{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:57:59Z","timestamp":1791928679023,"version":"4.3.4"},"reference-count":43,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"10","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2018,8,1]]},"DOI":"10.1167\/iovs.18-24320","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T03:32:51Z","timestamp":1533267171000},"page":"3932","source":"Crossref","is-referenced-by-count":16,"title":["Oxygen-Induced Retinopathy and Choroidopathy: In Vivo Longitudinal Observation of Vascular Changes Using OCTA"],"prefix":"10.1167","volume":"59","author":[{"given":"Yongjoo","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Yuseong-gu, Daejeon, Republic of Korea"},{"name":"KI for Health Science and Technology, Korea Advanced Institute of Science and Technology (KAIST), Yuseong-gu, Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Kyoung","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital (SNUBH), Seongnam, Gyeongi-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang Ryul","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Yuseong-gu, Daejeon, Republic of Korea"},{"name":"KI for Health Science and Technology, Korea Advanced Institute of Science and Technology (KAIST), Yuseong-gu, Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WooJhon","family":"Choi","sequence":"additional","affiliation":[{"name":"KI for Health Science and Technology, Korea Advanced Institute of Science and Technology (KAIST), Yuseong-gu, Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Joon","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital (SNUBH), Seongnam, Gyeongi-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Hyung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital (SNUBH), Seongnam, Gyeongi-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang-Yuhl","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Yuseong-gu, Daejeon, Republic of Korea"},{"name":"KI for Health Science and Technology, Korea Advanced Institute of Science and Technology (KAIST), Yuseong-gu, Daejeon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-59-10-3932-b01","doi-asserted-by":"crossref","unstructured":"Ashton N, Ward B, Serpell G. Effect of oxygen on developing retinal vessels with particular reference to the problem of retrolental fibroplasia. Br J Ophthalmol. 1954; 38: 397\u2013432.","DOI":"10.1136\/bjo.38.7.397"},{"key":"i1552-5783-59-10-3932-b02","unstructured":"McLeod DS, Brownstein R, Lutty GA. Vaso-obliteration in the canine model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 1996; 37: 300\u2013311."},{"key":"i1552-5783-59-10-3932-b03","unstructured":"Smith LE, Wesolowski E, McLellan A, et al. Oxygen-induced retinopathy in the mouse. Invest Ophthalmol Vis Sci. 1994; 35: 101\u2013111."},{"key":"i1552-5783-59-10-3932-b04","unstructured":"Penn JS, Tolman BL, Lowery LA. Variable oxygen exposure causes preretinal neovascularization in the newborn rat. Invest Ophthalmol Vis Sci. 1993; 34: 576\u2013585."},{"key":"i1552-5783-59-10-3932-b05","doi-asserted-by":"crossref","unstructured":"Danis RP, Davis MD. Proliferative diabetic retinopathy. In: Duh EJ, ed. Diabetic Retinopathy. Totowa, NJ: Humana Press; 2008: 29\u201365.","DOI":"10.1007\/978-1-59745-563-3_2"},{"key":"i1552-5783-59-10-3932-b06","doi-asserted-by":"crossref","unstructured":"Branch Vein Occlusion Study Group. Argon laser scatter photocoagulation for prevention of neovascularization and vitreous hemorrhage in branch vein occlusion. A randomized clinical trial. Arch Ophthalmol 1986; 104: 34\u201341.","DOI":"10.1001\/archopht.1986.01050130044017"},{"key":"i1552-5783-59-10-3932-b07","doi-asserted-by":"crossref","unstructured":"Scott A, Fruttiger M. Oxygen-induced retinopathy: a model for vascular pathology in the retina. Eye (Lond). 2010; 24: 416\u2013421.","DOI":"10.1038\/eye.2009.306"},{"key":"i1552-5783-59-10-3932-b08","doi-asserted-by":"crossref","unstructured":"Grossniklaus HE, Kang SJ, Berglin L. Animal models of choroidal and retinal neovascularization. Prog Retin Eye Res. 2010; 29: 500\u2013519.","DOI":"10.1016\/j.preteyeres.2010.05.003"},{"key":"i1552-5783-59-10-3932-b09","unstructured":"Larrazabal LI, Penn JS. Fluorescein angiography of the newborn rat. Implications in oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 1990; 31: 810\u2013818."},{"key":"i1552-5783-59-10-3932-b10","doi-asserted-by":"crossref","unstructured":"Mezu-Ndubuisi OJ, Teng PY, Wanek J, et al. In vivo retinal vascular oxygen tension imaging and fluorescein angiography in the mouse model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2013; 54: 6968\u20136972.","DOI":"10.1167\/iovs.13-12126"},{"key":"i1552-5783-59-10-3932-b11","doi-asserted-by":"crossref","unstructured":"Mezu-Ndubuisi OJ. In vivo angiography quantifies oxygen-induced retinopathy vascular recovery. Optom Vis Sci. 2016; 93: 1268\u20131279.","DOI":"10.1097\/OPX.0000000000000941"},{"key":"i1552-5783-59-10-3932-b12","doi-asserted-by":"crossref","unstructured":"Higgins RD, Yu K, Sanders RJ, Nandgaonkar BN, Rotschild T, Rifkin DB. Diltiazem reduces retinal neovascularization in a mouse model of oxygen induced retinopathy. Curr Eye Res. 1999; 18: 20\u201327.","DOI":"10.1076\/ceyr.18.1.20.5390"},{"key":"i1552-5783-59-10-3932-b13","doi-asserted-by":"crossref","unstructured":"Banin E, Dorrell MI, Aguilar E, et al. T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification. Invest Ophthalmol Vis Sci. 2006; 47: 2125\u20132134.","DOI":"10.1167\/iovs.05-1096"},{"key":"i1552-5783-59-10-3932-b14","doi-asserted-by":"crossref","unstructured":"Connor KM, Krah NM, Dennison RJ, et al. Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis. Nat Protoc. 2009; 4: 1565\u20131573.","DOI":"10.1038\/nprot.2009.187"},{"key":"i1552-5783-59-10-3932-b15","doi-asserted-by":"crossref","unstructured":"Stahl A, Connor KM, Sapieha P, et al. Computer-aided quantification of retinal neovascularization. Angiogenesis. 2009; 12: 297\u2013301.","DOI":"10.1007\/s10456-009-9155-3"},{"key":"i1552-5783-59-10-3932-b16","doi-asserted-by":"crossref","unstructured":"Moult E, Choi W, Waheed NK, et al. Ultrahigh-speed swept-source OCT angiography in exudative AMD. Ophthalmic Surg Lasers Imaging Retina. 2014; 45: 496\u2013505.","DOI":"10.3928\/23258160-20141118-03"},{"key":"i1552-5783-59-10-3932-b17","doi-asserted-by":"crossref","unstructured":"Ishibazawa A, Nagaoka T, Takahashi A, et al. Optical coherence tomography angiography in diabetic retinopathy: a prospective pilot study. Am J Ophthalmol. 2015; 160: 35\u201344 e1.","DOI":"10.1016\/j.ajo.2015.04.021"},{"key":"i1552-5783-59-10-3932-b18","doi-asserted-by":"crossref","unstructured":"Jia Y, Wei E, Wang X, et al. Optical coherence tomography angiography of optic disc perfusion in glaucoma. Ophthalmology. 2014; 121: 1322\u20131332.","DOI":"10.1016\/j.ophtha.2014.01.021"},{"key":"i1552-5783-59-10-3932-b19","doi-asserted-by":"crossref","unstructured":"Liu W, Li H, Shah RS, et al. Simultaneous optical coherence tomography angiography and fluorescein angiography in rodents with normal retina and laser-induced choroidal neovascularization. Opt Lett. 2015; 40: 5782\u20135785.","DOI":"10.1364\/OL.40.005782"},{"key":"i1552-5783-59-10-3932-b20","doi-asserted-by":"crossref","unstructured":"Park JR, Choi W, Hong HK, et al. Imaging laser-induced choroidal neovascularization in the rodent retina using optical coherence tomography angiography. Invest Ophthalmol Vis Sci. 2016; 57: OCT331\u2013OCT340.","DOI":"10.1167\/iovs.15-18946"},{"key":"i1552-5783-59-10-3932-b21","doi-asserted-by":"crossref","unstructured":"Zhi Z, Cepurna WO, Johnson EC, Morrison JC, Wang RK. Impact of intraocular pressure on changes of blood flow in the retina, choroid, and optic nerve head in rats investigated by optical microangiography. Biomed Opt Express. 2012; 3: 2220\u20132233.","DOI":"10.1364\/BOE.3.002220"},{"key":"i1552-5783-59-10-3932-b22","doi-asserted-by":"crossref","unstructured":"Soetikno BT, Shu X, Liu Q, et al. Optical coherence tomography angiography of retinal vascular occlusions produced by imaging-guided laser photocoagulation. Biomed Opt Express. 2017; 8: 3571\u20133582.","DOI":"10.1364\/BOE.8.003571"},{"key":"i1552-5783-59-10-3932-b23","doi-asserted-by":"crossref","unstructured":"Deliyanti D, Miller AG, Tan G, Binger KJ, Samson AL, Wilkinson-Berka JL. Neovascularization is attenuated with aldosterone synthase inhibition in rats with retinopathy. Hypertension. 2012; 59: 607\u2013613.","DOI":"10.1161\/HYPERTENSIONAHA.111.188136"},{"key":"i1552-5783-59-10-3932-b24","doi-asserted-by":"crossref","unstructured":"Varma SD, Chand D, Sharma YR, Kuck JF Jr, Richards RD. Oxidative stress on lens and cataract formation: role of light and oxygen. Curr Eye Res. 1984; 3: 35\u201357.","DOI":"10.3109\/02713688408997186"},{"key":"i1552-5783-59-10-3932-b25","unstructured":"Guillet R, Wyatt J, Baggs RB, Kellogg CK. Anesthetic-induced corneal lesions in developmentally sensitive rats. Invest Ophthalmol Vis Sci. 1988; 29: 949\u2013954."},{"key":"i1552-5783-59-10-3932-b26","unstructured":"Turner PV, Albassam MA. Susceptibility of rats to corneal lesions after injectable anesthesia. Comp Med. 2005; 55: 175\u2013182."},{"key":"i1552-5783-59-10-3932-b27","doi-asserted-by":"crossref","unstructured":"Guizar-Sicairos M, Thurman ST, Fienup JR. Efficient subpixel image registration algorithms. Opt Lett. 2008; 33: 156\u2013158.","DOI":"10.1364\/OL.33.000156"},{"key":"i1552-5783-59-10-3932-b28","doi-asserted-by":"crossref","unstructured":"Lee J, Jiang JY, Wu W, Lesage F, Boas DA. Statistical intensity variation analysis for rapid volumetric imaging of capillary network flux. Biomed Opt Express. 2014; 5: 1160\u20131172.","DOI":"10.1364\/BOE.5.001160"},{"key":"i1552-5783-59-10-3932-b29","doi-asserted-by":"crossref","unstructured":"Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis. Nat Methods. 2012; 9: 671\u2013675.","DOI":"10.1038\/nmeth.2089"},{"key":"i1552-5783-59-10-3932-b30","doi-asserted-by":"crossref","unstructured":"Stahl A, Connor KM, Sapieha P, et al. The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci. 2010; 51: 2813\u20132826.","DOI":"10.1167\/iovs.10-5176"},{"key":"i1552-5783-59-10-3932-b31","doi-asserted-by":"crossref","unstructured":"Li R, Yang X, Wang Y, et al. Effect(s) of preterm birth on normal retinal vascular development and oxygen-induced retinopathy in the neonatal rat. Curr Eye Res. 2013; 38: 1266\u20131273.","DOI":"10.3109\/02713683.2013.813556"},{"key":"i1552-5783-59-10-3932-b32","doi-asserted-by":"crossref","unstructured":"Guaiquil VH, Hewing NJ, Chiang MF, Rosenblatt MI, Chan RV, Blobel CP. A murine model for retinopathy of prematurity identifies endothelial cell proliferation as a potential mechanism for plus disease. Invest Ophthalmol Vis Sci. 2013; 54: 5294\u20135302.","DOI":"10.1167\/iovs.12-11492"},{"key":"i1552-5783-59-10-3932-b33","doi-asserted-by":"crossref","unstructured":"Beauchamp MH, Sennlaub F, Speranza G, et al. Redox-dependent effects of nitric oxide on microvascular integrity in oxygen-induced retinopathy. Free Radic Biol Med. 2004; 37: 1885\u20131894.","DOI":"10.1016\/j.freeradbiomed.2004.09.008"},{"key":"i1552-5783-59-10-3932-b34","doi-asserted-by":"crossref","unstructured":"Gu XL, El-Remessy AB, Brooks SE, Al-Shabrawey M, Tsai NT, Caldwell RB. Hyperoxia induces retinal vascular endothelial cell apoptosis through formation of peroxynitrite. Am J Physiol Cell Physiol. 2003; 285: C546\u2013C554.","DOI":"10.1152\/ajpcell.00424.2002"},{"key":"i1552-5783-59-10-3932-b35","doi-asserted-by":"crossref","unstructured":"Pierce EA, Foley ED, Smith LEH. Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity. Arch Ophthalmol. 1996; 114: 1219\u20131228.","DOI":"10.1001\/archopht.1996.01100140419009"},{"key":"i1552-5783-59-10-3932-b36","doi-asserted-by":"crossref","unstructured":"Wangsa-Wirawan ND, Linsenmeier RA. Retinal oxygen: fundamental and clinical aspects. Arch Ophthalmol. 2003; 121: 547\u2013557.","DOI":"10.1001\/archopht.121.4.547"},{"key":"i1552-5783-59-10-3932-b37","unstructured":"Penn JS, Tolman BL, Henry MM. Oxygen-induced retinopathy in the rat: relationship of retinal nonperfusion to subsequent neovascularization. Invest Ophthalmol Vis Sci. 1994; 35: 3429\u20133435."},{"key":"i1552-5783-59-10-3932-b38","doi-asserted-by":"crossref","unstructured":"Shao Z, Dorfman AL, Seshadri S, et al. Choroidal involution is a key component of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2011; 52: 6238\u20136248.","DOI":"10.1167\/iovs.10-6742"},{"key":"i1552-5783-59-10-3932-b39","doi-asserted-by":"crossref","unstructured":"Calderone L, Grimes P, Shalev M. Acute reversible cataract induced by xylazine and by ketamine-xylazine anesthesia in rats and mice. Exp Eye Res. 1986; 42: 331\u2013337.","DOI":"10.1016\/0014-4835(86)90026-6"},{"key":"i1552-5783-59-10-3932-b40","doi-asserted-by":"crossref","unstructured":"Penn JS, Henry MM, Tolman BL. Exposure to alternating hypoxia and hyperoxia causes severe proliferative retinopathy in the newborn rat. Pediatr Res. 1994; 36: 724\u2013731.","DOI":"10.1203\/00006450-199412000-00007"},{"key":"i1552-5783-59-10-3932-b41","unstructured":"Reynaud X, Dorey CK. Extraretinal neovascularization induced by hypoxic episodes in the neonatal rat. Invest Ophthalmol Vis Sci. 1994; 35: 3169\u20133177."},{"key":"i1552-5783-59-10-3932-b42","doi-asserted-by":"crossref","unstructured":"Gao GQ, Li Y, Fant J, Crosson CE, Becerra SP, Ma JX. Difference in ischemic regulation of vascular endothelial growth factor and pigment epithelium-derived factor in Brown Norway and Sprague Dawley rats contributing to different susceptibilities to retinal neovascularization. Diabetes. 2002; 51: 1218\u20131225.","DOI":"10.2337\/diabetes.51.4.1218"},{"key":"i1552-5783-59-10-3932-b43","doi-asserted-by":"crossref","unstructured":"van Wijngaarden P, Coster DJ, Brereton HM, Gibbins IL, Williams KA. Strain-dependent differences in oxygen-induced retinopathy in the inbred rat. Invest Ophthalmol Vis Sci. 2005; 46: 1445\u20131452.","DOI":"10.1167\/iovs.04-0708"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2696448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:30:56Z","timestamp":1791927056000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.18-24320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,1]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,8,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.18-24320","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8,1]]}}}