 2008; 294: F542\u2013F553.","DOI":"10.1152\/ajprenal.00201.2007"},{"key":"i1552-5783-59-7-3069-b56","doi-asserted-by":"crossref","unstructured":"Hossain Z, Ali SM, Ko HL, et al. Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1. Proc Natl Acad Sci U S A. 2007; 104: 1631\u20131636.","DOI":"10.1073\/pnas.0605266104"},{"key":"i1552-5783-59-7-3069-b57","doi-asserted-by":"crossref","unstructured":"Guo L, Teng L. YAP\/TAZ for cancer therapy: opportunities and challenges (review). Int J Oncol. 2015; 46: 1444\u20131452.","DOI":"10.3892\/ijo.2015.2877"},{"key":"i1552-5783-59-7-3069-b58","doi-asserted-by":"crossref","unstructured":"Varelas X, Sakuma R, Samavarchi-Tehrani P, et al. TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat Cell Biol. 2008; 10: 837\u2013848.","DOI":"10.1038\/ncb1748"},{"key":"i1552-5783-59-7-3069-b59","doi-asserted-by":"crossref","unstructured":"Cohen JS, Greff LJ, Novack GD, Wind BE. A placebo-controlled, double-masked evaluation of mitomycin C in combined glaucoma and cataract procedures. Ophthalmology. 1996; 103: 1934\u20131942.","DOI":"10.1016\/S0161-6420(96)30405-3"},{"key":"i1552-5783-59-7-3069-b60","doi-asserted-by":"crossref","unstructured":"The Fluorouracil Filtering Surgery Study Group. Five-year follow-up of the Fluorouracil Filtering Surgery Study. Am J Ophthalmol. 1996; 121: 349\u2013366.","DOI":"10.1016\/S0002-9394(14)70431-3"},{"key":"i1552-5783-59-7-3069-b61","unstructured":"Cordeiro MF, Gay JA, Khaw PT. Human anti-transforming growth factor-beta2 antibody: a new glaucoma anti-scarring agent. Invest Ophthalmol Vis Sci. 1999; 40: 2225\u20132234."},{"key":"i1552-5783-59-7-3069-b62","unstructured":"Nakamura H, Siddiqui SS, Shen X, et al. RNA interference targeting transforming growth factor-beta type II receptor suppresses ocular inflammation and fibrosis. Mol Vis. 2004; 10: 703\u2013711."},{"key":"i1552-5783-59-7-3069-b63","doi-asserted-by":"crossref","unstructured":"Grisanti S, Szurman P, Warga M, et al. Decorin modulates wound healing in experimental glaucoma filtration surgery: a pilot study. Invest Ophthalmol Vis Sci. 2005; 46: 191\u2013196.","DOI":"10.1167\/iovs.04-0902"},{"key":"i1552-5783-59-7-3069-b64","doi-asserted-by":"crossref","unstructured":"Khaw P , Grehn F , Hollo G , et al .; CAT-152 0102 Trabeculectomy Study Group. A phase III study of subconjunctival human anti-transforming growth factor beta(2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy. Ophthalmology. 2007; 114: 1822\u20131830.","DOI":"10.1016\/j.ophtha.2007.03.050"},{"key":"i1552-5783-59-7-3069-b65","doi-asserted-by":"crossref","unstructured":"Michels S, Schmidt-Erfurth U. Photodynamic therapy with verteporfin: a new treatment in ophthalmology. Semin Ophthalmol. 2001; 16: 201\u2013206.","DOI":"10.1076\/soph.16.4.201.10298"},{"key":"i1552-5783-59-7-3069-b66","doi-asserted-by":"crossref","unstructured":"Connor TB Jr, Roberts AB, Sporn MB, et al. Correlation of fibrosis and transforming growth factor-beta type 2 levels in the eye. J Clin Invest. 1989; 83: 1661\u20131666.","DOI":"10.1172\/JCI114065"},{"key":"i1552-5783-59-7-3069-b67","unstructured":"Tandon A, Tovey JC, Sharma A, Gupta R, Mohan RR. Role of transforming growth factor beta in corneal function, biology and pathology. Curr Mol Med. 2010; 10: 565\u2013578."}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2685920","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:30:54Z","timestamp":1791927054000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.18-24258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,19]]},"references-count":67,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,6,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.18-24258","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6,19]]}}}