{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:57:49Z","timestamp":1791928669021,"version":"4.3.4"},"reference-count":58,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"8","license":[{"start":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T00:00:00Z","timestamp":1530489600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2018,7,2]]},"DOI":"10.1167\/iovs.18-24518","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T12:56:31Z","timestamp":1530536191000},"page":"3209","source":"Crossref","is-referenced-by-count":29,"title":["Cone Vision Changes in the Enhanced S-Cone Syndrome Caused by\n                    <i>NR2E3<\/i>\n                    Gene Mutations"],"prefix":"10.1167","volume":"59","author":[{"given":"Alexandra V.","family":"Garafalo","sequence":"first","affiliation":[{"name":"Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Calzetti","sequence":"additional","affiliation":[{"name":"Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur V.","family":"Cideciyan","sequence":"additional","affiliation":[{"name":"Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro J.","family":"Roman","sequence":"additional","affiliation":[{"name":"Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supna","family":"Saxena","sequence":"additional","affiliation":[{"name":"Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Sumaroka","sequence":"additional","affiliation":[{"name":"Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Windy","family":"Choi","sequence":"additional","affiliation":[{"name":"Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan F.","family":"Wright","sequence":"additional","affiliation":[{"name":"Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel G.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-59-8-3209-b01","unstructured":"Jacobson SG, Marmor MF, Kemp CM, Knighton RW. SWS (blue) cone hypersensitivity in a newly identified retinal degeneration. Invest Ophthalmol Vis Sci. 1990; 31: 827\u2013838."},{"key":"i1552-5783-59-8-3209-b02","doi-asserted-by":"crossref","unstructured":"Marmor MF, Jacobson SG, Foerster MH, Kellner U, Weleber RG. Diagnostic clinical findings of a new syndrome with night blindness, maculopathy, and enhanced S cone sensitivity. Am J Ophthalmol. 1990; 110: 124\u2013134.","DOI":"10.1016\/S0002-9394(14)76980-6"},{"key":"i1552-5783-59-8-3209-b03","doi-asserted-by":"crossref","unstructured":"Jacobson SG, Rom\u00e1n AJ, Rom\u00e1n MI, Gass JD, Parker JA. Relatively enhanced S cone function in the Goldmann-Favre syndrome. Am J Ophthalmol. 1991; 111: 446\u2013453.","DOI":"10.1016\/S0002-9394(14)72379-7"},{"key":"i1552-5783-59-8-3209-b04","doi-asserted-by":"crossref","unstructured":"Sharon D, Sandberg MA, Caruso RC, Berson EL, Dryja TP. Shared mutations in NR2E3 in enhanced s-cone syndrome, Goldmann-Favre Syndrome, and many cases of clumped pigmentary retinal degeneration. Arch Ophthalmol. 2003; 121: 1316\u20131323.","DOI":"10.1001\/archopht.121.9.1316"},{"key":"i1552-5783-59-8-3209-b05","doi-asserted-by":"crossref","unstructured":"Audo I, Michaelides M, Robson AG, et al. Phenotypic variation in enhanced s-cone syndrome. Invest Ophthalmol Vis Sci. 2008; 49: 2082\u20132093.","DOI":"10.1167\/iovs.05-1629"},{"key":"i1552-5783-59-8-3209-b06","doi-asserted-by":"crossref","unstructured":"Schorderet DF, Escher P. NR2E3 mutations in enhanced S-cone sensitivity syndrome (ESCS), Goldmann-Favre syndrome (GFS), clumped pigmentary retinal degeneration (CPRD), and retinitis pigmentosa (RP). Hum Mutat. 2009; 30: 1475\u20131485.","DOI":"10.1002\/humu.21096"},{"key":"i1552-5783-59-8-3209-b07","doi-asserted-by":"crossref","unstructured":"Yzer S, Barbazetto I, Allikmets R, et al. Expanded clinical spectrum of enhanced S-cone syndrome. JAMA Ophthalmol. 2013; 131: 1324\u20131330.","DOI":"10.1001\/jamaophthalmol.2013.4349"},{"key":"i1552-5783-59-8-3209-b08","doi-asserted-by":"crossref","unstructured":"Hood DC, Cideciyan AV, Roman AJ, Jacobson SG. Enhanced S cone syndrome: evidence for an abnormally large number of S cones. Vision Res. 1995; 35: 1473\u20131481.","DOI":"10.1016\/0042-6989(95)98727-Q"},{"key":"i1552-5783-59-8-3209-b09","doi-asserted-by":"crossref","unstructured":"Greenstein VC, Zaidi Q, Hood DC, Spehar B, Cideciyan AV, Jacobson SG. The enhanced S cone syndrome: an analysis of receptoral and post-receptoral changes. Vision Res. 1996; 36: 3711\u20133722.","DOI":"10.1016\/0042-6989(96)00073-9"},{"key":"i1552-5783-59-8-3209-b10","doi-asserted-by":"crossref","unstructured":"Wikler KC, Rakic P. An array of early differentiating cones precedes the emergence of the photoreceptor mosaic in the fetal monkey retina. Proc Natl Acad Sci U S A. 1994; 91: 6534\u20136538.","DOI":"10.1073\/pnas.91.14.6534"},{"key":"i1552-5783-59-8-3209-b11","unstructured":"Hendrickson AE. Primate foveal development: a microcosm of current questions in neurobiology. Invest Ophthalmol Vis Sci. 1994; 35: 3129\u20133133."},{"key":"i1552-5783-59-8-3209-b12","doi-asserted-by":"crossref","unstructured":"Szel A, van Veen T, Rohlich P. Retinal cone differentiation. Nature. 1994; 370: 336.","DOI":"10.1038\/370336a0"},{"key":"i1552-5783-59-8-3209-b13","doi-asserted-by":"crossref","unstructured":"Haider NB, Jacobson SG, Cideciyan AV, et al. Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate. Nat Genet. 2000; 24: 127\u2013131.","DOI":"10.1038\/72777"},{"key":"i1552-5783-59-8-3209-b14","doi-asserted-by":"crossref","unstructured":"Cepko C. Giving in to the blues. Nat Genet. 2000; 24: 99\u2013100.","DOI":"10.1038\/72887"},{"key":"i1552-5783-59-8-3209-b15","doi-asserted-by":"crossref","unstructured":"Milam AH, Rose L, Cideciyan AV, et al. The nuclear receptor NR2E3 plays a role in human retinal photoreceptor differentiation and degeneration. Proc Natl Acad Sci U S A. 2002; 99: 473\u2013478.","DOI":"10.1073\/pnas.022533099"},{"key":"i1552-5783-59-8-3209-b16","doi-asserted-by":"crossref","unstructured":"Mollema N, Haider NB. Focus on molecules: nuclear hormone receptor Nr2e3: impact on retinal development and disease. Exp Eye Res. 2010; 91: 116\u2013117.","DOI":"10.1016\/j.exer.2010.04.013"},{"key":"i1552-5783-59-8-3209-b17","doi-asserted-by":"crossref","unstructured":"Forrest D. Swaroop A. Minireview: the role of nuclear receptors in photoreceptor differentiation and disease. Mol Endocrinol. 2012; 26: 905\u2013915.","DOI":"10.1210\/me.2012-1010"},{"key":"i1552-5783-59-8-3209-b18","unstructured":"Olivares AM, Moreno-Ramon OA, Haider NB. Role of nuclear receptors in central nervous system development and associated diseases. J Exp Neurosci. 2016; 9: 93\u2013121."},{"key":"i1552-5783-59-8-3209-b19","doi-asserted-by":"crossref","unstructured":"Zelinger L, Karakulah G, Chaitankar V, et al. Regulation of noncoding transcriptome in developing photoreceptors by rod differentiation factor NRL. Invest Ophthalmol Vis Sci. 2017; 58: 4422\u20134435.","DOI":"10.1167\/iovs.17-21805"},{"key":"i1552-5783-59-8-3209-b20","doi-asserted-by":"crossref","unstructured":"Olivares, AM, Jelcick AS, Reinecke J, et al. Multimodal regulation orchestrates normal and complex disease states in the retina. Sci Rep. 2017; 7: 690.","DOI":"10.1038\/s41598-017-00788-3"},{"key":"i1552-5783-59-8-3209-b21","doi-asserted-by":"crossref","unstructured":"Mollema NJ, Yuan Y, Jelcick AS, et al. Nuclear Receptor Rev-erb Alpha (Nr1d1) functions in concert with Nr2e3 to regulate transcriptional networks in the retina. PLoS One. 2011; 6: e17494.","DOI":"10.1371\/journal.pone.0017494"},{"key":"i1552-5783-59-8-3209-b22","doi-asserted-by":"crossref","unstructured":"Cruz NM, Yuan Y, Leehy BD, et al. Modifier genes as therapeutics: the nuclear hormone receptor Rev Erb alpha (Nr1d1) rescues Nr2e3 associated retinal disease. PLoS One. 2014; 9: e87942.","DOI":"10.1371\/journal.pone.0087942"},{"key":"i1552-5783-59-8-3209-b23","doi-asserted-by":"crossref","unstructured":"Jacobson SG, Yagasaki K, Feuer WJ, Roman AJ. Interocular asymmetry of visual function in heterozygotes of X-linked retinitis pigmentosa. Exp Eye Res. 1989; 48: 679\u2013691.","DOI":"10.1016\/0014-4835(89)90009-2"},{"key":"i1552-5783-59-8-3209-b24","doi-asserted-by":"crossref","unstructured":"Wright AF, Reddick AC, Schwartz SB, et al. Mutation analysis of NR2E3 and NRL genes in Enhanced S Cone Syndrome. Hum Mutat. 2004; 24: 439.","DOI":"10.1002\/humu.9285"},{"key":"i1552-5783-59-8-3209-b25","doi-asserted-by":"crossref","unstructured":"Grover S, Fishman GA, Brown J Jr. Patterns of visual field progression in patients with retinitis pigmentosa. Ophthalmology. 1998; 105: 1069\u20131075.","DOI":"10.1016\/S0161-6420(98)96009-2"},{"key":"i1552-5783-59-8-3209-b26","doi-asserted-by":"crossref","unstructured":"Herrera W, Aleman TS, Cideciyan AV, et al. Retinal disease in Usher syndrome III caused by mutations in the clarin-1 gene. Invest Ophthalmol Vis Sci. 2008; 49: 2651\u20132660.","DOI":"10.1167\/iovs.07-1505"},{"key":"i1552-5783-59-8-3209-b27","doi-asserted-by":"crossref","unstructured":"Stone EM, Luo X, Heon E, et al. Autosomal recessive retinitis pigmentosa caused by mutations in the MAK gene. Invest Ophthalmol Vis Sci. 2011; 52: 9665\u20139673.","DOI":"10.1167\/iovs.11-8527"},{"key":"i1552-5783-59-8-3209-b28","doi-asserted-by":"crossref","unstructured":"McGuigan DB, Heon E, Cideciyan AV, et al. EYS mutations causing autosomal recessive retinitis pigmentosa: changes of retinal structure and function with disease progression. Genes (Basel). 2017; 8: 178.","DOI":"10.3390\/genes8070178"},{"key":"i1552-5783-59-8-3209-b29","doi-asserted-by":"crossref","unstructured":"Pachydaki SI, Klaver CC, Barbazetto IA, et al. Phenotypic features of patients with NR2E3 mutations. Arch Ophthalmol. 2009; 127: 71\u201375.","DOI":"10.1001\/archophthalmol.2008.534"},{"key":"i1552-5783-59-8-3209-b30","doi-asserted-by":"crossref","unstructured":"Matsui R, Cideciyan AV, Schwartz SB, et al. Molecular heterogeneity within the clinical diagnosis of pericentral retinal degeneration. Invest Ophthalmol Vis Sci. 2015; 56: 6007\u20136018.","DOI":"10.1167\/iovs.15-17174"},{"key":"i1552-5783-59-8-3209-b31","doi-asserted-by":"crossref","unstructured":"Hull S, Arno G, Sergouniotis PI, et al. Clinical and molecular characterization of enhanced S-cone syndrome in children. JAMA Ophthalmol. 2014; 132: 1341\u20131349.","DOI":"10.1001\/jamaophthalmol.2014.2343"},{"key":"i1552-5783-59-8-3209-b32","doi-asserted-by":"crossref","unstructured":"Ross DF, Fishman GA, Gilbert LD, Anderson RJ. Variability of visual field measurements in normal subjects and patients with retinitis pigmentosa. Arch Ophthalmol. 1984; 102: 1004\u20131010.","DOI":"10.1001\/archopht.1984.01040030806021"},{"key":"i1552-5783-59-8-3209-b33","doi-asserted-by":"crossref","unstructured":"Roman AJ, Cideciyan AV, Schwartz SB, Olivares MB, Heon E, Jacobson SG. Intervisit variability of visual parameters in Leber congenital amaurosis caused by RPE65 mutations. Invest Ophthalmol Vis Sci. 2013; 54: 1378\u20131383.","DOI":"10.1167\/iovs.12-11341"},{"key":"i1552-5783-59-8-3209-b34","doi-asserted-by":"crossref","unstructured":"Huang WC, Wright AF, Roman AJ, et al. RPGR-associated retinal degeneration in human X-linked RP and a murine model. Invest Ophthalmol Vis Sci. 2012; 53: 5594\u20135608.","DOI":"10.1167\/iovs.12-10070"},{"key":"i1552-5783-59-8-3209-b35","unstructured":"Gouras P, MacKay C, Evers H, Eggers H. Computer assisted spectral electroretinography (CASE): a tool for examining hereditary retinal degenerations. In: Hollyfield J, LaVail M, eds. Retinal Degeneration: Experimental and Clinical Studies. New York: Alan R. Liss, Inc.; 1985: 115\u2013130."},{"key":"i1552-5783-59-8-3209-b36","unstructured":"Sandberg MA, Pawlyk BS, Berson EL. Isolation of focal rod electroretinograms from the dark-adapted human eye. Invest Ophthalmol Vis Sci. 1996; 37: 930\u2013934."},{"key":"i1552-5783-59-8-3209-b37","doi-asserted-by":"crossref","unstructured":"Bonilha VL, Fishman GA, Rayborn ME, Hollyfield JG. Retinal pathology of a patient with Goldmann-Favre syndrome. Ophthalmic Genet. 2009; 30: 172\u2013180.","DOI":"10.3109\/13816810903176765"},{"key":"i1552-5783-59-8-3209-b38","doi-asserted-by":"crossref","unstructured":"Jacobson SG, Sumaroka A, Aleman TS, et al. Nuclear receptor NR2E3 gene mutations distort human retinal laminar architecture and cause an unusual degeneration. Hum Mol Genet. 2004; 13: 1893\u20131902.","DOI":"10.1093\/hmg\/ddh198"},{"key":"i1552-5783-59-8-3209-b39","doi-asserted-by":"crossref","unstructured":"Curcio CA, Sloan KR, Kalina RE, Hendrickson AE. Human photoreceptor topography. J Comp Neurol. 1990; 292: 497\u2013523.","DOI":"10.1002\/cne.902920402"},{"key":"i1552-5783-59-8-3209-b40","doi-asserted-by":"crossref","unstructured":"Webber AL, Hodor P, Thut CJ, et al. Dual role of Nr2e3 in photoreceptor development and maintenance. Exp Eye Res. 2008 87: 35\u201348.","DOI":"10.1016\/j.exer.2008.04.006"},{"key":"i1552-5783-59-8-3209-b41","doi-asserted-by":"crossref","unstructured":"Mustafi D, Kevany BM, Genoud C, et al. Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration. FASEB J. 2011 25: 3157\u20133176.","DOI":"10.1096\/fj.11-186767"},{"key":"i1552-5783-59-8-3209-b42","doi-asserted-by":"crossref","unstructured":"Wang NK, Lai CC, Liu CH, et al. Origin of fundus hyperautofluorescent spots and their role in retinal degeneration in a mouse model of Goldmann-Favre syndrome. Dis Model Mech. 2013 6: 1113\u20131122.","DOI":"10.1242\/dmm.012112"},{"key":"i1552-5783-59-8-3209-b43","doi-asserted-by":"crossref","unstructured":"Bengtsson B, Heijl A. Diagnostic sensitivity of fast blue-yellow and standard automated perimetry in early glaucoma: a comparison between different test programs. Ophthalmology. 2006; 113: 1092\u20131097.","DOI":"10.1016\/j.ophtha.2005.12.028"},{"key":"i1552-5783-59-8-3209-b44","doi-asserted-by":"crossref","unstructured":"Jacobson SG, Voigt WJ, Parel JM, et al. Automated light- and dark-adapted perimetry for evaluating retinitis pigmentosa. Ophthalmology. 1986; 93: 1604\u20131611.","DOI":"10.1016\/S0161-6420(86)33522-X"},{"key":"i1552-5783-59-8-3209-b45","doi-asserted-by":"crossref","unstructured":"McGuigan DB, Roman AJ, Cideciyan AV, et al. Automated light- and dark-adapted perimetry for evaluating retinitis pigmentosa: filling a need to accommodate multicenter clinical trials. Invest Ophthalmol Vis Sci. 2016; 57: 3118\u20133128.","DOI":"10.1167\/iovs.16-19302"},{"key":"i1552-5783-59-8-3209-b46","doi-asserted-by":"crossref","unstructured":"Bennett LD, Klein M, Locke KG, Kiser K, Birch DG. Dark-adapted chromatic perimetry for measuring rod visual fields in patients with retinitis pigmentosa. Trans Vis Sci Tech. 2017; 6 (4): 15.","DOI":"10.1167\/tvst.6.4.15"},{"key":"i1552-5783-59-8-3209-b47","doi-asserted-by":"crossref","unstructured":"Akhmedov NB, Piriev NI, Chang B, et al. A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse. Proc Natl Acad Sci U S A. 2000; 97: 5551\u20135556.","DOI":"10.1073\/pnas.97.10.5551"},{"key":"i1552-5783-59-8-3209-b48","doi-asserted-by":"crossref","unstructured":"Corbo JC, Cepko CL. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. PLoS Genet. 2005; 1: e11.","DOI":"10.1371\/journal.pgen.0010011"},{"key":"i1552-5783-59-8-3209-b49","doi-asserted-by":"crossref","unstructured":"Haider NB, Mollema N, Gaule M, et al. Nr2e3-directed transcriptional regulation of genes involved in photoreceptor development and cell-type specific phototransduction. Exp Eye Res. 2009; 89: 365\u2013372.","DOI":"10.1016\/j.exer.2009.04.006"},{"key":"i1552-5783-59-8-3209-b50","doi-asserted-by":"crossref","unstructured":"Ueno S, Kondo M, Miyata K, et al. Physiological function of S-cone system is not enhanced in rd7 mice. Exp Eye Res. 2005; 81: 751\u2013758.","DOI":"10.1016\/j.exer.2005.04.013"},{"key":"i1552-5783-59-8-3209-b51","doi-asserted-by":"crossref","unstructured":"Haider NB, Naggert JK, Nishina PM. Excess cone cell proliferation due to lack of a functional NR2E3 causes retinal dysplasia and degeneration in rd7\/rd7 mice. Hum Mol Genet. 2001; 10: 1619\u20131626.","DOI":"10.1093\/hmg\/10.16.1619"},{"key":"i1552-5783-59-8-3209-b52","doi-asserted-by":"crossref","unstructured":"Haider NB, Demarco P, Nystuen AM, et al. The transcription factor Nr2e3 functions in retinal progenitors to suppress cone cell generation. Vis Neurosci. 2006; 23: 917\u2013929.","DOI":"10.1017\/S095252380623027X"},{"key":"i1552-5783-59-8-3209-b53","doi-asserted-by":"crossref","unstructured":"Chang B, Hawes NL, Hurd RE, Davisson MT, Nusinowitz S, Heckenlively JR. Retinal degeneration mutants in the mouse. Vision Res. 2002; 42: 517\u2013525.","DOI":"10.1016\/S0042-6989(01)00146-8"},{"key":"i1552-5783-59-8-3209-b54","doi-asserted-by":"crossref","unstructured":"Chen J, Nathans J. Genetic ablation of cone photoreceptors eliminates retinal folds in the retinal degeneration 7 (rd7) mouse. Invest Ophthalmol Vis. Sci. 2007; 48: 2799\u20132805.","DOI":"10.1167\/iovs.06-0922"},{"key":"i1552-5783-59-8-3209-b55","doi-asserted-by":"crossref","unstructured":"Wang NK, Fine HF, Chang S, et al. Cellular origin of fundus autofluorescence in patients and mice with a defective NR2E3 gene. Br J Ophthalmol. 2009; 93: 1234\u20131240.","DOI":"10.1136\/bjo.2008.153577"},{"key":"i1552-5783-59-8-3209-b56","doi-asserted-by":"crossref","unstructured":"Roger JE, Ranganath K, Zhao L, et al. Preservation of cone photoreceptors after a rapid yet transient degeneration and remodeling in cone-only Nrl-\/- mouse retina. J Neurosci. 2012; 32: 528\u2013541.","DOI":"10.1523\/JNEUROSCI.3591-11.2012"},{"key":"i1552-5783-59-8-3209-b57","doi-asserted-by":"crossref","unstructured":"Wright AF, Jacobson SG, Cideciyan AV, et al. Lifespan and mitochondrial control of neurodegeneration. Nat Genet. 2004; 36: 1153\u20131158.","DOI":"10.1038\/ng1448"},{"key":"i1552-5783-59-8-3209-b58","doi-asserted-by":"crossref","unstructured":"Cideciyan AV, Jacobson SG, Beltran WA, et al. Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement. Proc Natl Acad Sci U S A. 2013; 110: E517\u2013E525.","DOI":"10.1073\/pnas.1218933110"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2686995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:30:54Z","timestamp":1791927054000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.18-24518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,2]]},"references-count":58,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,7,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.18-24518","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7,2]]}}}